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List of works by Sébastien Lacroix-Desmazes

"Rational vaccine design" for HIV should take into account the adaptive potential of polyreactive antibodies

scientific article

A cellular viewpoint of anti-FVIII immune response in hemophilia A.

scientific article published on October 2009

A cryptic polyreactive antibody recognizes distinct clades of HIV-1 glycoprotein 120 by an identical binding mechanism

scientific article

A human FVIII inhibitor modulates FVIII surface electrostatics at a VWF-binding site distant from its epitope.

scientific article published on 30 March 2010

A novel molecular analysis of genes encoding catalytic antibodies

scientific article published on 10 February 2012

A role for exposed mannosylations in presentation of human therapeutic self-proteins to CD4+ T lymphocytes

scholarly article

Absence of a neutralizing antibody response to humanized cobra venom factor in mice.

scientific article published on 8 March 2018

Achievements, challenges and unmet needs for haemophilia patients with inhibitors: Report from a symposium in Paris, France on 20 November 2014.

scientific article published on January 2016

Acquired haemophilia A in early pregnancy associated with Plasmodium vivax malaria and hyperthyroidism

scientific article published in February 2007

Acquired protein S deficiency leads to obliterative portal venopathy and to compensatory nodular regenerative hyperplasia in HIV-infected patients

article

Activation state of platelets in experimental severe hemophilia A.

scientific article published on 14 March 2012

Affinity-purified respiratory syncytial virus antibodies from intravenous immunoglobulin exert potent antibody-dependent cellular cytotoxicity

scientific article published on 19 July 2013

Alloantibodies to therapeutic factor VIII in hemophilia A: the role of von Willebrand factor in regulating factor VIII immunogenicity

scientific article

Alterations of self-reactive antibody repertoires in HIV disease: An insight into the role of T cells in the selection of autoreactive B cells

article

Altered antibody repertoires of plasma IgM and IgG toward nonself antigens in patients with warm autoimmune hemolytic anemia

scientific article published on 01 April 2001

Altered control of self-reactive IgG by autologous IgM in patients with warm autoimmune hemolytic anemia

scientific article published on 01 January 2000

Amelioration of differentiation of dendritic cells from CVID patients by intravenous immunoglobulin

Analysis of antibody reactivities toward self antigens of IgM of patients with Waldenström's macroglobulinemia

scientific article published on 01 August 1997

Analysis of self-reactive antibody repertoires in normal pregnancy

scientific article published in June 1998

Analysis of the natural human IgG antibody repertoire: life-long stability of reactivities towards self antigens contrasts with age-dependent diversification of reactivities against bacterial antigens

scientific article published on 01 September 1995

Analysis of the normal human IgG antibody repertoire. Evidence that IgG autoantibodies of healthy adults recognize a limited and conserved set of protein antigens in homologous tissues

scientific article published on 01 June 1995

Antibodies to the FVIII light chain that neutralize FVIII procoagulant activity are present in plasma of nonresponder patients with severe hemophilia A and in normal polyclonal human IgG.

scientific article published in June 2000

Antibodies use heme as a cofactor to extend their pathogen elimination activity and to acquire new effector functions

scientific article published on 18 July 2007

Antibodies with hydrolytic activity towards factor VIII in patients with hemophilia A.

scientific article

Antibody polyreactivity in health and disease: statu variabilis

scientific article published on August 2013

Antibody profile in Indian severe haemophilia A patients with and without FVIII inhibitors

scientific article published on 30 September 2015

Antibody-mediated catalysis: induction and therapeutic relevance

scientific article

Anticorps catalytiques ou abzymes

scientific article published on 01 May 2003

Auditing protein therapeutics management by professional APCs: toward prevention of immune responses against therapeutic proteins.

scientific article published on August 2008

Autoantibodies to factor VIII with catalytic activity.

scientific article

Autoantibodies to factor VIII.

scientific article

Autoantibodies to heat shock protein 90 in the human natural antibody repertoire

scientific article published on 01 May 2002

Autoantibodies with enzymatic properties in human autoimmune diseases

scientific article

Autoimmunity as a predisposition for infectious diseases

scientific article

Bortezomib delays the onset of factor VIII inhibitors in experimental hemophilia A, but fails to eliminate established anti-factor VIII IgG-producing cells

scientific article published in April 2011

Breaking the law: unconventional strategies for antibody diversification

scientific article published on 01 June 2019

Broad alterations of self-reactive antibody-repertoires of plasma IgM and IgG in B-cell chronic lymphocytic leukemia (B-CLL) and B-CLL related target-restricted autoimmunity

scientific article published on 01 June 2001

CD4+CD25+ regulatory T cell-mediated changes in the expression of endocytic receptors and endocytosis process of human dendritic cells

scientific article published on 23 February 2011

CD4+CD25+ regulatory T cells modulate human dendritic cell chemokines via multiple mechanisms: comment on the article by Kolar et al

scientific article published on 01 September 2009

Catalytic IgG from patients with hemophilia A inactivate therapeutic factor VIII.

