List of works - Andreas Rummel

A camelid single-domain antibody neutralizes botulinum neurotoxin A by blocking host receptor binding.

scientific article

A lipid-binding loop of botulinum neurotoxin serotypes B, DC and G is an essential feature to confer their exquisite potency.

scientific article published on 2 May 2018

A viral-fusion-peptide-like molecular switch drives membrane insertion of botulinum neurotoxin A1

scientific article published in Nature Communications

Activation of metabotropic GABA receptors increases the energy barrier for vesicle fusion

scientific article

Arg(362) and Tyr(365) of the botulinum neurotoxin type a light chain are involved in transition state stabilization

scientific article published in February 2002

BoNT/AB hybrid maintains similar duration of paresis as BoNT/A wild-type in murine running wheel assay

scientific article

Botulinum Neurotoxin F Subtypes Cleaving the VAMP-2 Q⁻K Peptide Bond Exhibit Unique Catalytic Properties and Substrate Specificities

scientific article published on 01 August 2018

Botulinum Neurotoxin Is Shielded by NTNHA in an Interlocked Complex

scientific article

Botulinum Neurotoxin Serotype A Recognizes Its Protein Receptor SV2 by a Different Mechanism than Botulinum Neurotoxin B Synaptotagmin

scientific article published on 17 May 2016

Botulinum Neurotoxins: Qualitative and Quantitative Analysis Using the Mouse Phrenic Nerve Hemidiaphragm Assay (MPN)

scientific article published on 25 November 2015

Botulinum neurotoxin B recognizes its protein receptor with high affinity and specificity

scientific article

Botulinum neurotoxin C mutants reveal different effects of syntaxin or SNAP-25 proteolysis on neuromuscular transmission.

scientific article published on 11 August 2017

Botulinum neurotoxin G binds synaptotagmin-II in a mode similar to that of serotype B: tyrosine 1186 and lysine 1191 cause its lower affinity

scientific article published on 17 May 2013

Botulinum neurotoxin serotype D attacks neurons via two carbohydrate-binding sites in a ganglioside-dependent manner

scientific article published on 15 October 2010

Botulinum neurotoxin type D enables cytosolic delivery of enzymatically active cargo proteins to neurones via unfolded translocation intermediates

scientific article published in December 2004

Botulinum neurotoxins C, E and F bind gangliosides via a conserved binding site prior to stimulation-dependent uptake with botulinum neurotoxin F utilising the three isoforms of SV2 as second receptor

scientific article published on 23 July 2009

Cell entry strategy of clostridial neurotoxins

scientific article published on 28 April 2009

Clostridium difficile toxin B inhibits the secretory response of human mast cell line-1 (HMC-1) cells stimulated with high free-Ca²⁺ and GTPγS.

scientific article

Crystal Structure of the Receptor-Binding Domain of Botulinum Neurotoxin Type HA, Also Known as Type FA or H.

scientific article published on 08 March 2017

Detection, differentiation, and identification of botulinum neurotoxin serotypes C, CD, D, and DC by highly specific immunoassays and mass spectrometry.

scientific article published on 29 June 2016

Double receptor anchorage of botulinum neurotoxins accounts for their exquisite neurospecificity

scientific article published on 01 January 2013

Draft Genome Sequence of Bivalent Clostridium botulinum Strain IBCA10-7060, Encoding Botulinum Neurotoxin B and a New FA Mosaic Type

scientific article published on 11 December 2014

Exchange of the H(CC) domain mediating double receptor recognition improves the pharmacodynamic properties of botulinum neurotoxin

scientific article published on 22 June 2011

Exchanging the minimal cell binding fragments of tetanus neurotoxin in botulinum neurotoxin A and B impacts their toxicity at the neuromuscular junction and central neurons

scientific article published on 29 June 2013

Functional detection of botulinum neurotoxin serotypes A to F by monoclonal neoepitope-specific antibodies and suspension array technology

scientific article published on 02 April 2019

Generation and Characterization of Six Recombinant Botulinum Neurotoxins as Reference Material to Serve in an International Proficiency Test

scientific article

High-resolution crystal structure of HA33 of botulinum neurotoxin type B progenitor toxin complex

scientific article

Historical Perspectives and Guidelines for Botulinum Neurotoxin Subtype Nomenclature.

scientific article published on 18 January 2017

Human mast cell line-1 (HMC-1) cells exhibit a membrane capacitance increase when dialysed with high free-Ca(2+) and GTPγS containing intracellular solution

scientific article published on 24 October 2013

Human synaptotagmin-II is not a high affinity receptor for botulinum neurotoxin B and G: increased therapeutic dosage and immunogenicity

scientific journal article

Identification of the SV2 protein receptor-binding site of botulinum neurotoxin type E.

