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List of works by Yongchuan Gu

A novel fluorometric assay for aldo-keto reductase 1C3 predicts metabolic activation of the nitrogen mustard prodrug PR-104A in human leukaemia cells

scientific article

A phase I trial of PR-104, a pre-prodrug of the bioreductive prodrug PR-104A, given weekly to solid tumour patients

scientific article

Analysis of the hypoxia-activated dinitrobenzamide mustard phosphate pre-prodrug PR-104 and its alcohol metabolite PR-104A in plasma and tissues by liquid chromatography-mass spectrometry

scientific article published on 06 July 2007

Determination of Astragaloside IV in rat plasma by liquid chromatography electrospray ionization mass spectrometry

scientific article published on 01 March 2004

Glucuronidation of anticancer prodrug PR-104A: species differences, identification of human UDP-glucuronosyltransferases, and implications for therapy

scientific article published on 22 March 2011

Hypoxia-Induced WSB1 Promotes the Metastatic Potential of Osteosarcoma Cells.

scientific article published on 30 September 2015

Hypoxic selectivity and solubility--investigating the properties of A-ring substituted nitro seco-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-ones (nitroCBIs) as hypoxia-activated prodrugs for antitumor therapy.

scientific article published on 8 June 2010

Identification of P450 Oxidoreductase as a Major Determinant of Sensitivity to Hypoxia-Activated Prodrugs.

scientific article published on 21 August 2015

Improved HPLC method for the simultaneous determination of tramadol and O-desmethyltramadol in human plasma

scientific article published in July 2005

Initial testing of the hypoxia-activated prodrug PR-104 by the pediatric preclinical testing program.

scientific article

Novel nitroimidazole alkylsulfonamides as hypoxic cell radiosensitisers

scientific article published on 3 March 2014

PR-104 a bioreductive pre-prodrug combined with gemcitabine or docetaxel in a phase Ib study of patients with advanced solid tumours

scientific article

Phase I/II study of the hypoxia-activated prodrug PR104 in refractory/relapsed acute myeloid leukemia and acute lymphoblastic leukemia

scientific article

Photodegradation of the benzotriazine 1,4-Di-N-oxide hypoxia-activated prodrug SN30000 in aqueous solution

scientific article published on 11 September 2014

Pre-clinical activity of PR-104 as monotherapy and in combination with sorafenib in hepatocellular carcinoma.

scientific article

Rapid and sensitive ultra-high-pressure liquid chromatography-tandem mass spectrometry analysis of the novel anticancer agent PR-104 and its major metabolites in human plasma: Application to a pharmacokinetic study

scientific article published on 13 August 2009

Reductive Metabolism Influences the Toxicity and Pharmacokinetics of the Hypoxia-Targeted Benzotriazine Di-Oxide Anticancer Agent SN30000 in Mice.

scientific article published on 11 August 2017

Reductive metabolism of the dinitrobenzamide mustard anticancer prodrug PR-104 in mice.

scientific article

Roles of biotransformation in the antitumour activity and toxicology of the hypoxia-activated pre-prodrug PR-104 ⬇️

2010 doctoral thesis by Yongchuan Gu at University of Auckland

Selective Treatment of Hypoxic Tumor Cells In Vivo: Phosphate Pre‐Prodrugs of Nitro Analogues of the Duocarmycins ⬇️

scientific article published on February 17, 2011

The dual PI3K/mTOR inhibitor NVP-BEZ235 prevents epithelial-mesenchymal transition induced by hypoxia and TGF-β1.

scientific article published on 20 February 2014

The flavoprotein FOXRED2 reductively activates nitro-chloromethylbenzindolines and other hypoxia-targeting prodrugs

scientific article published on 13 March 2014

Transport and bioavailability studies of astragaloside IV, an active ingredient in Radix Astragali

scientific article published on 01 December 2004

Zinc finger nuclease knock-out of NADPH:cytochrome P450 oxidoreductase (POR) in human tumor cell lines demonstrates that hypoxia-activated prodrugs differ in POR dependence

scientific article

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