List of works - Michael Overduin

1H, 15N and 13C resonance assignments and monomeric structure of the amino-terminal extracellular domain of epithelial cadherin

scientific article

A method for detergent-free isolation of membrane proteins in their local lipid environment. ⬇️

scientific article

Ambidextrous binding of cell and membrane bilayers by soluble matrix metalloproteinase-12.

scientific article

Assignment of the 1H, 13C, and 15N resonances of the DNA binding domain of gpNu1, a genome packaging protein from bacteriophage lambda

article

Backbone resonance assignments of the catalytic and regulatory domains of Ca2+/calmodulin-dependent protein kinase 1D

scientific article published on 13 June 2020

Binding of the periplakin linker requires vimentin acidic residues D176 and E187

scientific article published on 21 February 2020

Binding to syntenin-1 protein defines a new mode of ubiquitin-based interactions regulated by phosphorylation

scientific article

Cell migration and signaling specificity is determined by the phosphatidylserine recognition motif of Rac1.

scientific article

Characterization of a Putative Receptor Binding Surface on Skint-1, a Critical Determinant of Dendritic Epidermal T Cell Selection.

scientific article

Cloning, Expression, and Characterization of a DNA Binding Domain of gpNu1, a Phage λ DNA Packaging Protein†

scientific article published in 1999

Cross-species chimeras reveal BamA POTRA and β-barrel domains must be fine-tuned for efficient OMP insertion

scientific article

Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides

scientific article

Detergent-free purification of ABC (ATP-binding-cassette) transporters.

scientific article published on July 2014

Discovery of novel membrane binding structures and functions

scientific article

Fold and function of polypeptide transport-associated domains responsible for delivering unfolded proteins to membranes

scientific article

Functional and biophysical analysis of the C-terminus of the CGRP-receptor; a family B GPCR.

scientific article published on 18 July 2008

G-protein coupled receptor solubilization and purification for biophysical analysis and functional studies, in the total absence of detergent.

scientific article published on 16 April 2015

Golgi protein FAPP2 tubulates membranes

scientific article

Hinged plakin domains provide specialized degrees of articulation in envoplakin, periplakin and desmoplakin

scientific article

Homogeneous nanodiscs of native membranes formed by stilbene-maleic-acid copolymers

scientific article published on 11 August 2020

In support of the BMRB.

scientific article published in September 2012

Increased mobility in the membrane targeting PX domain induced by phosphatidylinositol 3-phosphate.

scientific article published on August 2006

Insights into specific DNA recognition during the assembly of a viral genome packaging machine

scientific article

Investigation of the binding geometry of a peripheral membrane protein

scientific article published on December 2005

Key amino acid residues of ankyrin-sensitive phosphatidylethanolamine/phosphatidylcholine-lipid binding site of βI-spectrin.

scientific article

Lipid interaction networks of peripheral membrane proteins revealed by data-driven micelle docking

scientific article

Mechanism of intermediate filament recognition by plakin repeat domains revealed by envoplakin targeting of vimentin.

scientific article published on 3 March 2016

Mechanistic basis of desmosome-targeted diseases

scientific article

Membrane and Protein Interactions of the Pleckstrin Homology Domain Superfamily

scientific article

Membrane protein architects: the role of the BAM complex in outer membrane protein assembly.

scientific article

Membrane proteins solubilized intact in lipid containing nanoparticles bounded by styrene maleic acid copolymer

scientific article

Molecular Basis of Phosphatidylinositol 4-Phosphate and ARF1 GTPase Recognition by the FAPP1 Pleckstrin Homology (PH) Domain

scientific article

Molecular mechanism of NPF recognition by EH domains

scientific article

Molecular mechanism of membrane docking by the Vam7p PX domain

scientific article

Multifaceted membrane binding head of the SARS-CoV-2 spike protein

scientific article published on 16 May 2022

Multivalent mechanism of membrane insertion by the FYVE domain

scientific article published on 25 October 2003

Mutational and topological analysis of the Escherichia coli BamA protein.

scientific article

NMR of Membrane Proteins: Beyond Crystals

scientific article

NMR spectra of oligosaccharides at ultra-high field (900 MHz) have better resolution than expected due to favourable molecular tumbling

scientific article published on 19 June 2006

Native nanodiscs formed by styrene-maleic acid copolymer derivatives help recover infectious prion multimers bound to brain-derived lipids

scientific article published on 01 May 2020

Phosphatidylethanolamine has an essential role in Saccharomyces cerevisiae that is independent of its ability to form hexagonal phase structures

scientific article

Phosphatidylinositol 3-Phosphate Recognition by the FYVE Domain

article

Phosphoinositide, phosphopeptide and pyridone interactions of the Abl SH2 domain

scientific article published on March 2006

Phospholipid-interacting proteins by solution-state NMR spectroscopy

scientific article

Phosphorylation of conserved phosphoinositide binding pocket regulates sorting nexin membrane targeting.

