List of works - Martin J. Scanlon

19F NMR as a probe of ligand interactions with the iNOS binding site of SPRY domain-containing SOCS box protein 2.

scientific article published on 5 June 2014

A Backbone Linker for BOC-Based Peptide Synthesis and On-Resin Cyclization: Synthesis of Stylostatin 1†,§

scientific article published on 01 April 1999

A ligand-induced structural change in fatty acid-binding protein 1 is associated with potentiation of peroxisome proliferator-activated receptor α agonists

scientific article published on 31 December 2018

A marine snail neurotoxin shares with scorpion toxins a convergent mechanism of blockade on the pore of voltage-gated K channels

scientific article

A novel two-chain proteinase inhibitor generated by circularization of a multidomain precursor protein

scientific article

A simplified liquid chromatography assay for the quantitation of halofantrine and desbutylhalofantrine in plasma and identification of a degradation product of desbutylhalofantrine formed under alkaline conditions

article

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

scientific article

An improved method for the purification of rat liver-type fatty acid binding protein from Escherichia coli

scientific article published in November 2005

Application of fragment-based screening to the design of inhibitors of Escherichia coli DsbA

scientific article

Assignments of human integrin α1I domain in the apo and Mg2+ bound states

scientific article published on 22 January 2013

Backbone and side chain 1H, 15N and 13C assignments for the oxidised and reduced forms of the oxidoreductase protein DsbA from Staphylococcus aureus.

scientific article published on 20 November 2009

Backbone and side chain 1H, 15N and 13C assignments for the reduced form of the oxidoreductase protein DsbA from Vibrio cholerae

scientific article published on 05 June 2007

Backbone assignments of the 34 kDa ketopantoate reductase from E. coli.

scientific article published on 26 April 2008

Binding of CFA/I Pili of Enterotoxigenic Escherichia coli to Asialo-GM1 Is Mediated by the Minor Pilin CfaE

scientific article

Characterization of lipophilic drug binding to rat intestinal fatty acid binding protein

scientific article published on 22 January 2009

Characterization of the DsbA oxidative folding catalyst from Pseudomonas aeruginosa reveals a highly oxidizing protein that binds small molecules

scientific article

Characterization of the N-Methyltransferase Activities of the Multifunctional Polypeptide Cyclosporin Synthetase

scientific article published on 01 April 2011

Characterization of the drug binding specificity of rat liver fatty acid binding protein.

scientific article published on 6 June 2008

Characterization of two distinct modes of drug binding to human intestinal fatty acid binding protein

scientific article

Colloidal characteristics and formulation of pure protein particulate vaccines

scientific article published on 29 May 2012

Comparative Sequence, Structure and Redox Analyses of Klebsiella pneumoniae DsbA Show That Anti-Virulence Target DsbA Enzymes Fall into Distinct Classes

scientific article

Conformational selection of inhibitors and substrates by proteolytic enzymes: implications for drug design and polypeptide processing

scientific article

Conformationally constrained macrocycles that mimic tripeptide beta-strands in water and aprotic solvents

scientific article

Conserved features in TamA enable interaction with TamB to drive the activity of the translocation and assembly module

scientific article published on 5 August 2015

Controlled Construction of Cyclic d / l Peptide Nanorods

scientific article published on 05 December 2018

Crystal structure of the HIV-1 integrase core domain in complex with sucrose reveals details of an allosteric inhibitory binding site

scientific article

Cyclic Hexapeptide Mimics of the LEDGF Integrase Recognition Loop in Complex with HIV-1 Integrase

article

DSB proteins and bacterial pathogenicity.

scientific article published on 09 February 2009

Design of a Fragment-Screening Library

scientific article published on 19 October 2018

Design, Synthesis, and Characterization of Cyclic Peptidomimetics of the Inducible Nitric Oxide Synthase Binding Epitope That Disrupt the Protein-Protein Interaction Involving SPRY Domain-Containing Suppressor of Cytokine Signaling Box Protein (SPSB

scientific article published on 23 May 2016

Determinants of Proteolysis and Cell-Binding for the Shigella flexneri Cytotoxin, SigA.

scientific article published on 22 August 2015

Determination of ligand binding modes in weak protein-ligand complexes using sparse NMR data

scientific article

Dietary Docosahexaenoic Acid Supplementation Enhances Expression of Fatty Acid-Binding Protein 5 at the Blood-Brain Barrier and Brain Docosahexaenoic Acid Levels

scientific article published on 27 March 2018

Difficult Macrocyclizations: New Strategies for Synthesizing Highly Strained Cyclic Tetrapeptides

scientific article published on 01 July 2003

Distinct binding properties of TIAR RRMs and linker region

scientific article published on April 2013

Enhancing the immunogenicity and modulating the fine epitope recognition of antisera to a helical group A streptococcal peptide vaccine candidate from the M protein using lipid-core peptide technology

