List of works - Balbino Alarcón

A conformational change senses the strength of T cell receptor-ligand interaction during thymic selection

scholarly article

A native antibody-based mobility-shift technique (NAMOS-assay) to determine the stoichiometry of multiprotein complexes

scientific article

Activation outcomes induced in naïve CD8 T-cells by macrophages primed via "phagocytic" and nonphagocytic pathways

scientific article published on 12 December 2007

An orderly inactivation of intracellular retention signals controls surface expression of the T cell antigen receptor

scientific article

Aurora A drives early signalling and vesicle dynamics during T-cell activation

scientific article

Biochemical differences in the alphabeta T cell receptor.CD3 surface complex between CD8+ and CD4+ human mature T lymphocytes

scientific article published on April 2004

CD3ε recruits Numb to promote TCR degradation

scientific article published on 27 October 2015

Coexistence of multivalent and monovalent TCRs explains high sensitivity and wide range of response

scientific article

Conformational model

scientific article published on January 2008

Contribution of the R-Ras2 GTP-binding protein to primary breast tumorigenesis and late-stage metastatic disease

scientific article published on 14 May 2014

Crammed signaling motifs in the T-cell receptor

scientific article published on 27 May 2014

Different composition of the human and the mouse gammadelta T cell receptor explains different phenotypes of CD3gamma and CD3delta immunodeficiencies

scientific article published on 8 October 2007

End-binding protein 1 controls signal propagation from the T cell receptor

scientific article

Engaged and bystander T cell receptors are down-modulated by different endocytotic pathways

scientific article

H-ras and N-ras are dispensable for T-cell development and activation but critical for protective Th1 immunity

scientific journal article

Human TCR that incorporate CD3zeta induce highly preferred pairing between TCRalpha and beta chains following gene transfer

scientific article

Initiation of TCR signaling: regulation within CD3 dimers

scientific article

Interaction between the N-terminal SH3 domain of Nck-alpha and CD3-epsilon-derived peptides: non-canonical and canonical recognition motifs

scientific article

Ligand-induced conformational change in the T-cell receptor associated with productive immune synapses

scientific article

MTOC translocation modulates IS formation and controls sustained T cell signaling

scientific article published on September 2008

Nck Recruitment to the TCR Required for ZAP70 Activation during Thymic Development ⬇️

scientific article published on December 24, 2012

Organization of the resting TCR in nanoscale oligomers

scientific article

RRas2, RhoG and T-cell phagocytosis ⬇️

scientific article published on April 1, 2012

Receptor Pre-Clustering and T cell Responses: Insights into Molecular Mechanisms

scientific article published on 30 April 2014

Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation

scientific article

Role of Fyn in the rearrangement of tubulin cytoskeleton induced through TCR.

scientific article published on April 2006

Role of chimaerins, a group of Rac-specific GTPase activating proteins, in T-cell receptor signaling

scientific article published on 28 December 2007

T cell receptor engagement by peptide-MHC ligands induces a conformational change in the CD3 complex of thymocytes

scientific article published on February 2005

T cell receptor engagement triggers its CD3epsilon and CD3zeta subunits to adopt a compact, locked conformation

scientific article

T cell receptor internalization from the immunological synapse is mediated by TC21 and RhoG GTPase-dependent phagocytosis

scientific article

T-cell antigen-receptor stoichiometry: pre-clustering for sensitivity

scientific article

TCR Nanoclusters as the Framework for Transmission of Conformational Changes and Cooperativity ⬇️

scientific article published on 09 May 2012

TCR engagement induces proline-rich tyrosine kinase-2 (Pyk2) translocation to the T cell-APC interface independently of Pyk2 activity and in an immunoreceptor tyrosine-based activation motif-mediated fashion

scientific article published on July 2002

The CD3 conformational change in the γδ T cell receptor is not triggered by antigens but can be enforced to enhance tumor killing

scientific article

The Ras-like protein R-Ras2/TC21 is important for proper mammary gland development

scientific article

The Rho exchange factors Vav2 and Vav3 favor skin tumor initiation and promotion by engaging extracellular signaling loops

scientific article (publication date: July 2013)

