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List of works by Gianni Colotti

A gold-containing drug against parasitic polyamine metabolism: the X-ray structure of trypanothione reductase from Leishmania infantum in complex with auranofin reveals a dual mechanism of enzyme inhibition

scientific article

A small-molecule targeting the microRNA binding domain of argonaute 2 improves the retinoic acid differentiation response of the acute promyelocytic leukemia cell line NB4.

scientific article

Activation of the cardiac Na(+)-Ca(2+) exchanger by sorcin via the interaction of the respective Ca(2+)-binding domains.

scientific article

Applying Quality and Project Management methodologies in biomedical research laboratories: a public research network’s case study

Bacterial expression of Scapharca dimeric hemoglobin: a simple model system for investigating protein cooperatively

scientific article published on 01 June 1995

Binding of doxorubicin to Sorcin impairs cell death and increases drug resistance in cancer cells

scientific article published on 20 July 2017

Complex modulation of L-type Ca(2+) current inactivation by sorcin in isolated rabbit cardiomyocytes

scientific article

Cooperative Oxygen Binding toScapharca inaequivalvisHemoglobin in the Crystal

scientific article published in Journal of Biological Chemistry

GOLPH3 is essential for contractile ring formation and Rab11 localization to the cleavage site during cytokinesis in Drosophila melanogaster.

scientific article

Glucose transportation in the brain and its impairment in Huntington disease: one more shade of the energetic metabolism failure?

scientific article published on 10 April 2017

Green tea catechins can bind and modify ERp57/PDIA3 activity

scientific article published on 28 November 2012

Identification of chalcone-based antileishmanial agents targeting trypanothione reductase

article published in 2018

Identification of small molecule inhibitors of the Aurora-A/TPX2 complex

scientific article

Identification of the site of ferrocyanide binding involved in the intramolecular electron transfer process to oxidized heme in Scapharca dimeric hemoglobin

scientific article published on 01 May 1994

Information transfer in the penta-EF-hand protein sorcin does not operate via the canonical structural/functional pairing. A study with site-specific mutants

scientific article published on 23 April 2003

Inhibition of Leishmania infantum trypanothione reductase by azole-based compounds: a comparative analysis with its physiological substrate by X-ray crystallography

scientific article

Inhibition of Leishmania infantum trypanothione reductase by diaryl sulfide derivatives

scientific article published in December 2017

Inhibitory Effect of Silver Nanoparticles on Trypanothione Reductase Activity and Leishmania infantum Proliferation

scientific article

Inventory of the proteins in Neisseria meningitidis serogroup B strain MC58.

scientific article published in July 2005

Leishmania infantum trypanothione reductase is a promiscuous enzyme carrying an NADPH:O2 oxidoreductase activity shared by glutathione reductase

scientific article published on 29 May 2015

Ligand-linked changes at the subunit interfaces in Scapharca hemoglobins probed through the sulfhydryl infrared absorption

scientific article published on 01 August 1999

Metal- and metalloid-containing drugs for the treatment of trypanosomatid diseases

scientific article published on January 2018

Metal-based compounds as prospective antileishmanial agents: inhibition of trypanothione reductase by selected gold complexes

scientific article published on 23 August 2013

Molecular characterization of nitrite reductase gene (aniA) and gene product in Neisseria meningitidis isolates: is aniA essential for meningococcal survival?

scientific article published in September 2008

Mutation of residue Phe97 to Leu disrupts the central allosteric pathway in Scapharca dimeric hemoglobin

scientific article published on 01 May 1997

N6L pseudopeptide interferes with nucleophosmin protein-protein interactions and sensitizes leukemic cells to chemotherapy.

scientific article published on 27 October 2017

NMR structure of a non-conjugatable, ADP-ribosylation associated, ubiquitin-like domain from Tetrahymena thermophila polyubiquitin locus

scientific article published on 25 January 2019

Polyamine-trypanothione pathway: an update.

scientific article published on 13 December 2016

Quality-based model for Life Sciences research guidelines

Roles of Sorcin in Drug Resistance in Cancer: One Protein, Many Mechanisms, for a Novel Potential Anticancer Drug Target

scientific article published on 06 April 2020

Selective delivery of doxorubicin by novel stimuli-sensitive nano-ferritins overcomes tumor refractoriness.

