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List of works by Lewis Whitehead

An investigation into pharmaceutically relevant mutagenicity data and the influence on Ames predictive potential

scientific article

Antibacterial Optimization of 4-Aminothiazolyl Analogues of the Natural Product GE2270 A: Identification of the Cycloalkylcarboxylic Acids ⬇️

scientific article published on December 8, 2011

Application of non-parametric regression to quantitative structure-activity relationships.

scientific article published on April 2002

Atomic-scale characterization of conformational changes in the preQ1 riboswitch aptamer upon ligand binding ⬇️

scientific article published on July 22, 2011

Avoidance of the Ames test liability for aryl-amines via computation

scientific article published on 3 April 2011

Development of isoform selective PI3-kinase inhibitors as pharmacological tools for elucidating the PI3K pathway

scientific article published on 17 July 2012

Discovery of LFF571: an investigational agent for Clostridium difficile infection

scientific article

Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors

scientific article published in August 2011

In vitro and in vivo activities of novel, semisynthetic thiopeptide inhibitors of bacterial elongation factor Tu.

scientific article

Optimization of the in Vitro Cardiac Safety of Hydroxamate-Based Histone Deacetylase Inhibitors ⬇️

scientific article published on June 17, 2011

Small molecule-facilitated degradation of ANO1 protein: a new targeting approach for anticancer therapeutics.

scientific article published on 5 March 2014

The chemical tuning of a weak zinc binding motif for histone deacetylase using electronic effects

scientific article published on 15 May 2012

The design, synthesis and structure–activity relationships of novel isoindoline-based histone deacetylase inhibitors ⬇️

scientific article published on August 15, 2011

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