List of works - Junichiro Yamaguchi

A Highly Active 4-Siloxyproline Catalyst for Asymmetric Synthesis

A general catalyst for the β-selective C-H bond arylation of thiophenes with iodoarenes

scientific article published on 01 November 2010

Asymmetric Synthesis of a 5,7-Fused Ring System Enabled by an Intramolecular Buchner Reaction with Chiral Rhodium Catalyst

scientific article published on 06 December 2019

Branch-selective allylic C-H carboxylation of terminal alkenes by Pd/sox catalyst

scientific article published on 28 July 2014

C-H activation enables a rapid structure-activity relationship study of arylcyclopropyl amines for potent and selective LSD1 inhibitors.

scientific article published on 22 August 2016

C-H activation generates period-shortening molecules that target cryptochrome in the mammalian circadian clock.

scientific article published on 8 May 2015

C-H alkenylation of azoles with enols and esters by nickel catalysis.

scientific article published on 19 July 2013

C-H arylation and alkenylation of imidazoles by nickel catalysis: solvent-accelerated imidazole C-H activation.

scientific article

Casein kinase 1 family regulates PRR5 and TOC1 in the Arabidopsis circadian clock.

scientific article

Catalytic Deoxygenative Coupling of Aromatic Esters with Organophosphorus Compounds

scientific article published on 11 April 2020

Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth

scientific article published on 23 January 2019

Concise enantio- and diastereoselective total syntheses of fumagillol, RK-805, FR65814, ovalicin, and 5-demethylovalicin

scientific article

Concise syntheses of dictyodendrins A and F by a sequential C-H functionalization strategy

scientific article published on 6 January 2015

Cross-coupling of aromatic esters and amides.

scientific article

Cyanation of Phenol Derivatives with Aminoacetonitriles by Nickel Catalysis.

scientific article published on 12 August 2016

Dearomative Allylation of Naphthyl Cyanohydrins by Palladium Catalysis: Catalyst-Enhanced Site Selectivity

scientific article published on 09 April 2020

Decarbonylative C-H coupling of azoles and aryl esters: unprecedented nickel catalysis and application to the synthesis of muscoride A

scientific article published on 07 August 2012

Decarbonylative C-P Bond Formation Using Aromatic Esters and Organophosphorus Compounds

scientific article published on 02 February 2018

Decarbonylative Diaryl Ether Synthesis by Pd and Ni Catalysis

scientific article published on 19 February 2017

Decarbonylative Methylation of Aromatic Esters by a Nickel Catalyst

scientific article published on 08 May 2018

Decarbonylative organoboron cross-coupling of esters by nickel catalysis

scientific article

Design, synthesis and evaluation of γ-turn mimetics as LSD1-selective inhibitors

scientific article published on 2 January 2018

Determination by asymmetric total synthesis of the absolute configuration of lucilactaene, a cell-cycle inhibitor in p53-transfected cancer cells

scientific article published in May 2005

Diastereoselective total synthesis of both enantiomers of epolactaene

scientific article

Direct asymmetric alpha-amination of cyclic ketones catalyzed by siloxyproline

scientific article published in February 2008

Direct proline-catalyzed asymmetric alpha-aminoxylation of aldehydes and ketones

scientific article published in September 2004

Direct proline-catalyzed asymmetric alpha-aminoxylation of ketones

scientific article published in February 2004

Diverse modifications of the 4-methylphenyl moiety of TAK-779 by late-stage Suzuki-Miyaura cross-coupling

scientific article published on 12 November 2013

Enantio- and diastereoselective total synthesis of (+)-panepophenanthrin, a ubiquitin-activating enzyme inhibitor, and biological properties of its new derivatives.

scientific article published on December 2006

Ester dance reaction on the aromatic ring

scientific article published on 08 July 2020

Exploitation of an additional hydrophobic pocket of σ1 receptors: late-stage diverse modifications of spirocyclic thiophenes by C-H bond functionalization

scientific article published on 11 October 2011

Fe-catalyzed oxidative coupling of heteroarenes and methylamines

scientific article published on 01 September 2009

Improvement of σ1 receptor affinity by late-stage C-H-bond arylation of spirocyclic lactones

scientific article published on 31 January 2013

Isolation, structure, and reactivity of an arylnickel(II) pivalate complex in catalytic C-H/C-O biaryl coupling.

scientific article

Key mechanistic features of Ni-catalyzed C-H/C-O biaryl coupling of azoles and naphthalen-2-yl pivalates.

