List of works - Rui A. Carvalho

13C isotopomer analysis of glutamate by J-resolved heteronuclear single quantum coherence spectroscopy.

scientific article

2H2O incorporation into hepatic acetyl-CoA and de novo lipogenesis as measured by Krebs cycle-mediated 2H-enrichment of glutamate and glutamine.

scientific article

A (13)C isotopomer kinetic analysis of cardiac metabolism: influence of altered cytosolic redox and [Ca(2+)](o).

scientific article published on 25 March 2004

Adenosine A₁ receptors control the metabolic recovery after hypoxia in rat hippocampal slices

scientific article published on 28 December 2015

Adrenaline and reactive oxygen species elicit proteome and energetic metabolism modifications in freshly isolated rat cardiomyocytes

scientific article

Adrenaline in pro-oxidant conditions elicits intracellular survival pathways in isolated rat cardiomyocytes

scientific article published on 24 December 2008

Analysis of glucose metabolism in farmed European sea bass (Dicentrarchus labrax L.) using deuterated water.

scientific article

Anti-apoptotic protection afforded by cardioplegic celsior and histidine buffer solutions to hearts subjected to ischemia and ischemia/reperfusion.

scientific article published in December 2011

Assessing Sertoli Cell Metabolic Activity.

scientific article published in January 2018

Biochemical and metabolic effects of a short-term exposure to nanoparticles of titanium silicate in tadpoles of Pelophylax perezi (Seoane)

scientific article published on 25 December 2012

Bismuth(III) salt-catalyzed Westphalen and “backbone” rearrangements of 5β,6β-epoxysteroids

scientific article published on 18 January 2008

C isotopomer analysis of glutamate by heteronuclear multiple quantum coherence-total correlation spectroscopy (HMQC-TOCSY)

scientific article published on 01 December 1998

CB₁ receptor activation inhibits neuronal and astrocytic intermediary metabolism in the rat hippocampus

scientific article published on 09 November 2011

Caffeine Consumption Prevents Diabetes-Induced Memory Impairment and Synaptotoxicity in the Hippocampus of NONcZNO10/LTJ Mice ⬇️

scientific article published on April 13, 2012

Caffeine consumption attenuates neurochemical modifications in the hippocampus of streptozotocin-induced diabetic rats

scientific article published on 18 August 2009

Caloric restriction alters the hormonal profile and testicular metabolome, resulting in alterations of sperm head morphology

scientific article published on 26 November 2019

ClearPEM scanners: Performance results and studies in preclinical environment

Combined dual effect of modulation of human neutrophils' oxidative burst and inhibition of colon cancer cells proliferation by hydroxycinnamic acid derivatives

scientific article published on 30 May 2016

Comparative study of gene expression in patients with varicocele by microarray technology

scientific article published on 16 August 2011

Compartmentation of glycolysis and glycogenolysis in the perfused rat heart

scientific article published in April 2004

Conformation study of HA(306-318) antigenic peptide of the haemagglutinin influenza virus protein.

scientific article

Conformational studies of poly(9,9-dialkylfluorene)s in solution using NMR spectroscopy and density functional theory calculations.

scientific article published in September 2009

Cross-functioning between the extraneuronal monoamine transporter and multidrug resistance protein 1 in the uptake of adrenaline and export of 5-(glutathion-S-yl)adrenaline in rat cardiomyocytes

scientific journal article

DNA fragmentation in canine oocytes after in vitro maturation in TCM-199 medium supplemented with different proteins.

scientific article published on 22 July 2011

Dicationic alkylammonium bromide gemini surfactants. Membrane perturbation and skin irritation

scientific article

Differences in the serum metabolome and lipidome identify potential biomarkers for seronegative rheumatoid arthritis versus psoriatic arthritis

scientific article published on 20 February 2020

Different metabolism of glutamatergic and GABAergic compartments in superfused hippocampal slices characterized by nuclear magnetic resonance spectroscopy

scientific article published on 29 December 2006

Do Cyclodextrins Aggregate in Water? Insights from NMR Experiments

scientific article

Effect of Duration of Exposure to Fluoride and Type of Diet on Lipid Parameters and De Novo Lipogenesis

scientific article published on 16 October 2018

Effect of cyclodextrins and pH on the permeation of tetracaine: supramolecular assemblies and release behavior.

