List of works - Alan Boobis

4-Aminobiphenyl and DNA reactivity: case study within the context of the 2006 IPCS Human Relevance Framework for Analysis of a cancer mode of action for humans.

scientific article published on November 2006

A data-based assessment of alternative strategies for identification of potential human cancer hazards

scientific article

A sensitive and robust method for the determination of alkylphenol polyethoxylates and their carboxylic acids and their transformation in a trickling filter wastewater treatment plant

article

A strategy for investigating the CYP superfamily using targeted antibodies is a paradigm for functional genomic studies.

scientific article published on December 2003

Adduction of the chloroform metabolite phosgene to lysine residues of human histone H2B.

scientific article

Adducts of the chloroform metabolite phosgene

scientific article published in January 2001

Affinity and potency of proinhibitory antipeptide antibodies against CYP2D6 is enhanced using cyclic peptides as immunogens

scientific article published on 01 May 2000

Agricultural chemical safety assessment: A multisector approach to the modernization of human safety requirements.

scientific article

Alternative (non-animal) methods for cosmetics testing: current status and future prospects-2010.

scientific article

An assessment of human liver-derived in vitro systems to predict the in vivo metabolism and clearance of almokalant

scientific article published in May 2001

An inhibitory monoclonal anti-protein antibody and an anti-peptide antibody share an epitope on rat cytochrome P-450 enzymes CYP1A1 and CYP1A2.

scientific article published in January 1993

Analysis of the N-(deoxyguanosin-8-yl) adduct of the food derived carcinogen PhIP using capillary electrophoresis

scientific article published on 01 February 1997

Application of the TTC concept to unknown substances found in analysis of foods

scientific article published on 30 March 2011

Approaches to carcinogenic risk assessment for polycyclic aromatic hydrocarbons: a UK perspective

scientific article

Assay of caffeine metabolism in vitro by human liver microsomes using radio-high-performance liquid chromatography

scientific article published on 01 January 1990

Assessment of P450 induction in the marmoset monkey using targeted anti-peptide antibodies

scientific article published in March 2001

Assessment of uncertainty in a probabilistic model of consumer exposure to pesticide residues in food.

scientific article published in June 2006

BRAFO tiered approach for benefit–risk assessment of foods

scientific article published on 28 May 2010

Benchmark dose (BMD) modeling: current practice, issues, and challenges.

scientific article published on 8 March 2018

Bosentan decreases the plasma concentration of sildenafil when coprescribed in pulmonary hypertension

scientific article published in July 2005

C-terminal antibodies (CTAbs): a simple and broadly applicable approach for the rapid generation of protein-specific antibodies with predefined specificity

scientific article

CYP3A7 protein expression is high in a fraction of adult human livers and partially associated with the CYP3A7*1C allele

scientific article published in September 2005

Cancer Research UK procedures in manufacture and toxicology of radiotracers intended for pre-phase I positron emission tomography studies in cancer patients.

scientific article published on April 2002

Carbamazepine: a 'blind' assessment of CVP-associated metabolism and interactions in human liver-derived in vitro systems

scientific article published in June 2001

Chemical carcinogenicity revisited 3: Risk assessment of carcinogenic potential based on the current state of knowledge of carcinogenesis in humans

scientific article published on 08 January 2019

Combined assay for phenacetin and paracetamol in plasma using capillary column gas chromatography—negative-ion mass spectrometry ⬇️

scientific article published on August 23, 1991

Comparative analysis of CYP3A expression in human liver suggests only a minor role for CYP3A5 in drug metabolism

scientific article published in June 2003

Comparative studies on the cytochrome p450-associated metabolism and interaction potential of selegiline between human liver-derived in vitro systems

scientific article published in September 2003

Comparison of the in vivo and in vitro rates of formation of the three main oxidative metabolites of antipyrine in man ⬇️

scientific article published on December 1, 1981

Considering new methodologies in strategies for safety assessment of foods and food ingredients

scientific article

Critical analysis of literature on low-dose synergy for use in screening chemical mixtures for risk assessment

scientific article published on 10 February 2011

Critical appraisal of the assessment of benefits and risks for foods, 'BRAFO Consensus Working Group'

scientific article published on 02 November 2012

Cross-reaction of antibodies to coupling groups used in the production of anti-peptide antibodies

scientific article

Cruciferous vegetable consumption alters the metabolism of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in humans

scientific article published on 8 April 2004

Cumulative risk assessment of pesticide residues in food.

scientific article published on 08 June 2008

Current knowledge and recent developments in consumer exposure assessment of pesticides: a UK perspective.

scientific article

Cytochrome P450 3A expression in the human fetal liver: evidence that CYP3A5 is expressed in only a limited number of fetal livers

scientific article published on 01 January 2001

Cytochrome P450 expression in human hepatocytes and hepatoma cell lines: molecular mechanisms that determine lower expression in cultured cells

scientific article published in June 2002

Defective Spermatogenesis: Martin et al. Respond.

