List of works - Nicholas J. Hawkins

A correlation of the endoscopic characteristics of colonic laterally spreading tumours with genetic alterations

scientific article published in March 2013

Activation of the K-ras oncogene in colorectal neoplasms is associated with decreased apoptosis

scientific article published on 01 March 1997

Adaptive Tutorials Versus Web-Based Resources in Radiology: A Mixed Methods Comparison of Efficacy and Student Engagement.

scientific article published on 17 August 2015

Adverse Prognostic Effect of Methylation in Colorectal Cancer Is Reversed by Microsatellite Instability

article

Altered promoter nucleosome positioning is an early event in gene silencing

scientific article

Antibody immunity to the HER-2/neu oncogenic protein in patients with colorectal cancer

scientific article published on 01 June 1999

Authors' reply

scientific article 2006

Biodistribution of filamentous phage-Fab in nude mice

scientific article

C-kit mutations in gastrointestinal stromal tumours

scientific article published in August 2002

CD103+ intraepithelial lymphocytes—a unique population in microsatellite unstable sporadic colorectal cancer

scientific article published on 01 March 2003

Characterisation and clinicopathological correlates of serum anti-p53 antibodies in breast and colon cancer

scientific article published on 01 January 1996

Checking the scoreboard: the impact of cancer genetics on clinical practice.

scientific article

Cohesin Rad21 Mediates Loss of Heterozygosity and Is Upregulated via Wnt Promoting Transcriptional Dysregulation in Gastrointestinal Tumors

scientific article published in December 2014

Colorectal carcinomas arising in the hyperplastic polyposis syndrome progress through the chromosomal instability pathway

scientific article published on August 2000

Cytokine-Mediated Induction of HLA Antigen Expression on Human Glomerular Mesangial Cells

scientific article 1994

Detection of K-ras point mutation by enriched PCR-colorimetric plate assay.

scientific article published on February 1997

Detection of allelic imbalance in MLH1 expression by pyrosequencing serves as a tool for the identification of germline defects in Lynch syndrome

scientific article published in September 2010

Developmentally-regulated expression of murine K-ras isoforms.

scientific article published in October 1997

Different APC genotypes in proximal and distal sporadic colorectal cancers suggest distinct WNT/β-catenin signalling thresholds for tumourigenesis.

scientific article published on 22 October 2012

Disruption of a -35 kb Enhancer Impairs CTCF Binding and Expression in Colorectal Cells

scientific article published on 13 June 2018

Does MSI-low exist?

scientific article

Epigenetic inactivation of a cluster of genes flanking MLH1 in microsatellite-unstable colorectal cancer

scientific article

Epigenetic inactivation of the candidate tumor suppressor USP44 is a frequent and early event in colorectal neoplasia

scientific article published on 16 May 2014

Evaluation of different lymphoid tissue sources for the construction of human immunoglobulin gene libraries

scientific article published on October 1997

Expression of the novel Wnt receptor ROR2 is increased in breast cancer and may regulate both β-catenin dependent and independent Wnt signalling.

scientific article published on 11 September 2014

Germline epimutations of APC are not associated with inherited colorectal polyposis

scientific article published on April 2006

Histopathological and clinical evaluation of serrated adenomas of the colon and rectum

scientific article published in May 2003

Immunohistochemistry for PMS2 and MSH6 alone can replace a four antibody panel for mismatch repair deficiency screening in colorectal adenocarcinoma

scientific article published on 01 January 2011

Impact of microsatellite testing and mismatch repair protein expression on the clinical interpretation of genetic testing in hereditary non-polyposis colorectal cancer

scientific article published on 18 July 2002

Implementation of novel pyrosequencing assays to screen for common mutations of BRAF and KRAS in a cohort of sporadic colorectal cancers

scientific article published on June 2009

Inactivation of p16INK4a by CpG hypermethylation is not a frequent event in colorectal cancer.

scientific article

Inheritance of a Cancer-AssociatedMLH1Germ-Line Epimutation

scientific article published on 01 February 2007

Institutional biobanking: an integral part of contemporary pathology practice

scientific article published on 01 January 2015

Introducing research initiatives into healthcare: what do doctors think?

