List of works - Angel Messeguer

15N NMR spectroscopic and theoretical GIAO-DFT studies for the unambiguous characterization of disubstituted 1,2,3-triazoles

scientific article published on 01 November 2013

A chemical inhibitor of Apaf-1 exerts mitochondrioprotective functions and interferes with the intra-S-phase DNA damage checkpoint

scientific article

A fluorescent polarization-based assay for the identification of disruptors of the RCAN1-calcineurin A protein complex

scientific article

A novel free radical scavenger rescues retinal cells in vivo

scientific article published on 25 May 2011

A polymeric nanomedicine diminishes inflammatory events in renal tubular cells

scientific article

A semaphorin 3A inhibitor blocks axonal chemorepulsion and enhances axon regeneration

scientific article published on 16 July 2009

Advances in modulating thermosensory TRP channels.

scientific article published on 27 July 2012

Anti-Tat and anti-HIV activities of trimers of n-alkylglycines.

scientific article published on 6 January 2006

Antioxidant CR-6 protects against reperfusion injury after a transient episode of focal brain ischemia in rats.

scientific article

Apaf-1 inhibitors protect from unwanted cell death in in vivo models of kidney ischemia and chemotherapy induced ototoxicity

scientific article

Apaf1 inhibition promotes cell recovery from apoptosis.

scientific article published on 11 September 2015

Application of thermospray/high-performance liquid chromatography/mass spectrometry to the identification of glutathione conjugates derived from bioactive epoxides

scientific article published in October 1988

BH3-mimetics- and cisplatin-induced cell death proceeds through different pathways depending on the availability of death-related cellular components

scientific article

Biotransformation and clearance of 3-(phenylamino)propane-1,2-diol, a compound present in samples related to toxic oil syndrome, in C57BL/6 and A/J mice

scientific article published on 01 December 1999

CR-6 protects glutathione peroxidase activity in experimental diabetes

scientific article published on 14 August 2007

Cationic Peptides and Peptidomimetics Bind Glycosaminoglycans as Potential Sema3A Pathway Inhibitors.

scientific article

Chemical Modulation of Peptoids: Synthesis and Conformational Studies on Partially Constrained Derivatives

scientific article published on 24 May 2011

Combinatorial chemistry in cancer research.

scientific article

Dimethyldioxirane conversion of phosphine sulfides and phosphorothioates into their corresponding oxygen analogues

Dimethyldioxirane in organometallic chemistry. II. An improved procedure for the oxidative decomplexation of Fischer carbene complexes

Dynamic Covalent Identification of an Efficient Heparin Ligand

scientific article published on 10 August 2018

Effect of triazine derivatives on neuronal nicotinic receptors.

scientific article published on 7 July 2014

Efficient Synthesis of Conformationally Restricted Apoptosis Inhibitors Bearing a Triazole Moiety

scientific article published on 13 August 2015

First-in-class inhibitor of the T cell receptor for the treatment of autoimmune diseases.

scientific article published on December 2016

Generation of quinoneimine intermediates in the bioactivation of 3-(N-phenylamino)alanine (PAA) by human liver microsomes: a potential link between eosinophilia-myalgia syndrome and toxic oil syndrome

scientific article published on 25 September 2007

In vitro bioactivation of 3-(N-phenylamino)propane-1,2-diol by human and rat liver microsomes and recombinant P450 enzymes. Implications for toxic oil syndrome

scientific article published on 03 August 2007

In vitro biotransformation of 3,4-dihydro-6-hydroxy-2,2-dimethyl-7-methoxy-1(2H)-benzopyran (CR-6), a potent lipid peroxidation inhibitor and nitric oxide scavenger, in rat liver microsomes

scientific article published in July 2004

In vitro metabolism of juvenile hormone III and juvenile hormone III bisepoxide by Drosophila melanogaster and mammalian cytosolic epoxide hydrolase

scientific article

Inhibition of rat liver microsomal lipid peroxidation elicited by 2,2-dimethylchromenes and chromans containing fluorinated moieties resistant to cytochrome P-450 metabolism.

scientific article

Inhibitory effect of positively charged triazine antagonists of prokineticin receptors on the transient receptor vanilloid type-1 (TRPV1) channel.

scientific article published on 17 July 2015

LC-MS ion maps for the characterization of aniline derivatives of fatty acids and triglycerides in laboratory-denatured rapeseed oil

scientific article published on 01 April 2007

Metabolism of (R)- and (S)-3-(phenylamino)propane-1,2-diol in C57BL/6- and A/J-strain mice. Identification of new metabolites with potential toxicological significance to the toxic oil syndrome.

