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List of works by Aik Choon Tan

A Genome-Wide Loss-of-Function Screen Identifies SLC26A2 as a Novel Mediator of TRAIL Resistance.

scientific article published on 20 January 2017

A NOTCH1 gene copy number gain is a prognostic indicator of worse survival and a predictive biomarker to a Notch1 targeting antibody in colorectal cancer.

scientific article

A Phase I Dose-Escalation Study of Linsitinib (OSI-906), a Small-Molecule Dual Insulin-Like Growth Factor-1 Receptor/Insulin Receptor Kinase Inhibitor, in Combination with Irinotecan in Patients with Advanced Cancer.

scientific article published on 23 August 2018

A Pilot Study of Biomedical Text Comprehension using an Attention-Based Deep Neural Reader: Design and Experimental Analysis

scientific article published on 5 January 2018

A Survey of Computational Tools to Analyze and Interpret Whole Exome Sequencing Data

scientific article

A genetic screen identifies TCF3/E2A and TRIAP1 as pathway-specific regulators of the cellular response to p53 activation.

scientific article published on 16 May 2013

A mechanism of resistance to gefitinib mediated by cellular reprogramming and the acquisition of an FGF2-FGFR1 autocrine growth loop.

scientific article published on 25 March 2013

A patient tumor transplant model of squamous cell cancer identifies PI3K inhibitors as candidate therapeutics in defined molecular bins ⬇️

scientific article published on 04 April 2013

A pilot study of cetuximab and the hedgehog inhibitor IPI-926 in recurrent/metastatic head and neck squamous cell carcinoma

scientific article published on 15 December 2015

A receptor tyrosine kinase network composed of fibroblast growth factor receptors, epidermal growth factor receptor, v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, and hepatocyte growth factor receptor drives growth and survival of head

scientific article published on 31 January 2013

A resource for analysis of microRNA expression and function in pancreatic ductal adenocarcinoma cells

scientific article

ALDH+ tumor‐initiating cells exhibiting gain in NOTCH1 gene copy number have enhanced regrowth sensitivity to a γ‐secretase inhibitor and irinotecan in colorectal cancer ⬇️

scientific article published on March 28, 2012

ALK Inhibitor Response in Melanomas Expressing EML4-ALK Fusions and Alternate ALK Isoforms.

scientific article

ALK is a critical regulator of the MYC-signaling axis in ALK positive lung cancer.

scientific article published on 16 January 2018

AMPK/FIS1-Mediated Mitophagy Is Required for Self-Renewal of Human AML Stem Cells

scientific article published on 14 June 2018

ATM and MET kinases are synthetic lethal with nongenotoxic activation of p53 ⬇️

scientific article published on June 3, 2012

ATM/G6PD-driven redox metabolism promotes FLT3 inhibitor resistance in acute myeloid leukemia.

scientific article published on 10 October 2016

AZ1366: An Inhibitor of Tankyrase and the Canonical Wnt Pathway that Limits the Persistence of Non-Small Cell Lung Cancer Cells Following EGFR Inhibition ⬇️

scientific article published on 23 September 2016

Aging-associated inflammation promotes selection for adaptive oncogenic events in B cell progenitors

scientific article

An Inducible TGF-β2-TGFβR Pathway Modulates the Sensitivity of HNSCC Cells to Tyrosine Kinase Inhibitors Targeting Dominant Receptor Tyrosine Kinases.

scientific article published on 6 May 2015

An integrated bioinformatics analysis to dissect kinase dependency in triple negative breast cancer

scientific article published on 9 December 2015

Antitumor activity and molecular effects of the novel heat shock protein 90 inhibitor, IPI-504, in pancreatic cancer.

scientific article published on October 2008

Antitumor activity of a potent MEK inhibitor, TAK-733, against colorectal cancer cell lines and patient derived xenografts.

scientific article published on October 2015

Antitumor activity of the MEK inhibitor TAK-733 against melanoma cell lines and patient-derived tumor explants.

scientific article

Antitumor activity of the aurora a selective kinase inhibitor, alisertib, against preclinical models of colorectal cancer.

scientific article published on July 2016

Antitumor activity of the polo-like kinase inhibitor, TAK-960, against preclinical models of colorectal cancer.

scientific article published on 5 February 2018

Antitumor effects and biomarkers of activity of AZD0530, a Src inhibitor, in pancreatic cancer.

scientific article

Association of the epithelial-to-mesenchymal transition phenotype with responsiveness to the p21-activated kinase inhibitor, PF-3758309, in colon cancer models.

