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List of works by Stephen Wheatcroft

173 Insulin-like growth factor binding protein 2 (igfbp2): a positive regulator of angiogenesis?

232 Endothelial ship2 knockout causes nox2 nadph oxidase-dependent oxidative stress and endothelial dysfunction

26 Effect of Age and Gender on Outcomes Following Primary Percutaneous Coronary Intervention for ST-elevation Myocardial Infarction in a UK Tertiary Centre

33 Influence of ethnicity on outcomes in primary percutaneous coronary intervention for ST-elevation myocardial infarction

A heat-shock protein axis regulates VEGFR2 proteolysis, blood vessel development and repair

scientific article

Accelerated endothelial dysfunction in mild prediabetic insulin resistance: the early role of reactive oxygen species

scientific article published on 21 August 2007

Acute and one year clinical outcomes following implantation of bioresorbable vascular scaffolds: the ABSORB UK Registry

scientific article published on 14 November 2017

Ankle pressures in UK South Asians with diabetes mellitus: a case control study

scientific article

Assessing Coronary Blood Flow Physiology in the Cardiac Catheterisation Laboratory ⬇️

scientific article

Association of diabetes with increased all-cause mortality following primary percutaneous coronary intervention for ST-segment elevation myocardial infarction in the contemporary era.

scientific article published on 8 November 2011

Asymmetric dimethylarginine and reduced nitric oxide bioavailability in young Black African men.

scientific article published on 29 January 2007

Bilateral endophthalmitis and ARDS complicating group G streptococcal endocarditis

scientific article

Bivalirudin in patients undergoing primary percutaneous coronary intervention for acute ST-elevation myocardial infarction: outcomes in a large real-world population

scientific article published in May 2013

Cardiovascular risk in patients with small and medium abdominal aortic aneurysms, and no history of cardiovascular disease

scientific article published on 26 June 2014

Changing characteristics and mode of death associated with chronic heart failure caused by left ventricular systolic dysfunction: a study across therapeutic eras

scientific article published on 11 May 2011

Clinical and Preclinical Use of LOX-1-Specific Antibodies in Diagnostics and Therapeutics

scientific article published on 18 September 2015

Clinical outcomes following primary percutaneous coronary intervention for ST-elevation myocardial infarction according to sex and race ⬇️

scientific article

Detection and Quantification of Vascular Endothelial Growth Factor Receptor Tyrosine Kinases in Primary Human Endothelial Cells

scientific article published in January 2015

Diabetes mellitus and mortality after acute coronary syndrome as a first or recurrent cardiovascular event

scientific article

Diabetes mellitus is associated with adverse prognosis in chronic heart failure of ischaemic and non-ischaemic aetiology

scientific article

Direct ambulance admission to the cardiac catheterization laboratory significantly reduces door-to-balloon times in primary percutaneous coronary intervention

scientific article published on 5 March 2008

Diurnal variation in vascular and metabolic function in diet-induced obesity: divergence of insulin resistance and loss of clock rhythm

scientific article published on 4 February 2013

Does routine pressure wire assessment influence management strategy at coronary angiography for diagnosis of chest pain?: the RIPCORD study

scientific article published on 18 March 2014

Effect of endothelium-specific insulin resistance on endothelial function in vivo

scientific article published on 3 October 2008

Effects of insulin resistance on endothelial progenitor cells and vascular repair

scientific article published on 03 August 2009

Endothelial IGF-1 Receptor Signalling in Diabetes and Insulin Resistance

scientific article published on 19 December 2015

Endothelial Insulin Receptor Restoration Rescues Vascular Function in Male Insulin Receptor Haploinsufficient Mice ⬇️

Endothelial function and weight loss in obese humans

scientific article published in August 2005

Endothelium-specific insulin resistance leads to accelerated atherosclerosis in areas with disturbed flow patterns: a role for reactive oxygen species

scientific article published on 29 June 2013

Haploinsufficiency of the insulin-like growth factor-1 receptor enhances endothelial repair and favorably modifies angiogenic progenitor cell phenotype

scientific article published on 10 July 2014

How We Measure Heart Rate: Does it Matter?

scientific article published in September 2016

Human exercise-induced circulating progenitor cell mobilization is nitric oxide-dependent and is blunted in South Asian men.

scientific article published on 28 January 2010

Hyperglycaemia, in relation to sex, and mortality after acute coronary syndrome

scientific article published in October 2007

IGF-binding protein-2 protects against the development of obesity and insulin resistance

scientific article

IGF-dependent and IGF-independent actions of IGF-binding protein-1 and -2: implications for metabolic homeostasis

scientific article published on 06 April 2009

IGFBP-1 in Cardiometabolic Pathophysiology-Insights From Loss-of-Function and Gain-of-Function Studies in Male Mice

scientific article published on 04 November 2019

In silico design and biological evaluation of a dual specificity kinase inhibitor targeting cell cycle progression and angiogenesis ⬇️

scientific article

Increasing circulating IGFBP1 levels improves insulin sensitivity, promotes nitric oxide production, lowers blood pressure, and protects against atherosclerosis

scientific article published on 22 February 2012

Inducible nitric oxide synthase has divergent effects on vascular and metabolic function in obesity

scientific article published in April 2005

Inhibition of plasmin-mediated TAFI activation may affect development but not progression of abdominal aortic aneurysms ⬇️

scientific article

Insulin resistance and endothelial cell dysfunction: studies in mammalian models

scientific article published on 12 October 2007

Insulin resistance impairs circulating angiogenic progenitor cell function and delays endothelial regeneration ⬇️

scientific article

Insulin-Like Growth Factor Binding Protein 1 Could Improve Glucose Regulation and Insulin Sensitivity Through Its RGD Domain

scientific article published on 10 November 2016

Insulinlike Growth Factor-Binding Protein-1 Improves Vascular Endothelial Repair in Male Mice in the Setting of Insulin Resistance ⬇️

scientific article published on 24 November 2017

Inter-subject differences in constitutive expression levels of the clock gene in man.