scientific article published in August 2001

Modulation of cellular apoptosis with apoptotic protease-activating factor 1 (Apaf-1) inhibitors

scientific journal article

Molecules that modulate Apaf-1 activity

scientific article published on 22 January 2010

NMDA-induced neuroprotection in hippocampal neurons is mediated through the protein kinase A and CREB (cAMP-response element-binding protein) pathway.

scientific article published on 25 July 2008

Nanoconjugates as intracorporeal neutralizers of bacterial endotoxins.

scientific article published on 30 October 2009

Neuroprotection against excitotoxicity by N-alkylglycines in rat hippocampal neurons

scientific article published in January 2002

New anti-RNS and -RCS products for cosmetic treatment

scientific article published in October 2005

On the generation and outcome of 3-(N-phenylamino)propane-1,2-diol derivatives in deodorized model oils related to toxic oil syndrome

scientific article published in April 2005

Optimizing the control of apoptosis by amide/triazole isosteric substitution in a constrained peptoid.

scientific article published on 14 March 2013

Oxidative Decomplexation of Chromium Fischer Carbene Complexes Induced by Dioxiranes

scientific article published on 01 March 1999

Oxidative stress in rat retina and hippocampus after chronic MDMA ('ecstasy') administration.

scientific article published on 31 March 2007

Oxidative stress-induced apoptosis in retinal photoreceptor cells is mediated by calpains and caspases and blocked by the oxygen radical scavenger CR-6.

scientific article published on 21 June 2004

Participation of oxidative stress on rat middle cerebral artery changes induced by focal cerebral ischemia: beneficial effects of 3,4-dihydro-6-hydroxy-7-methoxy-2,2-dimethyl-1(2H)-benzopyran (CR-6).

scientific article published on 19 August 2009

Physiology and pharmacology of the vanilloid receptor

scientific article

Positional Scanning Synthesis of a Peptoid Library Yields New Inducers of Apoptosis that Target Karyopherins and Tubulin

scientific article published on 17 June 2015

Potential implication of aniline derivatives in the Toxic Oil Syndrome (TOS) ⬇️

scientific article published on October 21, 2010

Prevention of glutamate neurotoxicity in cultured neurons by 3,4-dihydro-6-hydroxy-7-methoxy-2,2-dimethyl-1(2H)-benzopyran (CR-6), a scavenger of nitric oxide

scientific article published on 01 July 1999

Prevention of in vivo excitotoxicity by a family of trialkylglycines, a novel class of neuroprotectants.

scientific article

Protein-protein interaction antagonists as novel inhibitors of non-canonical polyubiquitylation

scientific article

Regioselective Synthesis of a Family of β-Lactams Bearing a Triazole Moiety as Potential Apoptosis Inhibitors

scientific article

Smallest peptoids with antiproliferative activity on human neoplastic cells.

scientific article

Studies on toxic oil syndrome: development of an enzyme-linked immunosorbent assay for 3-(N-phenylamino)propane-1,2-diol in human urine

scientific article published on 17 April 2008

Studies on toxic oil syndrome: stereoselective hydrolysis of 3-(phenylamino)propane-1,2-diol esters by human pancreatic lipase

scientific article published in July 2004

Study of patients and carriers with 2-methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency: difficulties in the diagnosis

scientific article

Synthesis and in vitro, ex-vivo and in vivo activity of hybrid compounds linking a potent ROS and RNS scavenger activity with diverse substrates addressed to pass across the blood-brain barrier.

scientific article

Synthesis and stability studies of the glutathione and N-acetylcysteine adducts of an iminoquinone reactive intermediate generated in the biotransformation of 3-(N-phenylamino)propane-1,2-diol: implications for toxic oil syndrome

scientific article

Synthesis of a library of 3-oxopiperazinium and perhydro-3-oxo-1,4-diazepinium derivatives and identification of bioactive compounds.

