List of works - Silvana Grasso

1-Aryl-3,5-dihydro-4H-2,3-benzodiazepin-4-ones: novel AMPA receptor antagonists.

scientific article published in April 1997

1-Aryl-6,7-methylenedioxy-3 H -quinazolin-4-ones as anticonvulsant agents

scientific article published on 01 December 2003

7,8-Methylenedioxy-4H-2,3-benzodiazepin-4-ones as novel AMPA receptor antagonists

scientific article published on 01 April 1998

7-Chloro-1-(2,6-difluorophenyl)-1H,3H-thiazolo.

scientific article

A SIMPLE AND EFFICIENT SYNTHESIS OF GYKI 52466 AND GYKI 52895

Anticonvulsant activity of pyrrolo[1′,2′:1,2]imidazo[4,5-b]pyridines, pyrrolo[2′,1′:2,3]imidazo[4,5-c] pyridines and pyrrolo[2,1-f]purines in DBA/2 mice

scientific article published in September 1994

Characterization of the mechanism of anticonvulsant activity for a selected set of putative AMPA receptor antagonists

scientific article

Chromatographic determination of 7,8-methylenedioxy-4H-2,3-benzodiazepin-4-ones in rat plasma: relationship to their anticonvulsant activity

scientific article published in July 2002

Constrained peptidomimetics as antiplasmodial falcipain-2 inhibitors

scientific article published on 10 June 2010

Convulsant effects of some xanthine derivatives in genetically epilepsy-prone rats

scientific article published on 16 June 1997

Design of 1-substituted 2-arylmethyl-4,5-methylenedioxybenzene derivatives as antiseizure agents.

scientific article

Development of Novel Amides as Noncovalent Inhibitors of Immunoproteasomes

scientific article published on 26 March 2019

Development of Novel Peptidomimetics Containing a Vinyl Sulfone Moiety as Proteasome Inhibitors

article

Development of novel dipeptide-like rhodesain inhibitors containing the 3-bromoisoxazoline warhead in a constrained conformation.

scientific article published on 21 September 2015

Development of novel selective peptidomimetics containing a boronic acid moiety, targeting the 20S proteasome as anticancer agents

scientific article

Development of peptidomimetic boronates as proteasome inhibitors

article

Development of peptidomimetics with a vinyl sulfone warhead as irreversible falcipain-2 inhibitors.

scientific article published on 31 January 2008

Development of rhodesain inhibitors with a 3-bromoisoxazoline warhead

scientific article published on 15 November 2013

Enantioseparation, absolute configuration determination, and anticonvulsant activity of (±)-1-(4-aminophenyl)-7,8-methylenedioxy-1,2,3,5-tetrahydro-4H-2,3-benzodiazepin-4-one

scientific article published on 01 January 2007

GYKI 52466 and related 2,3-benzodiazepines as anticonvulsant agents in DBA/2 mice

scientific article published on 01 December 1995

Identification of a new series of amides as non-covalent proteasome inhibitors.

scientific article published on 25 January 2014

Mechanism and site of inhibition of AMPA receptors: substitution of one and two methyl groups at the 4-aminophenyl ring of 2,3-benzodiazepine and implications in the "E" site.

scientific article published on 12 May 2015

Mechanism of inhibition of GluA2 AMPA receptor channel opening by 2,3-benzodiazepine derivatives: functional consequences of replacing a 7,8-methylenedioxy with a 7,8-ethylenedioxy moiety

scientific article

Mechanism of inhibition of the GluR2 AMPA receptor channel opening by 2,3-benzodiazepine derivatives

scientific article

Molecular requirement for anticonvulsant activity in a series of thiazolo-1,4-benzodiazepine derivatives and comparison with classical benzodiazepines

scientific article published in July 1993

New 7,8-ethylenedioxy-2,3-benzodiazepines as noncompetitive AMPA receptor antagonists

scientific article

Nonpeptidic vinyl and allyl phosphonates as falcipain-2 inhibitors

scientific article published on July 2008

Novel 2H-isoquinolin-3-ones as antiplasmodial falcipain-2 inhibitors.

scientific article published on 12 August 2009

Novel Peptidomimetic Cysteine Protease Inhibitors as Potential Antimalarial Agents

scientific article published on 01 June 2006

Novel peptidomimetics containing a vinyl ester moiety as highly potent and selective falcipain-2 inhibitors.

