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List of works by Tilman Brummer

A cell-based MAPK reporter assay reveals synergistic MAPK pathway activity suppression by MAPK inhibitor combination in BRAF-driven pediatric low-grade glioma cells

scientific article published on 25 May 2020

A generic strategy for pharmacological caging of growth factors for tissue engineering.

scientific article published in July 2013

A novel MCF-10A line allowing conditional oncogene expression in 3D culture

scientific article

A revised and complete map of the chicken c-mil/raf-1 locus

scientific article published in April 2004

A self-enforcing CD44s/ZEB1 feedback loop maintains EMT and stemness properties in cancer cells.

scientific article published on 16 June 2015

Aberrant B-Raf signaling in human cancer -- 10 years from bench to bedside

scientific article published on January 2012

Activation loop phosphorylation regulates B-Raf in vivo and transformation by B-Raf mutants

scientific article

Adenosine and cAMP are potent inhibitors of the NF-kappa B pathway downstream of immunoreceptors

scientific article

Alterations of Gab2 signalling complexes in imatinib and dasatinib treated chronic myeloid leukaemia cells

scientific article published on 22 April 2013

Axitinib and sorafenib are potent in tyrosine kinase inhibitor resistant chronic myeloid leukemia cells

scientific article published on 24 February 2016

B-Raf activation loop phosphorylation revisited

scientific article published on 21 April 2016

B-Raf deficiency impairs tumor initiation and progression in a murine breast cancer model

scientific article published on 18 January 2019

B-Raf inhibitors induce epithelial differentiation in BRAF-mutant colorectal cancer cells

scientific article

BRAF inhibition in hairy cell leukemia with low-dose vemurafenib

scientific article

BRAF inhibition upregulates a variety of receptor tyrosine kinases and their downstream effector Gab2 in colorectal cancer cell lines

scientific article published on 12 January 2018

BRAF inhibitor-associated ERK activation drives development of chronic lymphocytic leukemia

scientific article

BRAF inhibitors in colorectal cancer: Toward a differentiation therapy?

scientific article published on 23 January 2015

BRAFV600E drives dedifferentiation in small intestinal and colonic organoids and cooperates with mutant p53 and Apc loss in transformation

scientific article published on 13 August 2020

Biglycan expression in the melanoma microenvironment promotes invasiveness via increased tissue stiffness inducing integrin-β1 expression

scientific article published on 17 April 2017

CDK9-mediated phosphorylation controls the interaction of TIP60 with the transcriptional machinery.

scientific article published on 15 January 2018

Cathepsin D deficiency in mammary epithelium transiently stalls breast cancer by interference with mTORC1 signaling

scientific article published on 12 October 2020

Combined targeted DNA and RNA sequencing of advanced NSCLC in routine molecular diagnostics: Analysis of the first 3,000 Heidelberg cases

scientific article published on 19 February 2019

DUSP26 negatively affects the proliferation of epithelial cells, an effect not mediated by dephosphorylation of MAPKs

scientific article

Depletion of STAT5 blocks TEL-SYK-induced APMF-type leukemia with myelofibrosis and myelodysplasia in mice.

scientific article published on 22 August 2014

Differential tyrosine phosphorylation controls the function of CNK1 as a molecular switch in signal transduction.

scientific article

Discrete cytosolic macromolecular BRAF complexes exhibit distinct activities and composition

scientific article published on 16 January 2017

Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling

scientific article

Dual-specificity phosphatases: critical regulators with diverse cellular targets

scientific article

EGFR-targeted TRAIL and a Smac mimetic synergize to overcome apoptosis resistance in KRAS mutant colorectal cancer cells

scientific article

ELF5 suppresses estrogen sensitivity and underpins the acquisition of antiestrogen resistance in luminal breast cancer.

scientific article

Effects of RAF inhibitors on PI3K/AKT signalling depend on mutational status of the RAS/RAF signalling axis

scientific article

Establishment and application of a novel patient-derived KIAA1549:BRAF-driven pediatric pilocytic astrocytoma model for preclinical drug testing

scientific article published on 17 December 2016

Exometabolom analysis of breast cancer cell lines: Metabolic signature

scientific article

Expression pattern and first functional characterization of riok-1 in Caenorhabditis elegans

scientific article published on 12 June 2014

FAM131B-BRAF Fusion Gene Resulting From 7q34 Deletion Leads to MAPK Pathway Activation in Pilocytic Astrocytoma

FAM131B-BRAF Fusion Gene Resulting From 7q34 Deletion Leads to MAPK Pathway Activation in Pilocytic Astrocytoma

Feedback regulation of lymphocyte signalling

scientific article published on April 2004

Function, regulation and pathological roles of the Gab/DOS docking proteins

scientific article

Functional characterization of a BRAF insertion mutant associated with pilocytic astrocytoma

scientific article published on 25 July 2011

Functional characterization of cancer-associated Gab1 mutations.