scientific article

Automatic context-specific subnetwork discovery from large interaction networks

scientific article

BEReX: Biomedical Entity-Relationship eXplorer

scientific article

BEST: Next-Generation Biomedical Entity Search Tool for Knowledge Discovery from Biomedical Literature

scientific article

BRONCO: Biomedical entity Relation ONcology COrpus for extracting gene-variant-disease-drug relations.

scientific article published on 13 April 2016

Barasertib (AZD1152), a Small Molecule Aurora B Inhibitor, Inhibits the Growth of SCLC Cell Lines In Vitro and In Vivo.

scientific article published on 5 August 2016

BiNGS!SL-seq: a bioinformatics pipeline for the analysis and interpretation of deep sequencing genome-wide synthetic lethal screen

scientific article published in January 2012

Big Data Mining and Adverse Event Pattern Analysis in Clinical Drug Trials

scientific article

Bioinformatics-driven discovery of rational combination for overcoming EGFR-mutant lung cancer resistance to EGFR therapy.

scientific article

Biomarker-driven trial in metastatic pancreas cancer: feasibility in a multicenter study of saracatinib, an oral Src inhibitor, in previously treated pancreatic cancer

scientific article published on 16 August 2012

Brusatol overcomes chemoresistance through inhibition of protein translation.

scientific article published on 26 December 2016

CD44 Facilitates Epithelial-to-Mesenchymal Transition Phenotypic Change at Acquisition of Resistance to EGFR Kinase Inhibitors in Lung Cancer

scientific article published on 26 July 2018

CDK1 interacts with Sox2 and promotes tumor initiation in human melanoma

article

Characterizing DNA methylation patterns in pancreatic cancer genome.

scientific article

Clinical implications of ALDH1A1 and ALDH1A3 mRNA expression in melanoma subtypes

scientific article published on 30 September 2019

Co-dependency of PKCδ and K-Ras: inverse association with cytotoxic drug sensitivity in KRAS mutant lung cancer

scientific article published on 3 April 2017

Collagen architecture in pregnancy-induced protection from breast cancer

scientific article published on 10 July 2013

Combined inhibition of MEK and Aurora A kinase in KRAS/PIK3CA double-mutant colorectal cancer models.

scientific article published on 16 June 2015

Common PIK3CA mutants and a novel 3' UTR mutation are associated with increased sensitivity to saracatinib.

scientific article published on May 2012

Comparative Haploid Genetic Screens Reveal Divergent Pathways in the Biogenesis and Trafficking of Glycophosphatidylinositol-Anchored Proteins.

scientific article published on 11 June 2015

Comprehensive Genetic Characterization of Human Thyroid Cancer Cell Lines: A Validated Panel for Preclinical Studies

scientific article published on 08 February 2019

Confident Predictability: Identifying reliable gene expression patterns for individualized tumor classification using a local minimax kernel algorithm ⬇️

scientific article published on January 24, 2011

Context-dependent role for chromatin remodeling component PBRM1/BAF180 in clear cell renal cell carcinoma.

scientific article published on 16 January 2017

Contrasting roles for C/EBPα and Notch in irradiation-induced multipotent hematopoietic progenitor cell defects.

scientific article published on April 2015

Coordinated epidermal growth factor receptor pathway gene overexpression predicts epidermal growth factor receptor inhibitor sensitivity in pancreatic cancer

scientific article published in April 2008

Coupling an EML4-ALK-centric interactome with RNA interference identifies sensitizers to ALK inhibitors

scientific article published on 18 October 2016

Crowdsourced identification of multi-target kinase inhibitors for RET- and TAU- based disease: The Multi-Targeting Drug DREAM Challenge

scientific article published on 14 September 2021

DSigDB: drug signatures database for gene set analysis.

scientific article

DeSigN: connecting gene expression with therapeutics for drug repurposing and development

scientific article

Deep learning of mutation-gene-drug relations from the literature

scientific article published on 25 January 2018

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies.

scientific article

Development of an integrated genomic classifier for a novel agent in colorectal cancer: approach to individualized therapy in early development.

scientific article

Direct reprogramming of human fibroblasts into dopaminergic neuron-like cells.

scientific article published on 22 November 2011

Dual Targeting of PDGFRα and FGFR1 Displays Synergistic Efficacy in Malignant Rhabdoid Tumors

scientific article (publication date: 25 October 2016)

