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List of works by Mark Kearney

173 Insulin-like growth factor binding protein 2 (igfbp2): a positive regulator of angiogenesis?

226 The impact of nadph oxidase 2 inhibition on skeletal muscle pathophysiology of atherosclerotic mice

232 Endothelial ship2 knockout causes nox2 nadph oxidase-dependent oxidative stress and endothelial dysfunction

47 Using Natriuretic Peptide Levels to Diagnose Heart Failure in Primary Care: An Evaluation of the 2010 United Kingdom National Institute of Clinical Excellence Guidelines on the Diagnosis of Chronic Heart Failure

A Novel and Practical Screening Tool for the Detection of Silent Myocardial Infarction in Patients With Type 2 Diabetes ⬇️

scientific article published on 14 June 2016

A heat-shock protein axis regulates VEGFR2 proteolysis, blood vessel development and repair

scientific article

A portable prototype magnetometer to differentiate ischemic and non-ischemic heart disease in patients with chest pain ⬇️

scientific article published on 19 January 2018

A prognostic index to predict long-term mortality in patients with mild to moderate chronic heart failure stabilised on angiotensin converting enzyme inhibitors

scientific article published in August 2003

Accelerated endothelial dysfunction in mild prediabetic insulin resistance: the early role of reactive oxygen species

scientific article published on 21 August 2007

Acute haemodynamic effects of lipolysis-induced increase of free fatty acids in healthy men.

scientific article published in May 2002

Ambulatory heart rate range predicts mode-specific mortality and hospitalisation in chronic heart failure ⬇️

scientific article published on 16 December 2015

An evaluation of 20 year survival in patients with diabetes mellitus and acute myocardial infarction

scientific article published on 22 October 2015

Aspirin and mortality in patients with diabetes sustaining acute coronary syndrome

scientific article published on 24 October 2007

Asymmetric dimethylarginine and reduced nitric oxide bioavailability in young Black African men.

scientific article published on 29 January 2007

Attenuation of oxidative stress-induced lesions in skeletal muscle in a mouse model of obesity-independent hyperlipidaemia and atherosclerosis through the inhibition of Nox2 activity ⬇️

Attenuation of skeletal muscle oxidative stress in atherosclerotic mice

Calcium, phosphate and calcium phosphate product are markers of outcome in patients with chronic heart failure ⬇️

scientific article published on 11 March 2014

Cardiac resynchronization therapy in pacemaker-dependent patients with left ventricular dysfunction ⬇️

scientific article

Cardiac resynchronization therapy outcomes in patients with chronic heart failure: cardiac resynchronization therapy with pacemaker versus cardiac resynchronization therapy with defibrillator

scientific article

Cardiac size, autonomic function, and 5-year follow-up of chronic heart failure patients with severe prolongation of ventricular activation

scientific article

Cardiovascular magnetic resonance measures of aortic stiffness in asymptomatic patients with type 2 diabetes: association with glycaemic control and clinical outcomes ⬇️

scientific article published on 5 March 2018

Changing characteristics and mode of death associated with chronic heart failure caused by left ventricular systolic dysfunction: a study across therapeutic eras

scientific article published on 11 May 2011

Changing the way we think about endothelial cell insulin sensitivity, nitric oxide, and the pathophysiology of type 2 diabetes: the FoxO is loose

scientific article published on May 2013

Characterisation of VOCs Surrounding Naum Gabo’s Construction in Space ‘Two Cones’, (Tate) by in situ SPME GC-MS Monitoring

Chronic heart failure and type 2 diabetes mellitus: The last battle?

scientific article published in July 2015

Chronotropic Incompetence Does Not Limit Exercise Capacity in Chronic Heart Failure ⬇️

scientific article

Constitutively active TRPC channels of adipocytes confer a mechanism for sensing dietary fatty acids and regulating adiponectin

scientific article published on 5 June 2012

Cre/lox Studies Identify Resident Macrophages as the Major Source of Circulating Coagulation Factor XIII-A. ⬇️

scientific article

Diabetes Mellitus, Microalbuminuria, and Subclinical Cardiac Disease: Identification and Monitoring of Individuals at Risk of Heart Failure ⬇️

scientific article

Diabetes mellitus and heart failure: a deadly duo.

