List of works by Eva Delpón

Angiotensin II, angiotensin II antagonists and spironolactone and their modulation of cardiac repolarization

scientific article

Assembly with the Kvbeta1.3 subunit modulates drug block of hKv1.5 channels

scientific article published in December 2002

Association of 14-3-3 proteins to beta1-adrenergic receptors modulates Kv11.1 K+ channel activity in recombinant systems.

scientific article published on 16 August 2006

Benzocaine enhances and inhibits the K+ current through a human cardiac cloned channel (Kv1.5).

scientific article published in May 1999

Block of human cardiac Kv1.5 channels by loratadine: voltage-, time- and use-dependent block at concentrations above therapeutic levels

scientific article published on August 1997

Blockade of cardiac potassium and other channels by antihistamines

scientific article

Brugada syndrome trafficking-defective Nav1.5 channels can trap cardiac Kir2.1/2.2 channels

Bupivacaine effects on hKv1.5 channels are dependent on extracellular pH

scientific article

Cancer chemotherapy and cardiac arrhythmias: a review.

scientific article published on February 2015

Cardiac electrical defects in progeroid mice and Hutchinson-Gilford progeria syndrome patients with nuclear lamina alterations

scientific article published on 31 October 2016

Cardiac electrophysiological effects of nitric oxide.

scientific article published on 28 June 2010

Cardiovascular effects of the novel potassium channel opener UR-8225.

scientific article published in August 1995

Chronic (-)-epicatechin improves vascular oxidative and inflammatory status but not hypertension in chronic nitric oxide-deficient rats.

scientific article published on 13 September 2011

Chronic atrial fibrillation increases microRNA-21 in human atrial myocytes decreasing L-type calcium current

scientific article published on 8 August 2014

Chronic atrial fibrillation up-regulates β1-Adrenoceptors affecting repolarizing currents and action potential duration

scientific article published on 11 October 2012

Cinaciguat, a soluble guanylate cyclase activator for the potential treatment of acute heart failure

scientific article published on September 1, 2010

Class I and III antiarrhythmic actions of prazosin in guinea-pig papillary muscles

scientific article published in March 1994

Class III antiarrhythmic effects of zatebradine. Time-, state-, use-, and voltage-dependent block of hKv1.5 channels

scientific article published in August 1996

Comparative Expression of Proteins in Left and Right Atrial Appendages From Patients With Mitral Valve Disease at Sinus Rhythm and Atrial Fibrillation

scientific article published in February 2010

Comparative effects of nonsedating histamine H1 receptor antagonists, ebastine and terfenadine, on human Kv1.5 channels

scientific article published on May 1997

Digenic Heterozigosity in SCN5A and CACNA1C Explains the Variable Expressivity of the Long QT Phenotype in a Spanish Family.

scientific article published on 21 April 2018

Diltiazem inhibits hKv1.5 and Kv4.3 currents at therapeutic concentrations

scientific article published in December 2004

Direct effects of candesartan and eprosartan on human cloned potassium channels involved in cardiac repolarization.

scientific article published on April 2001

Dronedarone

scientific article published in 2011

Drug-induced atrial fibrillation

scientific article published on 23 June 2012

Drug-induced atrial fibrillation: does it matter?

scientific article

Efectos del óxido nítrico sobre la función cardíaca

scientific article published in January 2006

Effect of descarboethoxyloratadine, the major metabolite of loratadine, on the human cardiac potassium channel Kv1.5.

scientific article

Effects of (S)-nafenodone on 45Ca2+ fluxes and contractions in rat isolated vascular smooth muscle

scientific article published in February 1993

Effects of (S)-nafenodone, a new antidepressant, in isolated guinea-pig atrial and ventricular muscle fibres

scientific article published in June 1991

Effects of MiRP1 and DPP6 beta-subunits on the blockade induced by flecainide of Kv4.3/KChIP2 channels

scientific article published on 21 April 2008

Effects of a quaternary bupivacaine derivative on delayed rectifier K(+) currents

scientific article published in May 2000

Effects of atorvastatin and simvastatin on atrial plateau currents.

scientific article published on 19 March 2007

Effects of bupivacaine and a novel local anesthetic, IQB-9302, on human cardiac K+ channels

scientific article

Effects of flecainide and quinidine on Kv4.2 currents: voltage dependence and role of S6 valines.

