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List of works by Sebastian Jimenez

Age-dependent accumulation of soluble amyloid beta (Abeta) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-alpha (sAPP(alpha)) by modulating phosphatidylinositol 3-kinase (PI3K)/Akt-GSK-3beta pathway in Alzheimer m

scientific article published on April 2011

Amyloid-β reduces the expression of neuronal FAIM-L, thereby shifting the inflammatory response mediated by TNFα from neuronal protection to death. ⬇️

scientific article published on 12 February 2015

Calretinin interneurons are early targets of extracellular amyloid-beta pathology in PS1/AbetaPP Alzheimer mice hippocampus

scientific article published in January 2010

Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus

scientific article published on 22 November 2012

Disruption of amyloid plaques integrity affects the soluble oligomers content from Alzheimer disease brains

scientific article

Early neuropathology of somatostatin/NPY GABAergic cells in the hippocampus of a PS1xAPP transgenic model of Alzheimer's disease

scientific article published on 3 November 2005

Extracellular amyloid-beta and cytotoxic glial activation induce significant entorhinal neuron loss in young PS1(M146L)/APP(751SL) mice

scientific article published in January 2009

In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer's disease pathology

scientific article published on 12 November 2013

Inflammatory response in the hippocampus of PS1M146L/APP751SL mouse model of Alzheimer's disease: age-dependent switch in the microglial phenotype from alternative to classic

scientific article published in November 2008

Inter-individual variability in the expression of the mutated form of hPS1M146L determined the production of Abeta peptides in the PS1xAPP transgenic mice.

scientific article

Regional difference in inflammatory response to LPS-injection in the brain: role of microglia cell density.

scientific article

Regulation of the phosphatase calcineurin by insulin-like growth factor I unveils a key role of astrocytes in Alzheimer's pathology.

scientific article published on 18 October 2011

Soluble phospho-tau from Alzheimer's disease hippocampus drives microglial degeneration

scientific article published on 14 October 2016

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