scientific article

Phox domain interaction with PtdIns(3)P targets the Vam7 t-SNARE to vacuole membranes.

scientific article

Production of membrane proteins without cells or detergents.

scientific article published on 21 July 2010

PtdIns(4)P signalling and recognition systems

scientific article published on January 2013

Purification and spectroscopic characterization of a recombinant amino-terminal polypeptide fragment of mouse epithelial cadherin

scientific article published on 01 October 1994

Rab1 guanine nucleotide exchange factor SidM is a major phosphatidylinositol 4-phosphate-binding effector protein of Legionella pneumophila.

scientific article

Resonance assignments of the human AKAP13-PH domain and stabilizing DH helix

Secondary structure and (1)H, (13)C and (15)N backbone resonance assignments of BamC, a component of the outer membrane protein assembly machinery in Escherichia coli.

scientific article

Secondary structure and (1)H, (13)C and (15)N resonance assignments of Skint-1: a selecting ligand for a murine γδ T cell subset implicated in tumour suppression

scientific article

Secondary structure and (1)H, (13)C, (15)N resonance assignments of the endosomal sorting protein sorting nexin 3

scientific article

Secondary structure and 1H, 13C and 15N resonance assignments of BamE, a component of the outer membrane protein assembly machinery in Escherichia coli

scientific article

Secondary structure and 1H, 13C and 15N resonance assignments of the Escherichia coli YaeT POTRA domain.

scientific article published on 21 July 2007

Secondary structure and 1H, 13C, 15N resonance assignments of the Golgi-specific PH domain of FAPP1

Secondary structure of Src homology 2 domain of c-Abl by heteronuclear NMR spectroscopy in solution

scientific article published on December 1992

Secondary structure, 1H, 13C and 15N resonance assignments and molecular interactions of the dishevelled DIX domain

scientific article published on March 2005

Sequence-specific 1H, 13C and 15N backbone resonance assignments of the 34 kDa catalytic domain of human PTPN7.

scientific article published on 30 May 2008

Sequence-specific 1H, 13C and 15N backbone resonance assignments of the plakin repeat domain of human envoplakin

scientific article published on 21 November 2015

Sequence-specific 1H, 15N and 13C resonance assignments for the third EH domain of Eps15

scientific article published on 01 January 2000

Sequence-specific 1H, 15N and 13C resonance assignments of the EEA1 FYVE domain

article

Signaling with phosphoinositides: better than binary.

scientific article published on August 2001

Size and conformation limits to secretion of disulfide-bonded loops in autotransporter proteins.

scientific article published on 17 October 2011

Small-Molecule Protein-Protein Interaction Inhibitor of Oncogenic Rho Signaling.

scientific article

Solution structure of Eps15's third EH domain reveals coincident Phe-Trp and Asn-Pro-Phe binding sites

scientific article

Solution structure of the C-terminal antiparallel coiled-coil domain from Escherichia coli osmosensor ProP

scientific article

Solution structure of the epithelial cadherin domain responsible for selective cell adhesion.

scientific article

Structural Insights into the Activation of the RhoA GTPase by the Lymphoid Blast Crisis (Lbc) Oncoprotein

scientific article

Structural Mechanisms and Drug Discovery Prospects of Rho GTPases

scientific article

Structural basis of calcium-induced E-cadherin rigidification and dimerization

scientific article

Structural basis of dynamic membrane recognition by trans-Golgi network specific FAPP proteins

scientific article published on 8 January 2015

Structural basis of ligand interactions of the large extracellular domain of tetraspanin CD81

scientific article

Structural basis of wedging the Golgi membrane by FAPP pleckstrin homology domains

scientific article

Structural characterization of recombinant human CD81 produced in Pichia pastoris

scientific article published on 24 October 2007

Structural mechanism of endosome docking by the FYVE domain

scientific article

Structure and Asn-Pro-Phe binding pocket of the Eps15 homology domain

scientific article

Structure and function of BamE within the outer membrane and the β-barrel assembly machine

scientific article

Structure of Sla1p homology domain 1 and interaction with the NPFxD endocytic internalization motif

scientific article

Surfactant-free purification of membrane proteins with intact native membrane environment

scientific article published on June 2011

Syntenin-1 is a new component of tetraspanin-enriched microdomains: mechanisms and consequences of the interaction of syntenin-1 with CD63.

