List of works by Juan Roa

A microRNA switch regulates the rise in hypothalamic GnRH production before puberty

scientific article

Advanced vaginal opening and precocious activation of the reproductive axis by KiSS-1 peptide, the endogenous ligand of GPR54.

scientific article published on 14 October 2004

Alterations in hypothalamic KiSS-1 system in experimental diabetes: early changes and functional consequences.

scientific article published on 9 October 2008

Changes in hypothalamic KiSS-1 system and restoration of pubertal activation of the reproductive axis by kisspeptin in undernutrition

scientific article published on 2 June 2005

Changes in keratin 8/18 expression in human granulosa cell lineage are associated to cell death/survival events: potential implications for the maintenance of the ovarian reserve.

scientific article published in February 2018

Characterization of the Potent Luteinizing Hormone-Releasing Activity of KiSS-1 Peptide, the Natural Ligand of GPR54

scientific article published on 16 September 2004

Connecting metabolism and gonadal function: Novel central neuropeptide pathways involved in the metabolic control of puberty and fertility

scientific article published on 25 July 2017

Connecting metabolism and reproduction: roles of central energy sensors and key molecular mediators

scientific article published on 05 October 2014

Crowding and Follicular Fate: Spatial Determinants of Follicular Reserve and Activation of Follicular Growth in the Mammalian Ovary

scientific article published on 7 December 2015

Defining a novel leptin-melanocortin-kisspeptin pathway involved in the metabolic control of puberty

scientific article published on 11 August 2016

Dependence of fertility on kisspeptin-Gpr54 signaling at the GnRH neuron

scientific article published in January 2013

Desensitization of gonadotropin responses to kisspeptin in the female rat: analyses of LH and FSH secretion at different developmental and metabolic states.

scientific article published on 15 April 2008

Development and validation of a method for precise dating of female puberty in laboratory rodents: The puberty ovarian maturation score (Pub-Score).

scientific article

Developmental and hormonally regulated messenger ribonucleic acid expression of KiSS-1 and its putative receptor, GPR54, in rat hypothalamus and potent luteinizing hormone-releasing activity of KiSS-1 peptide.

scientific article published on 8 July 2004

Differential modulation of gonadotropin responses to kisspeptin by aminoacidergic, peptidergic, and nitric oxide neurotransmission

scientific article

Direct Actions of Kisspeptins on GnRH Neurons Permit Attainment of Fertility but are Insufficient to Fully Preserve Gonadotropic Axis Activity.

scientific article

Direct regulation of GnRH neuron excitability by arcuate nucleus POMC and NPY neuron neuropeptides in female mice

scientific article published on 4 September 2012

Direct stimulatory effect of ghrelin on pituitary release of LH through a nitric oxide-dependent mechanism that is modulated by estrogen

scientific article

Effects and interactions of tachykinins and dynorphin on FSH and LH secretion in developing and adult rats

scientific article

Effects of KiSS-1 peptide, the natural ligand of GPR54, on follicle-stimulating hormone secretion in the rat.

scientific article published on 6 January 2005

Effects of galanin-like peptide on luteinizing hormone secretion in the rat: sexually dimorphic responses and enhanced sensitivity at male puberty

scientific article published on 18 July 2006

Effects of single or repeated intravenous administration of kisspeptin upon dynamic LH secretion in conscious male rats

scientific article published on 2 March 2006

Energy balance and puberty onset: emerging role of central mTOR signaling

scientific article published on 16 June 2010

Expression of KiSS-1 in rat ovary: putative local regulator of ovulation?

scientific article published on 6 July 2006

Expression of KiSS-1 in rat oviduct: possible involvement in prevention of ectopic implantation?

scientific journal article

Expression of hypothalamic KiSS-1 system and rescue of defective gonadotropic responses by kisspeptin in streptozotocin-induced diabetic male rats

scientific article published in September 2006

Follicle-stimulating hormone responses to kisspeptin in the female rat at the preovulatory period: modulation by estrogen and progesterone receptors

scientific article published on 17 July 2008

Ghrelin inhibits the proliferative activity of immature Leydig cells in vivo and regulates stem cell factor messenger ribonucleic acid expression in rat testis.

scientific article

Gonadal hormone-dependent vs. -independent effects of kisspeptin signaling in the control of body weight and metabolic homeostasis

scientific article published on 19 June 2019

Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance.

scientific article

Hypothalamic expression of KiSS-1 system and gonadotropin-releasing effects of kisspeptin in different reproductive states of the female Rat.