scientific article

Gab2 and Src co-operate in human mammary epithelial cells to promote growth factor independence and disruption of acinar morphogenesis.

scientific article published on 12 November 2007

Gab2 is essential for Bcr-Abl-mediated leukemic transformation and hydronephrosis in a chronic myeloid leukemia mouse model.

scientific article published on 29 April 2016

Gab2 regulates cytoskeletal organization and migration of mammary epithelial cells by modulating RhoA activation

scientific article

Gab2 signaling in chronic myeloid leukemia cells confers resistance to multiple Bcr-Abl inhibitors.

scientific article

Global gene expression profiling analysis reveals reduction of stemness after B-RAF inhibition in colorectal cancer cell lines

scientific article

Global kinome profiling reveals DYRK1A as critical activator of the human mitochondrial import machinery

scientific article published on 13 July 2021

How to Grb2 a Gab.

scientific article

Identification and characterization of a BRAF fusion oncoprotein with retained autoinhibitory domains

scientific article published on 26 September 2019

Identification of novel ERK-mediated feedback phosphorylation sites at the C-terminus of B-Raf

scientific article

Increased proliferation and altered growth factor dependence of human mammary epithelial cells overexpressing the Gab2 docking protein

scientific article

Inducible gene deletion reveals different roles for B-Raf and Raf-1 in B-cell antigen receptor signalling

scientific article published on November 2002

Insulin-like growth factor-1 receptor (IGF1R) as a novel target in chronic lymphocytic leukemia

scientific article published on 17 July 2013

Kidins220/ARMS associates with B-Raf and the TCR, promoting sustained Erk signaling in T cells

scientific article

Kidins220/ARMS binds to the B cell antigen receptor and regulates B cell development and activation

scientific article

MCL-1 inhibition provides a new way to suppress breast cancer metastasis and increase sensitivity to dasatinib

scientific article published on 08 December 2016

Metabolic reprogramming of donor T cells enhances graft-versus-leukemia effects in mice and humans

scientific article published on 01 October 2020

Metadherin exon 11 skipping variant enhances metastatic spread of ovarian cancer.

scientific article

MicroRNA-146a reduces MHC-II expression via targeting JAK/STAT signaling in dendritic cells after stem cell transplantation

scientific article published on 9 May 2017

Oncogenic FAM131B-BRAF fusion resulting from 7q34 deletion comprises an alternative mechanism of MAPK pathway activation in pilocytic astrocytoma

scientific article published on 20 March 2011

Oncogenic JAK2V617F causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms.

scientific article published in February 2018

PKD controls mitotic Golgi complex fragmentation through a Raf-MEK1 pathway

scientific article published on 14 December 2012

Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein

scientific article

Positive regulation of immune cell function and inflammatory responses by phosphatase PAC-1.

scientific article published on 12 February 2006

ROCK1/2 signaling contributes to corticosteroid-refractory acute graft-versus-host disease

scientific article published in 2024

Signalling by the EGF receptor in human cancers: accentuate the positive, eliminate the negative

Small-Molecule Stabilization of the 14-3-3/Gab2 Protein-Protein Interaction (PPI) Interface

scientific article

Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells.

scientific article published on 12 February 2018

Spontaneous activity of the mitochondrial apoptosis pathway drives chromosomal defects, the appearance of micronuclei and cancer metastasis through the Caspase-Activated DNAse

scientific article published on 07 April 2022

Strong negative feedback from Erk to Raf confers robustness to MAPK signalling.

scientific article published on May 2011

Targeting oncogenic Ras by the Clostridium perfringens toxin TpeL.

scientific article published on 27 March 2018

Targeting rare and non-canonical driver variants in NSCLC – An uncharted clinical field

scientific article published on 21 February 2021

The Atypical Kinase RIOK1 Promotes Tumor Growth and Invasive Behavior

scientific article published on 12 April 2017

The EMT-activator ZEB1 induces bone metastasis associated genes including BMP-inhibitors

scientific article

The RhoGAP protein Deleted in Liver Cancer 3 (DLC3) is essential for adherens junctions integrity

scientific article

The Senescence-associated Secretory Phenotype Mediates Oncogene-induced Senescence in Pediatric Pilocytic Astrocytoma

scientific article published on 07 December 2018

The Versatile Role of Gab1 in the Circulatory System

scientific article published on 11 July 2012

The adaptor protein SLP-65 acts as a tumor suppressor that limits pre-B cell expansion.

scientific article published on 18 November 2002

The immunohistochemical staining pattern of Gab2 correlates with distinct stages of chronic myeloid leukemia.

scientific article published on 2 February 2011

UV-B-induced cutaneous inflammation and prospects for antioxidant treatment in Kindler syndrome.

scientific article published on 23 October 2016

ZEB1 turns into a transcriptional activator by interacting with YAP1 in aggressive cancer types

scientific article published on 15 February 2016

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