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List of works by Jan Jakubik

Activation of muscarinic acetylcholine receptors via their allosteric binding sites.

scientific article published on August 1996

Agonist-Specific Conformations of the M2 Muscarinic Acetylcholine Receptor Assessed by Molecular Dynamics

scientific article published on 13 March 2020

Analysis of equilibrium binding of an orthosteric tracer and two allosteric modulators

scientific article published on 27 March 2019

Applications and limitations of fitting of the operational model to determine relative efficacies of agonists

scientific article published on 15 March 2019

Binding of N-methylscopolamine to the extracellular domain of muscarinic acetylcholine receptors

scientific article

Classical and atypical agonists activate M1 muscarinic acetylcholine receptors through common mechanisms.

scientific article

Constitutive activity of the M1-M4 subtypes of muscarinic receptors in transfected CHO cells and of muscarinic receptors in the heart cells revealed by negative antagonists

scientific article published on 01 December 1995

Effects of an Agonist, Allosteric Modulator, and Antagonist on Guanosine-γ-[35S]thiotriphosphate Binding to Liposomes with Varying Muscarinic Receptor/Go Protein Stoichiometry ⬇️

scientific article published on 01 November 1998

Guanidine Derivatives: How Simple Structural Modification of Histamine H<sub>3</sub>R Antagonists Has Led to the Discovery of Potent Muscarinic M<sub>2</sub>R/M<sub>4</sub>R Antagonists

scientific article published on 08 June 2021

Impairment of muscarinic transmission in transgenic APPswe/PS1dE9 mice

scientific article published on 30 November 2006

Lipid-Based Diets Improve Muscarinic Neurotransmission in the Hippocampus of Transgenic APPswe/PS1dE9 Mice.

scientific article

Long-term activation upon brief exposure to xanomleline is unique to M1 and M4 subtypes of muscarinic acetylcholine receptors.

scientific article published on 18 February 2014

Negative cooperativity in binding of muscarinic receptor agonists and GDP as a measure of agonist efficacy ⬇️

scientific article published on March 1, 2011

Novel M2 -selective, Gi -biased agonists of muscarinic acetylcholine receptors

scientific article published on 07 January 2020

Novel long-acting antagonists of muscarinic ACh receptors.

scientific article published on 2 March 2018

On homology modeling of the M₂ muscarinic acetylcholine receptor subtype.

scientific article published on 28 June 2013

Pharmacological evaluation of the long-term effects of xanomeline on the M(1) muscarinic acetylcholine receptor

scientific article

Positive Cooperativity of Acetylcholine and Other Agonists with Allosteric Ligands on Muscarinic Acetylcholine Receptors ⬇️

scientific article published on July 1, 1997

Positive allosteric interactions on cardiac muscarinic receptors: effects of chemical modifications of disulphide and carboxyl groups

scientific article published on 01 April 1995

Positive effects of allosteric modulators on the binding properties and the function of muscarinic acetylcholine receptors

scientific article published on 01 June 1998

Role of Receptor Protein and Membrane Lipids in Xanomeline Wash-Resistant Binding to Muscarinic M1Receptors ⬇️

scientific article published on October 20, 2003

Subtype differences in pre-coupling of muscarinic acetylcholine receptors

scientific article

Subtype-selective inhibition of [methyl-3H]-N-methylscopolamine binding to muscarinic receptors by alpha-truxillic acid esters.

scientific article published on July 1999

Synthesis of novel and functionally selective non-competitive muscarinic antagonists as chemical probes.

scientific article published on 24 June 2017

Towards predictive docking at aminergic G-protein coupled receptors

scientific article published on 09 October 2015

Uncoupling of M1 muscarinic receptor/G-protein interaction by amyloid β(1-42).

scientific article published on 30 November 2012

Use of a sandwich enzyme-linked immunosorbent assay strategy to study mechanisms of G protein-coupled receptor assembly

scientific article published on 01 January 1999

Wash-resistantly bound xanomeline inhibits acetylcholine release by persistent activation of presynaptic M(2) and M(4) muscarinic receptors in rat brain

scientific article

Weak toxin WTX from Naja kaouthia cobra venom interacts with both nicotinic and muscarinic acetylcholine receptors

scientific article published on 4 August 2009

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