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List of works by Richard N. Fedorak

A 29-year-old woman with Crohn disease considering pregnancy

scientific article published on 5 October 2015

A Randomized Controlled Trial of Four Precolonoscopy Bowel Cleansing Regimens ⬇️

scientific article published on December 1, 2011

A Systematic Review for the Development of a Core Outcome Set for Ulcerative Colitis Clinical Trials

scientific article

A defect in epithelial barrier integrity is not required for a systemic response to bacterial antigens or intestinal injury in T cell receptor-alpha gene-deficient mice

scientific article published in August 2006

A machine-learned predictor of colonic polyps based on urinary metabolomics.

scientific article

A one-hour infusion of infliximab during maintenance therapy is safe and well tolerated: a prospective cohort study

scientific article published on 25 May 2011

A randomised phase I study of etrolizumab (rhuMAb β7) in moderate to severe ulcerative colitis ⬇️

scientific article published on June 20, 2012

A randomized trial of Ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with moderate-to-severe Crohn's disease

article

A randomized trial of topical anesthesia comparing lidocaine versus lidocaine plus xylometazoline for unsedated transnasal upper gastrointestinal endoscopy

scientific article

A randomized, placebo-controlled trial of certolizumab pegol (CDP870) for treatment of Crohn's disease

scientific article

A randomized, placebo-controlled, double-blind trial of mesalamine in the maintenance of remission of Crohn's disease. The Canadian Mesalamine for Remission of Crohn's Disease Study Group

article

A study investigating the association of dermatological and infusion reactions to infliximab and infliximab trough levels

scientific article

Acetic acid-induced colitis results in bystander ileal injury

scientific article published on 01 January 1993

Adalimumab for induction of clinical remission in moderately to severely active ulcerative colitis: results of a randomised controlled trial

scientific article published on 05 January 2011

Adalimumab for maintenance treatment of Crohn's disease: results of the CLASSIC II trial.

scientific article published on 13 February 2007

Adalimumab for orbital myositis in a patient with Crohn's disease who discontinued infliximab: a case report and review of the literature

scientific article

Adalimumab versus infliximab for the treatment of moderate to severe ulcerative colitis in adult patients naïve to anti-TNF therapy: an indirect treatment comparison meta-analysis

scientific article published on February 2014

Allopurinol to prevent pancreatitis after endoscopic retrograde cholangiopancreatography: a randomized placebo-controlled trial

scientific article

American gastroenterological association consensus development conference on the use of biologics in the treatment of inflammatory bowel disease, June 21-23, 2006.

scientific article published on July 2007

An imbalance in mucosal cytokine profile causes transient intestinal inflammation following an animal's first exposure to faecal bacteria and antigens

scientific article published on 16 March 2010

Anti-TNF Therapy Within 2 Years of Crohn's Disease Diagnosis Improves Patient Outcomes: A Retrospective Cohort Study

scientific article published in April 2016

Association with selected bacteria does not cause enterocolitis in IL-10 gene-deficient mice despite a systemic immune response

scientific article

Bacterial antigens alone can influence intestinal barrier integrity, but live bacteria are required for initiation of intestinal inflammation and injury

scientific article published on 01 June 2006

Bacterial overgrowth and inflammation of small intestine after carboxymethylcellulose ingestion in genetically susceptible mice

scientific article

Bones and Crohnʼs

scientific article published on 01 May 2004

Breaks in the wall: increased gaps in the intestinal epithelium of irritable bowel syndrome patients identified by confocal laser endomicroscopy (with videos).

scientific article

Budesonide‐β‐D‐glucuronide: A Potential Prodrug for Treatment of Ulcerative Colitis

scientific article published on 01 June 1995

CD4+CD25+ regulatory T cells have divergent effects on intestinal inflammation in IL-10 gene-deficient mice

scientific article published in June 2008

Canadian Digestive Health Foundation Public Impact Series 3: Irritable Bowel Syndrome in Canada. Incidence, Prevalence, and Direct and Indirect Economic Impact ⬇️

scientific article published on May 1, 2012

Canadian Digestive Health Foundation Public Impact Series 4: Celiac Disease in Canada. Incidence, Prevalence, and Direct and Indirect Economic Impact ⬇️

scientific article published on June 1, 2012

Canadian Digestive Health Foundation Public Impact Series 5: Pancreatitis in Canada. Incidence, prevalence, and direct and indirect economic impact