scientific article published on 10 October 2014

Large nonlinear effect observed in the enantiomeric excess of proline in solution and that in the solid state

scientific article published in July 2006

Late-Stage C-H Coupling Enables Rapid Identification of HDAC Inhibitors: Synthesis and Evaluation of NCH-31 Analogues

scientific article published on 3 March 2014

Manganese-catalyzed intermolecular C-H/C-H coupling of carbonyls and heteroarenes

scientific article published on 01 April 2014

Mechanistic studies on the Pd-catalyzed direct C-H arylation of 2-substituted thiophene derivatives with arylpalladium bipyridyl complexes

scientific article published on 14 February 2012

Modular synthesis of heptaarylindole

scientific article published on 01 May 2018

Ni-Catalyzed α-arylation of esters and amides with phenol derivatives

scientific article published on 27 November 2014

Nickel-Catalyzed Aromatic C-H Functionalization.

scientific article published in August 2016

Nickel-Catalyzed C–H/C–O Coupling of Azoles with Phenol Derivatives

scientific article published on 08 December 2011

Nickel-catalyzed C-H arylation of azoles with haloarenes: scope, mechanism, and applications to the synthesis of bioactive molecules

scientific article published on 08 July 2011

Nickel-catalyzed biaryl coupling of heteroarenes and aryl halides/triflates

scientific article published on 01 April 2009

Nickel-catalyzed α-arylation of ketones with phenol derivatives

scientific article published on 20 May 2014

Organocatalyst-mediated enantioselective intramolecular aldol reaction featuring the rare combination of aldehyde as nucleophile and ketone as electrophile

scientific article published on 19 July 2007

Oxidative biaryl coupling of thiophenes and thiazoles with arylboronic acids through palladium catalysis: otherwise difficult C4-selective C-H arylation enabled by boronic acids.

scientific article published on 31 January 2011

Palladium-Catalyzed Decarbonylative Cross-Coupling of Azinecarboxylates with Arylboronic Acids.

scientific article

Palladium-Catalyzed Mizoroki-Heck Reaction of Nitroarenes and Styrene Derivatives

scientific article published on 02 April 2020

Pd-Catalyzed Dearomative Allylation of Benzyl Phosphates

scientific article published on 05 July 2018

Pd-Catalyzed Decarbonylative C-H Coupling of Azoles and Aromatic Esters

scientific article published on 22 May 2018

Pd-Catalyzed Denitrative Intramolecular C-H Arylation

scientific article published on 03 June 2019

Pd-Catalyzed Direct C–H Bond Functionalization of Spirocyclic σ1 Ligands: Generation of a Pharmacophore Model and Analysis of the Reverse Binding Mode by Docking into a 3D Homology Model of the σ1 Receptor

article

Rh-catalyzed regiodivergent hydrosilylation of acyl aminocyclopropanes controlled by monophosphine ligands.

scientific article published on 15 March 2017

Stereodivergent synthesis of arylcyclopropylamines by sequential C-H borylation and Suzuki-Miyaura coupling

scientific article published on 27 October 2014

Structure-activity relationships of epolactaene derivatives: structural requirements for inhibition of Hsp60 chaperone activity.

scientific article published in September 2004

Syntheses of fumagillin and ovalicin

scientific article

Synthesis and characterization of hexaarylbenzenes with five or six different substituents enabled by programmed synthesis.

scientific article

Synthesis of 1,9-dideoxy-pre-axinellamine

scientific article published on 01 January 2008

Synthesis of Decaarylanthracene with Nine Different Substituents

scientific article published on 17 November 2020

Synthesis of Octaaryl Naphthalenes and Anthracenes with Different Substituents

scientific article published on 4 October 2017

Synthesis of Triarylpyridines in Thiopeptide Antibiotics by Using a C-H Arylation/Ring-Transformation Strategy

scientific article published on 2 February 2016

Synthesis of fully arylated (hetero)arenes

scientific article published on 10 January 2017

Synthesis of thiophene-based TAK-779 analogues by C-H arylation

scientific article

Synthesis, binding affinity and structure-activity relationships of novel, selective and dual targeting CCR2 and CCR5 receptor antagonists

scientific article published in February 2015

The AMOR Arabinogalactan Sugar Chain Induces Pollen-Tube Competency to Respond to Ovular Guidance

scientific article published on 7 April 2016

The asymmetric total synthesis of (+)-cytotrienin a, an ansamycin-type anticancer drug

scientific article published in January 2008

Theoretical Elucidation of Potential Enantioselectivity in a Pd-Catalyzed Aromatic C-H Coupling Reaction.

