List of works - Jan Rozman

A broad phenotypic screen identifies novel phenotypes driven by a single mutant allele in Huntington's disease CAG knock-in mice

scientific article

A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains

scientific article

A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice

scientific article (publication date: 29 May 2009)

A novel N-ethyl-N-nitrosourea-induced mutation in phospholipase Cγ2 causes inflammatory arthritis, metabolic defects, and male infertility in vitro in a murine model

article

A paternal methyl donor-rich diet altered cognitive and neural functions in offspring mice.

scientific article

A review of standardized metabolic phenotyping of animal models

scientific article published on 09 September 2014

A systemic view on the distribution of diet-derived methanol and hepatic acetone in mice

scientific article published on 4 September 2017

Activation of the integrated stress response confers vulnerability to mitoribosome-targeting antibiotics in melanoma

scientific article published in 2021

An intronic single base exchange leads to a brown adipose tissue-specific loss of Ucp3 expression and an altered body mass trajectory

scientific article

Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics

scientific article

Behavioural mechanisms affecting energy regulation in mice prone or resistant to diet- induced obesity

scientific article published on 16 December 2009

Bezafibrate ameliorates diabetes via reduced steatosis and improved hepatic insulin sensitivity in diabetic TallyHo mice

scientific article published on 06 January 2017

Buccal swabs as a reliable source of DNA for sexing young and adult Common Swifts (Apus apus)

CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice

scientific article

Calcineurin Links Mitochondrial Elongation with Energy Metabolism

scientific article

Cardioprotection and lifespan extension by the natural polyamine spermidine.

scientific article

Characterization of the melanocortin-4-receptor nonsense mutation W16X in vitro and in vivo

scientific article published on 4 October 2011

Comparison of particle-exposure triggered pulmonary and systemic inflammation in mice fed with three different diets

scientific article

Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes

scientific article

Cytochrome c oxidase subunit 4 isoform 2-knockout mice show reduced enzyme activity, airway hyporeactivity, and lung pathology

scientific article

Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase

scientific article

Dll1 haploinsufficiency in adult mice leads to a complex phenotype affecting metabolic and immunological processes

scientific journal article

Does enamelin have pleiotropic effects on organs other than the teeth? Lessons from a phenotyping screen of two enamelin-mutant mouse lines

scientific journal article

Effects of diet-matrix on volatile organic compounds in breath in diet-induced obese mice

article

Endogenous FGF21-signaling controls paradoxical obesity resistance of UCP1-deficient mice

scientific article published on 31 January 2020

Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice.

scientific article

Expanding the body mass range: associations between BMR and tissue morphology in wild type and mutant dwarf mice (David mice).

scientific article published on 29 September 2006

Extensive phenotypic characterization of a new transgenic mouse reveals pleiotropic perturbations in physiology due to mesenchymal hGH minigene expression

scientific article

Functional compensation among HMGN variants modulates the DNase I hypersensitive sites at enhancers

scientific article published on 8 July 2015

Functional inactivation of the genome-wide association study obesity gene neuronal growth regulator 1 in mice causes a body mass phenotype

scientific journal article

Gene or size: metabolic rate and body temperature in obese growth hormone-deficient dwarf mice

scientific article published in September 2004

Generation of mice lacking DUF1220 protein domains: effects on fecundity and hyperactivity

scientific article

Glucose Tolerance Tests for Systematic Screening of Glucose Homeostasis in Mice

High fat diet-induced modifications in membrane lipid and mitochondrial-membrane protein signatures precede the development of hepatic insulin resistance in mice

scientific article

High-fat diet induced isoform changes of the Parkinson's disease protein DJ-1.