Dual pharmacological targeting of the MAP kinase and PI3K/mTOR pathway in preclinical models of colorectal cancer

scientific article (publication date: 2014)

Effects of checkpoint kinase 1 inhibition by prexasertib on the tumor immune microenvironment of head and neck squamous cell carcinoma

scientific article published on 30 December 2020

Efficacy and Molecular Mechanisms of Differentiated Response to the Aurora and Angiogenic Kinase Inhibitor ENMD-2076 in Preclinical Models of p53-Mutated Triple-Negative Breast Cancer

scientific article

Employing gene set top scoring pairs to identify deregulated pathway-signatures in dilated cardiomyopathy from integrated microarray gene expression data.

scientific article

Enabling Precision Medicine in Cancer Care Through a Molecular Data Warehouse: The Moffitt Experience

scientific article published on 01 May 2021

Ensemble machine learning on gene expression data for cancer classification.

scientific article

Evaluation of the efficacy of dasatinib, a Src/Abl inhibitor, in colorectal cancer cell lines and explant mouse model.

scientific article published in November 2017

Expanding the computational toolbox for interrogating cancer kinomes

scientific article published on 15 December 2015

Exploiting receptor tyrosine kinase co-activation for cancer therapy

scientific article

Exploring the molecular mechanisms of Traditional Chinese Medicine components using gene expression signatures and connectivity map

scientific article published on 04 April 2018

FGFR1 Expression Levels Predict BGJ398 Sensitivity of FGFR1-Dependent Head and Neck Squamous Cell Cancers

scientific article published in October 2015

FGFR1 mRNA and protein expression, not gene copy number, predict FGFR TKI sensitivity across all lung cancer histologies.

scientific article

Fibroblast Subtypes Regulate Responsiveness of Luminal Breast Cancer to Estrogen

scientific article

Final Report of a Phase I Trial of Olaparib with Cetuximab and Radiation for Heavy Smoker Patients with Locally Advanced Head and Neck Cancer

scientific article published on 03 July 2018

First-in-Class Phosphorylated-p68 Inhibitor RX-5902 Inhibits β-Catenin Signaling and Demonstrates Antitumor Activity in Triple-Negative Breast Cancer

scientific article published on 05 September 2019

From bench to bedside: lessons learned in translating preclinical studies in cancer drug development

scientific article (publication date: 2 October 2013)

Functional RNAi Screens Define Distinct Protein Kinase Vulnerabilities in EGFR-Dependent HNSCC Cell Lines

scientific article published on 25 September 2019

GSEA-InContext: identifying novel and common patterns in expression experiments.

scientific article published in July 2018

Gene Array and Fluorescence In situ Hybridization Biomarkers of Activity of Saracatinib (AZD0530), a Src Inhibitor, in a Preclinical Model of Colorectal Cancer ⬇️

scientific article published on 03 August 2010

Genetic analysis of 779 advanced differentiated and anaplastic thyroid cancers.

scientific article published on 3 April 2018

Genetically-defined novel oral squamous cell carcinoma cell lines for the development of molecular therapies.

scientific article published on April 2016

HiPub: translating PubMed and PMC texts to networks for knowledge discovery

scientific article published on 2 August 2016

Homeoprotein Six2 promotes breast cancer metastasis via transcriptional and epigenetic control of E-cadherin expression

scientific article

Host response transcriptional profiling reveals extracellular components and ABC (ATP-binding cassette) transporters gene enrichment in typhoid fever-infected Nigerian children ⬇️

scientific article published on September 13, 2011

IFITM3 knockdown reduces the expression of CCND1 and CDK4 and suppresses the growth of oral squamous cell carcinoma cells

scientific article published on 04 April 2019

IMPACT web portal: oncology database integrating molecular profiles with actionable therapeutics.

scientific article

IMPACT: a whole-exome sequencing analysis pipeline for integrating molecular profiles with actionable therapeutics in clinical samples.

scientific article published on 28 March 2016

Identification of predictive markers of response to the MEK1/2 inhibitor selumetinib (AZD6244) in K-ras-mutated colorectal cancer.

scientific article published on 05 October 2010

Identifying kinase dependency in cancer cells by integrating high-throughput drug screening and kinase inhibition data

scientific article

Innate Genetic Evolution of Lung Cancers and Spatial Heterogeneity: Analysis of Treatment-Naïve Lesions

scientific article published on 19 June 2018

Integrated genomic analyses identify WEE1 as a critical mediator of cell fate and a novel therapeutic target in acute myeloid leukemia.