scientific article published on April 2003

Effects of imipramine on the transient outward current in rabbit atrial single cells ⬇️

scientific article published on June 1, 1992

Effects of irbesartan on cloned potassium channels involved in human cardiac repolarization

scientific article published in February 2003

Effects of levobupivacaine, ropivacaine and bupivacaine on HERG channels: stereoselective bupivacaine block

scientific article published on December 2002

Effects of lisinopril on cardiac contractility and ionic currents

scientific article published on September 1994

Effects of lisinopril on electromechanical properties and membrane currents in guinea‐pig cardiac preparations ⬇️

scientific article published on July 1, 1993

Effects of platelet activating factor on contractile force and 45Ca fluxes in guinea-pig isolated atria

scientific article published in June 1990

Effects of propafenone and 5-hydroxy-propafenone on hKv1.5 channels

scientific article

Effects of propafenone and its main metabolite, 5-hydroxypropafenone, on HERG channels

scientific article published in March 2003

Effects of propafenone on 45Ca movements and contractile responses in vascular smooth muscle

scientific article published in June 1991

Effects of ropivacaine on a potassium channel (hKv1.5) cloned from human ventricle.

scientific article published in March 1997

Effects of rupatadine, a new dual antagonist of histamine and platelet-activating factor receptors, on human cardiac kv1.5 channels

scientific article

Effects of the two enantiomers, S-16257-2 and S-16260-2, of a new bradycardic agent on guinea-pig isolated cardiac preparations

scientific article published in July 1995

Electromechanical effects of zatebradine on isolated guinea pig cardiac preparations.

scientific article published in July 1995

Electrophysiologic interactions between mexiletine and propafenone in guinea pig papillary muscles

scientific article published in September 1989

Electrophysiological effects of CI-980, a tubulin binding agent, on guinea-pig papillary muscles.

scientific article

Electrophysiological effects of CRE-1087 in guinea-pig ventricular muscles ⬇️

scientific article published on October 1, 1992

Electrophysiological effects of E-3753, a new antiarrhythmic drug, in guinea-pig ventricular muscle

scientific article published on April 1989

Electrophysiological effects of the combination of mexiletine and flecainide in guinea-pig ventricular fibres

scientific article published in June 1991

Endocannabinoids and cannabinoid analogues block cardiac hKv1.5 channels in a cannabinoid receptor-independent manner.

scientific article published in January 2010

Endocannabinoids and cannabinoid analogues block human cardiac Kv4.3 channels in a receptor-independent manner.

scientific article published on 17 July 2009

Estimulación vagal y remodelado eléctrico auricular

scientific article published in July 2009

Farmacología clínica de la ranolazina, un nuevo fármaco en el tratamiento de la angina crónica estable

scientific article published in January 2010

Farmacología clínica de la ranolazina, un nuevo fármaco en el tratamiento de la angina crónica estable

scientific article published in June 2010

Flecainide increases Kir2.1 currents by interacting with cysteine 311, decreasing the polyamine-induced rectification

scientific article

Functional characterization of a novel frameshift mutation in the C-terminus of the Nav1.5 channel underlying a Brugada syndrome with variable expression in a Spanish family

scientific article

Functional effects of KCNE3 mutation and its role in the development of Brugada syndrome

scientific article

Functional effects of a missense mutation in HERG associated with type 2 long QT syndrome.

scientific article published on 23 November 2010

Further characterization of the effects of imipramine on plateau membrane currents in guinea-pig ventricular myocytes

scientific article published in December 1991

Genetically engineered mice as a model for studying cardiac arrhythmias

scientific article published on January 2007

Imipramine blocks rapidly activating and delays slowly activating K+ current activation in guinea pig ventricular myocytes.

scientific article

In humans, chronic atrial fibrillation decreases the transient outward current and ultrarapid component of the delayed rectifier current differentially on each atria and increases the slow component of the delayed rectifier current in both

scientific article

Interaction of angiotensin II with the angiotensin type 2 receptor inhibits the cardiac transient outward potassium current

scientific article published in April 2004

Investigational positive inotropic agents for acute heart failure.

scientific article published on September 2009

Kir2.1-Nav1.5 Channel Complexes Are Differently Regulated than Kir2.1 and Nav1.5 Channels Alone

scientific article published on 14 November 2017

Lipid-lowering therapy with statins, a new approach to antiarrhythmic therapy.

scientific article published on 29 December 2006

Mechanisms of block of a human cloned potassium channel by the enantiomers of a new bradycardic agent: S-16257-2 and S-16260-2.