scientific article

Thiazole-Based σ1 Receptor Ligands: Diversity by Late-Stage C-H Arylation of Thiazoles, Structure-Affinity and Selectivity Relationships, and Molecular Interactions

scientific article published on 24 May 2017

Total synthesis of (+)-epoxyquinols A and B.

scientific article

Total synthesis of (+/-)-axinellamines A and B

scientific article published on 01 January 2008

Total synthesis of marinomycins A-C and of their monomeric counterparts monomarinomycin A and iso-monomarinomycin A.

scientific article

[Studying Abroad Led to New Friendships and New Research Directions]

scientific article published on 01 January 2019

β-Selective C-H arylation of pyrroles leading to concise syntheses of lamellarins C and I

scientific article published on 15 September 2014

σ-Bond Hydroboration of Cyclopropanes

scientific article published on 15 June 2020

List of works by Junichiro Yamaguchi

A Highly Active 4-Siloxyproline Catalyst for Asymmetric Synthesis

A general catalyst for the β-selective C-H bond arylation of thiophenes with iodoarenes

Asymmetric Synthesis of a 5,7-Fused Ring System Enabled by an Intramolecular Buchner Reaction with Chiral Rhodium Catalyst

Branch-selective allylic C-H carboxylation of terminal alkenes by Pd/sox catalyst

C-H activation enables a rapid structure-activity relationship study of arylcyclopropyl amines for potent and selective LSD1 inhibitors.

C-H activation generates period-shortening molecules that target cryptochrome in the mammalian circadian clock.

C-H alkenylation of azoles with enols and esters by nickel catalysis.

C-H arylation and alkenylation of imidazoles by nickel catalysis: solvent-accelerated imidazole C-H activation.

Casein kinase 1 family regulates PRR5 and TOC1 in the Arabidopsis circadian clock.

Catalytic Deoxygenative Coupling of Aromatic Esters with Organophosphorus Compounds

Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth

Concise enantio- and diastereoselective total syntheses of fumagillol, RK-805, FR65814, ovalicin, and 5-demethylovalicin

Concise syntheses of dictyodendrins A and F by a sequential C-H functionalization strategy

Cross-coupling of aromatic esters and amides.

Cyanation of Phenol Derivatives with Aminoacetonitriles by Nickel Catalysis.

Dearomative Allylation of Naphthyl Cyanohydrins by Palladium Catalysis: Catalyst-Enhanced Site Selectivity

Decarbonylative C-H coupling of azoles and aryl esters: unprecedented nickel catalysis and application to the synthesis of muscoride A

Decarbonylative C-P Bond Formation Using Aromatic Esters and Organophosphorus Compounds

Decarbonylative Diaryl Ether Synthesis by Pd and Ni Catalysis

Decarbonylative Methylation of Aromatic Esters by a Nickel Catalyst

Decarbonylative organoboron cross-coupling of esters by nickel catalysis

Design, synthesis and evaluation of γ-turn mimetics as LSD1-selective inhibitors

Determination by asymmetric total synthesis of the absolute configuration of lucilactaene, a cell-cycle inhibitor in p53-transfected cancer cells

Diastereoselective total synthesis of both enantiomers of epolactaene

Direct asymmetric alpha-amination of cyclic ketones catalyzed by siloxyproline

Direct proline-catalyzed asymmetric alpha-aminoxylation of aldehydes and ketones

Direct proline-catalyzed asymmetric alpha-aminoxylation of ketones

Diverse modifications of the 4-methylphenyl moiety of TAK-779 by late-stage Suzuki-Miyaura cross-coupling

Enantio- and diastereoselective total synthesis of (+)-panepophenanthrin, a ubiquitin-activating enzyme inhibitor, and biological properties of its new derivatives.

Ester dance reaction on the aromatic ring

Exploitation of an additional hydrophobic pocket of σ1 receptors: late-stage diverse modifications of spirocyclic thiophenes by C-H bond functionalization

Fe-catalyzed oxidative coupling of heteroarenes and methylamines

Improvement of σ1 receptor affinity by late-stage C-H-bond arylation of spirocyclic lactones

Isolation, structure, and reactivity of an arylnickel(II) pivalate complex in catalytic C-H/C-O biaryl coupling.