scientific article published in July 2006

Catalytic activity of antibodies against factor VIII in patients with hemophilia A.

scientific article published in September 1999

Catalytic antibodies and severe sepsis.

scientific article

Catalytic antibodies in patients with systemic lupus erythematosus

scientific article published on 07 August 2018

Catalytic antibodies to factor VIII in haemophilia A.

scientific article published on June 2003

Common variable immunodeficiency is associated with defective functions of dendritic cells

scientific article

Comparison of the immunogenicity of different therapeutic preparations of human factor VIII in the murine model of hemophilia A.

scientific article published in October 2007

Complement C3 is a novel modulator of the anti-FVIII immune response

scientific article published on 16 November 2017

Contribution of myeloid dendritic cells to type I interferon-induced cytokines and chemokines

scientific article published on 01 July 2010

Correction to Mechanism and Functional Implications of the Heme-Induced Binding Promiscuity of IgE

scientific article published on 03 April 2015

Cryptic polyreactivity of IgG expressed by splenic marginal zone B-cell lymphoma.

scientific article published on 24 April 2014

Cutting edge: human CD4+CD25+ T cells restrain the maturation and antigen-presenting function of dendritic cells

scientific article published in April 2004

Defective self-reactive antibody repertoire of serum IgM in patients with hyper-IgM syndrome.

scientific article published in May 1999

Dendritic Cells in Autoimmune Diseases

Dendritic cells and autoimmunity

scientific article published on March 2004

Design of clinical trials for new products in hemophilia: communication from the SSC of the ISTH.

scientific article published on 13 April 2015

Designed ankyrin repeat proteins: a new approach to mimic complex antigens for diagnostic purposes?

scientific article

Development of inhibitory antibodies to therapeutic factor VIII in severe hemophilia A is associated with microsatellite polymorphisms in the HMOX1 promoter.

scientific article published on 28 May 2013

Diversification post-traductionnelle de la spécificité des immunoglobulines

scientific article published on 20 November 2013

Do proteolytic antibodies complete the panoply of the autoimmune response in acquired haemophilia A?

scientific article published on 12 October 2011

Dynamics of factor VIII interactions determine its immunologic fate in hemophilia A.

scientific article published on 09 May 2008

Effect of IVIg on human dendritic cell-mediated antigen uptake and presentation: Role of lipid accumulation

scientific article published on 15 June 2012

Efficacy of regulatory T-cell immunotherapy: are inflammatory cytokines key determinants?

scientific article published on 01 January 2008

Emerging benefits of Fc fusion technology in the context of recombinant factor VIII replacement therapy

scientific article published on 03 September 2020

Endocytic receptor for pro-coagulant factor VIII: Relevance to inhibitor formation

scientific article published on 30 September 2010

Expansion of CD4+CD25+ regulatory T cells by intravenous immunoglobulin: a critical factor in controlling experimental autoimmune encephalomyelitis

scientific article published on 11 October 2007

Exploitation of rolling circle amplification for the construction of large phage-display antibody libraries

scientific article

Exposure of IgG to an acidic environment results in molecular modifications and in enhanced protective activity in sepsis.

scientific article published on 8 June 2010

Factor VIII bypasses CD91/LRP for endocytosis by dendritic cells leading to T-cell activation.

scientific article published in January 2008

Factor VIII hydrolysis mediated by anti-factor VIII autoantibodies in acquired hemophilia.

scientific article

Factor VIII inhibitor with catalytic activity towards factor VIII

scientific article published on 01 January 2000

Factor VIII inhibitor with catalytic activity towards factor VIII.

scientific article published in October 2000

Factor VIII-hydrolyzing IgG in acquired and congenital hemophilia

scientific article

Ferrous ions and reactive oxygen species increase antigen-binding and anti-inflammatory activities of immunoglobulin G

scientific article published on 24 October 2005

Functional variability of antibodies upon oxidative processes

scientific article published on May 2008

Gain of function of immunoglobulins after partial unfolding or cofactor binding

scientific article published on 9 April 2013

Generation of Catalytic Antibodies Is an Intrinsic Property of an Individual's Immune System: A Study on a Large Cohort of Renal Transplant Patients.