scientific article published on January 2017

Diabetes mellitus and mortality after acute coronary syndrome as a first or recurrent cardiovascular event

scientific article

Diabetes mellitus is associated with adverse prognosis in chronic heart failure of ischaemic and non-ischaemic aetiology

scientific article

Diabetes mellitus is associated with adverse structural and functional cardiac remodelling in chronic heart failure with reduced ejection fraction ⬇️

scientific article published on 22 June 2016

Diurnal variation in vascular and metabolic function in diet-induced obesity: divergence of insulin resistance and loss of clock rhythm

scientific article published on 4 February 2013

Does symptom-limited cycle exercise cause low frequency diaphragm fatigue in patients with heart failure?

scientific article

Effect of endothelium-specific insulin resistance on endothelial function in vivo

scientific article published on 3 October 2008

Effect of transglutaminase 2 (TG2) deficiency on atherosclerotic plaque stability in the apolipoprotein E deficient mouse

scientific article

Effects of Vitamin D on Cardiac Function in Patients With Chronic HF: The VINDICATE Study ⬇️

scientific article published on 24 March 2016

Effects of inhibition of basal nitric oxide synthesis on carotid-femoral pulse wave velocity and augmentation index in humans

scientific article

Endothelial IGF-1 Receptor Signalling in Diabetes and Insulin Resistance

scientific article published on 19 December 2015

Endothelial Insulin Receptor Restoration Rescues Vascular Function in Male Insulin Receptor Haploinsufficient Mice ⬇️

Endothelial function and weight loss in obese humans

scientific article published in August 2005

Endothelial insulin resistance protects the heart against prolonged ischemia-reperfusion injury but does not prevent insulin transport across the endothelium in a mouse Langendorff model

scientific article published on 19 March 2014

Endothelium-specific insulin resistance leads to accelerated atherosclerosis in areas with disturbed flow patterns: a role for reactive oxygen species

scientific article published on 29 June 2013

Haploinsufficiency of the insulin-like growth factor-1 receptor enhances endothelial repair and favorably modifies angiogenic progenitor cell phenotype

scientific article published on 10 July 2014

Heart rate chaos as a mortality predictor in mild to moderate heart failure

scientific article published in January 2007

Heart rate turbulence and death due to cardiac decompensation in patients with chronic heart failure

scientific article published on 10 February 2006

Homotypic endothelial nanotubes induced by wheat germ agglutinin and thrombin. ⬇️

scientific article

Human exercise-induced circulating progenitor cell mobilization is nitric oxide-dependent and is blunted in South Asian men.

scientific article published on 28 January 2010

Hyperglycaemia, in relation to sex, and mortality after acute coronary syndrome

scientific article published in October 2007

IGF-binding protein-2 protects against the development of obesity and insulin resistance

scientific article

IGF-dependent and IGF-independent actions of IGF-binding protein-1 and -2: implications for metabolic homeostasis

scientific article published on 06 April 2009

Identification of cellulose nitrate X-ray film for the purpose of conservation: Organic elemental analysis

Importance of insulin resistance to vascular repair and regeneration ⬇️

scientific article published on 04 March 2013

In silico design and biological evaluation of a dual specificity kinase inhibitor targeting cell cycle progression and angiogenesis ⬇️

scientific article

Increasing circulating IGFBP1 levels improves insulin sensitivity, promotes nitric oxide production, lowers blood pressure, and protects against atherosclerosis

scientific article published on 22 February 2012

Inducible nitric oxide synthase has divergent effects on vascular and metabolic function in obesity