scientific article published on April 2009

Novel potent AMPA/kainate receptor antagonists: synthesis and anticonvulsant activity of a series of 2-[(4-alkylsemicarbazono)-(4-amino-phenyl)methyl]-4,5-methylenedioxyphenylacetic acid alkyl esters

scientific article published in September 2002

Optimization of peptidomimetic boronates bearing a P3 bicyclic scaffold as proteasome inhibitors

scientific article

Peptide-based proteasome inhibitors in anticancer drug design.

scientific article published on March 2014

Peptidomimetics containing a vinyl ketone warhead as falcipain-2 inhibitors

scientific article published on 03 March 2011

Structure-activity study of 2,3-benzodiazepin-4-ones noncompetitive AMPAR antagonists: identification of the 1-(4-amino-3-methylphenyl)-3,5-dihydro-7,8-ethylenedioxy-4H-2,3-benzodiazepin-4-one as neuroprotective agent

scientific article

Synthesis and Anticonvulsant Activity of Novel and Potent 2,3-Benzodiazepine AMPA/Kainate Receptor Antagonists

scientific article published on 01 October 1999

Synthesis and anticonvulsant activity of new 2,3-benzodiazepines as AMPA receptor antagonists

scientific article published on 01 March 1999

Synthesis and anticonvulsant activity of novel and potent 1-aryl-7,8-methylenedioxy-1,2,3,5-tetrahydro-4H-2,3-benzodiazepin-4-ones

scientific article published on 01 February 2001

Synthesis and antitumor activity of 1,3-benzodioxole derivatives.

scientific article published in October 2002

Synthesis and biological evaluation of papain-family cathepsin L-like cysteine protease inhibitors containing a 1,4-benzodiazepine scaffold as antiprotozoal agents

scientific article

Synthesis and cytotoxic activity of 1,3-benzodioxole derivatives. Note II.

scientific article published on May 2003

Synthesis and in vitro antitumour activity evaluation of 1-aryl-1H,3H-thiazolo[4,3-b]quinazolines

scientific article published on 01 December 2000

Synthesis and molecular modeling studies of derivatives of a highly potent peptidomimetic vinyl ester as falcipain-2 inhibitors.

scientific article

Synthesis of 2-semicarbazonomethyl-4,5-methylenedioxyphenylacetic acids as anticonvulsant agents

scientific article published on 01 March 2005

Synthesis of Novel 3-(Alkylcarbamoyl)-2-aryl-1,2-dihydro-6,7-(methylenedioxy)-3H-quinazolin-4-ones as Anticonvulsant Agents

scientific article published on 01 March 2006

Synthesis of novel peptidomimetics as inhibitors of protozoan cysteine proteases falcipain-2 and rhodesain

scientific article published on 14 April 2010

Synthesis, Chiral Resolution and Pharmacological Evaluation of a 2,3-Benzodiazepine-Derived Noncompetitive AMPA Receptor Antagonist

scientific article published on 01 March 2009

Synthesis, chiral resolution, and enantiopharmacology of a potent 2,3-benzodiazepine derivative as noncompetitive AMPA receptor antagonist.

scientific article published in January 2006

List of works by Silvana Grasso

1-Aryl-3,5-dihydro-4H-2,3-benzodiazepin-4-ones: novel AMPA receptor antagonists.

1-Aryl-6,7-methylenedioxy-3 H -quinazolin-4-ones as anticonvulsant agents

7,8-Methylenedioxy-4H-2,3-benzodiazepin-4-ones as novel AMPA receptor antagonists

7-Chloro-1-(2,6-difluorophenyl)-1H,3H-thiazolo.

A SIMPLE AND EFFICIENT SYNTHESIS OF GYKI 52466 AND GYKI 52895

Anticonvulsant activity of pyrrolo[1′,2′:1,2]imidazo[4,5-b]pyridines, pyrrolo[2′,1′:2,3]imidazo[4,5-c] pyridines and pyrrolo[2,1-f]purines in DBA/2 mice

Characterization of the mechanism of anticonvulsant activity for a selected set of putative AMPA receptor antagonists

Chromatographic determination of 7,8-methylenedioxy-4H-2,3-benzodiazepin-4-ones in rat plasma: relationship to their anticonvulsant activity

Constrained peptidomimetics as antiplasmodial falcipain-2 inhibitors

Convulsant effects of some xanthine derivatives in genetically epilepsy-prone rats

Design of 1-substituted 2-arylmethyl-4,5-methylenedioxybenzene derivatives as antiseizure agents.

Development of Novel Amides as Noncovalent Inhibitors of Immunoproteasomes

Development of Novel Peptidomimetics Containing a Vinyl Sulfone Moiety as Proteasome Inhibitors

Development of novel dipeptide-like rhodesain inhibitors containing the 3-bromoisoxazoline warhead in a constrained conformation.

