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List of works by Andrew W. Roberts

A Phase 1 study of the safety, pharmacokinetics and anti-leukemic activity of the anti-CD123 monoclonal antibody CSL360 in relapsed, refractory or high-risk acute myeloid leukemia

scientific article published on 20 November 2014

A Phase Ib Dose-Escalation and Expansion Study of the BCL2 Inhibitor Venetoclax Combined with Tamoxifen in ER and BCL2-Positive Metastatic Breast Cancer

scientific article published on 05 December 2018

A Prospective Multicenter Trial of Peripheral Blood Stem Cell Sibling Allografts for Acute Myeloid Leukemia in First Complete Remission Using Fludarabine-Cyclophosphamide Reduced Intensity Conditioning

scientific article published on 22 February 2007

A key role for G-CSF-induced neutrophil production and trafficking during inflammatory arthritis

scientific article published on 29 September 2008

A multicenter phase II trial of thalidomide and celecoxib for patients with relapsed and refractory multiple myeloma

scientific article published on August 2005

A phase I dose-escalation study of etoposide continuous infusion added to busulphan/cyclophosphamide as conditioning prior to autologous or allogeneic stem cell transplantation

scientific article published in November 2002

A pilot study of targeted itraconazole prophylaxis in patients with graft-versus-host disease at high risk of invasive mould infections following allogeneic stem cell transplantation

scientific article published in September 2004

A randomized comparison of empiric or pre-emptive antibiotic therapy after hematopoietic stem cell transplantation.

scientific article published on 30 April 2007

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

scientific article

AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies

scientific article published on 25 September 2018

Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1β.

scientific article published on 25 May 2015

Abnormal neutrophil phenotype and neutrophil FcRIII deficiency corrected by bone marrow transplantation

scientific article published on 01 October 1995

Absence of suppressor of cytokine signalling 3 reduces self-renewal and promotes differentiation in murine embryonic stem cells.

scientific article published on 25 August 2005

Acquisition of the Recurrent Gly101Val Mutation in BCL2 Confers Resistance to Venetoclax in Patients with Progressive Chronic Lymphocytic Leukemia

scientific article published on 04 December 2018

Acute left ventricular failure following melphalan and fludarabine conditioning

scientific article

All-trans retinoic acid - chemotherapy interactions in acute promyelocytic leukaemia

scientific article published on 01 December 1992

Allogeneic Stem Cell Transplantation with Peripheral Blood Stem Cells Mobilized by Pegylated G-CSF

scientific article published on 01 June 2006

BCL2 inhibition in double hit lymphoma.

scientific article

BET inhibition represses miR17-92 to drive BIM-initiated apoptosis of normal and transformed hematopoietic cells.

scientific article published on 08 March 2016

BH3 mimetic therapy: an emerging and promising approach to treating chronic lymphocytic leukemia.

scientific article published in February 2013

BH3-mimetics--the solution to chemoresistance?

scientific article

BTK inhibitor therapy is effective in patients with CLL resistant to venetoclax

scientific article published on 03 April 2020

Bcl-2, Bcl-x(L), and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells

scientific article

Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets

scientific article

Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic.

scholarly article

Bisphosphonate guidelines for treatment and prevention of myeloma bone disease

scientific article published in August 2017

Bortezomib: putting mantle cell lymphoma on death row.

scientific article published on April 2008

Both leukaemic and normal peripheral B lymphoid cells are highly sensitive to the selective pharmacological inhibition of prosurvival Bcl-2 with ABT-199.

scientific article

Broad inter‐individual variations in circulating progenitor cell numbers induced by granulocyte colony‐stimulating factor therapy

scientific article published on 01 September 1995

Changing of the guard…the old and the new

scientific article published on 01 January 2020

Clinical and immunohistochemical features associated with a response to bortezomib in patients with multiple myeloma

scientific article

Clinicopathological features and outcomes of progression of CLL on the BCL2 inhibitor venetoclax.

scientific article

Combining BH3-mimetics to target both BCL-2 and MCL1 has potent activity in pre-clinical models of acute myeloid leukemia.