scientific article

Canadian Digestive Health Foundation Public Impact Series. Inflammatory Bowel Disease in Canada: Incidence, Prevalence, and Direct and Indirect Economic Impact ⬇️

scientific article published on November 1, 2010

Canadian Digestive Health Foundation Public Impact Series: gastroesophageal reflux disease in Canada: incidence, prevalence, and direct and indirect economic impact

scientific article

Celiac Disease in Children With Inflammatory Bowel Disease: a Prospective Cohort Study

scientific article published on 01 March 2013

Certolizumab pegol in patients with moderate to severe Crohn's disease and secondary failure to infliximab

scientific article published on 6 May 2010

Certolizumab pegol, a monthly subcutaneously administered Fc-free anti-TNFalpha, improves health-related quality of life in patients with moderate to severe Crohn's disease

scientific article

Challenges to the design, execution, and analysis of randomized controlled trials for inflammatory bowel disease

scientific article published on 20 September 2012

Clinical experience with infliximab for Crohn's disease: the first 100 patients in Edmonton, Alberta

scientific article

Clinical trial: intravenous pantoprazole vs. ranitidine for the prevention of peptic ulcer rebleeding: a multicentre, multinational, randomized trial

scientific article

Colonic delivery of dexamethasone from a prodrug accelerates healing of colitis in rats without adrenal suppression

scientific article published in June 1995

Commentary: larazotide acetate - an exciting new development for coeliac patients? Authors' reply.

scientific article published in February 2013

Conservative approach to severe ulcerative colitis

scientific article published in January 2004

Crohn's disease genotypes of patients in remission vs relapses after infliximab discontinuation.

scientific article

Crypt cell production rate, enterocyte turnover time and appearance of transport along the jejunal villus of the rat

article

Development and validation of a highly sensitive urine-based test to identify patients with colonic adenomatous polyps

scientific article published on 20 March 2014

Development and validation of an administrative case definition for inflammatory bowel diseases

scientific article

Development of a core outcome set for clinical trials in inflammatory bowel disease: study protocol for a systematic review of the literature and identification of a core outcome set using a Delphi survey

scientific article published on 09 June 2017

Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study.

scientific article

Differential clustering of bowel biopsy-associated bacterial profiles of specimens collected in Mexico and Canada: what do these profiles represent?

article

Disease manifestations of Helicobacter pylori infection in Arctic Canada: using epidemiology to address community concerns

scientific article published on 08 January 2014

Distance management of inflammatory bowel disease: systematic review and meta-analysis

scientific article

Does the level of reproductive knowledge specific to inflammatory bowel disease predict childlessness among women with inflammatory bowel disease?

scientific article published in March 2015

Don't Forget the Doctor: Gastroenterologists' Preferences on the Development of mHealth Tools for Inflammatory Bowel Disease

scientific article

Drug-disease interaction: Crohn's disease elevates verapamil plasma concentrations but reduces response to the drug proportional to disease activity.

scientific article published on November 2011

Effect of misoprostol in preventing stress-induced intestinal fluid secretion in rats

scientific article published on 01 October 1989

Endpoints for clinical trials evaluating disease modification and structural damage in adults with Crohn's disease

scientific article published on October 2009

Epithelial Cell Extrusion Zones Observed on Confocal Laser Endomicroscopy Correlates with Immunohistochemical Staining of Mucosal Biopsy Samples

scientific article

Epithelial barrier disruption allows nondisease-causing bacteria to initiate and sustain IBD in the IL-10 gene-deficient mouse

scientific article published in August 2007

Epithelial cell extrusion leads to breaches in the intestinal epithelium

scientific article published in April 2013

Epithelial gaps in a rodent model of inflammatory bowel disease: a quantitative validation study

scientific article

FK506 increases permeability in rat intestine by inhibiting mitochondrial function

scientific article published in July 1995

HLA-DQA1-HLA-DRB1 variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants.

scientific article published on 14 September 2014

Health Care Resource Use and Costs for Crohn’s Disease before and after Infliximab Therapy ⬇️

scientific article published on September 1, 2011

Heterogeneity in Definitions of Efficacy and Safety Endpoints for Clinical Trials of Crohn's Disease: A Systematic Review for Development of a Core Outcome Set.