scientific article

Targeting of the FYVE domain to endosomal membranes is regulated by a histidine switch

scientific article

Targeting protein tyrosine phosphatase SHP2 for therapeutic intervention

scientific article

Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments

scientific article published on 10 March 2017

The CD63-Syntenin-1 Complex Controls Post-Endocytic Trafficking of Oncogenic Human Papillomaviruses

scientific article published on 31 August 2016

The DIX domain targets dishevelled to actin stress fibres and vesicular membranes

scientific article published in Nature

The ER chaperone calnexin controls mitochondrial positioning and respiration

scientific article published on 30 June 2020

The desmoglein-specific cytoplasmic region is intrinsically disordered in solution and interacts with multiple desmosomal protein partners.

scientific article published on 30 December 2008

The essential β-barrel assembly machinery complex components BamD and BamA are required for autotransporter biogenesis

scientific article

The nonlinear structure of the desmoplakin plakin domain and the effects of cardiomyopathy-linked mutations

scientific article (publication date: 2 September 2011)

The role of hydrophobic interactions in ankyrin–spectrin complex formation

scientific article published on 02 August 2010

The solution structure of Abl SH3, and its relationship to SH2 in the SH(32) construct

scientific article

Three-dimensional solution structure of the src homology 2 domain of c-abl

article

Uncoupling ITIM receptor G6b-B from tyrosine phosphatases Shp1 and Shp2 disrupts murine platelet homeostasis

scientific article published on 11 June 2018

Viral infection controlled by a calcium-dependent lipid-binding module in ALIX.

scientific article

List of works by Michael Overduin

1H, 15N and 13C resonance assignments and monomeric structure of the amino-terminal extracellular domain of epithelial cadherin

A method for detergent-free isolation of membrane proteins in their local lipid environment. ⬇️

Ambidextrous binding of cell and membrane bilayers by soluble matrix metalloproteinase-12.

Assignment of the 1H, 13C, and 15N resonances of the DNA binding domain of gpNu1, a genome packaging protein from bacteriophage lambda

Backbone resonance assignments of the catalytic and regulatory domains of Ca2+/calmodulin-dependent protein kinase 1D

Binding of the periplakin linker requires vimentin acidic residues D176 and E187

Binding to syntenin-1 protein defines a new mode of ubiquitin-based interactions regulated by phosphorylation

Cell migration and signaling specificity is determined by the phosphatidylserine recognition motif of Rac1.

Characterization of a Putative Receptor Binding Surface on Skint-1, a Critical Determinant of Dendritic Epidermal T Cell Selection.

Cloning, Expression, and Characterization of a DNA Binding Domain of gpNu1, a Phage λ DNA Packaging Protein†

Cross-species chimeras reveal BamA POTRA and β-barrel domains must be fine-tuned for efficient OMP insertion

Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides

Detergent-free purification of ABC (ATP-binding-cassette) transporters.

Discovery of novel membrane binding structures and functions

Fold and function of polypeptide transport-associated domains responsible for delivering unfolded proteins to membranes

Functional and biophysical analysis of the C-terminus of the CGRP-receptor; a family B GPCR.

G-protein coupled receptor solubilization and purification for biophysical analysis and functional studies, in the total absence of detergent.

Golgi protein FAPP2 tubulates membranes

Hinged plakin domains provide specialized degrees of articulation in envoplakin, periplakin and desmoplakin

Homogeneous nanodiscs of native membranes formed by stilbene-maleic-acid copolymers

In support of the BMRB.

Increased mobility in the membrane targeting PX domain induced by phosphatidylinositol 3-phosphate.

Insights into specific DNA recognition during the assembly of a viral genome packaging machine

Investigation of the binding geometry of a peripheral membrane protein

Key amino acid residues of ankyrin-sensitive phosphatidylethanolamine/phosphatidylcholine-lipid binding site of βI-spectrin.

Lipid interaction networks of peripheral membrane proteins revealed by data-driven micelle docking

Mechanism of intermediate filament recognition by plakin repeat domains revealed by envoplakin targeting of vimentin.

Mechanistic basis of desmosome-targeted diseases

Membrane and Protein Interactions of the Pleckstrin Homology Domain Superfamily

Membrane protein architects: the role of the BAM complex in outer membrane protein assembly.