Examination of the role of intestinal fatty acid-binding protein in drug absorption using a parallel artificial membrane permeability assay.

scientific article published in April 2007

Fatty Acid Binding Proteins Expressed at the Human Blood-Brain Barrier Bind Drugs in an Isoform-Specific Manner

scientific article published on 7 August 2015

Fatty Acid Binding Proteins: Potential Chaperones of Cytosolic Drug Transport in the Enterocyte?

scientific article published on 27 April 2011

Fatty Acid-Binding Protein 5 Facilitates the Blood-Brain Barrier Transport of Docosahexaenoic Acid.

scientific article published on 12 October 2015

Fatty Acid-Binding Protein 5 at the Blood-Brain Barrier Regulates Endogenous Brain Docosahexaenoic Acid Levels and Cognitive Function.

scientific article published in November 2016

Fatty Acid-binding Proteins 1 and 2 Differentially Modulate the Activation of Peroxisome Proliferator-activated Receptor α in a Ligand-selective Manner

scientific article published on 6 April 2015

Fatty acid binding protein 5 mediates the uptake of fatty acids, but not drugs, into human brain endothelial cells

scientific article published on 13 December 2017

Fragment library screening identifies hits that bind to the non-catalytic surface of Pseudomonas aeruginosa DsbA1

scientific article

Fragment-Based Discovery of Inhibitors of the Bacterial DnaG-SSB Interaction

scientific article published on 22 February 2018

Fragment-based design of ligands targeting a novel site on the integrase enzyme of human immunodeficiency virus 1

scientific article

H(N), N, C(α) and C(β) assignments of the two periplasmic domains of Neisseria meningitidis DsbD.

scientific article published on 06 June 2017

INHIBITION OF DIVERSE DsbA ENZYMES IN MULTI-DsbA ENCODING PATHOGENS.

scientific article published on 14 December 2017

Identification and characterization of two drug-like fragments that bind to the same cryptic binding pocket of Burkholderia pseudomallei DsbA

scientific article published on 01 January 2022

Identification of the Binding Site of Apical Membrane Antigen 1 (AMA1) Inhibitors Using a Paramagnetic Probe

scientific article published on 13 February 2019

Inhibitors of BCATm: A Tough Nut To Crack

article by Martin J. Scanlon published 4 September 2015 in Journal of Medicinal Chemistry

Interesterification of Soybean Oil with Propylene Glycol in Supercritical Carbon Dioxide and Analysis by NMR Spectroscopy

scientific article published on 09 January 2020

Isolation, solution structure, and insecticidal activity of kalata B2, a circular protein with a twist: do Möbius strips exist in nature?

scientific article published in January 2005

Ligand-induced conformational change of Plasmodium falciparum AMA1 detected using 19F NMR.

scientific article published on 5 August 2014

Molecular insights into the interaction between Plasmodium falciparum apical membrane antigen 1 and an invasion-inhibitory peptide ⬇️

scientific article

NMR fragment screening reveals a novel small molecule binding site near the catalytic surface of the disulfide-dithiol oxidoreductase enzyme DsbA from Burkholderia pseudomallei

scientific article published on 06 August 2020

Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief

scientific article published on May 2017

Parallel screening of low molecular weight fragment libraries: do differences in methodology affect hit identification?

scientific article

Peptide epitope binding and fluorescence quenching with the anti-mucin antibody C595

scientific article published on 01 April 1992

Phase behaviour of casein micelles and barley beta-glucan polymer molecules in dietary fibre-enriched dairy systems ⬇️

scientific article published on February 22, 2012

Preparation, crystallization and preliminary X-ray diffraction analysis of two intestinal fatty-acid binding proteins in the presence of 11-(dansylamino)undecanoic acid

scientific article

Primary sequence determination and molecular modelling of the variable region of an antiMUC1 mucin monoclonal antibody

scientific article published in January 1995

Probing the fibrate binding specificity of rat liver fatty acid binding protein.

scientific article published in September 2009

Probing the flexibility of the DsbA oxidoreductase from Vibrio cholerae--a 15N - 1H heteronuclear NMR relaxation analysis of oxidized and reduced forms of DsbA

scientific article

Production, biophysical characterization and initial crystallization studies of the N- and C-terminal domains of DsbD, an essential enzyme in Neisseria meningitidis.