scientific article published on 28 March 2014

High-throughput discovery of genetic determinants of circadian misalignment

scientific article published on 13 January 2020

Identification of genetic elements in metabolism by high-throughput mouse phenotyping

scientific article published on 18 January 2018

Inflammation and mitochondrial fatty acid beta-oxidation link obesity to early tumor promotion

scientific article

Innovations in phenotyping of mouse models in the German Mouse Clinic

scientific article

Irp2 regulates insulin production through iron-mediated Cdkal1-catalyzed tRNA modification

scientific article published on 15 January 2020

Large-scale phenotyping of an accurate genetic mouse model of JNCL identifies novel early pathology outside the central nervous system

scientific article

Liver lipid metabolism is altered by increased circulating estrogen to androgen ratio in male mouse

scientific article published on 9 December 2015

Long-term proteasomal inhibition in transgenic mice by UBB(+1) expression results in dysfunction of central respiration control reminiscent of brainstem neuropathology in Alzheimer patients

scientific article

Loss of the actin remodeler Eps8 causes intestinal defects and improved metabolic status in mice

scientific article (publication date: 2 March 2010)

Meis1: effects on motor phenotypes and the sensorimotor system in mice

scientific article published on 23 June 2017

Metabolic phenotyping of the Crohn's disease-like IBD etiopathology in the TNF(ΔARE/WT) mouse model

article

Microphthalmia, parkinsonism, and enhanced nociception in Pitx3 ( 416insG ) mice

scientific article published on 22 December 2009

Mildly compromised tetrahydrobiopterin cofactor biosynthesis due to Pts variants leads to unusual body fat distribution and abdominal obesity in mice

scientific article published in February 2016

Mitochondrial dysfunction and decrease in body weight of a transgenic knock-in mouse model for TDP-43.

scientific article

Mouse Genetics and Metabolic Mouse Phenotyping

article

Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density

scientific article published on 28 December 2020

Mouse phenotyping

scientific article

Neurobeachin, a regulator of synaptic protein targeting, is associated with body fat mass and feeding behavior in mice and body-mass index in humans

scientific article

Neuronal expression of glucosylceramide synthase in central nervous system regulates body weight and energy homeostasis.

scientific article

Normal distribution of body weight gain in male Sprague-Dawley rats fed a high-energy diet

scientific article published in November 2003

Novel missense mutation of uromodulin in mice causes renal dysfunction with alterations in urea handling, energy, and bone metabolism

scientific article published on 19 August 2009

Online breath gas analysis in unrestrained mice by hs-PTR-MS.

scientific article

PAX6 mutation alters circadian rhythm and β cell function in mice without affecting glucose tolerance

scientific article published on 30 October 2020

PC1/3 and PC2 gene expression and post-translational endoproteolytic pro-opiomelanocortin processing is regulated by photoperiod in the seasonal Siberian hamster (Phodopus sungorus).

scientific article

Peri-conceptional obesogenic exposure induces sex-specific programming of disease susceptibilities in adult mouse offspring.

scientific article

Pleiotropic functions for transcription factor zscan10.

scientific article

Rapamycin extends murine lifespan but has limited effects on aging

scientific article

Requirement of the RNA-editing enzyme ADAR2 for normal physiology in mice

scientific article

Restless legs syndrome-associated intronic common variant in Meis1 alters enhancer function in the developing telencephalon

scientific journal article

SMC6 is an essential gene in mice, but a hypomorphic mutant in the ATPase domain has a mild phenotype with a range of subtle abnormalities

scientific article published on 18 March 2013

Seasonal changes of myostatin expression and its relation to body Mass acclimation in the Djungarian hamster, Phodopus sungorus

scientific article published in November 2010

Standardized, systemic phenotypic analysis of Umod(C93F) and Umod(A227T) mutant mice

scientific article

Streptozotocin-induced β-cell damage, high fat diet, and metformin administration regulate Hes3 expression in the adult mouse brain

scientific article published in Scientific Reports

Systemic first-line phenotyping

scientific article published on January 2009

The First Scube3 Mutant Mouse Line with Pleiotropic Phenotypic Alterations.