scientific article published on April 2014

Kirsten ras mutations in patients with colorectal cancer: the 'RASCAL II' study

scientific article

Large-scale delineation of secreted protein biomarkers overexpressed in cancer tissue and serum

scientific article

MGMT methylation is associated primarily with the germline C>T SNP (rs16906252) in colorectal cancer and normal colonic mucosa

scientific article published on 4 September 2009

MLH1 Germline Epimutations as a Factor in Hereditary Nonpolyposis Colorectal Cancer

article

Methylation of the 3p22 region encompassing MLH1 is representative of the CpG island methylator phenotype in colorectal cancer.

scientific article

Microsatellite-stable diploid carcinoma: a biologically distinct and aggressive subset of sporadic colorectal cancer

scientific article published on January 2001

Molecular tumour clocks and colorectal cancer: seeing the unseen

scientific article

PIK3CA and PTEN gene and exon mutation-specific clinicopathologic and molecular associations in colorectal cancer

scientific article published on 30 April 2013

Poor-prognosis estrogen receptor-positive breast cancer identified by histopathologic subclassification

scientific article

Population-based molecular screening for Lynch syndrome: implications for personalized medicine

scientific article

Progress in gastrointestinal pathology in the genetic era

scientific article published in December 2002

Prohibitin expression is associated with high grade breast cancer but is not a driver of amplification at 17q21.33.

scientific article published on December 2013

RAD21 cohesin overexpression is a prognostic and predictive marker exacerbating poor prognosis in KRAS mutant colorectal carcinomas.

scientific article published on 18 February 2014

Regulation and expression of human Fabs under the control of the Escherichia coli arabinose promoter, PBAD

scientific article published on 01 October 1997

Relative Distribution of Folate Species Is Associated with Global DNA Methylation in Human Colorectal Mucosa

article

Retrieval of human antibodies from phage-display libraries using enzymatic cleavage

scientific article published on January 1996

Routine testing for mismatch repair deficiency in sporadic colorectal cancer is justified

article

SMAD2, SMAD3 and SMAD4 mutations in colorectal cancer

scientific article

Serrated and non-serrated polyps of the colorectum: their prevalence in an unselected case series and correlation of BRAF mutation analysis with the diagnosis of sessile serrated adenoma.

scientific article

Single nucleotide polymorphism array profiling identifies distinct chromosomal aberration patterns across colorectal adenomas and carcinomas.

scientific article

Survival in stage II/III colorectal cancer is independently predicted by chromosomal and microsatellite instability, but not by specific driver mutations

scientific article published on 17 September 2013

The CpG Island Methylator Phenotype Is Not Associated with a Personal or Family History of Cancer

article

The Role of hMLH1 Methylation in the Development of Synchronous Sporadic Colorectal Carcinomas

article

The relationship between hypomethylation and CpG island methylation in colorectal neoplasia

scientific article published on April 2003

Tolerance of whole-genome doubling propagates chromosomal instability and accelerates cancer genome evolution.

scientific article

Unconjugated antibodies for cancer therapy: lessons from the clinic.

scientific article published on September 1997

Wild-type APC predicts poor prognosis in microsatellite-stable proximal colon cancer

scientific article

List of works by Nicholas J. Hawkins

A correlation of the endoscopic characteristics of colonic laterally spreading tumours with genetic alterations

Activation of the K-ras oncogene in colorectal neoplasms is associated with decreased apoptosis

Adaptive Tutorials Versus Web-Based Resources in Radiology: A Mixed Methods Comparison of Efficacy and Student Engagement.

Adverse Prognostic Effect of Methylation in Colorectal Cancer Is Reversed by Microsatellite Instability

Altered promoter nucleosome positioning is an early event in gene silencing

Antibody immunity to the HER-2/neu oncogenic protein in patients with colorectal cancer

Authors' reply

Biodistribution of filamentous phage-Fab in nude mice

C-kit mutations in gastrointestinal stromal tumours

CD103+ intraepithelial lymphocytes—a unique population in microsatellite unstable sporadic colorectal cancer

Characterisation and clinicopathological correlates of serum anti-p53 antibodies in breast and colon cancer

Checking the scoreboard: the impact of cancer genetics on clinical practice.

Cohesin Rad21 Mediates Loss of Heterozygosity and Is Upregulated via Wnt Promoting Transcriptional Dysregulation in Gastrointestinal Tumors

Colorectal carcinomas arising in the hyperplastic polyposis syndrome progress through the chromosomal instability pathway

Cytokine-Mediated Induction of HLA Antigen Expression on Human Glomerular Mesangial Cells

Detection of K-ras point mutation by enriched PCR-colorimetric plate assay.