scientific article published on 11 April 2016

Haemarthrosis and arthropathy do not favour the development of factor VIII inhibitors in severe haemophilia A mice

scientific article published on 4 December 2014

Heme binds to factor VIII and inhibits its interaction with activated factor IX.

scientific article published in June 2012

Heme interacts with c1q and inhibits the classical complement pathway

scientific article

Heme: Modulator of Plasma Systems in Hemolytic Diseases

scientific article published on 11 February 2016

Heterogeneous antigen recognition behavior of induced polyspecific antibodies

scientific article published on 22 June 2010

High levels of catalytic antibodies correlate with favorable outcome in sepsis.

scientific article

Hydrolysis of coagulation factors by circulating IgG is associated with a reduced risk for chronic allograft nephropathy in renal transplanted patients

scientific article published in June 2008

IVIg treatment reduces catalytic antibody titers of renal transplanted patients

scientific article

Idiopathic membranous glomerulonephritis is associated with altered patterns of self-reactive IgM and IgG antibody repertoires

scientific article published on 01 November 2001

IgG-cleaving endopeptidase enables in vivo gene therapy in the presence of anti-AAV neutralizing antibodies

scientific article published on 01 June 2020

Immune response against therapeutic factor VIII in hemophilia A patients--a survey of probable risk factors.

scientific article published on 13 April 2007

Immunogenicity of long-lasting recombinant factor VIII products

scientific article published on 19 December 2015

Immunoglobulins and the regulation of autoimmunity through the immune network.

scientific article published on May 1996

Immunological defects after suicide gene therapy of experimental graft-versus-host disease.

scientific article

Immunomodulation by intravenous immunoglobulin: role of regulatory T cells

scientific article published on May 2010

Immunomodulation of autoimmunity by intravenous immunoglobulin through interaction with immune networks

scientific article

Immunoprotective effect of von Willebrand factor towards therapeutic factor VIII in experimental haemophilia A.

scientific article published on 2 November 2011

Impact of Antigen Density on the Binding Mechanism of IgG Antibodies

scientific article

Impact of polymorphisms of the major histocompatibility complex class II, interleukin-10, tumor necrosis factor-alpha and cytotoxic T-lymphocyte antigen-4 genes on inhibitor development in severe hemophilia A.

scientific article published in December 2009

Important parameters for evaluation of antibody avidity by immunosorbent assay

scientific article published on 26 July 2011

In silico calculated affinity of FVIII-derived peptides for HLA class II alleles predicts inhibitor development in haemophilia A patients with missense mutations in the F8 gene

scientific article published on 14 October 2013

Induction of heme oxygenase-1 in factor VIII-deficient mice reduces the immune response to therapeutic factor VIII.

scientific article published on 4 November 2009

Inhibition of differentiation, amplification, and function of human TH17 cells by intravenous immunoglobulin

scientific article published in February 2011

Inhibition of maturation and function of dendritic cells by intravenous immunoglobulin

scientific article published on 29 August 2002

Inhibitor development.

scientific article published on July 2008

Inhibitors of factor VIII in hemophilia

scientific article

Inhibitors-Recent insights

scientific article published on 30 June 2020

Inhibitory effect of IVIG on IL-17 production by Th17 cells is independent of anti-IL-17 antibodies in the immunoglobulin preparations

scientific article

Innovating immune tolerance induction for haemophilia.

scientific article

Insight into the mechanism of the acquired antibody auto-reactivity.

scientific article published on 18 April 2008

Intravenous Immunoglobulins in Autoimmune and Inflammatory Diseases: A Mechanistic Perspective

scientific article published on 01 September 2007

Intravenous gammaglobulin inhibits encephalitogenic potential of pathogenic T cells and interferes with their trafficking to the central nervous system, implicating sphingosine-1 phosphate receptor 1-mammalian target of rapamycin axis

scientific article

Intravenous immunoglobulin abrogates dendritic cell differentiation induced by interferon-? present in serum from patients with systemic lupus erythematosus

scientific article published on 01 December 2003

Intravenous immunoglobulin and dendritic cells.

scientific article

Intravenous immunoglobulin and immune response

article

Intravenous immunoglobulin for infectious diseases: back to the pre-antibiotic and passive prophylaxis era?

scientific article published on June 2004

Intravenous immunoglobulin for infectious diseases: tailor-made or universal?