scientific article

Synthesis of a positional scanning library of pentamers of N-alkylglycines assisted by microwave activation and validation via the identification of trypsin inhibitors

scientific article

Synthesis of enantiomerically pure perhydro-1,4-diazepine-2,5-dione and 1,4-piperazine-2,5-dione derivatives exhibiting potent activity as apoptosis inhibitors

scientific article published on 29 September 2012

The organochlorine pesticides gamma-hexachlorocyclohexane (lindane), alpha-endosulfan and dieldrin differentially interact with GABA(A) and glycine-gated chloride channels in primary cultures of cerebellar granule cells

scientific article

The radical scavenger CR-6 protects SH-SY5Y neuroblastoma cells from oxidative stress-induced apoptosis: effect on survival pathways.

scientific article published on 19 June 2006

Toxic oil syndrome: genetic restriction and immunomodulatory effects due to adulterated oils in a model of HLA transgenic mice.

scientific article published in November 2005

Triazine-based vanilloid 1 receptor open channel blockers: design, synthesis, evaluation, and SAR analysis

scientific article published on 10 October 2011

Vestibulotoxic properties of potential metabolites of allylnitrile.

scientific article published on 12 June 2013

List of works by Angel Messeguer

15N NMR spectroscopic and theoretical GIAO-DFT studies for the unambiguous characterization of disubstituted 1,2,3-triazoles

A chemical inhibitor of Apaf-1 exerts mitochondrioprotective functions and interferes with the intra-S-phase DNA damage checkpoint

A fluorescent polarization-based assay for the identification of disruptors of the RCAN1-calcineurin A protein complex

A novel free radical scavenger rescues retinal cells in vivo

A polymeric nanomedicine diminishes inflammatory events in renal tubular cells

A semaphorin 3A inhibitor blocks axonal chemorepulsion and enhances axon regeneration

Advances in modulating thermosensory TRP channels.

Anti-Tat and anti-HIV activities of trimers of n-alkylglycines.

Antioxidant CR-6 protects against reperfusion injury after a transient episode of focal brain ischemia in rats.

Apaf-1 inhibitors protect from unwanted cell death in in vivo models of kidney ischemia and chemotherapy induced ototoxicity

Apaf1 inhibition promotes cell recovery from apoptosis.

Application of thermospray/high-performance liquid chromatography/mass spectrometry to the identification of glutathione conjugates derived from bioactive epoxides

BH3-mimetics- and cisplatin-induced cell death proceeds through different pathways depending on the availability of death-related cellular components

Biotransformation and clearance of 3-(phenylamino)propane-1,2-diol, a compound present in samples related to toxic oil syndrome, in C57BL/6 and A/J mice

CR-6 protects glutathione peroxidase activity in experimental diabetes

Cationic Peptides and Peptidomimetics Bind Glycosaminoglycans as Potential Sema3A Pathway Inhibitors.

Chemical Modulation of Peptoids: Synthesis and Conformational Studies on Partially Constrained Derivatives

Combinatorial chemistry in cancer research.

Dimethyldioxirane conversion of phosphine sulfides and phosphorothioates into their corresponding oxygen analogues

Dimethyldioxirane in organometallic chemistry. II. An improved procedure for the oxidative decomplexation of Fischer carbene complexes

Dynamic Covalent Identification of an Efficient Heparin Ligand

Effect of triazine derivatives on neuronal nicotinic receptors.

Efficient Synthesis of Conformationally Restricted Apoptosis Inhibitors Bearing a Triazole Moiety

First-in-class inhibitor of the T cell receptor for the treatment of autoimmune diseases.

Generation of quinoneimine intermediates in the bioactivation of 3-(N-phenylamino)alanine (PAA) by human liver microsomes: a potential link between eosinophilia-myalgia syndrome and toxic oil syndrome

In vitro bioactivation of 3-(N-phenylamino)propane-1,2-diol by human and rat liver microsomes and recombinant P450 enzymes. Implications for toxic oil syndrome

In vitro biotransformation of 3,4-dihydro-6-hydroxy-2,2-dimethyl-7-methoxy-1(2H)-benzopyran (CR-6), a potent lipid peroxidation inhibitor and nitric oxide scavenger, in rat liver microsomes

In vitro metabolism of juvenile hormone III and juvenile hormone III bisepoxide by Drosophila melanogaster and mammalian cytosolic epoxide hydrolase

Inhibition of rat liver microsomal lipid peroxidation elicited by 2,2-dimethylchromenes and chromans containing fluorinated moieties resistant to cytochrome P-450 metabolism.

Inhibitory effect of positively charged triazine antagonists of prokineticin receptors on the transient receptor vanilloid type-1 (TRPV1) channel.

