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List of works by Norbert Arnold

A Fast, Highly Sensitive and Cheap Tool for Mutation Analysis of Complex Genes.

scientific article published in January 1999

A dendritic cell based hybrid cell vaccine generated by electrofusion for immunotherapy strategies in HNSCC.

scientific article published on June 2004

A genetic variant in the pre-miR-27a oncogene is associated with a reduced familial breast cancer risk

scientific article published on 18 November 2009

A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population

scientific article

A network of clinically and functionally relevant genes is involved in the reversion of the tumorigenic phenotype of MDA-MB-231 breast cancer cells after transfer of human chromosome 8.

scientific article

A nonsynonymous polymorphism in IRS1 modifies risk of developing breast and ovarian cancers in BRCA1 and ovarian cancer in BRCA2 mutation carriers

scientific article

A variant affecting a putative miRNA target site in estrogen receptor (ESR) 1 is associated with breast cancer risk in premenopausal women

scientific article published on 20 November 2008

A variant affecting miRNAs binding in the circadian gene Neuronal PAS domain protein 2 (NPAS2) is not associated with breast cancer risk

scientific article published on 8 December 2010

ADAM17 inhibition enhances platinum efficiency in ovarian cancer

scientific article published on 23 March 2018

Allelic loss analysis by denaturing high-performance liquid chromatography and electrospray ionization mass spectrometry.

scientific article

Alteration of STR profiles in ovarian carcinoma cells during primary culture

scientific article published on 29 January 2016

An easy and reliable procedure of microdissection technique for the analysis of chromosomal breakpoints and marker chromosomes

scientific article published on January 1999

An evaluation of the polymorphisms Ins16bp and Arg72Pro in p53 as breast cancer risk modifiers in BRCA1 and BRCA2 mutation carriers

scientific article published on September 2008

An integrated clinical-genomics approach identifies a candidate multi-analyte blood test for serous ovarian carcinoma

scientific article published in January 2007

An original phylogenetic approach identified mitochondrial haplogroup T1a1 as inversely associated with breast cancer risk in BRCA2 mutation carriers

scientific article published on 25 April 2015

Analysis of 30 putative BRCA1 splicing mutations in hereditary breast and ovarian cancer families identifies exonic splice site mutations that escape in silico prediction

scientific article

Array-CGH analysis of microdissected chromosome 19 markers in ovarian carcinoma identifies candidate target genes

scientific article published on 01 November 2010

Assessing associations between the AURKA-HMMR-TPX2-TUBG1 functional module and breast cancer risk in BRCA1/2 mutation carriers

scientific article

Association of Genomic Domains in BRCA1 and BRCA2 with Prostate Cancer Risk and Aggressiveness

scientific article published on 13 November 2019

Association of PHB 1630 C>T and MTHFR 677 C>T polymorphisms with breast and ovarian cancer risk in BRCA1/2 mutation carriers: results from a multicenter study

scientific article

Association of breast cancer risk in BRCA1 and BRCA2 mutation carriers with genetic variants showing differential allelic expression: identification of a modifier of breast cancer risk at locus 11q22.3.

scientific article

Association of death receptor 4 variant (683A > C) with ovarian cancer risk in BRCA1 mutation carriers

scientific article

Association of the variants CASP8 D302H and CASP10 V410I with breast and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers

scientific article

Association of type and location of BRCA1 and BRCA2 mutations with risk of breast and ovarian cancer

scientific article

Associations of common breast cancer susceptibility alleles with risk of breast cancer subtypes in BRCA1 and BRCA2 mutation carriers

scientific article published on 31 December 2014

Associations of genetic variants in the estrogen receptor coactivators PPARGC1A, PPARGC1B and EP300 with familial breast cancer

scientific article (publication date: November 2006)

Aurora kinase inhibitor AZD1152 has an additional effect of platinum on a sequential application at the human ovarian cancer cell line SKOV3.

scientific article published on 7 February 2013

BRIP1 loss-of-function mutations confer high risk for familial ovarian cancer, but not familial breast cancer

scientific article published on 24 January 2018

Breakpoint characterization of the der(19)t(11;19)(q13;p13) in the ovarian cancer cell line SKOV-3.

scientific article published on 30 January 2013

Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170.

scientific article

Candidate genetic modifiers for breast and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers

scientific article

Changes in classification of genetic variants in BRCA1 and BRCA2.