scientific article

Hypothalamic mTOR pathway mediates thyroid hormone-induced hyperphagia in hyperthyroidism.

scientific article published on 17 February 2012

In vivo and in vitro structure-activity relationships and structural conformation of Kisspeptin-10-related peptides

scientific article published on 23 April 2009

Intergenerational Influence of Paternal Obesity on Metabolic and Reproductive Health Parameters of the Offspring: Male-Preferential Impact and Involvement of Kiss1-Mediated Pathways

scientific article published on 22 December 2017

KiSS-1 in the mammalian ovary: distribution of kisspeptin in human and marmoset and alterations in KiSS-1 mRNA levels in a rat model of ovulatory dysfunction.

scientific article published on 13 January 2009

KiSS-1 system and reproduction: comparative aspects and roles in the control of female gonadotropic axis in mammals

scientific article published on 30 January 2007

KiSS-1/kisspeptins and the metabolic control of reproduction: physiologic roles and putative physiopathological implications

scientific article published on 21 June 2008

Kisspeptins and the control of gonadotropin secretion in male and female rodents.

scientific article published on 22 August 2008

Kisspeptins in reproductive biology: consensus knowledge and recent developments

scientific article published on 15 June 2011

Leptin deficiency and diet-induced obesity reduce hypothalamic kisspeptin expression in mice

scientific article published on 15 February 2011

Maternal serum ghrelin levels in early IVF pregnancies: lack of prognostic value for viable pregnancy and altered post-prandial responses

scientific article

Metabolic and Gonadotropic Impact of Sequential Obesogenic Insults in the Female: Influence of the Loss of Ovarian Secretion.

scientific article published on 18 May 2015

Metabolic control of puberty onset: new players, new mechanisms

scientific article published on 21 December 2009

Metabolic regulation of female puberty via hypothalamic AMPK-kisspeptin signaling

article published in the Proceedings of the National Academy of Sciences of the United States of America

Neuromedin s as novel putative regulator of luteinizing hormone secretion.

scientific article

New frontiers in kisspeptin/GPR54 physiology as fundamental gatekeepers of reproductive function

scientific article published on 11 August 2007

Novel expression and functional role of ghrelin in chicken ovary

Novel role of the anorexigenic peptide neuromedin U in the control of LH secretion and its regulation by gonadal hormones and photoperiod

scientific article (publication date: November 2007)

Opposite roles of estrogen receptor (ER)-alpha and ERbeta in the modulation of luteinizing hormone responses to kisspeptin in the female rat: implications for the generation of the preovulatory surge.

scientific article

Persistent impairment of hypothalamic KiSS-1 system after exposures to estrogenic compounds at critical periods of brain sex differentiation.

scientific article published on 23 December 2008

Physiological roles of gonadotropin-inhibitory hormone signaling in the control of mammalian reproductive axis: studies in the NPFF1 receptor null mouse

scientific article published on 13 May 2014

Role of GnRH Neurons and Their Neuronal Afferents as Key Integrators between Food Intake Regulatory Signals and the Control of Reproduction

scientific article published on 11 September 2013

SF1-Specific AMPKα1 Deletion Protects Against Diet-Induced Obesity

scientific article published on 13 August 2018

SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression

scientific article published in Nature Communications

Selective role of neuropeptide Y receptor subtype Y2 in the control of gonadotropin secretion in the rat.

scientific article

Serotonin acts through 5-HT1 and 5-HT2 receptors to exert biphasic actions on GnRH neuron excitability in the mouse

scientific article published on 21 November 2013

Sex-Biased Physiological Roles of NPFF1R, the Canonical Receptor of RFRP-3, in Food Intake and Metabolic Homeostasis Revealed by its Congenital Ablation in mice

scholarly article by Silvia Leon et al published October 2018 in Metabolism

Sexual differentiation of Kiss1 gene expression in the brain of the rat.

scientific article published on 4 January 2007

Stimulatory effect of PYY-(3-36) on gonadotropin secretion is potentiated in fasted rats

scientific article published on 3 January 2006

The Fusarium oxysporum sti35 gene functions in thiamine biosynthesis and oxidative stress response

scientific article published on 25 September 2007

The anorexigenic neuropeptide, nesfatin-1, is indispensable for normal puberty onset in the female rat.

scientific article published on June 2010

The mammalian target of rapamycin as novel central regulator of puberty onset via modulation of hypothalamic Kiss1 system.

scientific article published on 4 September 2009

Unique Features of a Unique Cell: The Wonder World of GnRH Neurons

scientific article published on 01 December 2018

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