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List of works by Sylvain V. Costes

A microRNA signature and TGF-β1 response were identified as the key master regulators for spaceflight response

scientific article published on 25 July 2018

Author Correction: Multi-omics analysis of multiple missions to space reveal a theme of lipid dysregulation in mouse liver

scientific article published on 27 January 2020

Automatic and quantitative measurement of protein-protein colocalization in live cells.

scientific article

Central Nervous System Responses to Simulated Galactic Cosmic Rays ⬇️

article

Characterizing the DNA Damage Response by Cell Tracking Algorithms and Cell Features Classification Using High-Content Time-Lapse Analysis

scientific article (publication date: 2015)

Combinatorial DNA damage pairing model based on X-ray-induced foci predicts the dose and LET dependence of cell death in human breast cells

scientific article published on 30 July 2014

Correction: Gadolinium-enhanced cardiac MR exams of human subjects are associated with significant increases in the DNA repair marker 53BP1, but not the damage marker γH2AX.

scientific article

Drosophila Histone Demethylase KDM4A Has Enzymatic and Non-enzymatic Roles in Controlling Heterochromatin Integrity

scientific article

Evaluating biomarkers to model cancer risk post cosmic ray exposure

scientific article

Evidence for formation of DNA repair centers and dose-response nonlinearity in human cells

scientific article

Gadolinium-enhanced cardiac MR exams of human subjects are associated with significant increases in the DNA repair marker 53BP1, but not the damage marker γH2AX.

scientific article published on 8 January 2018

GeneLab Database Analyses Suggest Long-Term Impact of Space Radiation on the Cardiovascular System by the Activation of Through Reactive Oxygen Species ⬇️

article

Genetic Background Modulates lncRNA-Coordinated Tissue Response to Low Dose Ionizing Radiation.

scientific article

Global transcriptomic analysis suggests carbon dioxide as an environmental stressor in spaceflight: A systems biology GeneLab case study

scientific article published on 8 March 2018

Human CD8+ T cells store RANTES in a unique secretory compartment and release it rapidly after TcR stimulation

scientific article published in February 2004

Image-based modeling reveals dynamic redistribution of DNA damage into nuclear sub-domains

scientific article

Imaging features that discriminate between foci induced by high- and low-LET radiation in human fibroblasts

scientific article published in May 2006

In Situ Detection of Complex DNA Damage Using Microscopy: A Rough Road Ahead

scientific article published on 06 November 2020

In vivo HIV-1 Rev multimerization in the nucleolus and cytoplasm identified by fluorescence resonance energy transfer

scientific article published on 3 August 2004

Inhibition of metastatic outgrowth from single dormant tumor cells by targeting the cytoskeleton.

scientific article published on August 2008

Intensity-based signal separation algorithm for accurate quantification of clustered centrosomes in tissue sections

scientific article

Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer

scientific article

Ionizing radiation predisposes nonmalignant human mammary epithelial cells to undergo transforming growth factor beta induced epithelial to mesenchymal transition

scientific article

Irradiation of juvenile, but not adult, mammary gland increases stem cell self-renewal and estrogen receptor negative tumors

scientific article

Knowledge Network Embedding of Transcriptomic Data from Spaceflown Mice Uncovers Signs and Symptoms Associated with Terrestrial Diseases

scientific article published in 2021

Lack of radiation dose or quality dependence of epithelial-to-mesenchymal transition (EMT) mediated by transforming growth factor β.

scientific article published in April 2011

Mesenchymal cells stimulate capillary morphogenesis via distinct proteolytic mechanisms.

scientific article

Multi-omics analysis of multiple missions to space reveal a theme of lipid dysregulation in mouse liver

scientific article published on 16 December 2019

Optimizing radiotherapy protocols using computer automata to model tumour cell death as a function of oxygen diffusion processes

scientific article

Phenotypic transition maps of 3D breast acini obtained by imaging-guided agent-based modeling.

scientific article

Radiation quality and tissue-specific microenvironments following exposure to 1 GeV/amu Fe.

scientific article published on January 2002

Rapid and automated multidimensional fluorescence microscopy profiling of 3D human breast cultures

scientific article published on 13 February 2013

Simulating Space Radiation-Induced Breast Tumor Incidence Using Automata.

scientific article published on 22 June 2016

Stochastic properties of radiation-induced DSB: DSB distributions in large scale chromatin loops, the HPRT gene and within the visible volumes of DNA repair foci.

scientific article published in November 2008

Targeted and nontargeted effects of ionizing radiation that impact genomic instability

scientific article published in October 2008

The Trp53 delta proline (Trp53ΔP) mouse exhibits increased genome instability and susceptibility to radiation-induced, but not spontaneous, tumor development

scientific article published on 27 August 2015

The cell cycle timing of centromeric chromatin assembly in Drosophila meiosis is distinct from mitosis yet requires CAL1 and CENP-C

scientific article (publication date: 2012)

The composition and organization of Drosophila heterochromatin are heterogeneous and dynamic

scientific article published on 11 August 2016

The scalable precision medicine open knowledge engine (SPOKE): a massive knowledge graph of biomedical information

scientific article published in February 2023

The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation

scientific journal article

Understanding cancer development processes after HZE-particle exposure: roles of ROS, DNA damage repair and inflammation.

scientific article published on 07 January 2015

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