scientific article published on 10 September 2018

Comprehensive Safety Analysis of Venetoclax Monotherapy for Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia

scientific article published on 12 June 2018

Consolidation therapy with low-dose thalidomide and prednisolone prolongs the survival of multiple myeloma patients undergoing a single autologous stem-cell transplantation procedure

scientific article published on 9 March 2009

Critical role for granulocyte colony-stimulating factor in inflammatory arthritis

scholarly article

Current challenges and novel treatment strategies in double hit lymphomas

scientific article

Cyclosporin, methotrexate and prednisolone for graft-versus-host disease prophylaxis in allogeneic peripheral blood progenitor cell transplants.

scientific article published on 7 January 2008

Deep profiling of apoptotic pathways with mass cytometry identifies a synergistic drug combination for killing myeloma cells

scientific article published on 27 January 2020

Deficiency of 5-hydroxyisourate hydrolase causes hepatomegaly and hepatocellular carcinoma in mice

scientific article

Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense

scientific journal article

Dok-related protein negatively regulates T cell development via its RasGTPase-activating protein and Nck docking sites

scientific article

Donald Metcalf (1929–2014)

scientific article published on 01 January 2015

Dynamic molecular monitoring reveals that SWI-SNF mutations mediate resistance to ibrutinib plus venetoclax in mantle cell lymphoma

scientific article published on 19 November 2018

Efficacy of venetoclax in relapsed chronic lymphocytic leukemia is influenced by disease and response variables

scientific article published on 25 April 2019

Enhancing venetoclax activity in acute myeloid leukemia by co-targeting MCL1.

scientific article

Fas regulates neutrophil lifespan during viral and bacterial infection

scientific article

Fas-mediated neutrophil apoptosis is accelerated by Bid, Bak, and Bax and inhibited by Bcl-2 and Mcl-1

scientific article

G-CSF: a key regulator of neutrophil production, but that's not all!

scientific article

GFI1B mutation causes a bleeding disorder with abnormal platelet function.

scientific article

Genetic heterogeneity of granulocytes for the JAK2 V617F mutation in essential thrombocythaemia: implications for mutation detection in peripheral blood

scientific article published on 01 August 2006

Genetic reduction of embryonic leukemia-inhibitory factor production rescues placentation in SOCS3-null embryos but does not prevent inflammatory disease

scientific article

Graft-versus-host disease, donor chimerism, and organ toxicity in stem cell transplantation after conditioning with fludarabine and melphalan

scientific article published in July 2003

Graft-versus-lymphoma effect in progressive hepatosplenic gamma/delta T-cell lymphoma

scientific article published on 01 July 2007

Granulocyte colony-stimulating factor and neutrophils--forgotten mediators of inflammatory disease

scientific article published on September 2006

Guidelines for the use of antifungal agents in the treatment of invasive Candida and mould infections.

scientific article published on April 2004

Hematopoietic abnormalities in mice deficient in gp130-mediated STAT signaling

scientific article

Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin.

scientific article published on February 1998

Hierarchy for targeting prosurvival BCL2 family proteins in multiple myeloma: pivotal role of MCL1.

scientific article

IL-6 promotes acute and chronic inflammatory disease in the absence of SOCS3.

scientific article

Ibrutinib plus Venetoclax for the Treatment of Mantle-Cell Lymphoma

scientific article published in March 2018

Idarubicin Dose Escalation During Consolidation Therapy for Adult Acute Myeloid Leukemia

scientific article

Identification of a genetic locus modulating splenomegaly induced by granulocyte colony-stimulating factor in mice

scientific article published on 01 April 2000

Immune thrombocytopenia complicating pulmonary tuberculosis: case report and investigation of mechanisms ⬇️

scientific article published on May 1, 1992

Improved survival for relapsed diffuse large B cell lymphoma is predicted by a negative pre-transplant FDG-PET scan following salvage chemotherapy

scientific article published on 07 May 2010

In vivo efficacy of the Bcl-2 antagonist ABT-737 against aggressive Myc-driven lymphomas

scholarly article

Long-term efficacy and safety of momelotinib, a JAK1 and JAK2 inhibitor, for the treatment of myelofibrosis

scientific article published on 16 November 2017

Low adhesion receptor levels on circulating platelets in patients with lymphoproliferative diseases before receiving Navitoclax (ABT-263).

scientific article published in February 2013

Management of systemic AL amyloidosis: recommendations of the Myeloma Foundation of Australia Medical and Scientific Advisory Group.

scientific article

Mcl-1 and Bcl-xL coordinately regulate megakaryocyte survival

article

Mechanism of crosstalk inhibition of IL-6 signaling in response to LPS and TNFα

scientific article published on 01 October 2007

Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets

scientific article

Mini-allografts' for haematological malignancies: an alternative to conventional myeloablative marrow transplantation.