Key mechanistic features of Ni-catalyzed C-H/C-O biaryl coupling of azoles and naphthalen-2-yl pivalates.

Large nonlinear effect observed in the enantiomeric excess of proline in solution and that in the solid state

Late-Stage C-H Coupling Enables Rapid Identification of HDAC Inhibitors: Synthesis and Evaluation of NCH-31 Analogues

Manganese-catalyzed intermolecular C-H/C-H coupling of carbonyls and heteroarenes

Mechanistic studies on the Pd-catalyzed direct C-H arylation of 2-substituted thiophene derivatives with arylpalladium bipyridyl complexes

Modular synthesis of heptaarylindole

Ni-Catalyzed α-arylation of esters and amides with phenol derivatives

Nickel-Catalyzed Aromatic C-H Functionalization.

Nickel-Catalyzed C–H/C–O Coupling of Azoles with Phenol Derivatives

Nickel-catalyzed C-H arylation of azoles with haloarenes: scope, mechanism, and applications to the synthesis of bioactive molecules

Nickel-catalyzed biaryl coupling of heteroarenes and aryl halides/triflates

Nickel-catalyzed α-arylation of ketones with phenol derivatives

Organocatalyst-mediated enantioselective intramolecular aldol reaction featuring the rare combination of aldehyde as nucleophile and ketone as electrophile

Oxidative biaryl coupling of thiophenes and thiazoles with arylboronic acids through palladium catalysis: otherwise difficult C4-selective C-H arylation enabled by boronic acids.

Palladium-Catalyzed Decarbonylative Cross-Coupling of Azinecarboxylates with Arylboronic Acids.

Palladium-Catalyzed Mizoroki-Heck Reaction of Nitroarenes and Styrene Derivatives

Pd-Catalyzed Dearomative Allylation of Benzyl Phosphates

Pd-Catalyzed Decarbonylative C-H Coupling of Azoles and Aromatic Esters

Pd-Catalyzed Denitrative Intramolecular C-H Arylation

Pd-Catalyzed Direct C–H Bond Functionalization of Spirocyclic σ1 Ligands: Generation of a Pharmacophore Model and Analysis of the Reverse Binding Mode by Docking into a 3D Homology Model of the σ1 Receptor

Rh-catalyzed regiodivergent hydrosilylation of acyl aminocyclopropanes controlled by monophosphine ligands.

Stereodivergent synthesis of arylcyclopropylamines by sequential C-H borylation and Suzuki-Miyaura coupling

Structure-activity relationships of epolactaene derivatives: structural requirements for inhibition of Hsp60 chaperone activity.

Syntheses of fumagillin and ovalicin

Synthesis and characterization of hexaarylbenzenes with five or six different substituents enabled by programmed synthesis.

Synthesis of 1,9-dideoxy-pre-axinellamine

Synthesis of Decaarylanthracene with Nine Different Substituents

Synthesis of Octaaryl Naphthalenes and Anthracenes with Different Substituents

Synthesis of Triarylpyridines in Thiopeptide Antibiotics by Using a C-H Arylation/Ring-Transformation Strategy

Synthesis of fully arylated (hetero)arenes

Synthesis of thiophene-based TAK-779 analogues by C-H arylation

Synthesis, binding affinity and structure-activity relationships of novel, selective and dual targeting CCR2 and CCR5 receptor antagonists

The AMOR Arabinogalactan Sugar Chain Induces Pollen-Tube Competency to Respond to Ovular Guidance

The asymmetric total synthesis of (+)-cytotrienin a, an ansamycin-type anticancer drug

Theoretical Elucidation of Potential Enantioselectivity in a Pd-Catalyzed Aromatic C-H Coupling Reaction.

Thiazole-Based σ1 Receptor Ligands: Diversity by Late-Stage C-H Arylation of Thiazoles, Structure-Affinity and Selectivity Relationships, and Molecular Interactions

Total synthesis of (+)-epoxyquinols A and B.

Total synthesis of (+/-)-axinellamines A and B

Total synthesis of marinomycins A-C and of their monomeric counterparts monomarinomycin A and iso-monomarinomycin A.

[Studying Abroad Led to New Friendships and New Research Directions]

β-Selective C-H arylation of pyrroles leading to concise syntheses of lamellarins C and I

σ-Bond Hydroboration of Cyclopropanes