scientific article

Promiscuous 2-aminothiazoles (PrATs): a frequent hitting scaffold.

scientific article published on 16 January 2015

Protein unfolding is essential for cleavage within the α-helix of a model protein substrate by the serine protease, thrombin.

scientific article

Pulse Flour Characteristics from a Wheat Flour Miller's Perspective: A Comprehensive Review

scientific article published on 15 January 2019

Redox-stable cyclic peptide inhibitors of the SPSB2-iNOS interaction

scientific article

Reduced blood-brain barrier expression of fatty acid-binding protein 5 is associated with increased vulnerability of APP/PS1 mice to cognitive deficits from low omega-3 fatty acid diets

scientific article

Self-micellization of gemfibrozil 1-O-beta acyl glucuronide in aqueous solution

scientific article

Sent packing: protein engineering generates a new crystal form of Pseudomonas aeruginosa DsbA1 with increased catalytic surface accessibility.

scientific article published on 26 November 2015

Small heat-shock proteins interact with a flanking domain to suppress polyglutamine aggregation.

scientific article

Small molecule inhibitors of disulfide bond formation by the bacterial DsbA-DsbB dual enzyme system

scientific article published on 27 January 2015

Solution NMR characterization of apical membrane antigen 1 and small molecule interactions as a basis for designing new antimalarials

scientific article published on 24 January 2016

Solution structure and DNA binding of the catalytic domain of the large serine resolvase TnpX.

scientific article published on 26 February 2015

Solution structure of BSTI: a new trypsin inhibitor from skin secretions of Bombina bombina

scientific article

Solution structure of the cardiostimulant polypeptide anthopleurin-B and comparison with anthopleurin-A ⬇️

scientific article published on August 15, 1995

Structural and biochemical characterization of the oxidoreductase NmDsbA3 from Neisseria meningitidis

scientific article

Structural and biochemical insights into the disulfide reductase mechanism of DsbD, an essential enzyme for neisserial pathogens

scientific article published on 04 September 2018

Structural and functional analysis of the Josephin domain of the polyglutamine protein ataxin-3

article

Structural basis for the inhibition of poxvirus assembly by the antibiotic rifampicin

article published in the Proceedings of the National Academy of Sciences of the United States of America

Structure and dynamics of apical membrane antigen 1 from Plasmodium falciparum FVO

scientific article

Structure and function of the oxidoreductase DsbA1 from Neisseria meningitidis

scientific article

Structure of the Chicken CD3 / Heterodimer and Its Assembly with the T Cell Receptor

scientific article

Structure-Activity Studies of β-Hairpin Peptide Inhibitors of the Plasmodium falciparum AMA1-RON2 Interaction

scientific article

Synthesis of Unsymmetrical 1,1′-Disubstituted Bis(1,2,3-triazole)s Using Monosilylbutadiynes

scientific article published on 12 January 2011

Targeting Bacterial Dsb Proteins for the Development of Anti-Virulence Agents

scientific article

Targeting virulence not viability in the search for future antibacterials.

scientific article

The 1.2 Å resolution crystal structure of TcpG, the Vibrio cholerae DsbA disulfide-forming protein required for pilus and cholera-toxin production

scientific article

The Fragment-Based Development of a Benzofuran Hit as a New Class of Escherichia coli DsbA Inhibitors

scientific article published on 18 October 2019

The Structure of Integrin 1I Domain in Complex with a Collagen-mimetic Peptide

scientific article

The Structure of the Bacterial Oxidoreductase Enzyme DsbA in Complex with a Peptide Reveals a Basis for Substrate Specificity in the Catalytic Cycle of DsbA Enzymes

scientific article

The binding interaction of synthetic ozonide antimalarials with natural and modified beta-cyclodextrins

scientific article published in January 2006

The cysteine-rich secretory protein domain of Tpx-1 is related to ion channel toxins and regulates ryanodine receptor Ca2+ signaling

scientific article

The first total synthesis and solution structure of a polypeptin, PE2, a cyclic lipopeptide with broad spectrum antibiotic activity.

scientific article published in August 2017

The interaction of lipophilic drugs with intestinal fatty acid-binding protein.

scientific article

The role of oxidoreductases in determining the function of the neisserial lipid A phosphoethanolamine transferase required for resistance to polymyxin.

scientific article

The structural impact of a polyglutamine tract is location-dependent

scientific article published on 10 October 2008

The three-dimensional solution structure of NaD1, a new floral defensin from Nicotiana alata and its application to a homology model of the crop defense protein alfAFP

scientific article

The ways and means of fragment-based drug design

scientific article

Three-dimensional structure in solution of the polypeptide cardiac stimulant anthopleurin-A

scientific article

Δ-Myrtoxin-Mp1a is a Helical Heterodimer from the Venom of the Jack Jumper Ant that has Antimicrobial, Membrane-Disrupting, and Nociceptive Activities

scientific article published on 17 May 2017

List of works by Martin J. Scanlon

19F NMR as a probe of ligand interactions with the iNOS binding site of SPRY domain-containing SOCS box protein 2.