scientific article

Determination of a human hepatic microsomal scaling factor for predicting in vivo drug clearance

scientific article published on 28 February 2006

Determination of steroid estrogens in wastewater by high performance liquid chromatography-tandem mass spectrometry

scientific article published on 10 October 2007

Development of a comprehensive panel of antibodies against the major xenobiotic metabolising forms of cytochrome P450 in humans

scientific article published on 01 August 1998

Developmental changes in hepatic activation of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in rabbit

scientific article published in March 1996

Diazinon is activated by CYP2C19 in human liver

scientific article published in November 2001

Differential expression of cytochrome P450 enzymes in cultured and intact foetal rat ventral mesencephalon

scientific article

Differential induction of antipyrine metabolism by rifampicin.

scientific article

Differential maintenance of cytochrome P450 enzymes in cultured precision-cut human liver slices

scientific article published on 01 October 2000

Dissociation of neutrophil emigration and metabolic activity in lobar pneumonia and bronchiectasis

scientific article published on 01 April 1997

Distribution and induction of CYP3A1 and CYP3A2 in rat liver and extrahepatic tissues

scientific article published on 01 December 1995

Drug interactions

scientific article published on 01 January 2009

Drug oxidation in Asian vegetarians

scientific article

Effect of cruciferous vegetable consumption on heterocyclic aromatic amine metabolism in man.

scientific article

Effect of washing the hepatic microsomal fraction in sucrose solutions and in sucrose solution containing EDTA upon the metabolism of foreign compounds

scientific article published on 01 October 1975

Effects of pharmaceuticals and other active chemicals at biological targets: mechanisms, interactions, and integration into PB-PK/PD models.

scientific article published on July 2009

Elucidation of toxicity pathways in lung epithelial cells induced by silicon dioxide nanoparticles

scientific article

Establishing the level of safety concern for chemicals in food without the need for toxicity testing.

scientific article published on 5 September 2013

Evaluation of the utility of the lifetime mouse bioassay in the identification of cancer hazards for humans

scientific article published on 15 August 2013

Evidence for a direct role of intracellular calcium in paracetamol toxicity

scientific article published on 01 April 1990

Evidence for nitric oxide participation in down-regulation of CYP2B1/2 gene expression at the pretranslational level

scientific article published on 01 February 1997

Exposure to and activation of dietary heterocyclic amines in humans.

scientific article published on November 1995

Expression and distribution of CYP2C enzymes in rat basal ganglia.

scientific article

Expression and localization of CYP3A4 and CYP3A5 in human lung

scientific article

Expression of CYP1A1, CYP1B1 and CYP3A, and polycyclic aromatic hydrocarbon-DNA adduct formation in bronchoalveolar macrophages of smokers and non-smokers

scientific article published on 01 June 2000

Expression of CYP3A4 in human breast tumour and non-tumour tissues

scientific article

Expression of cytochromes P450 3A and P-glycoprotein in human large intestine in paired tumour and normal samples

scientific article published on 01 April 2007

Expression of xenobiotic-metabolizing cytochrome P450 forms in human full-term placenta

scientific article

Expression of xenobiotic-metabolizing cytochrome P450s in human pulmonary tissues

scientific article published on 01 January 1998

Fate and occurrence of alkylphenolic compounds in sewage sludges determined by liquid chromatography tandem mass spectrometry.

scientific article published in December 2009

Food and Chemical Toxicology publishes papers that further scientific understanding of issues of public concern

scientific article published on 25 January 2010

Food-derived heterocyclic amine mutagens: variable metabolism and significance to humans

scientific article published on 01 April 2001

Genetic analysis of PHIP intestinal mutations in MutaMouse

scientific article published on 01 November 1998

Genetic and other sources of variation in the activity of serum paraoxonase/diazoxonase in humans: consequences for risk from exposure to diazinon

scientific article published in January 2005

Genetic polymorphism in drug oxidation: in vitro studies of human debrisoquine 4-hydroxylase and bufuralol 1'-hydroxylase activities

scientific article published on 01 January 1985

Global food supply. Reevaluate pesticides for food security and safety.

scientific article published in August 2013

Guidance for the classification of carcinogens under the Globally Harmonised System of Classification and Labelling of Chemicals (GHS).

scientific article published on March 2010

High affinity phenacetin O-deethylase is catalysed specifically by cytochrome P450d (P450IA2) in the liver of the rat

scientific article published on 01 February 1990

Human health and endocrine disruption: a simple multicriteria framework for the qualitative assessment of end point specific risks in a context of scientific uncertainty.

scientific article published on 25 January 2007

Human risk assessment of heavy metals: principles and applications.

scientific article published in January 2011

IPCS framework for analyzing the relevance of a cancer mode of action for humans.

scientific article published in November 2006

IPCS framework for analyzing the relevance of a noncancer mode of action for humans

scientific article from 2008

Identification of the epitope of a monoclonal antibody which binds to several cytochromes P450 in the CYP1A subfamily

scientific article published in April 1992

Identification of the epitope of an anti-peptide antibody which binds to CYP1A2 in many species including man

scientific article published on 01 July 1993

Immunohistochemical demonstration of the expression of CYP2E1 in human breast tumour and non-tumour tissues

scientific article published on 01 July 2003

Immunohistochemical localization of cytochrome P450b/e in hepatic and extrahepatic tissues of the rat

scientific article published on 01 October 1989

Immunopurification of cytochrome P-448 from microsomal fractions of rabbit liver with retention of metabolic activity

scientific article published on 01 May 1982

In vitro prediction of gastrointestinal absorption and bioavailability: an experts' meeting report.

