List of works - Irene Bolea

A comparison between radiometric and fluorimetric methods for measuring SSAO activity

scientific article published on 12 February 2013

A diet enriched in polyphenols and polyunsaturated fatty acids, LMN diet, induces neurogenesis in the subventricular zone and hippocampus of adult mouse brain

scientific article published in January 2009

A therapeutic approach to cerebrovascular diseases based on indole substituted hydrazides and hydrazines able to interact with human vascular adhesion protein-1, monoamine oxidases (A and B), AChE and BuChE.

scientific article

ASS234, As a New Multi-Target Directed Propargylamine for Alzheimer's Disease Therapy.

scientific article published on 28 June 2016

Catecholaminergic and cholinergic systems of mouse brain are modulated by LMN diet, rich in theobromine, polyphenols and polyunsaturated fatty acids

scientific article

Defined neuronal populations drive fatal phenotype in a mouse model of Leigh syndrome

scientific article published on 12 August 2019

Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil-indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease.

scientific article

Imaging of mitochondrial dynamics in motor and sensory axons of living mice

scientific article published in January 2014

LMN diet, rich in polyphenols and polyunsaturated fatty acids, improves mouse cognitive decline associated with aging and Alzheimer's disease

scientific article

Monoaminergic and Histaminergic Strategies and Treatments in Brain Diseases

scientific article

Multi-Target Directed Donepezil-Like Ligands for Alzheimer's Disease

scientific article published in 2016

Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine

scientific article published on 30 March 2012

Multipotent, permeable drug ASS234 inhibits Aβ aggregation, possesses antioxidant properties and protects from Aβ-induced apoptosis in vitro

scientific article published on October 2013

Neuroprotective Effects of the MAO-B Inhibitor, PF9601N, in anIn VivoModel of Excitotoxicity

scientific article published on 28 April 2014

Propargylamine-derived multitarget-directed ligands: fighting Alzheimer’s disease with monoamine oxidase inhibitors ⬇️

scientific article published on December 13, 2012

Sodium bicarbonate enhances membrane-bound and soluble human semicarbazide-sensitive amine oxidase activity in vitro

scientific article published on 10 September 2007

Synthesis, biological assessment and molecular modeling of new multipotent MAO and cholinesterase inhibitors as potential drugs for the treatment of Alzheimer's disease

scientific article published on 26 May 2011

Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of [...]

scientific article

List of works by Irene Bolea

A comparison between radiometric and fluorimetric methods for measuring SSAO activity

A diet enriched in polyphenols and polyunsaturated fatty acids, LMN diet, induces neurogenesis in the subventricular zone and hippocampus of adult mouse brain

A therapeutic approach to cerebrovascular diseases based on indole substituted hydrazides and hydrazines able to interact with human vascular adhesion protein-1, monoamine oxidases (A and B), AChE and BuChE.

ASS234, As a New Multi-Target Directed Propargylamine for Alzheimer's Disease Therapy.

Catecholaminergic and cholinergic systems of mouse brain are modulated by LMN diet, rich in theobromine, polyphenols and polyunsaturated fatty acids

Defined neuronal populations drive fatal phenotype in a mouse model of Leigh syndrome

Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil-indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease.

Imaging of mitochondrial dynamics in motor and sensory axons of living mice

LMN diet, rich in polyphenols and polyunsaturated fatty acids, improves mouse cognitive decline associated with aging and Alzheimer's disease

Monoaminergic and Histaminergic Strategies and Treatments in Brain Diseases

Multi-Target Directed Donepezil-Like Ligands for Alzheimer's Disease

Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine

Multipotent, permeable drug ASS234 inhibits Aβ aggregation, possesses antioxidant properties and protects from Aβ-induced apoptosis in vitro

Neuroprotective Effects of the MAO-B Inhibitor, PF9601N, in anIn VivoModel of Excitotoxicity

Propargylamine-derived multitarget-directed ligands: fighting Alzheimer’s disease with monoamine oxidase inhibitors ⬇️

Sodium bicarbonate enhances membrane-bound and soluble human semicarbazide-sensitive amine oxidase activity in vitro

Synthesis, biological assessment and molecular modeling of new multipotent MAO and cholinesterase inhibitors as potential drugs for the treatment of Alzheimer's disease

Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of [...]