scientific article

Effect of insulin deprivation on metabolism and metabolism-associated gene transcript levels of in vitro cultured human Sertoli cells

scientific article published in February 2012

Effects of an oral insulin nanoparticle administration on hepatic glucose metabolism assessed by ¹³C and ²H isotopomer analysis

scientific article published on 02 December 2011

Effects of dietary carbohydrate on hepatic de novo lipogenesis in European seabass (Dicentrarchus labrax L.).

scientific article

Effects of food-deprivation and refeeding on the regulation and sources of blood glucose appearance in European seabass (Dicentrarchus labrax L.).

scientific article

Effects of galactose on direct and indirect pathway estimates of hepatic glycogen synthesis.

scientific article published on 24 August 2010

Efficient pro-survival/angiogenic miRNA delivery by an MRI-detectable nanomaterial.

scientific article

Endometrial Cancer Spheres Show Cancer Stem Cells Phenotype and Preference for Oxidative Metabolism

scientific article published on 29 November 2018

Enzymatic synthesis of inulin-containing hydrogels

scientific article published in March 2002

Estudo do imprinting genómico em espermatozóides de pacientes com oligozoospermia

scientific article published in September 2005

Evaluation of hepatic glucose metabolism via gluconeogenesis and glycogenolysis after oral administration of insulin nanoparticles.

scientific article published on 13 February 2012

Evaluation of the impact of diabetes on retinal metabolites by NMR spectroscopy.

scientific article published on November 2010

Exemestane metabolites: Synthesis, stereochemical elucidation, biochemical activity and anti-proliferative effects in a hormone-dependent breast cancer cell line.

scientific article published on 28 September 2014

Exenatide and Dapagliflozin Combination Enhances Sertoli Cell Secretion of Key Metabolites for Spermatogenesis

scientific article published on 11 May 2022

Experimental (IR/Raman and 1H/13C NMR) and Theoretical (DFT) Studies of the Preferential Conformations Adopted by l-Lactic Acid Oligomers and Poly(l-lactic acid) Homopolymer

scientific article published on 20 December 2011

Exploring new chemical functionalities to improve aromatase inhibition of steroids.

scientific article published on 26 April 2016

Facilitated nanoscale delivery of insulin across intestinal membrane models

article

Fatty Acid Oxidation and Cardiovascular Risk during Menopause: A Mitochondrial Connection?

scientific article published in February 2012

Gastric Bypass with Different Biliopancreatic Limb Lengths Results in Similar Post-absorptive Metabolomics Profiles

scientific article published on 01 March 2020

Gender-dependent Metabolic Remodeling During Heart Preservation in Cardioplegic Celsior and Histidine Buffer Solution ⬇️

scientific article published on February 1, 2012

Ghrelin acts as energy status sensor of male reproduction by modulating Sertoli cells glycolytic metabolism and mitochondrial bioenergetics.

scientific article published on 5 July 2016

Glucose uptake and lipid metabolism are impaired in epicardial adipose tissue from heart failure patients with or without diabetes

scientific article published on 26 January 2016

High COX-2 expression is associated with increased angiogenesis, proliferation and tumoural inflammatory infiltrate in canine malignant mammary tumours: a multivariate survival study

scientific article published on 21 January 2016

High sucrose consumption induces memory impairment in rats associated with electrophysiological modifications but not with metabolic changes in the hippocampus.

scientific article

Hormonal control of Sertoli cell metabolism regulates spermatogenesis ⬇️

scientific article published on July 20, 2012

Impact of Caffeine Consumption on Type 2 Diabetes-Induced Spatial Memory Impairment and Neurochemical Alterations in the Hippocampus

scientific article published on 01 January 2018

Influence of 5α-dihydrotestosterone and 17β-estradiol on human Sertoli cells metabolism

scientific article published on 4 August 2011

Inhibition of mitochondrial complex III blocks neuronal differentiation and maintains embryonic stem cell pluripotency

scientific article

Interaction of Omeprazole with a Methylated Derivative of β-Cyclodextrin: Phase Solubility, NMR Spectroscopy and Molecular Simulation

scientific article published on 20 December 2006

Intermolecular interactions of highly stable paramagnetic lanthanide(III) chelates as studied by nuclear magnetic resonance spectroscopy

