Search filters

List of works by Xavier Lucas

3-Fluoro-4-hydroxyprolines: Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation

scientific article published on 12 July 2018

4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1)

scientific article

4-Acyl Pyrroles as Dual BET-BRD7/9 Bromodomain Inhibitors Address BETi Insensitive Human Cancer Cell Lines

scientific article published on 04 December 2020

4-Acyl pyrroles: mimicking acetylated lysines in histone code reading

scientific article

A thorough anion–π interaction study in biomolecules: on the importance of cooperativity effects† †Electronic supplementary information (ESI) available: Fig. 1 and 2, Tables 1–24 and all interactions. See DOI: 10.1039/c5sc01386k.

scientific article published on 5 June 2015

Beyond the BET Family: Targeting CBP/p300 with 4-Acyl Pyrroles.

scientific article published on 2 August 2017

ChemicalToolBoX and its application on the study of the drug like and purchasable space.

scientific article published on 11 March 2014

Counterintuitive substituent effect of the ethynyl group in ion-pi interactions

scientific article published in September 2009

Development and Benchmarking of Open Force Field v1.0.0—the Parsley Small-Molecule Force Field

scientific article published on 22 September 2021

Discovery of the inhibitory effect of a phosphatidylinositol derivative on P-glycoprotein by virtual screening followed by in vitro cellular studies

scientific article

Hidden Specificities in Enzyme Catalysis: Structural Basis of Substrate Structure-Selectivity Relationship of a Ketoreductase

scientific article published on 01 March 2019

Metabolic pathway monitoring of phenalinolactone biosynthesis from Streptomyces sp. Tü6071 by liquid chromatography/mass spectrometry coupling

scientific article published on 01 July 2014

Preparation data of the bromodomains BRD3(1), BRD3(2), BRD4(1), and BRPF1B and crystallization of BRD4(1)-inhibitor complexes.

scientific article

Recognition of substrate degrons by E3 ubiquitin ligases and modulation by small-molecule mimicry strategies.

scientific article published on 25 January 2017

StreptomeDB 2.0--an extended resource of natural products produced by streptomycetes

scientific article

StreptomeDB: a resource for natural compounds isolated from Streptomyces species

scientific article

Structural basis of PROTAC cooperative recognition for selective protein degradation

scientific article

Structural basis of molecular recognition of helical histone H3 tail by PHD finger domains.

scientific article

Structure-Based Design of a Macrocyclic PROTAC

scientific article published on 12 December 2019

Substituent effects in ion-pi interactions: fine-tuning via the ethynyl group

scientific article published on 01 February 2010

Surface Probing by Fragment-Based Screening and Computational Methods Identifies Ligandable Pockets on the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase

scholarly article by Xavier Lucas et al published 23 August 2018 in Journal of Medicinal Chemistry

Target Fishing by Cross-Docking to Explain Polypharmacological Effects

Targeting Ligandable Pockets on Plant Homeodomain (PHD) Zinc Finger Domains by a Fragment-Based Approach.

scientific article published on 12 March 2018

Targeting the BET family for the treatment of leukemia

scientific article published on 01 April 2014

Targeting xanthine oxidase by natural products as a therapeutic approach for mental disorders

scientific article published on 21 June 2020

The ChemicalToolbox: reproducible, user-friendly cheminformatics analysis on the Galaxy platform

scientific article published in June 2020

The Role of the Ethynyl Substituent on the π–π Stacking Affinity of Benzene: A Theoretical Study ⬇️

scientific article published on December 22, 2010

The purchasable chemical space: a detailed picture.

scientific article published on 30 April 2015

Thioamide substitution to probe the hydroxyproline recognition of VHL ligands.

scientific article published on 23 March 2018

Using chiral molecules as an approach to address low-druggability recognition sites.

scientific article

Very Long-Range Effects: Cooperativity between Anion-π and Hydrogen-Bonding Interactions

scientific article published on 01 September 2009

Paulina is supported by:

About Paulina

Help