scientific article published in July 2013

Identification of the protein receptor binding site of botulinum neurotoxins B and G proves the double-receptor concept.

scholarly article

Identification of the synaptic vesicle glycoprotein 2 receptor binding site in botulinum neurotoxin A

scientific journal article

Inhibiting oral intoxication of botulinum neurotoxin A complex by carbohydrate receptor mimics.

scientific article

Innovative and Highly Sensitive Detection of Enterotoxin Based on Receptor Interaction and Monoclonal Antibodies

scientific article

Isolation and functional characterization of the novel Clostridium botulinum neurotoxin A8 subtype.

scientific article

Medical aspects of toxin weapons.

scientific article

Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex

scientific article

N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A.

scientific article published on 13 June 2016

Neutralisation of specific surface carboxylates speeds up translocation of botulinum neurotoxin type B enzymatic domain.

scientific article published on 21 October 2013

Only the complex N559-glycan in the synaptic vesicle glycoprotein 2C mediates high affinity binding to botulinum neurotoxin serotype A1.

scientific article published on 16 June 2016

Optimization of SNAP-25 and VAMP-2 Cleavage by Botulinum Neurotoxin Serotypes A-F Employing Taguchi Design-of-Experiments

scientific article published on 11 October 2019

Preface Biological Toxins—Ancient Molecules Posing a Current Threat.

scientific article published on 8 December 2015

Qualitative and Quantitative Detection of Botulinum Neurotoxins from Complex Matrices: Results of the First International Proficiency Test.

scientific article

Receptor and substrate interactions of clostridial neurotoxins

scientific article published on 04 March 2009

SNARE tagging allows stepwise assembly of a multimodular medicinal toxin

scientific article

Structural basis of the pH-dependent assembly of a botulinum neurotoxin complex.

scientific article

Structure of a Bimodular Botulinum Neurotoxin Complex Provides Insights into Its Oral Toxicity

scientific article

Synaptotagmins I and II act as nerve cell receptors for botulinum neurotoxin G.

scientific article

The 25 kDa H<sub>CN</sub> Domain of Clostridial Neurotoxins Is Indispensable for Their Neurotoxicity

scientific article published on 26 November 2020

The HCC-domain of botulinum neurotoxins A and B exhibits a singular ganglioside binding site displaying serotype specific carbohydrate interaction

scientific article

The biological activity of botulinum neurotoxin type C is dependent upon novel types of ganglioside binding sites

scientific article

The long journey of botulinum neurotoxins into the synapse

scientific article published on 09 September 2015

The synaptic vesicle protein 2C mediates the uptake of botulinum neurotoxin A into phrenic nerves

scientific journal article

Two Feet on the Membrane: Uptake of Clostridial Neurotoxins

scientific article published in December 2016

Two carbohydrate binding sites in the H(CC)-domain of tetanus neurotoxin are required for toxicity

scientific article

List of works by Andreas Rummel

A camelid single-domain antibody neutralizes botulinum neurotoxin A by blocking host receptor binding.

A lipid-binding loop of botulinum neurotoxin serotypes B, DC and G is an essential feature to confer their exquisite potency.

A viral-fusion-peptide-like molecular switch drives membrane insertion of botulinum neurotoxin A1

Activation of metabotropic GABA receptors increases the energy barrier for vesicle fusion

Arg(362) and Tyr(365) of the botulinum neurotoxin type a light chain are involved in transition state stabilization

BoNT/AB hybrid maintains similar duration of paresis as BoNT/A wild-type in murine running wheel assay

Botulinum Neurotoxin F Subtypes Cleaving the VAMP-2 Q⁻K Peptide Bond Exhibit Unique Catalytic Properties and Substrate Specificities

Botulinum Neurotoxin Is Shielded by NTNHA in an Interlocked Complex

Botulinum Neurotoxin Serotype A Recognizes Its Protein Receptor SV2 by a Different Mechanism than Botulinum Neurotoxin B Synaptotagmin

Botulinum Neurotoxins: Qualitative and Quantitative Analysis Using the Mouse Phrenic Nerve Hemidiaphragm Assay (MPN)

Botulinum neurotoxin B recognizes its protein receptor with high affinity and specificity

Botulinum neurotoxin C mutants reveal different effects of syntaxin or SNAP-25 proteolysis on neuromuscular transmission.