Ki-67 and PCNA Expression in Canine Mammary Tumors and Adjacent Nonneoplastic Mammary Glands: Prognostic Impact by a Multivariate Survival Analysis

scientific article published on 9 May 2016

Leptin modulates human Sertoli cells acetate production and glycolytic profile: a novel mechanism of obesity-induced male infertility?

scientific article

Lipophilic phenolic antioxidants: correlation between antioxidant profile, partition coefficients and redox properties

scientific article

Magnetic resonance spectroscopy in cancer diagnostics

Measurement of Hepatic Glucose Output, Krebs Cycle, and Gluconeogenic Fluxes by NMR Analysis of a Single Plasma Glucose Sample ⬇️

scientific article published on October 1, 1998

Metabolic dynamics of human Sertoli cells are differentially modulated by physiological and pharmacological concentrations of GLP-1

article

Metabolic effects of hypoxia in colorectal cancer by 13C NMR isotopomer analysis

scientific article

Metabolic evaluations of cancer metabolism by NMR-based stable isotope tracer methodologies.

scientific article published on January 2015

Metabolic fingerprints in testicular biopsies from type 1 diabetic patients.

scientific article

Metabolic modulation induced by oestradiol and DHT in immature rat Sertoli cells culturedin vitro

scientific article published on 01 February 2012

Metabolic remodeling associated with subchronic doxorubicin cardiomyopathy.

scientific article published in February 2010

Metabolic remodeling triggered by salivation and diabetes in major salivary glands

scientific article published on 26 December 2016

Metal-induced phosphate extracellular nanoparticulate formation in Ochrobactrum tritici 5bvl1.

scientific article published on 7 October 2011

Methyl-β-cyclodextrin Inclusion Complex with β-Caryophyllene: Preparation, Characterization, and Improvement of Pharmacological Activities

scientific article published on 18 December 2017

Microwave synthesis and in vitro stability of diclofenac-β-cyclodextrin conjugate for colon delivery

scientific article

Mitochondrial Bioenergetics by 13C-NMR Isotopomer Analysis

scientific article published on 01 January 2018

Mitochondrial metabolism directs stemness and differentiation in P19 embryonal carcinoma stem cells

scientific article

Molecular modelling and 1H-NMR: ultimate tools for the investigation of tolbutamide: beta-cyclodextrin and tolbutamide: hydroxypropyl-beta-cyclodextrin complexes.

scientific article

Multicomponent complex formation between vinpocetine, cyclodextrins, tartaric acid and water-soluble polymers monitored by NMR and solubility studies.

scientific article

Multiple bond 13C-13C spin-spin coupling provides complementary information in a 13C NMR isotopomer analysis of glutamate

scientific article published on 01 July 1999

Mutational characterization of steroid 21-hydroxylase gene in Portuguese patients with congenital adrenal hyperplasia

scientific article published on 23 October 2009

NMR Methodologies for Studying Mitochondrial Bioenergetics ⬇️

scientific article published on January 1, 2012

Neuropharmacological evaluation of the putative anxiolytic effects of Passiflora edulis Sims, its sub-fractions and flavonoid constituents

scientific article published on 01 December 2006

New Structure–Activity Relationships of A- and D-Ring Modified Steroidal Aromatase Inhibitors: Design, Synthesis, and Biochemical Evaluation

scientific article published on 18 April 2012

New steroidal 17β-carboxy derivatives present anti-5α-reductase activity and anti-proliferative effects in a human androgen-responsive prostate cancer cell line

scientific article published on 9 August 2013

Ocular injectable formulation assessment for oxidized dextran-based hydrogels.

scientific article published on 11 February 2009

On the flocculation and re-dissolution of trivalent lanthanide metal ions by sodium dodecyl sulfate in aqueous solutions

scientific article

Oral administration of peptides and proteins: nanoparticles and cyclodextrins as biocompatible delivery systems.

