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List of works by Mathias Heikenwalder

A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development

scientific article published on September 2017

A lymphotoxin-driven pathway to hepatocellular carcinoma

scientific article published on October 2009

A positive feedback loop between RIP3 and JNK controls non-alcoholic steatohepatitis

scientific article

Accelerated type III secretion system 2-dependent enteropathogenesis by a Salmonella enterica serovar enteritidis PT4/6 strain

scientific article published on 15 June 2009

Adoptive T-cell therapy to treat liver cancer: is the liver microenvironment key?

scientific article published on August 2013

Aerosols transmit prions to immunocompetent and immunodeficient mice

scientific article published in 2011

Bacterial colitis increases susceptibility to oral prion disease

scientific article

Bcl-xL is an oncogenic driver in colorectal cancer

scientific article published on 18 August 2016

Brain Endothelial- and Epithelial-Specific Interferon Receptor Chain 1 Drives Virus-Induced Sickness Behavior and Cognitive Impairment

scientific article published on April 2016

CCL2-CCR2 Signaling in Disease Pathogenesis

scientific article published on January 2015

Cells and prions: a license to replicate

scientific article published on 13 June 2009

Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease

scientific article published on 6 October 2016

Chemokine-driven lymphocyte infiltration: an early intratumoural event determining long-term survival in resectable hepatocellular carcinoma

scientific article published on 19 September 2011

Chronic Salmonella enterica serovar Typhimurium-induced colitis and cholangitis in streptomycin-pretreated Nramp1+/+ mice

scientific article

Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote T(H)17 differentiation

scientific article

Clusters of secretagogin-expressing neurons in the aged human olfactory tract lack terminal differentiation

scientific article published on 2 April 2012

Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma

scientific article published on 21 September 2015

Correction: Aerosols transmit prions to immunocompetent and immunodeficient mice

scientific article published on 12 February 2016

Current concepts and controversies in prion immunopathology

scientific article published on January 2004

De novo generation of a transmissible spongiform encephalopathy by mouse transgenesis

scientific article

Development of autoimmune pancreatitis is independent of CDKN1A/p21-mediated pancreatic inflammation

scientific article published on 3 August 2017

Direct effects of hepatitis B virus-encoded proteins and chronic infection in liver cancer development

scientific article published on 17 June 2013

Disseminated and sustained HIV infection in CD34+ cord blood cell-transplanted Rag2-/-gamma c-/- mice

scholarly article

Distinct Functions of Senescence-Associated Immune Responses in Liver Tumor Surveillance and Tumor Progression

scientific article published on October 2016

Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma

scientific article

Efficient generation of multipotent mesenchymal stem cells from umbilical cord blood in stroma-free liquid culture

scientific article

Endothelial CCR2 signaling induced by colon carcinoma cells enables extravasation via the JAK2-Stat5 and p38MAPK pathway

scientific article

Endothelial cells translate pathogen signals into G-CSF-driven emergency granulopoiesis

scientific article

Endothelial chemokine receptors as facilitators of tumor cell extravasation?

scientific article published on September 2012

Follicular dendritic cells emerge from ubiquitous perivascular precursors

scientific article published on July 2012

Hepatocyte-specific deletion of the antiapoptotic protein myeloid cell leukemia-1 triggers proliferation and hepatocarcinogenesis in mice

scientific article

IFN-γ Hinders Recovery from Mucosal Inflammation during Antibiotic Therapy for Salmonella Gut Infection

scientific article published on 20 July 2016

Immune system and peripheral nerves in propagation of prions to CNS.

scientific article published on January 2003

Immunoprivileged status of the liver is controlled by Toll-like receptor 3 signaling

scientific article

Inducing Differentiation of Premalignant Hepatic Cells as a Novel Therapeutic Strategy in Hepatocarcinoma

scientific article published on 3 August 2016

Induction of cerebral beta-amyloidosis: intracerebral versus systemic Abeta inoculation

scholarly article

Inflammation-Induced Expression and Secretion of MicroRNA 122 Leads to Reduced Blood Levels of Kidney-Derived Erythropoietin and Anemia

scientific article

Insights into prion strains and neurotoxicity

scientific article published on July 2007

Intraepithelial and interstitial deposition of pathological prion protein in kidneys of scrapie-affected sheep

scientific article

Intratumor heterogeneity in hepatocellular carcinoma

scientific article published on 23 September 2014

IκB kinaseα/β control biliary homeostasis and hepatocarcinogenesis in mice by phosphorylating the cell-death mediator receptor-interacting protein kinase 1.

scientific article published on 11 July 2016

Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS.

scientific article

LINE(1)s of evidence in HBV-driven liver cancer

scientific article published on March 2014

Lethal recessive myelin toxicity of prion protein lacking its central domain

scientific article

Lineage fate of ductular reactions in liver injury and carcinogenesis

scientific article published on 27 April 2015

Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration

scientific article published on 25 January 2004

Lymphotoxin β receptor signalling executes Helicobacter pylori-driven gastric inflammation in a T4SS-dependent manner

scientific article published on 13 April 2016

Lymphotoxin, but not TNF, is required for prion invasion of lymph nodes

scientific article

Metabolic activation of intrahepatic CD8+ T cells and NKT cells causes nonalcoholic steatohepatitis and liver cancer via cross-talk with hepatocytes

scientific article

Metabolic and immunomodulatory effects of n-3 fatty acids are different in mesenteric and epididymal adipose tissue of diet-induced obese mice ⬇️