scientific article

Mobilization of dendritic cells in cancer patients treated with granulocyte colony-stimulating factor and chemotherapy

scientific article published in October 2002

Morphological effects of imatinib mesylate (STI571) on the bone marrow and blood of patients with Philadelphia chromosome (Ph) positive chronic myeloid leukaemia.

scientific article

Mouse loci for malaria-induced mortality and the control of parasitaemia.

scientific article published in December 1997

Nephrotic syndrome as a complication of chronic graft-versus-host disease after allogeneic haemopoietic stem cell transplantation

scientific article published on 01 June 2016

Neutrophils Require SHP1 To Regulate IL-1 Production and Prevent Inflammatory Skin Disease

scientific article published on 15 December 2010

Optimal Regimens for the Mobilization and Collection of Peripheral Blood Progenitor Cells from Normal Donors ⬇️

scientific article published on September 1, 1997

Overcoming blocks in apoptosis with BH3-mimetic therapy in haematological malignancies.

scientific article published on October 2011

Pathologic consequences of STAT3 hyperactivation by IL-6 and IL-11 during hematopoiesis and lymphopoiesis

scientific article published on 02 November 2006

Perturbed thymopoiesis in vitro in the absence of suppressor of cytokine signalling 1 and 3.

scientific article

Phase 1 study of the safety, pharmacokinetics, and antitumour activity of the BCL2 inhibitor navitoclax in combination with rituximab in patients with relapsed or refractory CD20+ lymphoid malignancies

scientific article

Phase 1 study of the selective BTK inhibitor zanubrutinib in B-cell malignancies and safety and efficacy evaluation in CLL

scientific article published on 24 July 2019

Phase I First-in-Human Study of Venetoclax in Patients With Relapsed or Refractory Non-Hodgkin Lymphoma

scientific article

Polyclonal Heterogeneity: The New Norm for Secondary Clinical Resistance to Targeted Monotherapy in Relapsed Leukemia?

scientific article published on 01 August 2019

Potent efficacy of MCL-1 inhibitor-based therapies in preclinical models of mantle cell lymphoma

scientific article published on 26 November 2019

Proapoptotic Bak and Bax guard against fatal systemic and organ-specific autoimmune disease

scientific article published on 24 January 2013

Programmed anuclear cell death delimits platelet life span.

scientific article

Progress in BCL2 inhibition for patients with chronic lymphocytic leukemia

scientific article published on 6 February 2016

Promising efficacy and acceptable safety of venetoclax plus bortezomib and dexamethasone in relapsed/refractory MM.

scientific article published on 28 August 2017

Ptpn6 inhibits caspase-8- and Ripk3/Mlkl-dependent inflammation

scientific article published on 09 December 2019

RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis

scientific article published on 8 May 2014

Rac2-deficient mice display perturbed T-cell distribution and chemotaxis, but only minor abnormalities in TH 1 responses

article

Rapid Inflammation in Mice Lacking Both SOCS1 and SOCS3 in Hematopoietic Cells

scientific article

Reduced-intensity allogeneic haemopoietic stem cell transplantation induces durable responses in patients with chronic B-lymphoproliferative disorders

article

Regulation of interleukin-1beta by interferon-gamma is species specific, limited by suppressor of cytokine signalling 1 and influences interleukin-17 production

scientific article

Regulation of multiple cytokine signalling pathways by SOCS3 is independent of SOCS2.

scientific article

Reply to M. Cavo

Results of a phase 2 study of pacritinib (SB1518), a JAK2/JAK2(V617F) inhibitor, in patients with myelofibrosis

scientific article

Role of the Guanosine Triphosphatase Rac2 in T Helper 1 Cell Differentiation

scientific article published on 01 June 2000

SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis

scientific article published in February 2004

SOCS3 negatively regulates IL-6 signaling in vivo

scientific article

SOCS3 regulates graft-versus-host disease

scientific article

Socs3 maintains the specificity of biological responses to cytokine signals during granulocyte and macrophage differentiation

scientific article published on 8 April 2008

Staged autologous peripheral blood progenitor cell transplantation for Ewing sarcoma and rhabdomyosarcoma.