scientific article published on April 2007

Oxidative Stress, DNA, Cell Cycle/Cell Cycle Associated Proteins and Multidrug Resistance Proteins: Targets of Human Amniotic Membrane in Hepatocellular Carcinoma

scientific article published on 10 March 2016

Quantifying hepatic glycogen synthesis by direct and indirect pathways in rats under normal ad libitum feeding conditions

scientific article

Resolving NMR signals of short-chain fatty acid mixtures using unsupervised component analysis.

scientific article

Restoration of direct pathway glycogen synthesis flux in the STZ-diabetes rat model by insulin administration.

scientific article

Salivary gland metabolism in an animal model of chronic kidney disease

scientific article published on 27 May 2019

Selective cytotoxicity and cell death induced by human amniotic membrane in hepatocellular carcinoma.

scientific article published on 27 October 2015

Senescence and declining reproductive potential: Insight into molecular mechanisms through testicular metabolomics

scientific article published on 29 July 2018

Sodium hydrosulfide improves the protective potential of the cardioplegic histidine buffer solution

scientific article published on 24 December 2010

Solid-state characterization and dissolution profiles of the inclusion complexes of omeprazole with native and chemically modified beta-cyclodextrin

scientific article published on 13 March 2007

Strategies toward the improved oral delivery of insulin nanoparticles via gastrointestinal uptake and translocation

scientific article published on January 2008

Substrate selection in hearts subjected to ischemia/reperfusion: role of cardioplegic solutions and gender

scientific article published on 28 January 2011

TCA cycle kinetics in the rat heart by analysis of (13)C isotopomers using indirect (1)H.

scientific article published in September 2001

The bile acid chenodeoxycholic acid directly modulates metabolic pathways in white adipose tissue in vitro: insight into how bile acids decrease obesity

scientific article published on 4 August 2016

The effects of the obesogen tributyltin on the metabolism of Sertoli cells cultured ex vivo

scientific article published on 9 October 2017

The role of L-arginine in inclusion complexes of omeprazole with cyclodextrins

scientific article

Toxicological in vivo studies of an oral insulin nanosystem

Tricarboxylic acid cycle inhibition by Li+ in the human neuroblastoma SH-SY5Y cell line: a 13C NMR isotopomer analysis

scientific article published on November 2005

Ursodeoxycholic acid treatment of hepatic steatosis: a (13)C NMR metabolic study

scientific article published on 27 April 2011

Use of a single (13)C NMR resonance of glutamate for measuring oxygen consumption in tissue

scientific article published on 01 December 1999

Use of poly(DL-lactide-ε-caprolactone) membranes and mesenchymal stem cells from the Wharton's jelly of the umbilical cord for promoting nerve regeneration in axonotmesis: in vitro and in vivo analysis.

scientific article

X-ray diffraction and (1)H NMR in solution: structural determination of lanthanide complexes of a Py(2)N(6)Ac(4) ligand

scientific article published in October 2002

miR-145-loaded micelleplexes as a novel therapeutic strategy to inhibit proliferation and migration of osteosarcoma cells

scientific article published on 18 July 2018

List of works by Rui A. Carvalho

13C isotopomer analysis of glutamate by J-resolved heteronuclear single quantum coherence spectroscopy.

2H2O incorporation into hepatic acetyl-CoA and de novo lipogenesis as measured by Krebs cycle-mediated 2H-enrichment of glutamate and glutamine.

A (13)C isotopomer kinetic analysis of cardiac metabolism: influence of altered cytosolic redox and [Ca(2+)](o).

Adenosine A₁ receptors control the metabolic recovery after hypoxia in rat hippocampal slices

Adrenaline and reactive oxygen species elicit proteome and energetic metabolism modifications in freshly isolated rat cardiomyocytes

Adrenaline in pro-oxidant conditions elicits intracellular survival pathways in isolated rat cardiomyocytes

Analysis of glucose metabolism in farmed European sea bass (Dicentrarchus labrax L.) using deuterated water.

Anti-apoptotic protection afforded by cardioplegic celsior and histidine buffer solutions to hearts subjected to ischemia and ischemia/reperfusion.

