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List of works by Denise Wootten

A Hydrogen-Bonded Polar Network in the Core of the Glucagon-Like Peptide-1 Receptor Is a Fulcrum for Biased Agonism: Lessons from Class B Crystal Structures

scientific article

A simple method to generate stable cell lines for the analysis of transient protein-protein interactions.

scientific article published on April 2013

Agonist-specific requirement for a glutamate in transmembrane helix 1 of the oxytocin receptor ⬇️

scientific article published on December 3, 2010

Allosteric ligands of the glucagon-like peptide 1 receptor (GLP-1R) differentially modulate endogenous and exogenous peptide responses in a pathway-selective manner: implications for drug screening.

scientific article

Allosteric modulation of endogenous metabolites as an avenue for drug discovery.

scientific article published on 10 May 2012

Allostery and Biased Agonism at Class B G Protein-Coupled Receptors

scientific article published on 4 April 2016

CGRP/Adrenomedullin

Characterization of signal bias at the GLP-1 receptor induced by backbone modification of GLP-1.

scientific article published on 28 March 2017

Characterization of signalling and regulation of common calcitonin receptor splice variants and polymorphisms

scientific article

Coexpressed Class B G Protein-Coupled Secretin and GLP-1 Receptors Self- and Cross-Associate: Impact on Pancreatic Islets

scientific article published on 29 March 2017

Consequences of splice variation on Secretin family G protein-coupled receptor function

scientific article

Differential activation and modulation of the glucagon-like peptide-1 receptor by small molecule ligands

scientific article published on 24 January 2013

Differential impact of amino acid substitutions on critical residues of the human glucagon-like peptide-1 receptor involved in peptide activity and small-molecule allostery.

scientific article published on 28 January 2015

Diverse Functional Motifs within the Three Intracellular Loops of the CGRP1Receptor†

scientific article published in October 2006

Emerging paradigms in GPCR allostery: implications for drug discovery ⬇️

scientific article published on August 1, 2013

Extracellular loops 2 and 3 of the calcitonin receptor selectively modify agonist binding and efficacy.

scientific article published on 15 February 2018

Glucagon-Like Peptide-1 and Its Class B G Protein-Coupled Receptors: A Long March to Therapeutic Successes ⬇️

scientific article

Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery.

scientific article

Glucagon-like peptide-1 receptor internalisation controls spatiotemporal signalling mediated by biased agonists

scientific article published on 07 September 2018

Improving virtual screening of G protein-coupled receptors via ligand-directed modeling.

scientific article published on 13 November 2017

Key interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in the glucagon-like peptide-1 receptor

scientific article

Lifting the lid on GPCRs: the role of extracellular loops

scientific article published on March 2012

Ligand-Dependent Modulation of G Protein Conformation Alters Drug Efficacy

scientific article published on 6 October 2016

Minireview: Signal bias, allosterism, and polymorphic variation at the GLP-1R: implications for drug discovery

scientific article published on 17 July 2013

Molecular mechanisms underlying physiological and receptor pleiotropic effects mediated by GLP-1R activation.

scientific article published on March 2014

Monotreme glucagon-like peptide-1 in venom and gut: one gene - two very different functions

scientific article published on 29 November 2016

Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex

scientific article published on 21 February 2018

Phase-plate cryo-EM structure of a class B GPCR-G-protein complex

scientific article published on 24 April 2017

Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations ⬇️

scientific article published on March 11, 2013

Polymorphism and ligand dependent changes in human glucagon-like peptide-1 receptor (GLP-1R) function: allosteric rescue of loss of function mutation.

scientific article

Positive allosteric mechanisms of adenosine A<sub>1</sub> receptor-mediated analgesia

scientific article published on 08 September 2021

Prediction of Loops in G Protein-Coupled Receptor Homology Models: Effect of Imprecise Surroundings and Constraints

scientific article published on 15 March 2016

RAMPs and CGRP receptors

scientific article published on January 2012

Recent advances in understanding GLP-1R (glucagon-like peptide-1 receptor) function.

scientific article published on February 2013

Receptor activity modifying proteins (RAMPs) interact with the VPAC2 receptor and CRF1 receptors and modulate their function

scientific article published in February 2013

Receptor activity modifying proteins and their potential as drug targets

scientific article published on January 2010

Receptor activity-modifying protein-dependent impairment of calcitonin receptor splice variant Δ(1-47)hCT((a)) function

scientific article published on February 2013

Routine sub-2.5 Å cryo-EM structure determination of GPCRs

scientific article published on 15 July 2021

Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) differentially regulates orthosteric but not allosteric agonist binding and function.

scientific article published on 6 December 2011

Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) has a critical role in GLP-1 peptide binding and receptor activation

scientific article published on 6 December 2011

Small molecule allosteric modulation of the glucagon-like Peptide-1 receptor enhances the insulinotropic effect of oxyntomodulin.

scientific article published on 28 August 2012

Structural and functional insights into the juxtamembranous amino-terminal tail and extracellular loop regions of class B GPCRs.

scientific article published on March 2014

Structural basis of Gs and Gi recognition by the human glucagon receptor

scientific article

Structural biology: meet the B family

scientific article published on 17 July 2013

Structural features embedded in G protein-coupled receptor co-crystal structures are key to their success in virtual screening

scientific article

Structure of the adenosine-bound human adenosine A1 receptor–Gi complex

scientific article published in Nature

Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity

scientific article published on 04 June 2021

Systematic analysis of the entire second extracellular loop of the V(1a) vasopressin receptor: key residues, conserved throughout a G-protein-coupled receptor family, identified.

scientific article published on 2 April 2007

The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism

scientific article

The complexity of signalling mediated by the glucagon-like peptide-1 receptor.

scientific article published on April 2016

Two distinct domains of the glucagon-like peptide-1 receptor control peptide-mediated biased agonism.

scientific article published in May 2018

What determines the magnitude of cellular response for activation of G protein-coupled receptors?

scientific article

β-Arrestin-Biased Agonists of the GLP-1 Receptor from β-Amino Acid Residue Incorporation into GLP-1 Analogues.

scientific article published on 4 November 2016

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