scientific article published on November 2003

Intravenous immunoglobulin in autoimmune and inflammatory diseases: more than mere transfer of antibodies.

scientific article published on 31 August 2007

Intravenous immunoglobulin in autoimmune disorders: an insight into the immunoregulatory mechanisms.

scientific article

Intravenous immunoglobulin in neurological disorders: a mechanistic perspective

scientific article

Intravenous immunoglobulin induces proliferation and immunoglobulin synthesis from B cells of patients with common variable immunodeficiency: A mechanism underlying the beneficial effect of IVIg in primary immunodeficiencies

article

Intravenous immunoglobulin: an update on the clinical use and mechanisms of action.

scientific article published on 11 March 2007

Intravenous immunoglobulins in immunodeficiencies: more than mere replacement therapy

scientific article published on June 2011

Japanese encephalitis virus expands regulatory T cells by increasing the expression of PD-L1 on dendritic cells

scientific article published on 24 March 2014

Key insights to understand the immunogenicity of FVIII products.

scientific article published on 16 August 2016

Kinetics and thermodynamics of interaction of coagulation factor VIII with a pathogenic human antibody

scientific article published on 6 October 2009

Mannose-sensitive receptors mediate the uptake of factor VIII therapeutics by human dendritic cells

scientific article published on 14 February 2012

Maternally transferred anti-factor VIII IgG reduce the anti-factor VIII humoral immune response in factor VIII-deficient mice.

scientific article published in December 2010

Materno-Fetal Transfer of Preproinsulin Through the Neonatal Fc Receptor Prevents Autoimmune Diabetes

scientific article published on 27 April 2015

Mechanism and functional implications of the heme-induced binding promiscuity of IgE.

scientific article

Mechanisms of action of intravenous immunoglobulin in autoimmune and inflammatory diseases

scientific article published on 01 June 2003

Mechanisms of action of intravenous immunoglobulin in autoimmune and inflammatory diseases.

scientific article

Methods for Posttranslational Induction of Polyreactivity of Antibodies

scientific article published in January 2017

Modulation of autoimmune responses by intravenous immunoglobulin (IVIg).

scientific article published on April 1997

Modulation of dendritic cell maturation and function by B lymphocytes

scientific article

Modulation of human dendritic cell maturation and function by natural IgG antibodies

scientific article published on 07 May 2008

Molecular basis for bacterial peptidoglycan recognition by LysM domains

scientific article

Molecular characterization of human B domain-specific anti-factor VIII monoclonal antibodies generated in transgenic mice

scientific article published on 01 July 2007

Monoclonal antibody and intravenous immunoglobulin therapy for rheumatic diseases: rationale and mechanisms of action.

scientific article published on May 2007

Monoepitopic anti-FVIII T-cell response

scientific article published on 01 October 2016

Multitarget selection of catalytic antibodies with β-lactamase activity using phage display

scientific article

Natural Autoantibodies to Fcγ Receptors in Intravenous Immunoglobulins

scientific article published on 01 April 2014

Natural and Induced Antibody Polyreactivity.

scientific article published on 15 July 2015

Natural antibodies sustain differentiation and maturation of human dendritic cells

scholarly article

Natural antibodies to factor VIII.

scientific article

Natural autoantibodies: immune homeostasis and therapeutic intervention

scientific article published on 01 July 2005

Natural human polyreactive IgM induce apoptosis of lymphoid cell lines and human peripheral blood mononuclear cells.

scientific article published on March 2004

Natural recognition repertoire and the evolutionary emergence of the combinatorial immune system

scientific article

Neutralization of Japanese Encephalitis Virus by heme-induced broadly reactive human monoclonal antibody

scientific article

Noncanonical Functions of Antibodies

scientific article published on 06 April 2020

Novel cellular and molecular mechanisms of induction of immune responses by aluminum adjuvants

scientific article published on 11 May 2009

Novel therapeutic strategies for multiple sclerosis: potential of intravenous immunoglobulin

scientific article published on 01 July 2009

Oxidation of factor VIII increases its immunogenicity in mice with severe hemophilia A.

scientific article published on 30 January 2018

Parameters that influence the prediction of epidemiological benefits of more-effective tuberculosis vaccines, drugs, and diagnosis

scientific article published on 26 October 2009

Pathophysiology of catalytic antibodies

scientific article

Pathophysiology of inhibitors to factor VIII in patients with haemophilia A.

scientific article

Peptide decoys selected by phage display block in vitro and in vivo activity of a human anti-FVIII inhibitor.

