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List of works by Anne-Marie Malfait

A commentary on modelling osteoarthritis pain in small animals

scientific article

A high performance liquid chromatography assay for monitoring proprotein convertase activity

scientific article published on 07 March 2007

A role for PACE4 in osteoarthritis pain: evidence from human genetic association and null mutant phenotype

scientific article published on 22 March 2012

ADAM-8 isolated from human osteoarthritic chondrocytes cleaves fibronectin at Ala(271).

scientific article published in September 2009

ADAMTS-4 (aggrecanase-1): N-terminal activation mechanisms

scientific article

ADAMTS-4 and ADAMTS-5

Aggrecan degradation in human articular cartilage explants is mediated by both ADAMTS-4 and ADAMTS-5.

scientific article

An emerging role for Toll-like receptors at the neuroimmune interface in osteoarthritis

scientific article published on 01 September 2019

An immunoaffinity liquid chromatography-tandem mass spectrometry assay for detection of endogenous aggrecan fragments in biological fluids: Use as a biomarker for aggrecanase activity and cartilage degradation

scientific journal article

Anti-IL-12 and anti-TNF antibodies synergistically suppress the progression of murine collagen-induced arthritis

scientific article published on 01 July 1999

Blockade of IL-12 during the induction of collagen-induced arthritis (CIA) markedly attenuates the severity of the arthritis

scientific article published on 01 February 1998

Can we target CCR2 to treat osteoarthritis? The trick is in the timing!

scientific article

DEGENERATIVE CHANGES OF INTERVERTEBRAL DISC AND VERTEBRAL ENDPLATE IN ADAMTS5 (AGGRECANASE-2) KNOCKOUT MICE

Damage-associated molecular patterns generated in osteoarthritis directly excite murine nociceptive neurons through Toll-like receptor 4.

scientific article

Genetically Engineered Mouse Models Reveal the Importance of Proteases as Osteoarthritis Drug Targets

scientific article

High resolution crystal structure of the catalytic domain of ADAMTS-5 (aggrecanase-2)

scientific article

Identification and characterization of UK-201844, a novel inhibitor that interferes with human immunodeficiency virus type 1 gp160 processing

scientific article

Identification of an ADAMTS-4 cleavage motif using phage display leads to the development of fluorogenic peptide substrates and reveals matrilin-3 as a novel substrate

scientific article

Identification of fibronectin neoepitopes present in human osteoarthritic cartilage

scientific article published on 01 September 2006

Intra-articular injection of tumor necrosis factor-alpha in the rat: an acute and reversible in vivo model of cartilage proteoglycan degradation

scientific article published in November 2008

Knockout of ADAMTS5 does not eliminate cartilage aggrecanase activity but abrogates joint fibrosis and promotes cartilage aggrecan deposition in murine osteoarthritis models

scientific article published on 26 October 2010

Modelling pain in post-traumatic osteoarthritis of the knee

scientific article published on 22 October 2011

Monoclonal Antibody Therapy in Rheumatoid Arthritis

scholarly article by Filip Keyser et al published February 1994 in BioDrugs

Nanoparticles for improved local retention after intra-articular injection into the knee joint

scientific article

On the predictive utility of animal models of osteoarthritis

scientific article

Osteoarthritis

Osteoarthritis joint pain: the cytokine connection

scientific article

Osteoarthritis year in review 2015: biology

scientific article

P-selectin glycoprotein ligand 1 therapy ameliorates established collagen-induced arthritis in DBA/1 mice partly through the suppression of tumour necrosis factor.

scientific article published on April 2004

PCSK6-mediated corin activation is essential for normal blood pressure

scientific article

Proprotein convertase activation of aggrecanases in cartilage in situ.

scientific article

Proprotein convertase furin interacts with and cleaves pro-ADAMTS4 (Aggrecanase-1) in the trans-Golgi network

scientific article

Proteoglycan metabolism in isolated chondrocytes from human cartilage. Influence of niflumic acid

scientific article published in March 1990

Proteoglycan metabolism in tissue-cultured human articular cartilage. Influence of niflumic acid

scientific article published in January 1990

Size distribution of native aggrecan aggregates of human articular chondrocytes in agarose

scientific article published in May 1993

Spinal microglial activation in a murine surgical model of knee osteoarthritis

scientific article

Standardization of nutrient media for isolated human articular chondrocytes in gelified agarose suspension culture

scientific article

Structure analysis reveals the flexibility of the ADAMTS-5 active site

scientific article

Substrate-dependent inhibition kinetics of an active site-directed inhibitor of ADAMTS-4 (Aggrecanase 1).

scientific article published on 8 May 2007

Synovial fluid from patients with early osteoarthritis modulates fibroblast-like synoviocyte responses to toll-like receptor 4 and toll-like receptor 2 ligands via soluble CD14.

scientific article

T cell receptor V beta usage in rheumatoid nodules: marked oligoclonality among IL-2 expanded lymphocytes

scientific article published in July 1993

The Role of Peripheral Nociceptive Neurons in the Pathophysiology of Osteoarthritis Pain

scientific article

The role of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) in a model of cartilage degradation

scientific article published on 01 August 2001

The usual suspects: Verdict not guilty?

scientific article published on 01 December 2003

Therapeutic effects of an anti-ADAMTS-5 antibody on joint damage and mechanical allodynia in a murine model of osteoarthritis.

scientific article published on 24 September 2015

Time to be positive about negative data?

scientific article published in March 2017

Towards a mechanism-based approach to pain management in osteoarthritis

scientific article

Will the real aggrecanase(s) step up: evaluating the criteria that define aggrecanase activity in osteoarthritis.

scientific article published on February 2008

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