LC-MS ion maps for the characterization of aniline derivatives of fatty acids and triglycerides in laboratory-denatured rapeseed oil

Metabolism of (R)- and (S)-3-(phenylamino)propane-1,2-diol in C57BL/6- and A/J-strain mice. Identification of new metabolites with potential toxicological significance to the toxic oil syndrome.

Modulation of cellular apoptosis with apoptotic protease-activating factor 1 (Apaf-1) inhibitors

Molecules that modulate Apaf-1 activity

NMDA-induced neuroprotection in hippocampal neurons is mediated through the protein kinase A and CREB (cAMP-response element-binding protein) pathway.

Nanoconjugates as intracorporeal neutralizers of bacterial endotoxins.

Neuroprotection against excitotoxicity by N-alkylglycines in rat hippocampal neurons

New anti-RNS and -RCS products for cosmetic treatment

On the generation and outcome of 3-(N-phenylamino)propane-1,2-diol derivatives in deodorized model oils related to toxic oil syndrome

Optimizing the control of apoptosis by amide/triazole isosteric substitution in a constrained peptoid.

Oxidative Decomplexation of Chromium Fischer Carbene Complexes Induced by Dioxiranes

Oxidative stress in rat retina and hippocampus after chronic MDMA ('ecstasy') administration.

Oxidative stress-induced apoptosis in retinal photoreceptor cells is mediated by calpains and caspases and blocked by the oxygen radical scavenger CR-6.

Participation of oxidative stress on rat middle cerebral artery changes induced by focal cerebral ischemia: beneficial effects of 3,4-dihydro-6-hydroxy-7-methoxy-2,2-dimethyl-1(2H)-benzopyran (CR-6).

Physiology and pharmacology of the vanilloid receptor

Positional Scanning Synthesis of a Peptoid Library Yields New Inducers of Apoptosis that Target Karyopherins and Tubulin

Potential implication of aniline derivatives in the Toxic Oil Syndrome (TOS) ⬇️

Prevention of glutamate neurotoxicity in cultured neurons by 3,4-dihydro-6-hydroxy-7-methoxy-2,2-dimethyl-1(2H)-benzopyran (CR-6), a scavenger of nitric oxide

Prevention of in vivo excitotoxicity by a family of trialkylglycines, a novel class of neuroprotectants.

Protein-protein interaction antagonists as novel inhibitors of non-canonical polyubiquitylation

Regioselective Synthesis of a Family of β-Lactams Bearing a Triazole Moiety as Potential Apoptosis Inhibitors

Smallest peptoids with antiproliferative activity on human neoplastic cells.

Studies on toxic oil syndrome: development of an enzyme-linked immunosorbent assay for 3-(N-phenylamino)propane-1,2-diol in human urine

Studies on toxic oil syndrome: stereoselective hydrolysis of 3-(phenylamino)propane-1,2-diol esters by human pancreatic lipase

Study of patients and carriers with 2-methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency: difficulties in the diagnosis

Synthesis and in vitro, ex-vivo and in vivo activity of hybrid compounds linking a potent ROS and RNS scavenger activity with diverse substrates addressed to pass across the blood-brain barrier.

Synthesis and stability studies of the glutathione and N-acetylcysteine adducts of an iminoquinone reactive intermediate generated in the biotransformation of 3-(N-phenylamino)propane-1,2-diol: implications for toxic oil syndrome

Synthesis of a library of 3-oxopiperazinium and perhydro-3-oxo-1,4-diazepinium derivatives and identification of bioactive compounds.

Synthesis of a positional scanning library of pentamers of N-alkylglycines assisted by microwave activation and validation via the identification of trypsin inhibitors

Synthesis of enantiomerically pure perhydro-1,4-diazepine-2,5-dione and 1,4-piperazine-2,5-dione derivatives exhibiting potent activity as apoptosis inhibitors

The organochlorine pesticides gamma-hexachlorocyclohexane (lindane), alpha-endosulfan and dieldrin differentially interact with GABA(A) and glycine-gated chloride channels in primary cultures of cerebellar granule cells

The radical scavenger CR-6 protects SH-SY5Y neuroblastoma cells from oxidative stress-induced apoptosis: effect on survival pathways.

Toxic oil syndrome: genetic restriction and immunomodulatory effects due to adulterated oils in a model of HLA transgenic mice.

Triazine-based vanilloid 1 receptor open channel blockers: design, synthesis, evaluation, and SAR analysis

Vestibulotoxic properties of potential metabolites of allylnitrile.