scientific article published on 13 January 2012

Integrated preclinical and clinical development of mTOR inhibitors in pancreatic cancer.

scientific article

Integrating heterogeneous drug sensitivity data from cancer pharmacogenomic studies.

scientific article

K-Map: connecting kinases with therapeutics for drug repurposing and development

scientific article

Kinase gene fusions in defined subsets of melanoma

scientific article published on 19 November 2016

Kinome RNAi Screens Reveal Synergistic Targeting of MTOR and FGFR1 Pathways for Treatment of Lung Cancer and HNSCC.

scientific article published on 10 September 2015

Long term storage of dry versus frozen RNA for next generation molecular studies.

scientific article

MERTK receptor tyrosine kinase is a therapeutic target in melanoma.

scientific article

MIR29B regulates expression of MLLT11 (AF1Q), an MLL fusion partner, and low MIR29B expression associates with adverse cytogenetics and poor overall survival in AML.

scientific article published on 18 April 2011

MSAT: a multiple sequence alignment tool based on TOPS.

scientific article

Maintenance of hormone responsiveness in luminal breast cancers by suppression of Notch

scientific article published on 3 October 2011

Mammary epithelial cell phagocytosis downstream of TGF-β3 is characterized by adherens junction reorganization

scientific article

Merging microarray data from separate breast cancer studies provides a robust prognostic test

scientific article

Multi-class protein fold classification using a new ensemble machine learning approach.

scientific article

Obesity and overfeeding affecting both tumor and systemic metabolism activates the progesterone receptor to contribute to postmenopausal breast cancer

scientific article

Optimizing the detection of lung cancer patients harboring anaplastic lymphoma kinase (ALK) gene rearrangements potentially suitable for ALK inhibitor treatment.

scientific article

Overcoming IGF1R/IR resistance through inhibition of MEK signaling in colorectal cancer models.

scientific article published on 17 September 2013

PAGER 2.0: an update to the pathway, annotated-list and gene-signature electronic repository for Human Network Biology.

scientific article published on 8 November 2017

PKCδ regulates integrin αVβ3 expression and transformed growth of K-ras dependent lung cancer cells.

scientific article published on 21 February 2016

Patient-derived tumour xenografts as models for oncology drug development

scientific article

Phase I study of oral rigosertib (ON 01910.Na), a dual inhibitor of the PI3K and Plk1 pathways, in adult patients with advanced solid malignancies

scientific article

Plasma-based circulating MicroRNA biomarkers for Parkinson's disease

scientific article

Potent antitumor activity of cabozantinib, a c-MET and VEGFR2 inhibitor, in a colorectal cancer patient-derived tumor explant model.

scientific article

Preclinical activity of the rational combination of selumetinib (AZD6244) in combination with vorinostat in KRAS-mutant colorectal cancer models.

scientific article published on 15 December 2011

Predictive biomarkers of sensitivity to the aurora and angiogenic kinase inhibitor ENMD-2076 in preclinical breast cancer models.

scientific article published on 7 November 2012

Quantitative proteomic analysis of ovarian cancer cells identified mitochondrial proteins associated with Paclitaxel resistance.

scientific article

RIP1 negatively regulates basal autophagic flux through TFEB to control sensitivity to apoptosis

scientific article published on 23 April 2015

Rational Combination of a MEK Inhibitor, Selumetinib, and the Wnt/Calcium Pathway Modulator, Cyclosporin A, in Preclinical Models of Colorectal Cancer ⬇️

scientific article published on June 11, 2013

ReSimNet: drug response similarity prediction using Siamese neural networks

scientific article published on 01 December 2019

Redox-dependent Brca1 transcriptional regulation by an NADH-sensor CtBP1.

scientific article

Regulation of Head and Neck Squamous Cancer Stem Cells by PI3K and SOX2.

scientific article published on 15 September 2016

Resistance to RET-Inhibition in RET-Rearranged NSCLC Is Mediated By Reactivation of RAS/MAPK Signaling

scientific article published on 12 May 2017

Resistance to ROS1 inhibition mediated by EGFR pathway activation in non-small cell lung cancer

scientific article

Resistance to Radiotherapy and PD-L1 Blockade Is Mediated by TIM-3 Upregulation and Regulatory T-Cell Infiltration

scientific article published on 24 July 2018

Resistance to Src inhibition alters the BRAF-mutant tumor secretome to promote an invasive phenotype and therapeutic escape through a FAK>p130Cas>c-Jun signaling axis

scientific article published on 10 December 2018

Reversal of Triple-Negative Breast Cancer EMT by miR-200c Decreases Tryptophan Catabolism and a Program of Immunosuppression

scientific article published on 13 September 2018

Robust prostate cancer marker genes emerge from direct integration of inter-study microarray data

scientific article

Salivary gland cancer patient-derived xenografts enable characterization of cancer stem cells and new gene fusions associated with tumor progression.