Detection of allelic imbalance in MLH1 expression by pyrosequencing serves as a tool for the identification of germline defects in Lynch syndrome

Developmentally-regulated expression of murine K-ras isoforms.

Different APC genotypes in proximal and distal sporadic colorectal cancers suggest distinct WNT/β-catenin signalling thresholds for tumourigenesis.

Disruption of a -35 kb Enhancer Impairs CTCF Binding and Expression in Colorectal Cells

Does MSI-low exist?

Epigenetic inactivation of a cluster of genes flanking MLH1 in microsatellite-unstable colorectal cancer

Epigenetic inactivation of the candidate tumor suppressor USP44 is a frequent and early event in colorectal neoplasia

Evaluation of different lymphoid tissue sources for the construction of human immunoglobulin gene libraries

Expression of the novel Wnt receptor ROR2 is increased in breast cancer and may regulate both β-catenin dependent and independent Wnt signalling.

Germline epimutations of APC are not associated with inherited colorectal polyposis

Histopathological and clinical evaluation of serrated adenomas of the colon and rectum

Immunohistochemistry for PMS2 and MSH6 alone can replace a four antibody panel for mismatch repair deficiency screening in colorectal adenocarcinoma

Impact of microsatellite testing and mismatch repair protein expression on the clinical interpretation of genetic testing in hereditary non-polyposis colorectal cancer

Implementation of novel pyrosequencing assays to screen for common mutations of BRAF and KRAS in a cohort of sporadic colorectal cancers

Inactivation of p16INK4a by CpG hypermethylation is not a frequent event in colorectal cancer.

Inheritance of a Cancer-AssociatedMLH1Germ-Line Epimutation

Institutional biobanking: an integral part of contemporary pathology practice

Introducing research initiatives into healthcare: what do doctors think?

Kirsten ras mutations in patients with colorectal cancer: the 'RASCAL II' study

Large-scale delineation of secreted protein biomarkers overexpressed in cancer tissue and serum

MGMT methylation is associated primarily with the germline C>T SNP (rs16906252) in colorectal cancer and normal colonic mucosa

MLH1 Germline Epimutations as a Factor in Hereditary Nonpolyposis Colorectal Cancer

Methylation of the 3p22 region encompassing MLH1 is representative of the CpG island methylator phenotype in colorectal cancer.

Microsatellite-stable diploid carcinoma: a biologically distinct and aggressive subset of sporadic colorectal cancer

Molecular tumour clocks and colorectal cancer: seeing the unseen

PIK3CA and PTEN gene and exon mutation-specific clinicopathologic and molecular associations in colorectal cancer

Poor-prognosis estrogen receptor-positive breast cancer identified by histopathologic subclassification

Population-based molecular screening for Lynch syndrome: implications for personalized medicine

Progress in gastrointestinal pathology in the genetic era

Prohibitin expression is associated with high grade breast cancer but is not a driver of amplification at 17q21.33.

RAD21 cohesin overexpression is a prognostic and predictive marker exacerbating poor prognosis in KRAS mutant colorectal carcinomas.

Regulation and expression of human Fabs under the control of the Escherichia coli arabinose promoter, PBAD

Relative Distribution of Folate Species Is Associated with Global DNA Methylation in Human Colorectal Mucosa

Retrieval of human antibodies from phage-display libraries using enzymatic cleavage

Routine testing for mismatch repair deficiency in sporadic colorectal cancer is justified

SMAD2, SMAD3 and SMAD4 mutations in colorectal cancer

Serrated and non-serrated polyps of the colorectum: their prevalence in an unselected case series and correlation of BRAF mutation analysis with the diagnosis of sessile serrated adenoma.

Single nucleotide polymorphism array profiling identifies distinct chromosomal aberration patterns across colorectal adenomas and carcinomas.

Survival in stage II/III colorectal cancer is independently predicted by chromosomal and microsatellite instability, but not by specific driver mutations

The CpG Island Methylator Phenotype Is Not Associated with a Personal or Family History of Cancer

The Role of hMLH1 Methylation in the Development of Synchronous Sporadic Colorectal Carcinomas

The relationship between hypomethylation and CpG island methylation in colorectal neoplasia

Tolerance of whole-genome doubling propagates chromosomal instability and accelerates cancer genome evolution.

Unconjugated antibodies for cancer therapy: lessons from the clinic.

Wild-type APC predicts poor prognosis in microsatellite-stable proximal colon cancer