scientific article published on March 1996

Modifications by Olmesartan medoxomil treatment of the platelet protein profile of moderate hypertensive patients

scientific article published on 21 July 2008

Molecular determinants of stereoselective bupivacaine block of hKv1.5 channels

scientific article published on December 1997

Nav1.5 N-terminal domain binding to α1-syntrophin increases membrane density of human Kir2.1, Kir2.2 and Nav1.5 channels

scientific article published on 19 January 2016

New Therapeutic Approaches for the Treatment of Hyperkalemia in Patients Treated with Renin-Angiotensin-Aldosterone System Inhibitors

scientific article published on 25 January 2018

New drugs for the treatment of hyperkalemia in patients treated with renin-angiotensin-aldosterone system inhibitors -- hype or hope?

scientific article

New insights into the pharmacology of sodium channel blockers

scientific article published on November 1, 1992

New investigational drugs for the management of acute heart failure syndromes.

scientific article published on January 2010

New therapeutic targets for the development of positive inotropic agents

scientific article

Nitric oxide blocks hKv1.5 channels by S-nitrosylation and by a cyclic GMP-dependent mechanism.

scientific article published on 27 June 2006

Nitric oxide increases cardiac IK1 by nitrosylation of cysteine 76 of Kir2.1 channels.

scientific article published on 16 July 2009

Nitric oxide inhibits Kv4.3 and human cardiac transient outward potassium current (Ito1).

scientific article

Optimization of beta-blockers' pharmacology.

scientific article

PITX2 insufficiency leads to atrial electrical and structural remodeling linked to arrhythmogenesis

scientific article published on 21 April 2011

Pharmacological Approaches in the Treatment of Atrial Fibrillation

scientific article

Pharmacological reasons that may explain why randomized clinical trials have failed in acute heart failure syndromes

scientific article published on 9 November 2016

Pharmacology of CRE-1087, A New Antiarrhythmic Drug

scholarly article by Eva Delpón et al published September 1992 in Cardiovascular Drug Reviews

Pharmacology of cardiac potassium channels.

scientific article published on April 2004

Pitx2c increases in atrial myocytes from chronic atrial fibrillation patients enhancing IKs and decreasing ICa,L.

scientific article

Propafenone blocks human cardiac Kir2.x channels by decreasing the negative electrostatic charge in the cytoplasmic pore.

scientific article published on 3 May 2013

Propafenone preferentially blocks the rapidly activating component of delayed rectifier K+ current in guinea pig ventricular myocytes. Voltage-independent and time-dependent block of the slowly activating component.

scientific article

Putative binding sites for benzocaine on a human cardiac cloned channel (Kv1.5).

scientific article published on October 2002

Ranolazine: an antianginal drug with antiarrhythmic properties

scientific article published on July 2011

Spironolactone and its main metabolite canrenoic acid block hKv1.5, Kv4.3 and Kv7.1 + minK channels

scientific article published on September 2005

Spironolactone and its main metabolite, canrenoic acid, block human ether-a-go-go-related gene channels

scientific article published in February 2003

Stereoselective block of a human cardiac potassium channel (Kv1.5) by bupivacaine enantiomers

scientific article

Stereoselective effects of the enantiomers of a new local anaesthetic, IQB-9302, on a human cardiac potassium channel (Kv1.5)

scientific article

Structural basis of drugs that increase cardiac inward rectifier Kir2.1 currents.

scientific article published on 9 September 2014

Structural determinants of potency and stereoselective block of hKv1.5 channels induced by local anesthetics

scientific article published in July 1998

Tbx20 controls the expression of the KCNH2 gene and of hERG channels

scientific article published on 03 January 2017

The Renin–Angiotensin System and Bone

scientific article published on 26 July 2015

The safety of digoxin as a pharmacological treatment of atrial fibrillation.

scientific article

Tonic and Phasic Vmax Block Induced by 5-Hydroxypropafenone in Guinea Pig Ventricular Muscles

scientific article published on 01 October 1988

Tonic and frequency-dependent Vmax block induced by (S)-nafenodone, a new antidepressant drug, in guinea-pig papillary muscles

scientific article published in June 1991

Tonic and frequency-dependent Vmax block induced by imipramine in guinea pig ventricular muscle fibers

scientific article

Treatment of left ventricular hypertrophy in hypertensive patients.

scientific article

miR-208b upregulation interferes with calcium handling in HL-1 atrial myocytes: Implications in human chronic atrial fibrillation

scientific article published on 18 August 2016

p.D1690N Nav1.5 rescues p.G1748D mutation gating defects in a compound heterozygous Brugada syndrome patient

scientific journal article

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