scientific article published in April 2005

Inspiratory muscle load and capacity in chronic heart failure

scientific article published on June 2004

Inspiratory muscle load and capacity in chronic heart failure

scientific article published in September 2004

Insulin and endothelial function: physiological environment defines effect on atherosclerotic risk

scientific article published on February 2006

Insulin resistance and endothelial cell dysfunction: studies in mammalian models

scientific article published on 12 October 2007

Insulin resistance impairs circulating angiogenic progenitor cell function and delays endothelial regeneration ⬇️

scientific article

Insulin resistance, lipotoxicity and endothelial dysfunction

scientific article published on 08 October 2009

Insulin- and Growth Factor-Resistance Impairs Vascular Regeneration in Diabetes Mellitus ⬇️

scientific article published on May 1, 2012

Insulin-Like Growth Factor Binding Protein 1 Could Improve Glucose Regulation and Insulin Sensitivity Through Its RGD Domain

scientific article published on 10 November 2016

Insulinlike Growth Factor-Binding Protein-1 Improves Vascular Endothelial Repair in Male Mice in the Setting of Insulin Resistance ⬇️

scientific article published on 24 November 2017

Inter-subject differences in constitutive expression levels of the clock gene in man.

scientific article published in March 2007

Lung Function Abnormalities in Smokers with Ischemic Heart Disease

scientific article published on 21 July 2016

Moderate Intensity Exercise Rectifies Reduced Circulating Endothelial Progenitor Cell Numbers In Post-menopausal Women

Mortality Reduction Associated With β-Adrenoceptor Inhibition in Chronic Heart Failure Is Greater in Patients With Diabetes ⬇️

scientific article published on 5 October 2017

Nitric oxide and myocardial function in heart failure: friend or foe?

scientific article published on December 2002

Novel role of the IGF-1 receptor in endothelial function and repair: studies in endothelium-targeted IGF-1 receptor transgenic mice ⬇️

scientific article

Nox2 NADPH oxidase has a critical role in insulin resistance-related endothelial cell dysfunction

scientific article published on 24 January 2013

Opposing roles of p47phox in basal versus angiotensin II-stimulated alterations in vascular O2- production, vascular tone, and mitogen-activated protein kinase activation

scientific article published in March 2004

Orai1 and CRAC channel dependence of VEGF-activated Ca2+ entry and endothelial tube formation

scientific article published on 24 March 2011

Orai3 Surface Accumulation and Calcium Entry Evoked by Vascular Endothelial Growth Factor ⬇️

scientific article published on 9 July 2015

Oxidized LDL activates blood platelets through CD36/NOX2-mediated inhibition of the cGMP/protein kinase G signaling cascade ⬇️

scientific article

Pacing-associated left ventricular dysfunction? Think reprogramming first!

scientific article published on 15 January 2014

Patients with long-term permanent pacemakers have a high prevalence of left ventricular dysfunction ⬇️

scientific article published on 28 June 2014

Percutaneous coronary revascularization reduces plasma N-terminal pro-B-type natriuretic peptide concentration in stable coronary artery disease

scientific article published on 11 June 2007

Performance of 2014 NICE defibrillator implantation guidelines in heart failure risk stratification ⬇️

scientific article published on 8 February 2016

Piezo1 channel agonist mimics high glucose as a stimulator of insulin release

scientific article published on 29 October 2018

Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance ⬇️

scientific article published on 24 August 2017

Predicting death due to progressive heart failure in patients with mild-to-moderate chronic heart failure

scientific article

Predicting sudden death in patients with mild to moderate chronic heart failure

scientific article published on October 2004

Pregnenolone sulphate- and cholesterol-regulated TRPM3 channels coupled to vascular smooth muscle secretion and contraction

scientific article

Preserved glucoregulation but attenuation of the vascular actions of insulin in mice heterozygous for knockout of the insulin receptor

scientific article published in October 2004

Prevalence and Predictors of Sepsis Death in Patients With Chronic Heart Failure and Reduced Left Ventricular Ejection Fraction ⬇️

scientific article published in October 2018

Prognosis in heart failure with preserved left ventricular systolic function: prospective cohort study

scientific article

Prospective development and validation of a model to predict heart failure hospitalisation ⬇️

scientific article

Prospective evaluation and long-term follow-up of patients referred to secondary care based upon natriuretic peptide levels in primary care ⬇️