Development of novel selective peptidomimetics containing a boronic acid moiety, targeting the 20S proteasome as anticancer agents

Development of peptidomimetic boronates as proteasome inhibitors

Development of peptidomimetics with a vinyl sulfone warhead as irreversible falcipain-2 inhibitors.

Development of rhodesain inhibitors with a 3-bromoisoxazoline warhead

Enantioseparation, absolute configuration determination, and anticonvulsant activity of (±)-1-(4-aminophenyl)-7,8-methylenedioxy-1,2,3,5-tetrahydro-4H-2,3-benzodiazepin-4-one

GYKI 52466 and related 2,3-benzodiazepines as anticonvulsant agents in DBA/2 mice

Identification of a new series of amides as non-covalent proteasome inhibitors.

Mechanism and site of inhibition of AMPA receptors: substitution of one and two methyl groups at the 4-aminophenyl ring of 2,3-benzodiazepine and implications in the "E" site.

Mechanism of inhibition of GluA2 AMPA receptor channel opening by 2,3-benzodiazepine derivatives: functional consequences of replacing a 7,8-methylenedioxy with a 7,8-ethylenedioxy moiety

Mechanism of inhibition of the GluR2 AMPA receptor channel opening by 2,3-benzodiazepine derivatives

Molecular requirement for anticonvulsant activity in a series of thiazolo-1,4-benzodiazepine derivatives and comparison with classical benzodiazepines

New 7,8-ethylenedioxy-2,3-benzodiazepines as noncompetitive AMPA receptor antagonists

Nonpeptidic vinyl and allyl phosphonates as falcipain-2 inhibitors

Novel 2H-isoquinolin-3-ones as antiplasmodial falcipain-2 inhibitors.

Novel Peptidomimetic Cysteine Protease Inhibitors as Potential Antimalarial Agents

Novel peptidomimetics containing a vinyl ester moiety as highly potent and selective falcipain-2 inhibitors.

Novel potent AMPA/kainate receptor antagonists: synthesis and anticonvulsant activity of a series of 2-[(4-alkylsemicarbazono)-(4-amino-phenyl)methyl]-4,5-methylenedioxyphenylacetic acid alkyl esters

Optimization of peptidomimetic boronates bearing a P3 bicyclic scaffold as proteasome inhibitors

Peptide-based proteasome inhibitors in anticancer drug design.

Peptidomimetics containing a vinyl ketone warhead as falcipain-2 inhibitors

Structure-activity study of 2,3-benzodiazepin-4-ones noncompetitive AMPAR antagonists: identification of the 1-(4-amino-3-methylphenyl)-3,5-dihydro-7,8-ethylenedioxy-4H-2,3-benzodiazepin-4-one as neuroprotective agent

Synthesis and Anticonvulsant Activity of Novel and Potent 2,3-Benzodiazepine AMPA/Kainate Receptor Antagonists

Synthesis and anticonvulsant activity of new 2,3-benzodiazepines as AMPA receptor antagonists

Synthesis and anticonvulsant activity of novel and potent 1-aryl-7,8-methylenedioxy-1,2,3,5-tetrahydro-4H-2,3-benzodiazepin-4-ones

Synthesis and antitumor activity of 1,3-benzodioxole derivatives.

Synthesis and biological evaluation of papain-family cathepsin L-like cysteine protease inhibitors containing a 1,4-benzodiazepine scaffold as antiprotozoal agents

Synthesis and cytotoxic activity of 1,3-benzodioxole derivatives. Note II.

Synthesis and in vitro antitumour activity evaluation of 1-aryl-1H,3H-thiazolo[4,3-b]quinazolines

Synthesis and molecular modeling studies of derivatives of a highly potent peptidomimetic vinyl ester as falcipain-2 inhibitors.

Synthesis of 2-semicarbazonomethyl-4,5-methylenedioxyphenylacetic acids as anticonvulsant agents

Synthesis of Novel 3-(Alkylcarbamoyl)-2-aryl-1,2-dihydro-6,7-(methylenedioxy)-3H-quinazolin-4-ones as Anticonvulsant Agents

Synthesis of novel peptidomimetics as inhibitors of protozoan cysteine proteases falcipain-2 and rhodesain

Synthesis, Chiral Resolution and Pharmacological Evaluation of a 2,3-Benzodiazepine-Derived Noncompetitive AMPA Receptor Antagonist

Synthesis, chiral resolution, and enantiopharmacology of a potent 2,3-benzodiazepine derivative as noncompetitive AMPA receptor antagonist.