Assessing Sertoli Cell Metabolic Activity.

Biochemical and metabolic effects of a short-term exposure to nanoparticles of titanium silicate in tadpoles of Pelophylax perezi (Seoane)

Bismuth(III) salt-catalyzed Westphalen and “backbone” rearrangements of 5β,6β-epoxysteroids

C isotopomer analysis of glutamate by heteronuclear multiple quantum coherence-total correlation spectroscopy (HMQC-TOCSY)

CB₁ receptor activation inhibits neuronal and astrocytic intermediary metabolism in the rat hippocampus

Caffeine Consumption Prevents Diabetes-Induced Memory Impairment and Synaptotoxicity in the Hippocampus of NONcZNO10/LTJ Mice ⬇️

Caffeine consumption attenuates neurochemical modifications in the hippocampus of streptozotocin-induced diabetic rats

Caloric restriction alters the hormonal profile and testicular metabolome, resulting in alterations of sperm head morphology

ClearPEM scanners: Performance results and studies in preclinical environment

Combined dual effect of modulation of human neutrophils' oxidative burst and inhibition of colon cancer cells proliferation by hydroxycinnamic acid derivatives

Comparative study of gene expression in patients with varicocele by microarray technology

Compartmentation of glycolysis and glycogenolysis in the perfused rat heart

Conformation study of HA(306-318) antigenic peptide of the haemagglutinin influenza virus protein.

Conformational studies of poly(9,9-dialkylfluorene)s in solution using NMR spectroscopy and density functional theory calculations.

Cross-functioning between the extraneuronal monoamine transporter and multidrug resistance protein 1 in the uptake of adrenaline and export of 5-(glutathion-S-yl)adrenaline in rat cardiomyocytes

DNA fragmentation in canine oocytes after in vitro maturation in TCM-199 medium supplemented with different proteins.

Dicationic alkylammonium bromide gemini surfactants. Membrane perturbation and skin irritation

Differences in the serum metabolome and lipidome identify potential biomarkers for seronegative rheumatoid arthritis versus psoriatic arthritis

Different metabolism of glutamatergic and GABAergic compartments in superfused hippocampal slices characterized by nuclear magnetic resonance spectroscopy

Do Cyclodextrins Aggregate in Water? Insights from NMR Experiments

Effect of Duration of Exposure to Fluoride and Type of Diet on Lipid Parameters and De Novo Lipogenesis

Effect of cyclodextrins and pH on the permeation of tetracaine: supramolecular assemblies and release behavior.

Effect of insulin deprivation on metabolism and metabolism-associated gene transcript levels of in vitro cultured human Sertoli cells

Effects of an oral insulin nanoparticle administration on hepatic glucose metabolism assessed by ¹³C and ²H isotopomer analysis

Effects of dietary carbohydrate on hepatic de novo lipogenesis in European seabass (Dicentrarchus labrax L.).

Effects of food-deprivation and refeeding on the regulation and sources of blood glucose appearance in European seabass (Dicentrarchus labrax L.).

Effects of galactose on direct and indirect pathway estimates of hepatic glycogen synthesis.

Efficient pro-survival/angiogenic miRNA delivery by an MRI-detectable nanomaterial.

Endometrial Cancer Spheres Show Cancer Stem Cells Phenotype and Preference for Oxidative Metabolism

Enzymatic synthesis of inulin-containing hydrogels

Estudo do imprinting genómico em espermatozóides de pacientes com oligozoospermia

Evaluation of hepatic glucose metabolism via gluconeogenesis and glycogenolysis after oral administration of insulin nanoparticles.

Evaluation of the impact of diabetes on retinal metabolites by NMR spectroscopy.

Exemestane metabolites: Synthesis, stereochemical elucidation, biochemical activity and anti-proliferative effects in a hormone-dependent breast cancer cell line.

Exenatide and Dapagliflozin Combination Enhances Sertoli Cell Secretion of Key Metabolites for Spermatogenesis

Experimental (IR/Raman and 1H/13C NMR) and Theoretical (DFT) Studies of the Preferential Conformations Adopted by l-Lactic Acid Oligomers and Poly(l-lactic acid) Homopolymer

Exploring new chemical functionalities to improve aromatase inhibition of steroids.