Botulinum neurotoxin G binds synaptotagmin-II in a mode similar to that of serotype B: tyrosine 1186 and lysine 1191 cause its lower affinity

Botulinum neurotoxin serotype D attacks neurons via two carbohydrate-binding sites in a ganglioside-dependent manner

Botulinum neurotoxin type D enables cytosolic delivery of enzymatically active cargo proteins to neurones via unfolded translocation intermediates

Botulinum neurotoxins C, E and F bind gangliosides via a conserved binding site prior to stimulation-dependent uptake with botulinum neurotoxin F utilising the three isoforms of SV2 as second receptor

Cell entry strategy of clostridial neurotoxins

Clostridium difficile toxin B inhibits the secretory response of human mast cell line-1 (HMC-1) cells stimulated with high free-Ca²⁺ and GTPγS.

Crystal Structure of the Receptor-Binding Domain of Botulinum Neurotoxin Type HA, Also Known as Type FA or H.

Detection, differentiation, and identification of botulinum neurotoxin serotypes C, CD, D, and DC by highly specific immunoassays and mass spectrometry.

Double receptor anchorage of botulinum neurotoxins accounts for their exquisite neurospecificity

Draft Genome Sequence of Bivalent Clostridium botulinum Strain IBCA10-7060, Encoding Botulinum Neurotoxin B and a New FA Mosaic Type

Exchange of the H(CC) domain mediating double receptor recognition improves the pharmacodynamic properties of botulinum neurotoxin

Exchanging the minimal cell binding fragments of tetanus neurotoxin in botulinum neurotoxin A and B impacts their toxicity at the neuromuscular junction and central neurons

Functional detection of botulinum neurotoxin serotypes A to F by monoclonal neoepitope-specific antibodies and suspension array technology

Generation and Characterization of Six Recombinant Botulinum Neurotoxins as Reference Material to Serve in an International Proficiency Test

High-resolution crystal structure of HA33 of botulinum neurotoxin type B progenitor toxin complex

Historical Perspectives and Guidelines for Botulinum Neurotoxin Subtype Nomenclature.

Human mast cell line-1 (HMC-1) cells exhibit a membrane capacitance increase when dialysed with high free-Ca(2+) and GTPγS containing intracellular solution

Human synaptotagmin-II is not a high affinity receptor for botulinum neurotoxin B and G: increased therapeutic dosage and immunogenicity

Identification of the SV2 protein receptor-binding site of botulinum neurotoxin type E.

Identification of the protein receptor binding site of botulinum neurotoxins B and G proves the double-receptor concept.

Identification of the synaptic vesicle glycoprotein 2 receptor binding site in botulinum neurotoxin A

Inhibiting oral intoxication of botulinum neurotoxin A complex by carbohydrate receptor mimics.

Innovative and Highly Sensitive Detection of Enterotoxin Based on Receptor Interaction and Monoclonal Antibodies

Isolation and functional characterization of the novel Clostridium botulinum neurotoxin A8 subtype.

Medical aspects of toxin weapons.

Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex

N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A.

Neutralisation of specific surface carboxylates speeds up translocation of botulinum neurotoxin type B enzymatic domain.

Only the complex N559-glycan in the synaptic vesicle glycoprotein 2C mediates high affinity binding to botulinum neurotoxin serotype A1.

Optimization of SNAP-25 and VAMP-2 Cleavage by Botulinum Neurotoxin Serotypes A-F Employing Taguchi Design-of-Experiments

Preface Biological Toxins—Ancient Molecules Posing a Current Threat.

Qualitative and Quantitative Detection of Botulinum Neurotoxins from Complex Matrices: Results of the First International Proficiency Test.

Receptor and substrate interactions of clostridial neurotoxins

SNARE tagging allows stepwise assembly of a multimodular medicinal toxin

Structural basis of the pH-dependent assembly of a botulinum neurotoxin complex.

Structure of a Bimodular Botulinum Neurotoxin Complex Provides Insights into Its Oral Toxicity

Synaptotagmins I and II act as nerve cell receptors for botulinum neurotoxin G.

The 25 kDa H<sub>CN</sub> Domain of Clostridial Neurotoxins Is Indispensable for Their Neurotoxicity

The HCC-domain of botulinum neurotoxins A and B exhibits a singular ganglioside binding site displaying serotype specific carbohydrate interaction

The biological activity of botulinum neurotoxin type C is dependent upon novel types of ganglioside binding sites

The long journey of botulinum neurotoxins into the synapse

The synaptic vesicle protein 2C mediates the uptake of botulinum neurotoxin A into phrenic nerves

Two Feet on the Membrane: Uptake of Clostridial Neurotoxins

Two carbohydrate binding sites in the H(CC)-domain of tetanus neurotoxin are required for toxicity