scientific article

Physiopathology of catalytic antibodies: the case for factor VIII-hydrolyzing immunoglobulin G.

scientific article

Polyreactivity of disease-associated anti-RBC IgG autoantibodies of patients with warm autoimmune haemolytic anaemia and natural anti-RBC IgG autoantibodies of healthy individuals

scientific article published on 01 August 2000

Predictive immunogenicity of Refacto AF.

scientific article published on 30 December 2013

Prevalence and gene characteristics of antibodies with cofactor-induced HIV-1 specificity.

scientific article

Proteolytic antibodies activate factor IX in patients with acquired hemophilia.

scientific article published on 3 December 2010

Red blood cell transfusions are associated with alterations in self-reactive antibody repertoires of plasma IgM and IgG, independent of the presence of a specific immune response toward RBC antigens

scientific article published on 01 October 2002

Regulation of immune responses to protein therapeutics by transplacental induction of T cell tolerance

scientific article published in February 2015

Relationship between natural and heme-mediated antibody polyreactivity.

scientific article

Role of coagulation-associated processes on factor VIII immunogenicity in a mouse model of severe hemophilia A.

scientific article published on 25 October 2014

Role of natural antibodies in immune homeostasis: IVIg perspective.

scientific article published on 28 April 2008

Role of the intrinsic coagulation pathway in atherogenesis assessed in hemophilic apolipoprotein E knockout mice

scientific article

Selective impairment of serum antibody repertoires toward muscle and thymus antigens in patients with seronegative and seropositive myasthenia gravis

scientific article published on 01 August 1998

Self-reactive antibodies (natural autoantibodies) in healthy individuals

scientific article published on 01 July 1998

Sialylation may be dispensable for reciprocal modulation of helper T cells by intravenous immunoglobulin.

scientific article

Splenic marginal zone antigen-presenting cells are critical for the primary allo-immune response to therapeutic factor VIII in hemophilia A.

scientific article

Stability of natural self-reactive antibody repertoires during aging

scientific article published on 01 January 1999

Standardizing terms, definitions and concepts for describing and interpreting unwanted immunogenicity of biopharmaceuticals: recommendations of the Innovative Medicines Initiative ABIRISK consortium

scientific article

Summary report of the First International Conference on inhibitors in haemophilia A.

scientific article published on 25 November 2016

Surveillance of antigen-presenting cells by CD4+ CD25+ regulatory T cells in autoimmunity: immunopathogenesis and therapeutic implications.

scientific article published on 06 April 2009

T cell-derived IL-22 amplifies IL-1β-driven inflammation in human adipose tissue: relevance to obesity and type 2 diabetes.

scientific article published on 11 February 2014

The ADAMTS131239-1253 peptide is a dominant HLA-DR1-restricted CD4+ T-cell epitope

scientific article published on 27 July 2017

The C1 and C2 domains of blood coagulation factor VIII mediate its endocytosis by dendritic cells.

scientific article published on 06 October 2016

The antiinflammatory IgG.

scientific article

The interaction between factor H and VWF increases factor H cofactor activity and regulates VWF prothrombotic status

scientific article published on 6 September 2013

The prevalence of proteolytic antibodies against factor VIII in hemophilia A.

scientific article

The role of VWF in the immunogenicity of FVIII.

scientific article published on January 2008

The self-reactive antibody repertoire of normal human serum IgM is acquired in early childhood and remains conserved throughout life

scientific article published on 01 September 1996

Therapeutic factor VIII does not trigger TLR1.2 and TLR2.6 signalling in vitro.

scientific article published on 18 December 2012

Thermodynamic analysis of the interaction of factor VIII with von Willebrand factor.

scientific article

Thermodynamic stability contributes to immunoglobulin specificity

scientific article published on 28 March 2014

Transition towards antigen-binding promiscuity of a monospecific antibody

scientific article published on 09 November 2006

VWF protects FVIII from endocytosis by dendritic cells and subsequent presentation to immune effectors.

scientific article published on 19 September 2006

Varied immune response to FVIII: presence of proteolytic antibodies directed to factor VIII in different human pathologies

scientific article published on October 2009

[Immunomodulatory effects of intravenous immunoglobulins in autoimmune diseases]

scientific article published on 01 January 1999

[Regulation of autoreactivity by the idiotypic network and therapeutic modulation of autoimmunity by polyvalent intravenous immunoglobulins (IgIV)]

scientific article published on 01 May 1996

[Use of intravenous polyclonal immunoglobulins in autoimmune and inflammatory disorders].

scientific article

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