scientific article published on 26 March 2018

Human anti-tumor necrosis factor monoclonal antibody (adalimumab) in Crohn's disease: the CLASSIC-I trial

scientific article

Inadequate knowledge of immunization guidelines: a missed opportunity for preventing infection in immunocompromised IBD patients

scientific article published on 18 February 2011

Increased epithelial gaps in the small intestine are predictive of hospitalization and surgery in patients with inflammatory bowel disease

scientific article

Increased epithelial gaps in the small intestines of patients with inflammatory bowel disease: density matters

scientific article

Increased permeability occurs in rat ileum following induction of pancolitis

scientific article published on 01 February 1996

Inflammatory bowel disease patients are frequently nonadherent to scheduled induction and maintenance infliximab therapy: A Canadian cohort study.

scientific article

Infliximab maintenance therapy for fistulizing Crohn's disease

scientific article (publication date: 26 February 2004)

Innovative Online Educational Portal Improves Disease-Specific Reproductive Knowledge Among Patients With Inflammatory Bowel Disease

scientific article published on 01 November 2018

Insulin downregulates diabetic-enhanced intestinal glucose transport rapidly in ileum and slowly in jejunum

scientific article published on 01 December 1996

Interleukin 10 prevents cytokine-induced disruption of T84 monolayer barrier integrity and limits chloride secretion

scientific article published on 01 July 1997

Intravenous Injection of Endogenous Microbial Components Abrogates DSS-Induced Colitis

scientific article published on 01 September 2011

Iron replacement therapy in inflammatory bowel disease patients with iron deficiency anemia: a systematic review and meta-analysis

scientific article published on 26 October 2011

Is it time to re-classify Crohn's disease?

scientific article

Jejunum is preferable for construction of a bianchi bowel-lengthening procedure in swine short bowel

scientific article published on 01 January 1993

Knowledge of Fecal Calprotectin and Infliximab Trough Levels Alters Clinical Decision-making for IBD Outpatients on Maintenance Infliximab Therapy.

scientific article published on June 2015

Lack of Interleukin-10 Leads to Intestinal Inflammation, Independent of the Time at Which Luminal Microbial Colonization Occurs

scientific article published on 01 March 2003

Lack of effect of intravenous administration on time to respond to azathioprine for steroid-treated Crohn's disease

article

Lactobacillus species prevents colitis in interleukin 10 gene–deficient mice

article

Larazotide acetate for persistent symptoms of celiac disease despite a gluten-free diet: a randomized controlled trial.

scientific article published on 13 February 2015

Living with inflammatory bowel disease: A Crohn's and Colitis Canada survey

scientific article

Low-Dose Cyclosporine for the Treatment of Crohn's Disease

article

Lymphoproliferative disorders in inflammatory bowel disease patients on immunosuppression: Lessons from other inflammatory disorders

scientific article

Maintenance of clinical benefit in Crohn's disease patients after discontinuation of infliximab: long-term follow-up of a single centre cohort.

scientific article published on 30 August 2010

Metabolomic profiles are gender, disease and time specific in the interleukin-10 gene-deficient mouse model of inflammatory bowel disease

scientific article published on 09 July 2013

Metabolomics and Detection of Colorectal Cancer in Humans: A Systematic Review ⬇️

scientific article published on September 1, 2010

Metagenomic analysis of microbiome in colon tissue from subjects with inflammatory bowel diseases reveals interplay of viruses and bacteria

scientific article

Methotrexate for the Treatment of Crohn's Disease

article

Methotrexate in combination with infliximab is no more effective than infliximab alone in patients with Crohn's disease

scientific article published on 21 November 2013

Mind the gaps: confocal endomicroscopy showed increased density of small bowel epithelial gaps in inflammatory bowel disease.

scientific article

Misoprostol therapy following trinitrobenzene sulfonic acid-induced colitis accelerates healing

scientific article published on 01 April 1992

Molecular patterns in human ulcerative colitis and correlation with response to infliximab

scientific article published on December 2014

Mucosal protective effects of vitamin E and misoprostol during acute radiation-induced enteritis in rats

scientific article published on 01 February 1992

Multiple doses of intravenous interleukin 10 in steroid-refractory Crohn's disease. Crohn's Disease Study Group ⬇️

scientific article published on August 1, 1997

Murine ileocolic bowel resection with primary anastomosis.