scientific article published in March 2007

Life-threatening coronary artery spasm following sirolimus-eluting stent deployment

scientific article published on 17 April 2006

Novel role of the IGF-1 receptor in endothelial function and repair: studies in endothelium-targeted IGF-1 receptor transgenic mice ⬇️

scientific article

Nox2 NADPH oxidase has a critical role in insulin resistance-related endothelial cell dysfunction

scientific article published on 24 January 2013

OBTAIN: a study of the occurrence of bleeding and thrombosis during anti-platelet therapy in non-cardiac surgery

scientific article published in June 2011

Opposing roles of p47phox in basal versus angiotensin II-stimulated alterations in vascular O2- production, vascular tone, and mitogen-activated protein kinase activation

scientific article published in March 2004

Oxidized LDL activates blood platelets through CD36/NOX2-mediated inhibition of the cGMP/protein kinase G signaling cascade ⬇️

scientific article

Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance ⬇️

scientific article published on 24 August 2017

Pregnenolone sulphate- and cholesterol-regulated TRPM3 channels coupled to vascular smooth muscle secretion and contraction

scientific article

Preservation of vascular endothelial repair in mice with diet-induced obesity

scientific article published on 26 June 2018

Preserved glucoregulation but attenuation of the vascular actions of insulin in mice heterozygous for knockout of the insulin receptor

scientific article published in October 2004

Real-world outcome from ST elevation myocardial infarction in the very elderly before and after the introduction of a 24/7 primary percutaneous coronary intervention service

scientific article published in June 2010

Reply to: "Zimarino M et al. The adequacy of myocardial revascularization in patients with multivessel coronary artery disease".

scientific article published on 7 September 2013

Restoring Akt1 activity in outgrowth endothelial cells from South Asian men rescues vascular reparative potential ⬇️

scientific article published in October 2014

Scavenger receptor structure and function in health and disease ⬇️

scientific article

Scavenger receptors and their potential as therapeutic targets in the treatment of cardiovascular disease

scientific article

Selective Enhancement of Insulin Sensitivity in the Endothelium In Vivo Reveals a Novel Proatherosclerotic Signaling Loop ⬇️

scientific article published on 5 December 2016

Strain-dependent variation in vascular responses to nitric oxide in the isolated murine heart

scientific article published in October 2002

TRPC5 ion channel permeation promotes weight gain in hypercholesterolaemic mice

scientific article published in Scientific Reports

Teaching an old drug new tricks: can paroxetine ease the burden of cardiovascular disease in diabetes?

scientific article published in March 2013

The S100A6 calcium-binding protein regulates endothelial cell-cycle progression and senescence

scientific article published on 22 November 2012

The association between saphenous vein endothelial function, systemic inflammation, and statin therapy in patients undergoing coronary artery bypass surgery

scientific article published on August 2007

The impact of insulin resistance on endothelial function, progenitor cells and repair

scientific article published on June 2007

The insulin like growth factor and binding protein family: Novel therapeutic targets in obesity & diabetes ⬇️

scientific article published on 24 October 2018

The insulin-like growth factor-1 receptor is a negative regulator of nitric oxide bioavailability and insulin sensitivity in the endothelium

scientific journal article

The role of IGF-I and its binding proteins in the development of type 2 diabetes and cardiovascular disease

scientific article published on March 2008

Three-year clinical outcome with the Endeavor™ zotarolimus-eluting stent in primary percutaneous coronary intervention for ST elevation myocardial infarction: the Endeavor™ primary PCI study (E-PPCI).

scientific article published on 25 August 2011

Tpl2 is required for VEGF-A-stimulated signal transduction and endothelial cell function.

scientific article published on 17 May 2019

Transcoronary pacing to assess myocardial viability prior to percutaneous coronary intervention: Pilot study to assess feasibility

scientific article

Ubiquitination of basal VEGFR2 regulates signal transduction and endothelial function ⬇️

scientific article

VEGF-A isoform-specific regulation of calcium ion flux, transcriptional activation and endothelial cell migration ⬇️

scientific article published on 24 April 2015

VEGF-A isoforms differentially regulate ATF-2-dependent VCAM-1 gene expression and endothelial-leukocyte interactions ⬇️

scientific article

VEGF-A isoforms program differential VEGFR2 signal transduction, trafficking and proteolysis ⬇️

scientific article published on 3 April 2016

VEGFR2 Trafficking, Signaling and Proteolysis is Regulated by the Ubiquitin Isopeptidase USP8. ⬇️

scientific article published on 13 October 2015

Vascular endothelial function and blood pressure homeostasis in mice overexpressing IGF binding protein-1.

scientific article published in August 2003

Vascular endothelial growth factor A-stimulated signaling from endosomes in primary endothelial cells ⬇️

scientific article published in January 2014

Vascular endothelial growth factors: multitasking functionality in metabolism, health and disease

scientific article published on 14 April 2015

Vascular insulin-like growth factor-I resistance and diet-induced obesity

scientific article published on 16 July 2009

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