scientific article published on 19 March 2018

Sorafenib targets the mitochondrial electron transport chain complexes and ATP synthase to activate the PINK1-Parkin pathway and modulate cellular drug response.

scientific article published on 3 July 2017

Summarizing internal dynamics boosts differential analysis and functional interpretation of super enhancers ⬇️

scientific article published on 01 April 2022

Systematic analysis of tumour cell-extracellular matrix adhesion identifies independent prognostic factors in breast cancer.

scientific article published on 17 August 2016

Systems Pharmacology-Based Approach of Connecting Disease Genes in Genome-Wide Association Studies with Traditional Chinese Medicine.

scientific article

Systems biology approaches for advancing the discovery of effective drug combinations

scientific article (publication date: 2015)

TWIST1-Induced miR-424 Reversibly Drives Mesenchymal Programming while Inhibiting Tumor Initiation ⬇️

scientific article published on 25 February 2015

Tankyrase and the Canonical Wnt Pathway Protect Lung Cancer Cells from EGFR Inhibition ⬇️

scientific article published on June 27, 2012

Targeting the protein ubiquitination machinery in melanoma by the NEDD8-activating enzyme inhibitor pevonedistat (MLN4924).

scientific article published on 25 October 2016

The Insulin-like Growth Factor I Receptor/Insulin Receptor Tyrosine Kinase Inhibitor PQIP Exhibits Enhanced Antitumor Effects in Combination with Chemotherapy Against Colorectal Cancer Models ⬇️

scientific article published on October 13, 2010

The Jumonji-domain histone demethylase inhibitor JIB-04 deregulates oncogenic programs and increases DNA damage in Ewing Sarcoma, resulting in impaired cell proliferation and survival, and reduced tumor growth

scientific article published on 04 September 2018

The Mitogen-Activated Protein Kinase Pathway Facilitates Resistance to the Src Inhibitor Dasatinib in Thyroid Cancer.

scientific article published on 24 May 2016

The Six1 oncoprotein downregulates p53 via concomitant regulation of RPL26 and microRNA-27a-3p.

scientific article

The landscape of tyrosine kinase inhibitors in sarcomas: looking beyond pazopanib

scientific article published on 13 November 2019

The miR-106b-25 cluster targets Smad7, activates TGF-β signaling, and induces EMT and tumor initiating cell characteristics downstream of Six1 in human breast cancer.

scientific article published on 30 January 2012

The mutational landscape of mucosal melanoma

scientific article published on 23 October 2019

Thioredoxin interacting protein (TXNIP) is a novel tumor suppressor in thyroid cancer

scientific article published on 19 March 2014

Transcatheter aortic valve replacements alter circulating serum factors to mediate myofibroblast deactivation

scientific article published on 01 September 2019

Tumor P-Glycoprotein Correlates with Efficacy of PF-3758309 in in vitro and in vivo Models of Colorectal Cancer ⬇️

scientific article published on March 22, 2013

Tumor engraftment in nude mice and enrichment in stroma- related gene pathways predict poor survival and resistance to gemcitabine in patients with pancreatic cancer.

scientific article published on 8 July 2011

Tumours with elevated levels of the Notch and Wnt pathways exhibit efficacy to PF-03084014, a γ-secretase inhibitor, in a preclinical colorectal explant model

scientific article published on 18 July 2013

Uncovering drug repurposing candidates for head and neck cancers: insights from systematic pharmacogenomics data analysis

scientific article published on 14 December 2021

Whole-exome sequencing identifies recurrent SF3B1 R625 mutation and comutation of NF1 and KIT in mucosal melanoma

scientific article published on 14 March 2017

XactMice: humanizing mouse bone marrow enables microenvironment reconstitution in a patient-derived xenograft model of head and neck cancer

scientific article

iCOSSY: An Online Tool for Context-Specific Subnetwork Discovery from Gene Expression Data

scientific article

p53 Family Members Regulate Phenotypic Response to Aurora Kinase A Inhibition in Triple-Negative Breast Cancer

scientific article published on 10 March 2015

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