Rate-Response Programming Tailored to the Force-Frequency Relationship Improves Exercise Tolerance in Chronic Heart Failure ⬇️

scientific article published on 27 November 2017

Real-Time 3D Echo in Patient Selection for Cardiac Resynchronization Therapy ⬇️

scientific article published on January 1, 2011

Reduced nicotinamide adenine dinucleotide phosphate oxidase-derived superoxide and vascular endothelial dysfunction in human heart failure

scientific article published in April 2008

Reducing the risk of stroke in type 2 diabetes: pathophysiological and therapeutic perspectives

scientific article published on 29 April 2009

Reply

item in Journal of the American College of Cardiology (September 2016)

Response by Viswambharan and Kearney to Letter Regarding Article, "Selective Enhancement of Insulin Sensitivity in the Endothelium In Vivo Reveals a Novel Proatherosclerotic Signaling Loop".

scientific article published in February 2017

Response to Comment on: Sukumar et al. Nox2 NADPH oxidase has a critical role in insulin resistance-related endothelial cell dysfunction. Diabetes 2013;62:2130-2134.

scientific article published on December 2013

Restoring Akt1 activity in outgrowth endothelial cells from South Asian men rescues vascular reparative potential ⬇️

scientific article published in October 2014

Role of IGF-1 in glucose regulation and cardiovascular disease

scientific article published on September 2008

Selective Enhancement of Insulin Sensitivity in the Endothelium In Vivo Reveals a Novel Proatherosclerotic Signaling Loop ⬇️

scientific article published on 5 December 2016

Socioeconomic deprivation and mode-specific outcomes in patients with chronic heart failure ⬇️

scientific article published on 31 January 2018

Somatostatin receptor subtype expression in the human heart: differential expression by myocytes and fibroblasts

scientific article published in December 2005

Sympathetic activation and vasoregulation in response to carbohydrate ingestion in patients with congestive heart failure

scientific article published on 30 May 2012

TRPC5 ion channel permeation promotes weight gain in hypercholesterolaemic mice

scientific article published in Scientific Reports

The IGF-1 receptor and regulation of nitric oxide bioavailability and insulin signalling in the endothelium ⬇️

scientific article published on January 22, 2013

The association between saphenous vein endothelial function, systemic inflammation, and statin therapy in patients undergoing coronary artery bypass surgery

scientific article published on August 2007

The insulin-like growth factor-1 receptor is a negative regulator of nitric oxide bioavailability and insulin sensitivity in the endothelium

scientific journal article

The microvascular effects of insulin resistance and diabetes on cardiac structure, function, and perfusion: a cardiovascular magnetic resonance study

scientific article

The role of IGF-1 resistance in obesity and type 2 diabetes-mellitus-related insulin resistance and vascular disease

scientific article published on December 2010

The role of IGF-I and its binding proteins in the development of type 2 diabetes and cardiovascular disease

scientific article published on March 2008

Trends in incidence and prognosis of heart failure; You always pass failure on the way to success

scientific article published in February 2004

Uric acid and prognosis in chronic heart failure

scientific article published in November 2003

VEGF-A isoforms program differential VEGFR2 signal transduction, trafficking and proteolysis ⬇️

scientific article published on 3 April 2016

Vascular dysfunction and reduced circulating endothelial progenitor cells in young healthy UK South Asian men.

scientific article

Vascular endothelial function and blood pressure homeostasis in mice overexpressing IGF binding protein-1.

scientific article published in August 2003

Vascular insulin-like growth factor-I resistance and diet-induced obesity

scientific article published on 16 July 2009

Viral myocarditis and dilated cardiomyopathy: mechanisms, manifestations, and management

scientific article

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