scientific article

The German Mouse Clinic – Running an Open Access Platform

article

The German Mouse Clinic: a platform for systemic phenotype analysis of mouse models.

scientific article

The development of diet-induced obesity and associated metabolic impairments in Dj-1 deficient mice

scientific article published on 2 October 2014

The hepatic phosphatidylcholine transporter ABCB4 as modulator of glucose homeostasis

scientific article

Toxicity modelling of Plk1-targeted therapies in genetically engineered mice and cultured primary mammalian cells

scientific article

Wheel running affects seasonal acclimatization of physiological and morphological traits in the Djungarian hamster (Phodopus sungorus).

scientific article published on 27 June 2007

eIF6 coordinates insulin sensitivity and lipid metabolism by coupling translation to transcription

scientific journal article

List of works by Jan Rozman

A broad phenotypic screen identifies novel phenotypes driven by a single mutant allele in Huntington's disease CAG knock-in mice

A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains

A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice

A novel N-ethyl-N-nitrosourea-induced mutation in phospholipase Cγ2 causes inflammatory arthritis, metabolic defects, and male infertility in vitro in a murine model

A paternal methyl donor-rich diet altered cognitive and neural functions in offspring mice.

A review of standardized metabolic phenotyping of animal models

A systemic view on the distribution of diet-derived methanol and hepatic acetone in mice

Activation of the integrated stress response confers vulnerability to mitoribosome-targeting antibiotics in melanoma

An intronic single base exchange leads to a brown adipose tissue-specific loss of Ucp3 expression and an altered body mass trajectory

Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics

Behavioural mechanisms affecting energy regulation in mice prone or resistant to diet- induced obesity

Bezafibrate ameliorates diabetes via reduced steatosis and improved hepatic insulin sensitivity in diabetic TallyHo mice

Buccal swabs as a reliable source of DNA for sexing young and adult Common Swifts (Apus apus)

CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice

Calcineurin Links Mitochondrial Elongation with Energy Metabolism

Cardioprotection and lifespan extension by the natural polyamine spermidine.

Characterization of the melanocortin-4-receptor nonsense mutation W16X in vitro and in vivo

Comparison of particle-exposure triggered pulmonary and systemic inflammation in mice fed with three different diets

Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes

Cytochrome c oxidase subunit 4 isoform 2-knockout mice show reduced enzyme activity, airway hyporeactivity, and lung pathology

Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase

Dll1 haploinsufficiency in adult mice leads to a complex phenotype affecting metabolic and immunological processes

Does enamelin have pleiotropic effects on organs other than the teeth? Lessons from a phenotyping screen of two enamelin-mutant mouse lines

Effects of diet-matrix on volatile organic compounds in breath in diet-induced obese mice

Endogenous FGF21-signaling controls paradoxical obesity resistance of UCP1-deficient mice

Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice.

Expanding the body mass range: associations between BMR and tissue morphology in wild type and mutant dwarf mice (David mice).

Extensive phenotypic characterization of a new transgenic mouse reveals pleiotropic perturbations in physiology due to mesenchymal hGH minigene expression

Functional compensation among HMGN variants modulates the DNase I hypersensitive sites at enhancers

Functional inactivation of the genome-wide association study obesity gene neuronal growth regulator 1 in mice causes a body mass phenotype

Gene or size: metabolic rate and body temperature in obese growth hormone-deficient dwarf mice

Generation of mice lacking DUF1220 protein domains: effects on fecundity and hyperactivity

Glucose Tolerance Tests for Systematic Screening of Glucose Homeostasis in Mice

High fat diet-induced modifications in membrane lipid and mitochondrial-membrane protein signatures precede the development of hepatic insulin resistance in mice

High-fat diet induced isoform changes of the Parkinson's disease protein DJ-1.