Membrane proteins solubilized intact in lipid containing nanoparticles bounded by styrene maleic acid copolymer

Molecular Basis of Phosphatidylinositol 4-Phosphate and ARF1 GTPase Recognition by the FAPP1 Pleckstrin Homology (PH) Domain

Molecular mechanism of NPF recognition by EH domains

Molecular mechanism of membrane docking by the Vam7p PX domain

Multifaceted membrane binding head of the SARS-CoV-2 spike protein

Multivalent mechanism of membrane insertion by the FYVE domain

Mutational and topological analysis of the Escherichia coli BamA protein.

NMR of Membrane Proteins: Beyond Crystals

NMR spectra of oligosaccharides at ultra-high field (900 MHz) have better resolution than expected due to favourable molecular tumbling

Native nanodiscs formed by styrene-maleic acid copolymer derivatives help recover infectious prion multimers bound to brain-derived lipids

Phosphatidylethanolamine has an essential role in Saccharomyces cerevisiae that is independent of its ability to form hexagonal phase structures

Phosphatidylinositol 3-Phosphate Recognition by the FYVE Domain

Phosphoinositide, phosphopeptide and pyridone interactions of the Abl SH2 domain

Phospholipid-interacting proteins by solution-state NMR spectroscopy

Phosphorylation of conserved phosphoinositide binding pocket regulates sorting nexin membrane targeting.

Phox domain interaction with PtdIns(3)P targets the Vam7 t-SNARE to vacuole membranes.

Production of membrane proteins without cells or detergents.

PtdIns(4)P signalling and recognition systems

Purification and spectroscopic characterization of a recombinant amino-terminal polypeptide fragment of mouse epithelial cadherin

Rab1 guanine nucleotide exchange factor SidM is a major phosphatidylinositol 4-phosphate-binding effector protein of Legionella pneumophila.

Resonance assignments of the human AKAP13-PH domain and stabilizing DH helix

Secondary structure and (1)H, (13)C and (15)N backbone resonance assignments of BamC, a component of the outer membrane protein assembly machinery in Escherichia coli.

Secondary structure and (1)H, (13)C and (15)N resonance assignments of Skint-1: a selecting ligand for a murine γδ T cell subset implicated in tumour suppression

Secondary structure and (1)H, (13)C, (15)N resonance assignments of the endosomal sorting protein sorting nexin 3

Secondary structure and 1H, 13C and 15N resonance assignments of BamE, a component of the outer membrane protein assembly machinery in Escherichia coli

Secondary structure and 1H, 13C and 15N resonance assignments of the Escherichia coli YaeT POTRA domain.

Secondary structure and 1H, 13C, 15N resonance assignments of the Golgi-specific PH domain of FAPP1

Secondary structure of Src homology 2 domain of c-Abl by heteronuclear NMR spectroscopy in solution

Secondary structure, 1H, 13C and 15N resonance assignments and molecular interactions of the dishevelled DIX domain

Sequence-specific 1H, 13C and 15N backbone resonance assignments of the 34 kDa catalytic domain of human PTPN7.

Sequence-specific 1H, 13C and 15N backbone resonance assignments of the plakin repeat domain of human envoplakin

Sequence-specific 1H, 15N and 13C resonance assignments for the third EH domain of Eps15

Sequence-specific 1H, 15N and 13C resonance assignments of the EEA1 FYVE domain

Signaling with phosphoinositides: better than binary.

Size and conformation limits to secretion of disulfide-bonded loops in autotransporter proteins.

Small-Molecule Protein-Protein Interaction Inhibitor of Oncogenic Rho Signaling.

Solution structure of Eps15's third EH domain reveals coincident Phe-Trp and Asn-Pro-Phe binding sites

Solution structure of the C-terminal antiparallel coiled-coil domain from Escherichia coli osmosensor ProP

Solution structure of the epithelial cadherin domain responsible for selective cell adhesion.

Structural Insights into the Activation of the RhoA GTPase by the Lymphoid Blast Crisis (Lbc) Oncoprotein

Structural Mechanisms and Drug Discovery Prospects of Rho GTPases

Structural basis of calcium-induced E-cadherin rigidification and dimerization

Structural basis of dynamic membrane recognition by trans-Golgi network specific FAPP proteins

Structural basis of ligand interactions of the large extracellular domain of tetraspanin CD81

Structural basis of wedging the Golgi membrane by FAPP pleckstrin homology domains

Structural characterization of recombinant human CD81 produced in Pichia pastoris

Structural mechanism of endosome docking by the FYVE domain

Structure and Asn-Pro-Phe binding pocket of the Eps15 homology domain

Structure and function of BamE within the outer membrane and the β-barrel assembly machine