scientific article

Characterization of two supernumerary marker chromosomes in a patient with signs of Klinefelter syndrome, mild facial anomalies, and severe speech delay

scientific article published in March 2006

Chromosomal mosaicisms in prenatal diagnosis: correlation with first trimester screening and clinical outcome

scientific article published on 06 January 2012

Combination of enzastaurin and pemetrexed inhibits cell growth and induces apoptosis of chemoresistant ovarian cancer cells regulating extracellular signal-regulated kinase 1/2 phosphorylation

scientific article published on August 2009

Combined PARP and Dual Topoisomerase Inhibition Potentiates Genome Instability and Cell Death in Ovarian Cancer

scientific article published in 2022

Combined genetic and splicing analysis of BRCA1 c.[594-2A>C; 641A>G] highlights the relevance of naturally occurring in-frame transcripts for developing disease gene variant classification algorithms

scientific article published on 23 March 2016

Combined treatment with TRAIL and PPARγ ligands overcomes chemoresistance of ovarian cancer cell lines

scientific article published on 29 September 2010

Common alleles at 6q25.1 and 1p11.2 are associated with breast cancer risk for BRCA1 and BRCA2 mutation carriers

scientific article published on 18 May 2011

Common breast cancer susceptibility alleles and the risk of breast cancer for BRCA1 and BRCA2 mutation carriers: implications for risk prediction

scientific article

Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2.

scientific article published on 2 November 2011

Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers

scientific article

Common genetic variants and modification of penetrance of BRCA2-associated breast cancer

scientific article

Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers

scientific article

Common variants at the 19p13.1 and ZNF365 loci are associated with ER subtypes of breast cancer and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers

scientific article published on 20 February 2012

Common variants in LSP1, 2q35 and 8q24 and breast cancer risk for BRCA1 and BRCA2 mutation carriers

scientific article published on 05 August 2009

Common variants of the BRCA1 wild-type allele modify the risk of breast cancer in BRCA1 mutation carriers

scientific article

Comparison of gene expression data from human and mouse breast cancers: identification of a conserved breast tumor gene set.

scientific article

Contralateral breast cancer risk in BRCA1 and BRCA2 mutation carriers

scientific article published on 26 October 2009

Correction: Common Genetic Variants and Modification of Penetrance of BRCA2-Associated Breast Cancer

scholarly article by Mia M Gaudet published in November 2010

DNA glycosylases involved in base excision repair may be associated with cancer risk in BRCA1 and BRCA2 mutation carriers

scientific article

Decreased expression of angiogenesis antagonist EFEMP1 in sporadic breast cancer is caused by aberrant promoter methylation and points to an impact of EFEMP1 as molecular biomarker

scientific article published in April 2009

Delineation of a complex karyotypic rearrangement by microdissection and CGH in a family affected with split foot

scientific article

Double heterozygosity for mutations in BRCA1 and BRCA2 in German breast cancer patients: implications on test strategies and clinical management

scientific article published on 26 April 2012

Evaluation of Polygenic Risk Scores for Breast and Ovarian Cancer Risk Prediction in BRCA1 and BRCA2 Mutation Carriers

scientific article

Evaluation of SNPs in miR-146a, miR196a2 and miR-499 as low-penetrance alleles in German and Italian familial breast cancer cases

scientific article

Evaluation of a candidate breast cancer associated SNP in ERCC4 as a risk modifier in BRCA1 and BRCA2 mutation carriers. Results from the Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA).

scientific article

Evaluation of potentially predictive markers for anti-angiogenic therapy with sunitinib in recurrent ovarian cancer patients

scientific article published on June 2013

FISH-microdissection (FISH-MD) analysis of complex chromosome rearrangements

scientific article published on January 2000

Frequent translocations of 11q13.2 and 19p13.2 in ovarian cancer

scientific article published on 24 February 2014

Gene panel testing of 5589 BRCA1/2-negative index patients with breast cancer in a routine diagnostic setting: results of the German Consortium for Hereditary Breast and Ovarian Cancer

scientific article published on 9 March 2018

GeneChip analyses point to novel pathogenetic mechanisms in mantle cell lymphoma

scientific article

Genetic background of different cancer cell lines influences the gene set involved in chromosome 8 mediated breast tumor suppression

scientific article published on June 2006

Genetic characteristics of the human hepatic stellate cell line LX-2.

