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List of works by Paolo Tosco

1,2,5-Oxadiazole analogues of leflunomide and related compounds

scientific article published on 03 November 2010

6-Cyclohexylmethoxy-5-(cyano-NNO-azoxy)pyrimidine-4-amine: a new scaffold endowed with potent CDK2 inhibitory activity

scientific article published on 11 August 2013

A 3D-QSAR-driven approach to binding mode and affinity prediction

scientific article published on 01 December 2011

A mechanistic hypothesis for the aspirin-induced switch in lipid mediator production by cyclooxygenase-2

scientific article published on 05 July 2013

A new class of NO-donor H3-antagonists

scientific article published in May 2004

Bringing the MMFF force field to the RDKit: implementation and validation

scientific article (publication date: 12 July 2014)

Brute-force pharmacophore assessment and scoring with Open3DQSAR.

scientific article published on 19 April 2011

COSMOsar3D: Molecular Field Analysis Based on Local COSMO σ-Profiles

article

Complementary three-dimensional quantitative structure-activity relationship modeling of binding affinity and functional potency: a study on alpha4beta2 nicotinic ligands.

scientific article published on April 2009

Design and Synthesis of a γ(1)β(8)-Cyclodextrin Oligomer: A New Platform with Potential Application as a Dendrimeric Multicarrier

scientific article

Edaravone derivatives containing NO-donor functions

scientific article

Furoxan analogues of the histamine H3-receptor antagonist imoproxifan and related furazan derivatives

scientific article published in August 2005

Hydroxy-1,2,5-oxadiazolyl moiety as bioisoster of the carboxy function. A computational study on gamma-aminobutyric acid (GABA) related compounds

scientific article

Mechanistic insights into cyclooxygenase irreversible inactivation by aspirin.

scientific article

Multitarget drugs: Focus on the NO-donor hybrid drugs

NO-Donor COX-2 Inhibitors. New Nitrooxy-Substituted 1,5-Diarylimidazoles Endowed with COX-2 Inhibitory and Vasodilator Properties

scientific article published on 03 March 2007

NO-donor melatonin derivatives: synthesis and in vitro pharmacological characterization

scientific article published on 01 April 2007

New inhibitors of dihydroorotate dehydrogenase (DHODH) based on the 4-hydroxy-1,2,5-oxadiazol-3-yl (hydroxyfurazanyl) scaffold

scientific article published on 03 January 2012

Nitrooxyacyl derivatives of salicylic acid: aspirin-like molecules that covalently inactivate cyclooxygenase-1.

scientific article published on 5 January 2011

Non-imidazole histamine NO-donor H3-antagonists

scientific article published in June 2005

Novel small molecule protein arginine deiminase 4 (PAD4) inhibitors

scientific article

Open3DALIGN: an open-source software aimed at unsupervised ligand alignment.

scientific article published on 27 July 2011

Open3DQSAR: a new open-source software aimed at high-throughput chemometric analysis of molecular interaction fields.

scientific article published on 11 April 2010

Physicochemical Profiling of Sartans: A Detailed Study of Ionization Constants and Distribution Coefficients

SDF2XYZ2SDF: how to exploit TINKER power in cheminformatics projects

scientific article published on 15 May 2011

Structure-antioxidant activity relationships in a series of NO-donor phenols

scientific article published in September 2008

Synthesis and preliminary pharmacological characterisation of a new class of nitrogen-containing bisphosphonates (N-BPs).

scientific article published in March 2010

Synthesis and vasodilating properties of N-alkylamide derivatives of 4-amino-3-furoxancarboxylic acid and related azo derivatives.

scientific article published in September 2003

The role of fluorine in stabilizing the bioactive conformation of dihydroorotate dehydrogenase inhibitors.

scientific article published on 10 November 2012

Thymopentin down-regulates both activity and expression of iNOS in blood cells of Sézary syndrome patients

scientific article published on 18 June 2012

[3-(1H-imidazol-4-yl)propyl]guanidines containing furoxan moieties: a new class of H3-antagonists endowed with NO-donor properties

scientific article published in April 2003

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