scientific article published on March 12, 2013

Microbe sampling by mucosal dendritic cells is a discrete, MyD88-independent step in DeltainvG S. Typhimurium colitis

scientific article published on 11 February 2008

Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways

scientific article

Mitochondrial function controls intestinal epithelial stemness and proliferation

scientific article published on 27 October 2016

Modeling human liver cancer heterogeneity: virally induced transgenic models and mouse genetic models of chronic liver inflammation

scientific article published on December 2014

Molecular detection of hepatitis E virus (HEV) in liver biopsies after liver transplantation

scientific article published on 21 November 2014

Mouse models of hepatocarcinogenesis: What can we learn for the prevention of human hepatocellular carcinoma? ⬇️

scientific article published on September 1, 2010

Multiple factors contribute to the peripheral induction of cerebral β-amyloidosis.

scientific article published on July 2014

Multiplexed pancreatic genome engineering and cancer induction by transfection-based CRISPR/Cas9 delivery in mice

scientific article

MyD88 protects from lethal encephalitis during infection with vesicular stomatitis virus

scientific article published on September 2007

NADPH oxidase deficient mice develop colitis and bacteremia upon infection with normally avirulent, TTSS-1- and TTSS-2-deficient Salmonella Typhimurium

scientific article (publication date: 2013)

NAFLD causes selective CD4(+) T lymphocyte loss and promotes hepatocarcinogenesis

scientific article published on 2 March 2016

Nonredundant function of soluble LTα3 produced by innate lymphoid cells in intestinal homeostasis

scientific article

Overexpression of lymphotoxin in T cells induces fulminant thymic involution

scientific article published on 15 May 2008

P(URI)fying Novel Drivers of NASH and HCC: A Feedforward Loop of IL17A via White Adipose Tissue

scientific article published on July 2016

Pancreatic Premalignant Lesions Secrete Tissue Inhibitor of Metalloproteinases-1, Which Activates Hepatic Stellate Cells Via CD63 Signaling to Create a Premetastatic Niche in the Liver

scientific article published on 6 August 2016

Pathogenesis of prion diseases: current status and future outlook

scientific article published on October 2006

Peripheral blood CD34+ cells efficiently engraft human cytokine knock-in mice

scientific article published on 19 August 2016

Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis

scientific article published on 21 October 2010

Prion pathogenesis in the absence of Toll-like receptor signalling

scientific article

Prions and peripheral nerves: a deadly rendezvous

scientific article published on September 2007

Prions, cytokines, and chemokines: a meeting in lymphoid organs

scientific article

Progress and problems in the biology, diagnostics, and therapeutics of prion diseases

scientific article

Prostaglandin E2 modulates TNF-alpha-induced MCP-1 synthesis in pancreatic acinar cells in a PKA-dependent manner

scientific article

RAG2-/- gamma(c)-/- mice transplanted with CD34+ cells from human cord blood show low levels of intestinal engraftment and are resistant to rectal transmission of human immunodeficiency virus

scientific article published on 08 October 2008

RIP3, a kinase promoting necroptotic cell death, mediates adverse remodelling after myocardial infarction

scientific article published on 11 June 2014

RIPK3 Restricts Myeloid Leukemogenesis by Promoting Cell Death and Differentiation of Leukemia Initiating Cells

scientific article published on July 2016

Repetitive immunization enhances the susceptibility of mice to peripherally administered prions

scientific article

Reversible microbial colonization of germ-free mice reveals the dynamics of IgA immune responses

scientific article published on June 2010

Salmonella transiently reside in luminal neutrophils in the inflamed gut

scientific article (publication date: 2012)

Spatiotemporally restricted arenavirus replication induces immune surveillance and type I interferon-dependent tumour regression

scientific article published on March 2017

Targeting of CCL2-CCR2-Glycosaminoglycan Axis Using a CCL2 Decoy Protein Attenuates Metastasis through Inhibition of Tumor Cell Seeding

scientific article published on January 2016

Tetraspanin CD63 acts as a pro-metastatic factor via β-catenin stabilization

scientific article

The Liver at the Nexus of Host-Microbial Interactions

scientific article published on November 2016

The lymphotoxin β receptor is a potential therapeutic target in renal inflammation

scientific article published on 23 September 2015

The microbiota mediates pathogen clearance from the gut lumen after non-typhoidal Salmonella diarrhea

scientific article (publication date: 2010)

The necroptosis-inducing kinase RIPK3 dampens adipose tissue inflammation and glucose intolerance

scientific article

The role of lymphotoxin signaling in the development of autoimmune pancreatitis and associated secondary extra-pancreatic pathologies

scientific article published on 10 January 2014

Toll-Like Receptor 3 Expressing Tumor Parenchyma and Infiltrating Natural Killer Cells in Hepatocellular Carcinoma Patients ⬇️

scientific article published on November 29, 2012

Towards autotrophic tissue engineering: Photosynthetic gene therapy for regeneration

scientific article

Transcriptional signature induced by a metastasis-promoting c-Src mutant in a human breast cell line

scientific article

Tumor-necrosis factor impairs CD4(+) T cell-mediated immunological control in chronic viral infection

scientific article

Uncoupling Malt1 threshold function from paracaspase activity results in destructive autoimmune inflammation

scientific article published on 13 November 2014

Urinary alpha1-antichymotrypsin: a biomarker of prion infection

scientific article

mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype

scientific article

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