scientific article published on 11 August 2016

Short peptides from leucyl-tRNA synthetase rescue disease-causing mitochondrial tRNA point mutations.

scientific article published on 31 December 2015

Small Molecule Inhibitors of KDM5 Histone Demethylases Increase the Radiosensitivity of Breast Cancer Cells Overexpressing JARID1B

scientific article published on 04 May 2019

Small Molecules Targeting the miRNA-Binding Domain of Argonaute 2: From Computer-Aided Molecular Design to RNA Immunoprecipitation.

scientific article published in January 2017

Small molecules targeted to the microtubule-Hec1 interaction inhibit cancer cell growth through microtubule stabilization

scientific article published on 18 September 2017

Sorcin is an early marker of neurodegeneration, Ca2+ dysregulation and endoplasmic reticulum stress associated to neurodegenerative diseases

scientific article published on 15 October 2020

Sorcin links calcium signaling to vesicle trafficking, regulates Polo-like kinase 1 and is necessary for mitosis

scientific article (publication date: 2014)

Sorcin modulates cardiac L-type Ca2+ current by functional interaction with the alpha1C subunit in rabbits

scientific article published on 4 July 2008

Sorcin, a calcium binding protein involved in the multidrug resistance mechanisms in cancer cells.

scientific article published on 05 September 2014

Structural basis of Sorcin-mediated calcium-dependent signal transduction

scientific article published on 18 November 2015

Structural insights into the enzymes of the trypanothione pathway: targets for antileishmaniasis drugs.

scientific article published on October 2013

Structure-based discovery of the first non-covalent inhibitors of Leishmania major tryparedoxin peroxidase by high throughput docking

scientific article published on 7 May 2015

Structure-function relationships in sorcin, a member of the penta EF-hand family. Interaction of sorcin fragments with the ryanodine receptor and an Escherichia coli model system

scientific article published on 01 February 2000

Structure-guided approach to identify a novel class of anti-leishmaniasis diaryl sulfide compounds targeting the trypanothione metabolism

scientific article published on 29 April 2019

Surface Plasmon Resonance: A Useful Strategy for the Identification of Small Molecule Argonaute 2 Protein Binders.

scientific article published in January 2017

Targeting Trypanothione Reductase, a Key Enzyme in the Redox Trypanosomatid Metabolism, to Develop New Drugs against Leishmaniasis and Trypanosomiases

scientific article published on 21 April 2020

The Crystal Structures of the Tryparedoxin-Tryparedoxin Peroxidase Couple Unveil the Structural Determinants of Leishmania Detoxification Pathway ⬇️

scientific article published on August 21, 2012

The W105G and W99G sorcin mutants demonstrate the role of the D helix in the Ca(2+)-dependent interaction with annexin VII and the cardiac ryanodine receptor

scientific journal article

The apolar distal histidine mutant (His69-->Val) of the homodimeric Scapharca hemoglobin is in an R-like conformation

scientific article published on 01 April 1998

The crystal structure of the sorcin calcium binding domain provides a model of Ca2+-dependent processes in the full-length protein

scientific article

The desaturase from Bacillus subtilis, a promising tool for the selective olefination of phospholipids

scientific article published on 18 August 2005

The homodimeric hemoglobin from Scapharca can be locked into new cooperative structures upon reaction of Cys92, located at the subunit interface, with organomercurials

scientific article published on 01 December 1992

The isolated carboxy-terminal domain of human mitochondrial leucyl-tRNA synthetase rescues the pathological phenotype of mitochondrial tRNA mutations in human cells

scientific article published on 10 January 2014

The multiple cellular functions of the oncoprotein Golgi phosphoprotein 3

scientific article

The presence of glutamate residues on the PAS sequence of the stimuli-sensitive nano-ferritin improves in vivo biodistribution and mitoxantrone encapsulation homogeneity

scientific article published on 20 February 2018

Toward a Drug Against All Kinetoplastids: From LeishBox to Specific and Potent Trypanothione Reductase Inhibitors

scientific article published on 27 June 2018

Trypanothione reductase from Leishmania infantum: cloning, expression, purification, crystallization and preliminary X-ray data analysis

scientific article

Two different crystal forms of sorcin, a penta-EF-hand Ca2+-binding protein

scientific article published on 25 May 2001

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