scientific article published in July 2004

Structural Basis for Apoptosis Inhibition by Epstein-Barr Virus BHRF1

scientific article

Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations

scientific article published on 03 June 2019

Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: results of a phase I study of navitoclax in patients with relapsed or refractory disease

scientific article

Successful allogeneic stem cell transplant after invasive pulmonary zygomycosis

scientific article

Suppressor screen in Mpl-/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling

scientific article

Targeting BCL-2-like Proteins to Kill Cancer Cells

scientific article published on 30 July 2016

Targeting BCL2 With BH3 Mimetics: Basic Science and Clinical Application of Venetoclax in Chronic Lymphocytic Leukemia and Related B Cell Malignancies

scientific article published on 2 November 2016

Targeting BCL2 with Venetoclax in Relapsed Chronic Lymphocytic Leukemia

scientific article

Targeting GM-CSF in inflammatory diseases

scientific article

Targeting apoptotic pathways to treat lymphoid malignancies

scientific article published on January 2016

Targeting of acute myeloid leukemia in vitro and in vivo with an anti-CD123 mAb engineered for optimal ADCC.

scientific article published on 7 April 2014

The BCL2 selective inhibitor venetoclax induces rapid onset apoptosis of CLL cells in patients via a TP53-independent mechanism.

scientific article published on 11 April 2016

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

scientific article published on November 2006

The BH3 mimetic compound, ABT-737, synergizes with a range of cytotoxic chemotherapy agents in chronic lymphocytic leukemia.

scientific article published on 30 July 2009

The Bcl-2 homology domain 3 mimetic ABT-737 targets the apoptotic machinery in acute lymphoblastic leukemia resulting in synergistic in vitro and in vivo interactions with established drugs

scientific article published on 28 December 2009

The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models

scientific article published on 19 October 2016

The SOCS box of suppressor of cytokine signaling-3 contributes to the control of G-CSF responsiveness in vivo

scientific article

The equivalents of human blood and spleen dendritic cell subtypes can be generated in vitro from human CD34+ stem cells in the presence of fms-like tyrosine kinase 3 ligand and thrombopoietin ⬇️

scientific article published on October 22, 2012

The genomic landscape of hypodiploid acute lymphoblastic leukemia

scientific article published on 20 January 2013

The hyper-CVAD–rituximab chemotherapy programme followed by high-dose busulfan, melphalan and autologous stem cell transplantation produces excellent event-free survival in patients with previously untreated mantle cell lymphoma

scientific article published on 07 November 2006

The threshold of gp130-dependent STAT3 signaling is critical for normal regulation of hematopoiesis

scientific article published on 13 January 2005

Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene

scientific article

Towards a Four-Dimensional View of Neutrophils ⬇️

scientific article published on January 1, 2012

Treatment of patients with Waldenström macroglobulinaemia: clinical practice guidelines from the Myeloma Foundation of Australia Medical and Scientific Advisory Group.

scientific article published in January 2017

Treatment of patients with multiple myeloma who are eligible for stem cell transplantation: position statement of the Myeloma Foundation of Australia Medical and Scientific Advisory Group.

scientific article published on January 2015

Treatment of patients with multiple myeloma who are not eligible for stem cell transplantation: position statement of the myeloma foundation of Australia Medical and Scientific Advisory Group

scientific article

Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function.

scientific article published on 22 April 2009

Undetectable peripheral blood MRD should be the goal of venetoclax in CLL, but attainment plateaus after 24 months

scientific article published on 01 January 2020

Validating the allogeneic stem cell transplantation disease risk index: sample size, follow-up, and local data are important

scientific article

Vascular endothelial growth factor inhibition is not an effective therapeutic strategy for relapsed or refractory multiple myeloma: a phase 2 study of pazopanib (GW786034).

scientific article published in May 2009

Venetoclax for Patients With Chronic Lymphocytic Leukemia With 17p Deletion: Results From the Full Population of a Phase II Pivotal Trial

scientific article published in May 2018

Venetoclax in Patients with Previously Treated Chronic Lymphocytic Leukemia

scientific article published on 18 January 2017

Venetoclax in relapsed or refractory chronic lymphocytic leukaemia with 17p deletion: a multicentre, open-label, phase 2 study

scientific article

Venetoclax plus rituximab in relapsed or refractory chronic lymphocytic leukaemia: a phase 1b study

scientific article

Venetoclax responses of pediatric ALL xenografts reveal sensitivity of MLL-rearranged leukemia.

scientific article

Venetoclax: a primer

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