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List of works by Enrico De Smaele

Alternative splicing of the ErbB-4 cytoplasmic domain and its regulation by hedgehog signaling identify distinct medulloblastoma subsets.

scientific article published on 31 July 2006

An integrated approach identifies Nhlh1 and Insm1 as Sonic Hedgehog-regulated genes in developing cerebellum and medulloblastoma

scientific article

Cell survival and a Gadd45-factor deficiency

scientific article published in Nature

Concerted microRNA control of Hedgehog signalling in cerebellar neuronal progenitor and tumour cells

scientific article

Curcumin blocks autophagy and activates apoptosis of malignant mesothelioma cell lines and increases the survival of mice intraperitoneally transplanted with a malignant mesothelioma cell line.

scientific article

Delta-cell-specific expression of hedgehog pathway Ptch1 receptor in murine and human endocrine pancreas.

scientific article

Druggable glycolytic requirement for Hedgehog-dependent neuronal and medulloblastoma growth

scientific article published on January 2014

ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP

scientific article published on 24 July 2019

EZH2, JMJD3, and UTX epigenetically regulate hepatic plasticity inducing retro-differentiation and proliferation of liver cells

scientific article published on 08 July 2019

Ferritin Heavy Chain Upregulation by NF-κB Inhibits TNFα-Induced Apoptosis by Suppressing Reactive Oxygen Species

scientific article published in November 2004

Foxm1 controls a pro-stemness microRNA network in neural stem cells.

scientific article published on 23 February 2018

Gadd45 beta mediates the NF-kappa B suppression of JNK signalling by targeting MKK7/JNKK2

scientific article (publication date: February 2004)

Gadd45 beta mediates the protective effects of CD40 costimulation against Fas-induced apoptosis

scientific article (publication date: November 2003)

Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors.

scientific article

Glucocorticoids and neonatal brain injury: the hedgehog connection.

scientific article published on February 2009

Hedgehog antagonist REN(KCTD11) regulates proliferation and apoptosis of developing granule cell progenitors

scientific journal article

Hedgehog checkpoints in medulloblastoma: the chromosome 17p deletion paradigm.

scientific article

Hedgehog controls neural stem cells through p53-independent regulation of Nanog

scientific article published on 25 June 2010

Hedgehog signaling pathway and its targets for treatment in basal cell carcinoma

scientific article

Hedgehog signaling pathway in neural development and disease.

scientific article published on 9 July 2007

Hedgehog/Gli control by ubiquitination/acetylation interplay.

scientific article published on January 2012

Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation

scientific article

Identification and characterization of KCASH2 and KCASH3, 2 novel Cullin3 adaptors suppressing histone deacetylase and Hedgehog activity in medulloblastoma.

scientific article

Identification of nuclei from apoptotic, necrotic, and viable lymphoid cells by using multiparameter flow cytometry

scientific article published on 01 February 1999

In vitro and in vivo inhibition of breast cancer cell growth by targeting the Hedgehog/GLI pathway with SMO (GDC-0449) or GLI (GANT-61) inhibitors.

scientific article published on 28 January 2016

Induction of gadd45beta by NF-kappaB downregulates pro-apoptotic JNK signalling.

scientific article

Insights into the Structural Basis of the GADD45β-mediated Inactivation of the JNK Kinase, MKK7/JNKK2

scientific article published in Journal of Biological Chemistry

Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis.

scientific article published on 7 March 2018

KCTD15 inhibits the Hedgehog pathway in Medulloblastoma cells by increasing protein levels of the oncosuppressor KCASH2

scientific article published on 04 November 2019

MicroRNA profiling in human medulloblastoma.

scientific article published in February 2009

Mitogen-activated kinase kinase kinase 1 inhibits hedgehog signaling and medulloblastoma growth through GLI1 phosphorylation

scientific article published on 19 November 2018

Molecular organization of the cullin E3 ligase adaptor KCTD11.

scientific article published on 13 January 2011

NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration

scientific article

Non-canonical Hedgehog/AMPK-Mediated Control of Polyamine Metabolism Supports Neuronal and Medulloblastoma Cell Growth

scientific article

Noncanonical GLI1 signaling promotes stemness features and in vivo growth in lung adenocarcinoma

scientific article published on 3 April 2017

Numb Isoforms Deregulation in Medulloblastoma and Role of p66 Isoform in Cancer and Neural Stem Cells

scientific article published on 01 November 2018

Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal

scientific article published on September 6, 2010

Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination

scientific article published on 19 November 2006

PCAF ubiquitin ligase activity inhibits Hedgehog/Gli1 signaling in p53-dependent response to genotoxic stress

scientific article published on 6 September 2013

Pharmacological activation of mGlu4 metabotropic glutamate receptors inhibits the growth of medulloblastomas.

scientific article

Protection by herpes simplex virus glycoprotein D against Fas-mediated apoptosis: role of nuclear factor kappaB.

scientific article published on 4 July 2003

REN(KCTD11) is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma

scholarly article

Regulation of the gadd45beta promoter by NF-kappaB

scientific article (publication date: July 2002)

SMO-M2 mutation does not support cell-autonomous Hedgehog activity in cerebellar granule cell precursors

scientific article published on 23 December 2019

Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma.

scientific article published on 09 March 2017

Sonic Hedgehog Medulloblastoma Cancer Stem Cells Mirnome and Transcriptome Highlight Novel Functional Networks

scientific article published on 08 August 2018

Suppressors of hedgehog signaling: Linking aberrant development of neural progenitors and tumorigenesis.

scientific article published on December 2006

The centrosomal deubiquitylase USP21 regulates Gli1 transcriptional activity and stability.

scientific article published on 12 September 2016

The energy sensor AMPK regulates Hedgehog signaling in human cells through a unique Gli1 metabolic checkpoint

scientific article published on 29 January 2016

c-FLIP efficiently rescues TRAF-2-/- cells from TNF-induced apoptosis

scientific article published on 01 February 2002

microRNA-17-92 cluster is a direct Nanog target and controls neural stem cell through Trp53inp1.

scientific article published on 27 September 2013

β-arrestin1-mediated acetylation of Gli1 regulates Hedgehog/Gli signaling and modulates self-renewal of SHH medulloblastoma cancer stem cells.

scientific article