List of works - Simon Schenk

A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange

scientific article

A novel pathway of insulin sensitivity in chromogranin A null mice: a crucial role for pancreastatin in glucose homeostasis.

scientific article published on 25 August 2009

Acute glucoregulatory and vascular outcomes of three strategies for interrupting prolonged sitting time in postmenopausal women: A pilot, laboratory-based, randomized, controlled, 4-condition, 4-period crossover trial.

scientific article

Acute inhibition of protein deacetylases does not impact skeletal muscle insulin action

scientific article published on 28 August 2019

Alterations in carbohydrate metabolism in response to short-term dietary carbohydrate restriction

scientific article published on 29 March 2005

Application of the [γ-32P] ATP kinase assay to study anabolic signaling in human skeletal muscle

scientific article

AttenuatedPik3r1Expression Prevents Insulin Resistance and Adipose Tissue Macrophage Accumulation in Diet-Induced Obese Mice ⬇️

scientific article published on June 14, 2012

Ceramides contained in LDL are elevated in type 2 diabetes and promote inflammation and skeletal muscle insulin resistance

scientific article published on 8 November 2012

Coimmunoprecipitation of FAT/CD36 and CPT I in skeletal muscle increases proportionally with fat oxidation after endurance exercise training

scientific article published on 02 May 2006

Combined overexpression of SIRT1 and knockout of GCN5 in adult skeletal muscle does not affect glucose homeostasis or exercise performance in mice

scientific article published on 03 December 2019

Commentaries on viewpoint: does SIRT1 determine exercise-induced skeletal muscle mitochondrial biogenesis: differences between in vitro and in vivo experiments?

scientific article published on 01 March 2012

Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase.

scientific article

Different glycemic indexes of breakfast cereals are not due to glucose entry into blood but to glucose removal by tissue ⬇️

scientific article published on October 1, 2003

Dried Plum Ingestion Increases the Osteoblastogenic Capacity of Human Serum.

scientific article published on 26 April 2017

Effects of dietary carbohydrate restriction with high protein intake on protein metabolism and the somatotropic axis

scientific article published on 21 June 2005

Energy deficit after exercise augments lipid mobilization but does not contribute to the exercise-induced increase in insulin sensitivity

scientific article

Exercise and high-fat feeding remodel transcript-metabolite interactive networks in mouse skeletal muscle.

scientific article published on 18 October 2017

G protein-coupled receptor 21 deletion improves insulin sensitivity in diet-induced obese mice

scientific journal article

Germline or inducible knockout of p300 or CBP in skeletal muscle does not alter insulin sensitivity

scientific article published on 19 March 2019

Heterogeneous muscle gene expression patterns in patients with massive rotator cuff tears

scientific article published on 2 January 2018

High fatty acid availability after exercise alters the regulation of muscle lipid metabolism

scientific article

High-fat diet elevates resting intramuscular triglyceride concentration and whole body lipolysis during exercise ⬇️

scientific article published on October 14, 2003

High-fat diet-induced impairment of skeletal muscle insulin sensitivity is not prevented by SIRT1 overexpression

scientific article

Histological Evidence of Muscle Degeneration in Advanced Human Rotator Cuff Disease.

scientific article published in February 2017

Improved insulin sensitivity after weight loss and exercise training is mediated by a reduction in plasma fatty acid mobilization, not enhanced oxidative capacity

scientific article published in September 2009

Increased adipocyte O2 consumption triggers HIF-1α, causing inflammation and insulin resistance in obesity

scientific article

Inducible nitric oxide synthase deficiency in myeloid cells does not prevent diet-induced insulin resistance

scientific article

Interaction between lipid availability,endurance exercise and insulin sensitivity

scientific article published on 09 September 2014

Is acetylation a metabolic rheostat that regulates skeletal muscle insulin action?

scientific article

Knock-down of IL-1Ra in obese mice decreases liver inflammation and improves insulin sensitivity

scientific article

Knockout of STAT3 in skeletal muscle does not prevent high-fat diet-induced insulin resistance

scientific article published on 13 May 2015

Manipulation of dietary carbohydrate and muscle glycogen affects glucose uptake during exercise when fat oxidation is impaired by beta-adrenergic blockade

scientific article

Muscle architectural changes after massive human rotator cuff tear.

scientific article published on 6 April 2016

Muscle gene expression patterns in human rotator cuff pathology.

scientific article

Muscle-specific knockout of general control of amino acid synthesis 5 (GCN5) does not enhance basal or endurance exercise-induced mitochondrial adaptation.

