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List of works by Steve Chan

2-[(1-methylpropyl)dithio]-1H-imidazole inhibits tubulin polymerization through cysteine oxidation.

scientific article

A phase III randomized comparison of lapatinib plus capecitabine versus capecitabine alone in women with advanced breast cancer that has progressed on trastuzumab: updated efficacy and biomarker analyses

scientific article published on 11 January 2008

A pooled analysis of gemcitabine plus docetaxel versus capecitabine plus docetaxel in metastatic breast cancer

scientific article

A review of selective estrogen receptor modulators in the treatment of breast and endometrial cancer.

scientific article

Adverse prognostic and predictive significance of low DNA-dependent protein kinase catalytic subunit (DNA-PKcs) expression in early-stage breast cancers

scientific article

Bcl2 is an independent prognostic marker of triple negative breast cancer (TNBC) and predicts response to anthracycline combination (ATC) chemotherapy (CT) in adjuvant and neoadjuvant settings

scientific article published in August 2013

Brain metastases from breast cancer: identification of a high-risk group

scientific article published in August 2004

C-erbB2 expression predicts response to preoperative chemotherapy for locally advanced breast cancer

scientific article published on 01 September 1998

CEREBEL (EGF111438): A Phase III, Randomized, Open-Label Study of Lapatinib Plus Capecitabine Versus Trastuzumab Plus Capecitabine in Patients With Human Epidermal Growth Factor Receptor 2-Positive Metastatic Breast Cancer.

scientific article published on 20 January 2015

Calpain-1 expression is associated with relapse-free survival in breast cancer patients treated with trastuzumab following adjuvant chemotherapy

scientific article published on 8 March 2011

Calpain-1 is associated with adverse relapse free survival in breast cancer: a confirmatory study

scientific article published on 25 October 2015

Calpain‐2 expression is associated with response to platinum based chemotherapy, progression‐free and overall survival in ovarian cancer ⬇️

scientific article published on October 1, 2012

Can computerised tomography replace bone scintigraphy in detecting bone metastases from breast cancer? A prospective study

scientific article

Carboplatin in BRCA1/2-mutated and triple-negative breast cancer BRCAness subgroups: the TNT Trial

scientific article published on 30 April 2018

Central pathology review with two-stage quality assurance for pathological response after neoadjuvant chemotherapy in the ARTemis Trial

scientific article published on 26 May 2017

Characterisation of HER heterodimers in breast cancer using in situ proximity ligation assay

scientific article

Chk1 phosphorylated at serine345 is a predictor of early local recurrence and radio-resistance in breast cancer

scientific article published on 3 October 2015

Clinicopathological and prognostic significance of RECQL5 helicase expression in breast cancers.

scientific article

Clinicopathological significance of ATM-Chk2 expression in sporadic breast cancers: a comprehensive analysis in large cohorts.

scientific article

Clinicopathological significance of human apurinic/apyrimidinic endonuclease 1 (APE1) expression in oestrogen-receptor-positive breast cancer

scientific article published on 01 January 2014

Continuous chemotherapy in responsive metastatic breast cancer: a role for tumour markers?

scientific article

DNA polymerase β deficiency is linked to aggressive breast cancer: a comprehensive analysis of gene copy number, mRNA and protein expression in multiple cohorts

scientific article published on 10 January 2014

DNA repair prognostic index modelling reveals an essential role for base excision repair in influencing clinical outcomes in ER negative and triple negative breast cancers

scientific article

ERCC1-XPF deficiency is a predictor of olaparib induced synthetic lethality and platinum sensitivity in epithelial ovarian cancers

scientific article published on 21 February 2019

Effects of the addition of gemcitabine, and paclitaxel-first sequencing, in neoadjuvant sequential epirubicin, cyclophosphamide, and paclitaxel for women with high-risk early breast cancer (Neo-tAnGo): an open-label, 2×2 factorial randomised phase 3

scientific article

Efficacy of neoadjuvant bevacizumab added to docetaxel followed by fluorouracil, epirubicin, and cyclophosphamide, for women with HER2-negative early breast cancer (ARTemis): an open-label, randomised, phase 3 trial

scientific article published on 11 May 2015

Estrogen receptor expression and docetaxel efficacy in patients with metastatic breast cancer: a pooled analysis of four randomized trials.

scientific article published on 26 April 2010

Frequency and patterns of metastatic disease in locally advanced inflammatory and non-inflammatory breast cancer

scientific article published on 5 May 2011

Genomic and protein expression analysis reveals flap endonuclease 1 (FEN1) as a key biomarker in breast and ovarian cancer

scientific article

Growth fraction as a predictor of response to chemotherapy in node-negative breast cancer

scientific article published in April 2010

HAGE (DDX43) is a biomarker for poor prognosis and a predictor of chemotherapy response in breast cancer

scientific article

HAGE in Triple-Negative Breast Cancer Is a Novel Prognostic, Predictive, and Actionable Biomarker: A Transcriptomic and Protein Expression Analysis

scientific article published on 3 August 2015

HER2/HER3 heterodimers and p21 expression are capable of predicting adjuvant trastuzumab response in HER2+ breast cancer

scientific article published on 06 April 2014

Imaging of metastatic breast cancer: distribution and radiological assessment at presentation

scientific article published in January 2001

Is Mammography of Value in Women with Disseminated Cancer of Unknown Origin?