Facilitated nanoscale delivery of insulin across intestinal membrane models

Fatty Acid Oxidation and Cardiovascular Risk during Menopause: A Mitochondrial Connection?

Gastric Bypass with Different Biliopancreatic Limb Lengths Results in Similar Post-absorptive Metabolomics Profiles

Gender-dependent Metabolic Remodeling During Heart Preservation in Cardioplegic Celsior and Histidine Buffer Solution ⬇️

Ghrelin acts as energy status sensor of male reproduction by modulating Sertoli cells glycolytic metabolism and mitochondrial bioenergetics.

Glucose uptake and lipid metabolism are impaired in epicardial adipose tissue from heart failure patients with or without diabetes

High COX-2 expression is associated with increased angiogenesis, proliferation and tumoural inflammatory infiltrate in canine malignant mammary tumours: a multivariate survival study

High sucrose consumption induces memory impairment in rats associated with electrophysiological modifications but not with metabolic changes in the hippocampus.

Hormonal control of Sertoli cell metabolism regulates spermatogenesis ⬇️

Impact of Caffeine Consumption on Type 2 Diabetes-Induced Spatial Memory Impairment and Neurochemical Alterations in the Hippocampus

Influence of 5α-dihydrotestosterone and 17β-estradiol on human Sertoli cells metabolism

Inhibition of mitochondrial complex III blocks neuronal differentiation and maintains embryonic stem cell pluripotency

Interaction of Omeprazole with a Methylated Derivative of β-Cyclodextrin: Phase Solubility, NMR Spectroscopy and Molecular Simulation

Intermolecular interactions of highly stable paramagnetic lanthanide(III) chelates as studied by nuclear magnetic resonance spectroscopy

Ki-67 and PCNA Expression in Canine Mammary Tumors and Adjacent Nonneoplastic Mammary Glands: Prognostic Impact by a Multivariate Survival Analysis

Leptin modulates human Sertoli cells acetate production and glycolytic profile: a novel mechanism of obesity-induced male infertility?

Lipophilic phenolic antioxidants: correlation between antioxidant profile, partition coefficients and redox properties

Magnetic resonance spectroscopy in cancer diagnostics

Measurement of Hepatic Glucose Output, Krebs Cycle, and Gluconeogenic Fluxes by NMR Analysis of a Single Plasma Glucose Sample ⬇️

Metabolic dynamics of human Sertoli cells are differentially modulated by physiological and pharmacological concentrations of GLP-1

Metabolic effects of hypoxia in colorectal cancer by 13C NMR isotopomer analysis

Metabolic evaluations of cancer metabolism by NMR-based stable isotope tracer methodologies.

Metabolic fingerprints in testicular biopsies from type 1 diabetic patients.

Metabolic modulation induced by oestradiol and DHT in immature rat Sertoli cells culturedin vitro

Metabolic remodeling associated with subchronic doxorubicin cardiomyopathy.

Metabolic remodeling triggered by salivation and diabetes in major salivary glands

Metal-induced phosphate extracellular nanoparticulate formation in Ochrobactrum tritici 5bvl1.

Methyl-β-cyclodextrin Inclusion Complex with β-Caryophyllene: Preparation, Characterization, and Improvement of Pharmacological Activities

Microwave synthesis and in vitro stability of diclofenac-β-cyclodextrin conjugate for colon delivery

Mitochondrial Bioenergetics by 13C-NMR Isotopomer Analysis

Mitochondrial metabolism directs stemness and differentiation in P19 embryonal carcinoma stem cells

Molecular modelling and 1H-NMR: ultimate tools for the investigation of tolbutamide: beta-cyclodextrin and tolbutamide: hydroxypropyl-beta-cyclodextrin complexes.

Multicomponent complex formation between vinpocetine, cyclodextrins, tartaric acid and water-soluble polymers monitored by NMR and solubility studies.

Multiple bond 13C-13C spin-spin coupling provides complementary information in a 13C NMR isotopomer analysis of glutamate