scientific article

Genetic characteristics of the human hepatic stellate cell line LX–2

Genetic imbalances in precursor lesions of endometrial cancer detected by comparative genomic hybridization

scientific article published on June 2000

Genetic variants within miR-126 and miR-335 are not associated with breast cancer risk

scientific article published on 3 November 2010

Genetic variation at 9p22.2 and ovarian cancer risk for BRCA1 and BRCA2 mutation carriers

scientific article

Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk

scientific article (publication date: 2013)

Germline mutations in the PALB2 gene are population specific and occur with low frequencies in familial breast cancer.

scientific article published on 24 February 2011

Head-to-head comparison of the impact of Aurora A, Aurora B, Repp86, CDK1, CDK2 and Ki67 expression in two of the most relevant gynaecological tumor entities

scientific article published on 21 April 2016

High expression of crystallin αB represents an independent molecular marker for unfavourable ovarian cancer patient outcome and impairs TRAIL- and cisplatin-induced apoptosis in human ovarian cancer cells.

scientific article published on 27 December 2012

High resolution copy number analysis of IRF4 translocation-positive diffuse large B-cell and follicular lymphomas

scientific article published on 17 October 2012

Highly comprehensive karyotype analysis by a combination of spectral karyotyping (SKY), microdissection, and reverse painting (SKY-MD).

scientific article published on January 2001

Human BRCA1-Associated Breast Cancer: No Increase in Numerical Chromosomal Instability Compared to Sporadic Tumors ⬇️

scientific article published on October 24, 2011

Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer

scientific article

Identification of a BRCA2-specific modifier locus at 6p24 related to breast cancer risk

scientific article published on 27 March 2013

Identification of a DMBT1 polymorphism associated with increased breast cancer risk and decreased promoter activity

scientific article

Identification of brain- and bone-specific breast cancer metastasis genes

scientific article

Identification of candidate tumour suppressor gene loci for Hodgkin and Reed-Sternberg cells by characterisation of homozygous deletions in classical Hodgkin lymphoma cell lines

scientific article published on 30 July 2008

Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer

scientific article published on 23 October 2017

Inheritance of deleterious mutations at both BRCA1 and BRCA2 in an international sample of 32,295 women

scientific article

Interaction of Werner and Bloom syndrome genes with p53 in familial breast cancer

scientific article published on 25 February 2006

Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer

scientific article

Is the Ki-67 labelling index ready for clinical use?

scientific article published on 01 March 2011

Isolated trisomy 7q21.2-31.31 resulting from a complex familial rearrangement involving chromosomes 7, 9 and 10.

scientific article published on 5 December 2011

Large BRCA1 gene deletions are found in 3% of German high-risk breast cancer families.

scientific article published in December 2004

Limited relevance of the CHEK2 gene in hereditary breast cancer

scientific article published in June 2004

Low-risk variants FGFR2, TNRC9 and LSP1 in German familial breast cancer patients

scientific article published in June 2010

Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2.

scientific article

Mammary fibroblasts regulate morphogenesis of normal and tumorigenic breast epithelial cells by mechanical and paracrine signals

scientific article published on 07 July 2012

Molecular and prognostic distinction between serous ovarian carcinomas of varying grade and malignant potential

scientific article

Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

scientific article published on April 2013

Mutation of an IKK phosphorylation site within the transactivation domain of REL in two patients with B-cell lymphoma enhances REL's in vitro transforming activity

scientific article published on 30 October 2006

Mutational Spectrum in a Worldwide Study of 29,700 Families with BRCA1 or BRCA2 Mutations

scientific article published on 15 February 2018

Neutrophil gelatinase-associated lipocalin (NGAL) predicts response to neoadjuvant chemotherapy and clinical outcome in primary human breast cancer

scientific article

No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer.

scientific article published in May 2015

Nuclear receptor coregulator SNP discovery and impact on breast cancer risk

scientific article

Oocyte morphology on day 0 correlates with aneuploidy as detected by polar body biopsy and FISH.