scientific article published on 01 January 1999

Is there a role for base excision repair in estrogen/estrogen receptor-driven breast cancers?

scientific article

Localisation of lung cancer by a radiolabelled monoclonal antibody against the c-myc oncogene product

scientific article

Locally advanced breast cancer: early results of a randomised trial of multimodal therapy versus initial hormone therapy

scientific article published on 01 January 1997

Locally advanced primary breast cancer: medium-term results of a randomised trial of multimodal therapy versus initial hormone therapy.

scientific article published in December 2001

Neoadjuvant doxorubicin/cyclophosphamide followed by ixabepilone or paclitaxel in early stage breast cancer and evaluation of βIII-tubulin expression as a predictive marker.

scientific article published on 12 July 2013

Outcome and prognostic factors in 110 consecutive patients with primary uterine leiomyosarcoma: A Rare Cancer Network study.

scientific article

Patterns of metastatic breast carcinoma: influence of tumour histological grade

scientific article published on 01 December 2004

Phase 2 study of single-agent IV vinflunine as third-line treatment of metastatic breast cancer after failure of anthracycline-/taxane-based chemotherapy.

scientific article published in August 2009

Phase II study of buparlisib (BKM120) and trastuzumab in patients with HER2+ locally advanced or metastatic breast cancer resistant to trastuzumab-based therapy

scientific article published on 2 December 2017

Phase II study of temsirolimus (CCI-779), a novel inhibitor of mTOR, in heavily pretreated patients with locally advanced or metastatic breast cancer

scientific article

Phase III study of gemcitabine plus docetaxel compared with capecitabine plus docetaxel for anthracycline-pretreated patients with metastatic breast cancer

scientific article published on 9 March 2009

Phosphorylation of activating transcription factor-2 (ATF-2) within the activation domain is a key determinant of sensitivity to tamoxifen in breast cancer

scientific article published on 22 August 2014

Pictilisib PI3Kinase inhibitor (a phosphatidylinositol 3-kinase [PI3K] inhibitor) plus paclitaxel for the treatment of hormone receptor-positive, HER2-negative, locally recurrent, or metastatic breast cancer: interim analysis of the multicentre, pla

scientific article published on 29 August 2016

RECQL4 helicase has oncogenic potential in sporadic breast cancers

scientific article published on 22 December 2015

SHON expression predicts response and relapse risk of breast cancer patients after anthracycline-based combination chemotherapy or tamoxifen treatment

scientific article published on 28 February 2019

SHON is a novel estrogen-regulated oncogene in mammary carcinoma that predicts patient response to endocrine therapy

scientific article published in December 2013

SPAG5 as a prognostic biomarker and chemotherapy sensitivity predictor in breast cancer: a retrospective, integrated genomic, transcriptomic, and protein analysis.

scientific article published on 13 June 2016

SRC3 Phosphorylation at Serine 543 Is a Positive Independent Prognostic Factor in ER-Positive Breast Cancer

scientific article published on 14 September 2015

Serological monitoring of advanced breast cancer treated by systemic cytotoxic using a combination of ESR, CEA, and CA 15.3: fact or fiction?

scientific article published on 01 May 1991

Single-strand selective monofunctional uracil-DNA glycosylase (SMUG1) deficiency is linked to aggressive breast cancer and predicts response to adjuvant therapy

scientific article

Targeting BRCA1-BER deficient breast cancer by ATM or DNA-PKcs blockade either alone or in combination with cisplatin for personalized therapy

scientific article published on 27 August 2014

Targeting XRCC1 deficiency in breast cancer for personalized therapy.

scientific article published on 19 December 2012

Targeting ataxia telangiectasia-mutated- and Rad3-related kinase (ATR) in PTEN-deficient breast cancers for personalized therapy

scientific article

Taxanes alone or in combination with anthracyclines as first-line therapy of patients with metastatic breast cancer.

scientific article published in April 2008

The localization of pre mRNA splicing factor PRPF38B is a novel prognostic biomarker that may predict survival benefit of trastuzumab in patients with breast cancer overexpressing HER2.

scientific article published on 18 November 2017

The mTOR downstream regulator (p-4EBP1) is a novel independent prognostic marker in ovarian cancer

scientific article published on 04 February 2019

The prognostic and predictive power of redox protein expression for anthracycline-based chemotherapy response in locally advanced breast cancer

scientific article

The prognostic significance of computerised tomography findings in women with liver metastases from breast cancer

scientific article published on 18 May 2011

The relationship of CDK18 expression in breast cancer to clinicopathological parameters and therapeutic response

scientific article published on 29 June 2018

The role of PTEN and its signalling pathways, including AKT, in breast cancer; an assessment of relationships with other prognostic factors and with outcome

scientific article

The role of blood tumor marker measurement (using a biochemical index score and c-erbB2) in directing chemotherapy in metastatic breast cancer

scientific article published on 01 July 2000

Thioredoxin and related redox systems as targets in breast cancer

scientific article published on 18 May 2010

Transcriptomic and Protein Expression Analysis Reveals Clinicopathological Significance of Bloom Syndrome Helicase (BLM) in Breast Cancer.

scientific article

Untangling the ATR-CHEK1 network for prognostication, prediction and therapeutic target validation in breast cancer

scientific article

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