List of works - Paul Brear

A Random Forest Model for Predicting Allosteric and Functional Sites on Proteins.

scientific article published on 21 January 2016

A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066.

scientific article published on 30 April 2017

Affinity maturation of the RLIP76 Ral binding domain to inform the design of stapled peptides targeting the Ral GTPases

scientific article published on 19 November 2020

Aqueous methods for the preparation of 5'-substituted guanosine derivatives.

scientific article published on 6 July 2009

Aqueous synthesis of N,S-dialkylthiophosphoramidates: design, optimisation and application to library construction and antileishmanial testing.

scientific article

Chain alignment of collagen I deciphered using computationally designed heterotrimers

scientific article published on 06 January 2020

Efficient development of stable and highly functionalised peptides targeting the CK2α/CK2β protein-protein interaction.

scientific article published on 12 April 2019

Evolutionary plasticity in the allosteric regulator-binding site of pyruvate kinase isoform PykA from Pseudomonas aeruginosa

scientific article published on 04 September 2019

Gluconeogenic precursor availability regulates flux through the glyoxylate shunt in Pseudomonas aeruginosa

scientific article published on 20 July 2018

Novel non-ATP competitive small molecules targeting the CK2 α/β interface

scientific article published in July 2018

Proposed Allosteric Inhibitors Bind to the ATP Site of CK2α

scientific article published on 29 October 2020

Second-generation CK2α inhibitors targeting the αD pocket.

scientific article

Specific inhibition of CK2α from an anchor outside the active site

scientific article published on 12 July 2016

Structure, Function and Regulation of a Second Pyruvate Kinase Isozyme in <i>Pseudomonas aeruginosa</i>

scientific article published on 16 November 2021

Synthesis and structural characterisation of selective non-carbohydrate-based inhibitors of bacterial sialidases

scientific article

Targeting of Fumarate Hydratase from Mycobacterium tuberculosis Using Allosteric Inhibitors with a Dimeric-Binding Mode

scientific article published on 27 September 2019

List of works by Paul Brear

A Random Forest Model for Predicting Allosteric and Functional Sites on Proteins.

A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066.

Affinity maturation of the RLIP76 Ral binding domain to inform the design of stapled peptides targeting the Ral GTPases

Aqueous methods for the preparation of 5'-substituted guanosine derivatives.

Aqueous synthesis of N,S-dialkylthiophosphoramidates: design, optimisation and application to library construction and antileishmanial testing.

Chain alignment of collagen I deciphered using computationally designed heterotrimers

Efficient development of stable and highly functionalised peptides targeting the CK2α/CK2β protein-protein interaction.

Evolutionary plasticity in the allosteric regulator-binding site of pyruvate kinase isoform PykA from Pseudomonas aeruginosa

Gluconeogenic precursor availability regulates flux through the glyoxylate shunt in Pseudomonas aeruginosa

Novel non-ATP competitive small molecules targeting the CK2 α/β interface

Proposed Allosteric Inhibitors Bind to the ATP Site of CK2α

Second-generation CK2α inhibitors targeting the αD pocket.

Specific inhibition of CK2α from an anchor outside the active site

Structure, Function and Regulation of a Second Pyruvate Kinase Isozyme in <i>Pseudomonas aeruginosa</i>

Synthesis and structural characterisation of selective non-carbohydrate-based inhibitors of bacterial sialidases

Targeting of Fumarate Hydratase from Mycobacterium tuberculosis Using Allosteric Inhibitors with a Dimeric-Binding Mode