High-throughput discovery of genetic determinants of circadian misalignment

Identification of genetic elements in metabolism by high-throughput mouse phenotyping

Inflammation and mitochondrial fatty acid beta-oxidation link obesity to early tumor promotion

Innovations in phenotyping of mouse models in the German Mouse Clinic

Irp2 regulates insulin production through iron-mediated Cdkal1-catalyzed tRNA modification

Large-scale phenotyping of an accurate genetic mouse model of JNCL identifies novel early pathology outside the central nervous system

Liver lipid metabolism is altered by increased circulating estrogen to androgen ratio in male mouse

Long-term proteasomal inhibition in transgenic mice by UBB(+1) expression results in dysfunction of central respiration control reminiscent of brainstem neuropathology in Alzheimer patients

Loss of the actin remodeler Eps8 causes intestinal defects and improved metabolic status in mice

Meis1: effects on motor phenotypes and the sensorimotor system in mice

Metabolic phenotyping of the Crohn's disease-like IBD etiopathology in the TNF(ΔARE/WT) mouse model

Microphthalmia, parkinsonism, and enhanced nociception in Pitx3 ( 416insG ) mice

Mildly compromised tetrahydrobiopterin cofactor biosynthesis due to Pts variants leads to unusual body fat distribution and abdominal obesity in mice

Mitochondrial dysfunction and decrease in body weight of a transgenic knock-in mouse model for TDP-43.

Mouse Genetics and Metabolic Mouse Phenotyping

Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density

Mouse phenotyping

Neurobeachin, a regulator of synaptic protein targeting, is associated with body fat mass and feeding behavior in mice and body-mass index in humans

Neuronal expression of glucosylceramide synthase in central nervous system regulates body weight and energy homeostasis.

Normal distribution of body weight gain in male Sprague-Dawley rats fed a high-energy diet

Novel missense mutation of uromodulin in mice causes renal dysfunction with alterations in urea handling, energy, and bone metabolism

Online breath gas analysis in unrestrained mice by hs-PTR-MS.

PAX6 mutation alters circadian rhythm and β cell function in mice without affecting glucose tolerance

PC1/3 and PC2 gene expression and post-translational endoproteolytic pro-opiomelanocortin processing is regulated by photoperiod in the seasonal Siberian hamster (Phodopus sungorus).

Peri-conceptional obesogenic exposure induces sex-specific programming of disease susceptibilities in adult mouse offspring.

Pleiotropic functions for transcription factor zscan10.

Rapamycin extends murine lifespan but has limited effects on aging

Requirement of the RNA-editing enzyme ADAR2 for normal physiology in mice

Restless legs syndrome-associated intronic common variant in Meis1 alters enhancer function in the developing telencephalon

SMC6 is an essential gene in mice, but a hypomorphic mutant in the ATPase domain has a mild phenotype with a range of subtle abnormalities

Seasonal changes of myostatin expression and its relation to body Mass acclimation in the Djungarian hamster, Phodopus sungorus

Standardized, systemic phenotypic analysis of Umod(C93F) and Umod(A227T) mutant mice

Streptozotocin-induced β-cell damage, high fat diet, and metformin administration regulate Hes3 expression in the adult mouse brain

Systemic first-line phenotyping

The First Scube3 Mutant Mouse Line with Pleiotropic Phenotypic Alterations.

The German Mouse Clinic – Running an Open Access Platform

The German Mouse Clinic: a platform for systemic phenotype analysis of mouse models.

The development of diet-induced obesity and associated metabolic impairments in Dj-1 deficient mice

The hepatic phosphatidylcholine transporter ABCB4 as modulator of glucose homeostasis

Toxicity modelling of Plk1-targeted therapies in genetically engineered mice and cultured primary mammalian cells

Wheel running affects seasonal acclimatization of physiological and morphological traits in the Djungarian hamster (Phodopus sungorus).

eIF6 coordinates insulin sensitivity and lipid metabolism by coupling translation to transcription

“Bug-eggs” for Common Swifts and other small birds: minimally-invasive and stress-free blood sampling during incubation