scientific article published on 24 July 2013

Ovarian cancer susceptibility alleles and risk of ovarian cancer in BRCA1 and BRCA2 mutation carriers

scientific article

Pathology of breast and ovarian cancers among BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA)

scientific article published on 5 December 2011

Polymorphisms in BRCA2 resulting in aberrant codon-usage and their analysis on familial breast cancer risk

scientific article

Polymorphisms in a Putative Enhancer at the 10q21.2 Breast Cancer Risk Locus Regulate NRBF2 Expression

scientific article published on 11 June 2015

Polymorphisms in the Janus kinase 2 (JAK)/signal transducer and activator of transcription (STAT) genes: putative association of the STAT gene region with familial breast cancer

scientific article published on 01 June 2007

Prediction of Breast and Prostate Cancer Risks in Male BRCA1 and BRCA2 Mutation Carriers Using Polygenic Risk Scores

scientific article

Premature ovarian failure in a patient with a complex chromosome rearrangement involving the critical region Xq24, characterized by analysis using fluorescence in situ hybridization by chromosome microdissection

scientific article published on 07 May 2007

Prevalence of BRCA1/2 germline mutations in 21 401 families with breast and ovarian cancer

scientific article

Prevalence of pathogenic BRCA1/2 germline mutations among 802 women with unilateral triple-negative breast cancer without family cancer history

scientific article published on 7 March 2018

Prognostic value of human epidermal growth factor receptor 2 (Her-2)/neu in patients with advanced ovarian cancer treated with platinum/paclitaxel as first-line chemotherapy: a retrospective evaluation of the AGO-OVAR 3 Trial by the AGO OVAR Germany

scientific article published in January 2009

Progression-free survival in ovarian cancer is reflected in epigenetic DNA methylation profiles

scientific article

Proof of partial imbalances 6q and 11q due to maternal complex balanced translocation analyzed by microdissection of multicolor labeled chromosomes (FISH-MD) in a patient with Dandy-Walker variant

scientific article published in January 2006

RAD51 135G-->C modifies breast cancer risk among BRCA2 mutation carriers: results from a combined analysis of 19 studies

scientific article published on 16 October 2007

Reconstruction of genomic rearrangements in great apes and gibbons by chromosome painting ⬇️

scientific article published on September 15, 1992

Recurrent loss of the Y chromosome and homozygous deletions within the pseudoautosomal region 1: association with male predominance in mantle cell lymphoma

scientific article published on 01 June 2008

Recurrent loss, but lack of mutations, of the SMARCB1 tumor suppressor gene in T-cell prolymphocytic leukemia with TCL1A-TCRAD juxtaposition

scientific article published in July 2009

Refined histopathological predictors of BRCA1 and BRCA2 mutation status: a large-scale analysis of breast cancer characteristics from the BCAC, CIMBA, and ENIGMA consortia

scientific article

Reverse painting of microdissected chromosome 19 markers in ovarian carcinoma identifies a complex rearrangement map.

scientific article published on February 2009

S3-Guideline on Diagnostics, Therapy and Follow-up of Malignant Ovarian Tumours: Short version 1.0 - AWMF registration number: 032/035OL, June 2013.

scientific article published on September 2013

SNPs in ultraconserved elements and familial breast cancer risk

scientific article published on 03 January 2008

Screening for large rearrangements of the BRCA1 gene in German breast or ovarian cancer families using semi-quantitative multiplex PCR method

scientific article published in July 2003

Sham-controlled implantation after preimplantation genetic screening by polar body biopsy and FISH.

scientific article

Simultaneous congener-specific determination of selected organochlorine compounds and nitro musks in human whole blood samples by solid-phase extraction and capillary gas chromatography with electron capture detection

scientific article published in March 2005

Spectrum of genetic variants of BRCA1 and BRCA2 in a German single center study

scientific article

Strong evidence that the common variant S384F in BRCA2 has no pathogenic relevance in hereditary breast cancer

scientific article

The BRCA1 c. 5096G>A p.Arg1699Gln (R1699Q) intermediate risk variant: breast and ovarian cancer risk estimation and recommendations for clinical management from the ENIGMA consortium

scientific article published on 10 May 2017

The CpG island methylator phenotype in breast cancer is associated with the lobular subtype

scientific article published on 27 October 2014

The TP53 Arg72Pro and MDM2 309G>T polymorphisms are not associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers

scientific article published on 25 August 2009

The functional genetic variant Ile646Val located in the kinase binding domain of the A-kinase anchoring protein 10 is associated with familial breast cancer

scientific article published on 06 September 2006

The impact of electrical charge on the viability and physiology of dendritic cells.

scientific article

The origin of human chromosome 2 analyzed by comparative chromosome mapping with a DNA microlibrary

scientific article published on September 1994

The prognostic and predictive value of immunohistochemically detected HER-2/neu overexpression in 361 patients with ovarian cancer: a multicenter study

Validation of the Manchester scoring system for predicting BRCA1/2 mutations in 9,390 families suspected of having hereditary breast and ovarian cancer

scientific article published on 25 April 2014

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