The extracellular part of zeta is buried in the T cell antigen receptor complex

scientific article published on 31 December 2007

The immunological synapse: a cause or consequence of T-cell receptor triggering?

scientific article published on 02 June 2011

Tubulin and actin interplay at the T cell and antigen-presenting cell interface

scientific article published on 4 July 2011

Two receptors, two kinases, and T cell lineage determination

scientific article published on 23 March 2010

List of works by Balbino Alarcón

A conformational change senses the strength of T cell receptor-ligand interaction during thymic selection

A native antibody-based mobility-shift technique (NAMOS-assay) to determine the stoichiometry of multiprotein complexes

Activation outcomes induced in naïve CD8 T-cells by macrophages primed via "phagocytic" and nonphagocytic pathways

An orderly inactivation of intracellular retention signals controls surface expression of the T cell antigen receptor

Aurora A drives early signalling and vesicle dynamics during T-cell activation

Biochemical differences in the alphabeta T cell receptor.CD3 surface complex between CD8+ and CD4+ human mature T lymphocytes

CD3ε recruits Numb to promote TCR degradation

Coexistence of multivalent and monovalent TCRs explains high sensitivity and wide range of response

Conformational model

Contribution of the R-Ras2 GTP-binding protein to primary breast tumorigenesis and late-stage metastatic disease

Crammed signaling motifs in the T-cell receptor

Different composition of the human and the mouse gammadelta T cell receptor explains different phenotypes of CD3gamma and CD3delta immunodeficiencies

End-binding protein 1 controls signal propagation from the T cell receptor

Engaged and bystander T cell receptors are down-modulated by different endocytotic pathways

H-ras and N-ras are dispensable for T-cell development and activation but critical for protective Th1 immunity

Human TCR that incorporate CD3zeta induce highly preferred pairing between TCRalpha and beta chains following gene transfer

Initiation of TCR signaling: regulation within CD3 dimers

Interaction between the N-terminal SH3 domain of Nck-alpha and CD3-epsilon-derived peptides: non-canonical and canonical recognition motifs

Ligand-induced conformational change in the T-cell receptor associated with productive immune synapses

MTOC translocation modulates IS formation and controls sustained T cell signaling

Nck Recruitment to the TCR Required for ZAP70 Activation during Thymic Development ⬇️

Organization of the resting TCR in nanoscale oligomers

RRas2, RhoG and T-cell phagocytosis ⬇️

Receptor Pre-Clustering and T cell Responses: Insights into Molecular Mechanisms

Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation

Role of Fyn in the rearrangement of tubulin cytoskeleton induced through TCR.

Role of chimaerins, a group of Rac-specific GTPase activating proteins, in T-cell receptor signaling

T cell receptor engagement by peptide-MHC ligands induces a conformational change in the CD3 complex of thymocytes

T cell receptor engagement triggers its CD3epsilon and CD3zeta subunits to adopt a compact, locked conformation

T cell receptor internalization from the immunological synapse is mediated by TC21 and RhoG GTPase-dependent phagocytosis

T-cell antigen-receptor stoichiometry: pre-clustering for sensitivity

TCR Nanoclusters as the Framework for Transmission of Conformational Changes and Cooperativity ⬇️

TCR engagement induces proline-rich tyrosine kinase-2 (Pyk2) translocation to the T cell-APC interface independently of Pyk2 activity and in an immunoreceptor tyrosine-based activation motif-mediated fashion

The CD3 conformational change in the γδ T cell receptor is not triggered by antigens but can be enforced to enhance tumor killing

The Ras-like protein R-Ras2/TC21 is important for proper mammary gland development

The Rho exchange factors Vav2 and Vav3 favor skin tumor initiation and promotion by engaging extracellular signaling loops

The extracellular part of zeta is buried in the T cell antigen receptor complex

The immunological synapse: a cause or consequence of T-cell receptor triggering?

Tubulin and actin interplay at the T cell and antigen-presenting cell interface

Two receptors, two kinases, and T cell lineage determination