scientific article published on 29 October 2014

Natalizumab for the treatment of active Crohn's disease: results of the ENCORE Trial

scientific article published on 21 March 2007

Naturally occurring glycoalkaloids in potatoes aggravate intestinal inflammation in two mouse models of inflammatory bowel disease

scientific article published on 3 March 2010

Neonatal exposure to fecal antigens reduces intestinal inflammation

scientific article published on 07 September 2010

Noninvasive Fecal Immunochemical Testing and Fecal Calprotectin Predict Mucosal Healing in Inflammatory Bowel Disease: A Prospective Cohort Study

scientific article published on 01 September 2017

Normal Breast Milk Limits the Development of Colitis in IL-10–Deficient Mice

article

Nutritional and intestinal effects of the novel immunosuppressive agents: Deoxyspergualin, rapamycin, and mycophenolate mofetil

scientific article published on 01 August 1996

Onercept for Moderate-to-Severe Crohn’s Disease: A Randomized, Double-Blind, Placebo-Controlled Trial

article

Oral administration of curcumin emulsified in carboxymethyl cellulose has a potent anti-inflammatory effect in the IL-10 gene-deficient mouse model of IBD.

scientific article

Oral versus intravenous iron replacement therapy distinctly alters the gut microbiota and metabolome in patients with IBD.

scientific article published on 4 February 2016

Oropharyngeal Crohn’s disease ⬇️

scientific article published on December 4, 2008

Patients Undergoing Colorectal Cancer Screening Underestimate Their Cancer Risk and Delay Presentation for Screening ⬇️

scientific article published on July 1, 2012

Patients with Active Luminal Crohn's Disease Have Evidence of Significant Functional and Clinical Pulmonary Involvement.

scientific article published in August 2015

Patients with inflammatory bowel disease exhibit dysregulated responses to microbial DNA

scientific article

Peptic ulcer bleeding outcomes adversely affected by end-stage renal disease

scientific article published in January 2010

Phenotypic features of Crohn's disease associated with failure of medical treatment.

scientific article published on 24 August 2013

Pneumococcal pneumonia: potential for diagnosis through a urinary metabolic profile.

scientific article

Postoperative Crohn's disease.

scientific article

Practical Considerations and the Intestinal Microbiome in Disease: Antibiotics for IBD Therapy.

scientific article

Predicting, treating and preventing postoperative recurrence of Crohn's disease: the state of the field

scientific article

Primary Outcomes From a Phase 3, Randomized, Double-Blind, Active-Controlled Trial of Surotomycin in Subjects With Clostridium difficile Infection

scientific article

Probiotic preparation VSL#3 induces remission in children with mild to moderate acute ulcerative colitis: a pilot study

scientific article published in May 2009

Probiotics and nutraceuticals: non-medicinal treatments of gastrointestinal diseases

scientific article

Probiotics and prebiotics in gastrointestinal disorders.

scientific article

Probiotics and the management of inflammatory bowel disease.

scientific article published in May 2004

Probiotics in the management of inflammatory bowel disease.

scientific article

Probiotics in the management of ulcerative colitis ⬇️

scientific article published on November 1, 2010

Probiotics in the treatment of inflammatory bowel disease.

scientific article

Prospective Study of the Quality of Colonoscopies Performed by Primary Care Physicians: The Alberta Primary Care Endoscopy (APC-Endo) Study

scientific article

Randomised clinical trial: vercirnon, an oral CCR9 antagonist, vs. placebo as induction therapy in active Crohn's disease

scientific article published on 23 September 2015

Randomized trial of etidronate plus calcium and vitamin D for treatment of low bone mineral density in Crohn's disease

scientific article published in February 2005

Randomized, double-blind, placebo-controlled trial of the oral interleukin-12/23 inhibitor apilimod mesylate for treatment of active Crohn's disease

scientific article

Real-Life Treatment Paradigms Show Adalimumab Is Cost-Effective for the Management of Ulcerative Colitis.

scientific article published on 03 October 2016

Real-life treatment paradigms show infliximab is cost-effective for management of ulcerative colitis

scientific article published on 24 March 2014

Recommendations for probiotic use--2008.

scientific article

Recurrent Fevers After Infliximab Therapy for Ulcerative Colitis

scientific article published on 25 November 2015

Review article: a clinician's guide for therapeutic drug monitoring of infliximab in inflammatory bowel disease.

scientific article published on 14 July 2013

Review article: acid suppression in non-variceal acute upper gastrointestinal bleeding.

scientific article

Risedronate improves bone mineral density in Crohn's disease: a two year randomized controlled clinical trial

scientific article published on 10 February 2012

Role of Vitamin D in Infliximab-induced Remission in Adult Patients with Crohnʼs Disease

scientific article published on 01 January 2016

Similar Clinical and Surgical Outcomes Achieved with Early Compared to Late Anti-TNF Induction in Mild-to-Moderate Ulcerative Colitis: A Retrospective Cohort Study

scientific article published on 11 July 2016

Small bowel fibrosis and systemic inflammatory response after ileocolonic anastomosis in IL-10 null mice

scientific article published on 31 March 2012

Small intestinal function following syngeneic transplantation in the rat.