scientific article published on 16 October 2017

NAD+/NADH and skeletal muscle mitochondrial adaptations to exercise ⬇️

scientific article published on March 20, 2012

New opportunities and novel paradigms to support neuromuscular research.

scientific article published on February 2012

Novel liver-specific TORC2 siRNA corrects hyperglycemia in rodent models of type 2 diabetes

scientific journal article

Overload-mediated skeletal muscle hypertrophy is not impaired by loss of myofiber STAT3.

scientific article

Perm1 enhances mitochondrial biogenesis, oxidative capacity, and fatigue resistance in adult skeletal muscle.

scientific article

Postexercise insulin sensitivity is not impaired after an overnight lipid infusion

scientific article

Rapamycin does not prevent increases in myofibrillar or mitochondrial protein synthesis following endurance exercise.

scientific article published on 30 July 2015

Regulation of plasma ceramide levels with fatty acid oversupply: evidence that the liver detects and secretes de novo synthesised ceramide.

scientific article published on 27 July 2012

Relatively low endogenous fatty acid mobilization and uptake helps preserve insulin sensitivity in obese women.

scientific article

Role of the cytoskeleton in muscle transcriptional responses to altered use

scientific article

SIRT1 regulates nuclear number and domain size in skeletal muscle fibers.

scientific article published on 25 March 2018

Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction

scientific article

Sirtuin 1 (SIRT1) deacetylase activity is not required for mitochondrial biogenesis or peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) deacetylation following endurance exercise.

scientific article

Skeletal muscle Nur77 expression enhances oxidative metabolism and substrate utilization

scientific article

Skeletal muscle action of estrogen receptor α is critical for the maintenance of mitochondrial function and metabolic homeostasis in females

scientific article published on April 2016

Skeletal muscle fiber-type specific succinate dehydrogenase activity in cerebral palsy

scientific article published on 12 August 2016

Skeletal muscle mitochondrial function and exercise capacity are not impaired in mice with knockout of STAT3

scientific article published on 12 September 2019

Skeletal muscle-specific overexpression of SIRT1 does not enhance whole-body energy expenditure or insulin sensitivity in young mice

scientific article published on 19 April 2013

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

scientific article

Specific Sirt1 Activator-mediated Improvement in Glucose Homeostasis Requires Sirt1-Independent Activation of AMPK.

scientific article

Temporal overexpression of SIRT1 in skeletal muscle of adult mice does not improve insulin sensitivity or markers of mitochondrial biogenesis.

scientific article published on 22 May 2017

The PGC-1α-related coactivator promotes mitochondrial and myogenic adaptations in C2C12 myotubes.

scientific article

Understanding the acetylome: translating targeted proteomics into meaningful physiology

scientific article

Unraveling the complexities of SIRT1-mediated mitochondrial regulation in skeletal muscle.

scientific article published on July 2013

mTOR regulates peripheral nerve response to tensile strain.

scientific article published in March 2017

p300 is not required for metabolic adaptation to endurance exercise training.

scientific article published on 28 December 2015

List of works by Simon Schenk

A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange

A novel pathway of insulin sensitivity in chromogranin A null mice: a crucial role for pancreastatin in glucose homeostasis.

Acute glucoregulatory and vascular outcomes of three strategies for interrupting prolonged sitting time in postmenopausal women: A pilot, laboratory-based, randomized, controlled, 4-condition, 4-period crossover trial.

Acute inhibition of protein deacetylases does not impact skeletal muscle insulin action

Alterations in carbohydrate metabolism in response to short-term dietary carbohydrate restriction

Application of the [γ-32P] ATP kinase assay to study anabolic signaling in human skeletal muscle

AttenuatedPik3r1Expression Prevents Insulin Resistance and Adipose Tissue Macrophage Accumulation in Diet-Induced Obese Mice ⬇️

Ceramides contained in LDL are elevated in type 2 diabetes and promote inflammation and skeletal muscle insulin resistance

Coimmunoprecipitation of FAT/CD36 and CPT I in skeletal muscle increases proportionally with fat oxidation after endurance exercise training

Combined overexpression of SIRT1 and knockout of GCN5 in adult skeletal muscle does not affect glucose homeostasis or exercise performance in mice

Commentaries on viewpoint: does SIRT1 determine exercise-induced skeletal muscle mitochondrial biogenesis: differences between in vitro and in vivo experiments?

Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase.

Different glycemic indexes of breakfast cereals are not due to glucose entry into blood but to glucose removal by tissue ⬇️

Dried Plum Ingestion Increases the Osteoblastogenic Capacity of Human Serum.