A Backbone Linker for BOC-Based Peptide Synthesis and On-Resin Cyclization: Synthesis of Stylostatin 1†,§

A ligand-induced structural change in fatty acid-binding protein 1 is associated with potentiation of peroxisome proliferator-activated receptor α agonists

A marine snail neurotoxin shares with scorpion toxins a convergent mechanism of blockade on the pore of voltage-gated K channels

A novel two-chain proteinase inhibitor generated by circularization of a multidomain precursor protein

A simplified liquid chromatography assay for the quantitation of halofantrine and desbutylhalofantrine in plasma and identification of a degradation product of desbutylhalofantrine formed under alkaline conditions

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

An improved method for the purification of rat liver-type fatty acid binding protein from Escherichia coli

Application of fragment-based screening to the design of inhibitors of Escherichia coli DsbA

Assignments of human integrin α1I domain in the apo and Mg2+ bound states

Backbone and side chain 1H, 15N and 13C assignments for the oxidised and reduced forms of the oxidoreductase protein DsbA from Staphylococcus aureus.

Backbone and side chain 1H, 15N and 13C assignments for the reduced form of the oxidoreductase protein DsbA from Vibrio cholerae

Backbone assignments of the 34 kDa ketopantoate reductase from E. coli.

Binding of CFA/I Pili of Enterotoxigenic Escherichia coli to Asialo-GM1 Is Mediated by the Minor Pilin CfaE

Characterization of lipophilic drug binding to rat intestinal fatty acid binding protein

Characterization of the DsbA oxidative folding catalyst from Pseudomonas aeruginosa reveals a highly oxidizing protein that binds small molecules

Characterization of the N-Methyltransferase Activities of the Multifunctional Polypeptide Cyclosporin Synthetase

Characterization of the drug binding specificity of rat liver fatty acid binding protein.

Characterization of two distinct modes of drug binding to human intestinal fatty acid binding protein

Colloidal characteristics and formulation of pure protein particulate vaccines

Comparative Sequence, Structure and Redox Analyses of Klebsiella pneumoniae DsbA Show That Anti-Virulence Target DsbA Enzymes Fall into Distinct Classes

Conformational selection of inhibitors and substrates by proteolytic enzymes: implications for drug design and polypeptide processing

Conformationally constrained macrocycles that mimic tripeptide beta-strands in water and aprotic solvents

Conserved features in TamA enable interaction with TamB to drive the activity of the translocation and assembly module

Controlled Construction of Cyclic d / l Peptide Nanorods

Crystal structure of the HIV-1 integrase core domain in complex with sucrose reveals details of an allosteric inhibitory binding site

Cyclic Hexapeptide Mimics of the LEDGF Integrase Recognition Loop in Complex with HIV-1 Integrase

DSB proteins and bacterial pathogenicity.

Design of a Fragment-Screening Library

Design, Synthesis, and Characterization of Cyclic Peptidomimetics of the Inducible Nitric Oxide Synthase Binding Epitope That Disrupt the Protein-Protein Interaction Involving SPRY Domain-Containing Suppressor of Cytokine Signaling Box Protein (SPSB

Determinants of Proteolysis and Cell-Binding for the Shigella flexneri Cytotoxin, SigA.

Determination of ligand binding modes in weak protein-ligand complexes using sparse NMR data

Dietary Docosahexaenoic Acid Supplementation Enhances Expression of Fatty Acid-Binding Protein 5 at the Blood-Brain Barrier and Brain Docosahexaenoic Acid Levels

Difficult Macrocyclizations: New Strategies for Synthesizing Highly Strained Cyclic Tetrapeptides

Distinct binding properties of TIAR RRMs and linker region

Enhancing the immunogenicity and modulating the fine epitope recognition of antisera to a helical group A streptococcal peptide vaccine candidate from the M protein using lipid-core peptide technology

Examination of the role of intestinal fatty acid-binding protein in drug absorption using a parallel artificial membrane permeability assay.

Fatty Acid Binding Proteins Expressed at the Human Blood-Brain Barrier Bind Drugs in an Isoform-Specific Manner

Fatty Acid Binding Proteins: Potential Chaperones of Cytosolic Drug Transport in the Enterocyte?