scientific article published in March 1996

Steroid-sparing properties of sargramostim in patients with corticosteroid-dependent Crohn's disease: a randomised, double-blind, placebo-controlled, phase 2 study.

scientific article

Systematic review of stimulant and nonstimulant laxatives for the treatment of functional constipation

scientific article

Systematic review with meta-analysis: endoscopic and histologic placebo rates in induction and maintenance trials of ulcerative colitis

scientific article published on 25 April 2018

TACROLIMUS (FK506)-ITS EFFECTS ON INTESTINAL GLUCOSE TRANSPORT1

scientific article published on 01 February 1996

TP53 codon 72 Arg/Arg polymorphism is associated with a higher risk for inflammatory bowel disease development.

scientific article

Targeted delivery, safety, and efficacy of oral enteric-coated formulations of budesonide

scientific article

The Canadian Registry on Nonvariceal Upper Gastrointestinal Bleeding and Endoscopy (RUGBE): Endoscopic hemostasis and proton pump inhibition are associated with improved outcomes in a real-life setting

scientific article published in July 2004

The bacteriology of biopsies differs between newly diagnosed, untreated, Crohn's disease and ulcerative colitis patients

scientific article published in August 2006

The buried gastrostomy bumper syndrome: prevention and endoscopic approaches to removal

article

The epidemiology of inflammatory bowel disease in Canada: a population-based study

scientific article

The incidence rate of colectomy for medically refractory ulcerative colitis has declined in parallel with increasing anti-TNF use: a time-trend study

scientific article published on 13 July 2014

The oral toll-like receptor-7 agonist GS-9620 in patients with chronic hepatitis B virus infection

scientific article published on 27 February 2015

The physiology of adaptation to small bowel resection in the pig: An integrated study of morphological and functional changes

scientific article published on 01 June 1990

The probiotic VSL#3 has anti-inflammatory effects and could reduce endoscopic recurrence after surgery for Crohn's disease

scientific article

The role of antibiotic and probiotic therapies in current and future management of inflammatory bowel disease.

scientific article published on December 2006

The role of enteric microflora in inflammatory bowel disease: human and animal studies with probiotics and prebiotics.

scientific article

The sensitivity and specificity of guaiac and immunochemical fecal occult blood tests for the detection of advanced colonic adenomas and cancer

article

Treatment of active Crohn's disease with MLN0002, a humanized antibody to the alpha4beta7 integrin

scientific article

Treatment of ulcerative colitis with a humanized antibody to the alpha4beta7 integrin

scientific article published in June 2005

Tumor necrosis factor-α monoclonal antibodies in the treatment of inflammatory bowel disease: clinical practice pharmacology

scientific article published on September 2010

Ulcerative Colitis Patients With Clostridium difficile are at Increased Risk of Death, Colectomy, and Postoperative Complications: A Population-Based Inception Cohort Study.

scientific article published on 19 April 2016

Understanding why probiotic therapies can be effective in treating IBD.

scientific article

Urinary NMR metabolomic profiles discriminate inflammatory bowel disease from healthy ⬇️

scientific article published on May 22, 2012

Urinary metabolic profiles of inflammatory bowel disease in interleukin-10 gene-deficient mice

scientific article published on 18 June 2008

VSL#3 Probiotic-Mixture Induces Remission in Patients with Active Ulcerative Colitis

scientific article published on 01 July 2005

Validation of a point-of-care desk top device to quantitate fecal calprotectin and distinguish inflammatory bowel disease from irritable bowel syndrome

scientific article published on 7 September 2011

Vanadate treatment rapidly improves glucose transport and activates 6-phosphofructo-1-kinase in diabetic rat intestine

scientific article published in April 1995

Varicella zoster meningitis complicating combined anti-tumor necrosis factor and corticosteroid therapy in Crohn’s disease ⬇️

scientific article published on June 7, 2013

Vedolizumab as induction and maintenance therapy for Crohn's disease

scientific article

Vertebral Fractures and Role of Low Bone Mineral Density in Crohn’s Disease

scientific article published on 04 May 2007

Vitamin D improves inflammatory bowel disease outcomes: basic science and clinical review

scientific article

World Gastroenterology Organisation Global Guidelines: probiotics and prebiotics October 2011.

scientific article

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