Effects of dietary carbohydrate restriction with high protein intake on protein metabolism and the somatotropic axis

Energy deficit after exercise augments lipid mobilization but does not contribute to the exercise-induced increase in insulin sensitivity

Exercise and high-fat feeding remodel transcript-metabolite interactive networks in mouse skeletal muscle.

G protein-coupled receptor 21 deletion improves insulin sensitivity in diet-induced obese mice

Germline or inducible knockout of p300 or CBP in skeletal muscle does not alter insulin sensitivity

Heterogeneous muscle gene expression patterns in patients with massive rotator cuff tears

High fatty acid availability after exercise alters the regulation of muscle lipid metabolism

High-fat diet elevates resting intramuscular triglyceride concentration and whole body lipolysis during exercise ⬇️

High-fat diet-induced impairment of skeletal muscle insulin sensitivity is not prevented by SIRT1 overexpression

Histological Evidence of Muscle Degeneration in Advanced Human Rotator Cuff Disease.

Improved insulin sensitivity after weight loss and exercise training is mediated by a reduction in plasma fatty acid mobilization, not enhanced oxidative capacity

Increased adipocyte O2 consumption triggers HIF-1α, causing inflammation and insulin resistance in obesity

Inducible nitric oxide synthase deficiency in myeloid cells does not prevent diet-induced insulin resistance

Interaction between lipid availability,endurance exercise and insulin sensitivity

Is acetylation a metabolic rheostat that regulates skeletal muscle insulin action?

Knock-down of IL-1Ra in obese mice decreases liver inflammation and improves insulin sensitivity

Knockout of STAT3 in skeletal muscle does not prevent high-fat diet-induced insulin resistance

Manipulation of dietary carbohydrate and muscle glycogen affects glucose uptake during exercise when fat oxidation is impaired by beta-adrenergic blockade

Muscle architectural changes after massive human rotator cuff tear.

Muscle gene expression patterns in human rotator cuff pathology.

Muscle-specific knockout of general control of amino acid synthesis 5 (GCN5) does not enhance basal or endurance exercise-induced mitochondrial adaptation.

NAD+/NADH and skeletal muscle mitochondrial adaptations to exercise ⬇️

New opportunities and novel paradigms to support neuromuscular research.

Novel liver-specific TORC2 siRNA corrects hyperglycemia in rodent models of type 2 diabetes

Overload-mediated skeletal muscle hypertrophy is not impaired by loss of myofiber STAT3.

Perm1 enhances mitochondrial biogenesis, oxidative capacity, and fatigue resistance in adult skeletal muscle.

Postexercise insulin sensitivity is not impaired after an overnight lipid infusion

Rapamycin does not prevent increases in myofibrillar or mitochondrial protein synthesis following endurance exercise.

Regulation of plasma ceramide levels with fatty acid oversupply: evidence that the liver detects and secretes de novo synthesised ceramide.

Relatively low endogenous fatty acid mobilization and uptake helps preserve insulin sensitivity in obese women.

Role of the cytoskeleton in muscle transcriptional responses to altered use

SIRT1 regulates nuclear number and domain size in skeletal muscle fibers.

Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction

Sirtuin 1 (SIRT1) deacetylase activity is not required for mitochondrial biogenesis or peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) deacetylation following endurance exercise.

Skeletal muscle Nur77 expression enhances oxidative metabolism and substrate utilization

Skeletal muscle action of estrogen receptor α is critical for the maintenance of mitochondrial function and metabolic homeostasis in females

Skeletal muscle fiber-type specific succinate dehydrogenase activity in cerebral palsy

Skeletal muscle mitochondrial function and exercise capacity are not impaired in mice with knockout of STAT3

Skeletal muscle-specific overexpression of SIRT1 does not enhance whole-body energy expenditure or insulin sensitivity in young mice

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

Specific Sirt1 Activator-mediated Improvement in Glucose Homeostasis Requires Sirt1-Independent Activation of AMPK.

Temporal overexpression of SIRT1 in skeletal muscle of adult mice does not improve insulin sensitivity or markers of mitochondrial biogenesis.

The PGC-1α-related coactivator promotes mitochondrial and myogenic adaptations in C2C12 myotubes.

Understanding the acetylome: translating targeted proteomics into meaningful physiology

Unraveling the complexities of SIRT1-mediated mitochondrial regulation in skeletal muscle.

mTOR regulates peripheral nerve response to tensile strain.

p300 is not required for metabolic adaptation to endurance exercise training.