Fatty Acid-Binding Protein 5 Facilitates the Blood-Brain Barrier Transport of Docosahexaenoic Acid.

Fatty Acid-Binding Protein 5 at the Blood-Brain Barrier Regulates Endogenous Brain Docosahexaenoic Acid Levels and Cognitive Function.

Fatty Acid-binding Proteins 1 and 2 Differentially Modulate the Activation of Peroxisome Proliferator-activated Receptor α in a Ligand-selective Manner

Fatty acid binding protein 5 mediates the uptake of fatty acids, but not drugs, into human brain endothelial cells

Fragment library screening identifies hits that bind to the non-catalytic surface of Pseudomonas aeruginosa DsbA1

Fragment-Based Discovery of Inhibitors of the Bacterial DnaG-SSB Interaction

Fragment-based design of ligands targeting a novel site on the integrase enzyme of human immunodeficiency virus 1

H(N), N, C(α) and C(β) assignments of the two periplasmic domains of Neisseria meningitidis DsbD.

INHIBITION OF DIVERSE DsbA ENZYMES IN MULTI-DsbA ENCODING PATHOGENS.

Identification and characterization of two drug-like fragments that bind to the same cryptic binding pocket of Burkholderia pseudomallei DsbA

Identification of the Binding Site of Apical Membrane Antigen 1 (AMA1) Inhibitors Using a Paramagnetic Probe

Inhibitors of BCATm: A Tough Nut To Crack

Interesterification of Soybean Oil with Propylene Glycol in Supercritical Carbon Dioxide and Analysis by NMR Spectroscopy

Isolation, solution structure, and insecticidal activity of kalata B2, a circular protein with a twist: do Möbius strips exist in nature?

Ligand-induced conformational change of Plasmodium falciparum AMA1 detected using 19F NMR.

Molecular insights into the interaction between Plasmodium falciparum apical membrane antigen 1 and an invasion-inhibitory peptide ⬇️

NMR fragment screening reveals a novel small molecule binding site near the catalytic surface of the disulfide-dithiol oxidoreductase enzyme DsbA from Burkholderia pseudomallei

Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief

Parallel screening of low molecular weight fragment libraries: do differences in methodology affect hit identification?

Peptide epitope binding and fluorescence quenching with the anti-mucin antibody C595

Phase behaviour of casein micelles and barley beta-glucan polymer molecules in dietary fibre-enriched dairy systems ⬇️

Preparation, crystallization and preliminary X-ray diffraction analysis of two intestinal fatty-acid binding proteins in the presence of 11-(dansylamino)undecanoic acid

Primary sequence determination and molecular modelling of the variable region of an antiMUC1 mucin monoclonal antibody

Probing the fibrate binding specificity of rat liver fatty acid binding protein.

Probing the flexibility of the DsbA oxidoreductase from Vibrio cholerae--a 15N - 1H heteronuclear NMR relaxation analysis of oxidized and reduced forms of DsbA

Production, biophysical characterization and initial crystallization studies of the N- and C-terminal domains of DsbD, an essential enzyme in Neisseria meningitidis.

Promiscuous 2-aminothiazoles (PrATs): a frequent hitting scaffold.

Protein unfolding is essential for cleavage within the α-helix of a model protein substrate by the serine protease, thrombin.

Pulse Flour Characteristics from a Wheat Flour Miller's Perspective: A Comprehensive Review

Redox-stable cyclic peptide inhibitors of the SPSB2-iNOS interaction

Reduced blood-brain barrier expression of fatty acid-binding protein 5 is associated with increased vulnerability of APP/PS1 mice to cognitive deficits from low omega-3 fatty acid diets

Self-micellization of gemfibrozil 1-O-beta acyl glucuronide in aqueous solution

Sent packing: protein engineering generates a new crystal form of Pseudomonas aeruginosa DsbA1 with increased catalytic surface accessibility.

Small heat-shock proteins interact with a flanking domain to suppress polyglutamine aggregation.

Small molecule inhibitors of disulfide bond formation by the bacterial DsbA-DsbB dual enzyme system

Solution NMR characterization of apical membrane antigen 1 and small molecule interactions as a basis for designing new antimalarials

Solution structure and DNA binding of the catalytic domain of the large serine resolvase TnpX.

Solution structure of BSTI: a new trypsin inhibitor from skin secretions of Bombina bombina

Solution structure of the cardiostimulant polypeptide anthopleurin-B and comparison with anthopleurin-A ⬇️

Structural and biochemical characterization of the oxidoreductase NmDsbA3 from Neisseria meningitidis