scientific article

Increased expression of histone proteins during estrogen-mediated cell proliferation

scientific article published on 7 February 2009

Induction of aryl hydrocarbon (benzo[a]pyrene) hydroxylase and 2-acetylaminofluorene N-hydroxylase by polycyclic hydrocarbons in regenerating liver from inbred strains of mice

scientific article published on 01 August 1977

Induction of cytochrome P450 enzymes in cultured precision-cut human liver slices

scientific article published in March 2003

Influence of operating parameters on the biodegradation of steroid estrogens and nonylphenolic compounds during biological wastewater treatment processes

scientific article published in September 2009

Interindividual variability in metabolic activation in humans in vivo

scientific article

Interlaboratory comparison of the assessment of P450 activities in human hepatic microsomal samples

scientific article published in May 1998

Interpretation of the margin of exposure for genotoxic carcinogens – Elicitation of expert knowledge about the form of the dose response curve at human relevant exposures

article

Is the activation of aflatoxin B1 catalysed by the same form of cytochrome P-450 as that 4-hydroxylating debrisoquine in rat and/or man?

scientific article published in February 1986

Kinetics of lung macrophages monitored in vivo following particulate challenge in rabbits

scientific article published on 01 August 2002

Local kinetics and dynamics of xenobiotics

scientific article published on 01 January 2008

Managing the challenge of chemically reactive metabolites in drug development.

scientific article published on April 2011

Mass spectrometric detection and measurement of N2-(2'-deoxyguanosin-8-yl)PhIP adducts in DNA.

scientific article

Mechanisms of cell toxicity.

scientific article published on April 1990

Meta-analysis of studies of alcohol and breast cancer with consideration of the methodological issues

scientific article published in August 2006

Mode of action in relevance of rodent liver tumors to human cancer risk.

scientific article published on 12 October 2005

Molecular approaches to the identification of biomarkers of exposure and effect--report of an expert meeting organized by COST Action B15. November 28, 2003.

scientific article

Molecular basis for differences in susceptibility to toxicants: introduction.

scientific article published on December 1992

Monoclonal antibodies to rabbit liver cytochrome P-448 ⬇️

scientific article published on 01 October 1981

Mutational spectra of the dietary carcinogen 2-amino-1-methyl-6- phenylimidazo[4,5-b]pyridine(PhIP) at the Chinese hamsters hprt locus.

scientific article

New developments in the evolution and application of the WHO/IPCS framework on mode of action/species concordance analysis.

scientific article published on 25 October 2013

Paracetamol metabolism, hepatotoxicity, biomarkers and therapeutic interventions: a perspective

scientific article published on 06 March 2018

Paracetamol toxicity in hamster isolated hepatocytes: the increase in cytosolic calcium accompanies, rather than precedes, loss of viability

scientific article published on 01 January 1992

Physiologically-based Kinetic Modelling (PBK Modelling): meeting the 3Rs agenda. The report and recommendations of ECVAM Workshop 63

scientific article published on 01 December 2007

Polymorphic debrisoquine 4-hydroxylase activity in the rat is due to differences in CYP2D2 expression

scientific article published on 01 June 1999

Polymorphisms in the cytochrome P450 CYP1A2 gene (CYP1A2) in colorectal cancer patients and controls: allele frequencies, linkage disequilibrium and influence on caffeine metabolism.

scientific article published on January 2003

Positron emission tomography in the quantification of cellular and biochemical responses to intrapulmonary particulates.

scientific article

Proteomic analysis of human breast cell lines using SELDI-TOF MS shows that mixtures of estrogenic compounds exhibit simple similar action (concentration additivity).

scientific article

Pulmonary fibrosis correlates with duration of tissue neutrophil activation

scientific article published in August 1998

Re: Guyton, Kathryn Z., Barone, Stanley, Jr., Brown, Rebecca C., Euling, Susan Y., Jinot, Jennifer, Makris, Susan (2008). Mode of action frameworks: a critical analysis. Journal of Toxicology and Environmental Health, Part B, 11(1): 16-31

scientific article published on 01 October 2008

Risk assessment of combined exposure to multiple chemicals: A WHO/IPCS framework

scientific article published on 02 April 2011

Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: reaching a consensus on values of human microsomal protein and hepatocellularity per gram of liver.

scientific article

Selection of appropriate tumour data sets for Benchmark Dose Modelling (BMD) and derivation of a Margin of Exposure (MoE) for substances that are genotoxic and carcinogenic: considerations of biological relevance of tumour type, data quality and unc

scientific article

Selective localisation of P450 enzymes and NADPH-P450 oxidoreductase in rat basal ganglia using anti-peptide antisera

scientific article published on December 1996

Short synthetic peptides exploited for reliable and specific targeting of antibodies to the C-termini of cytochrome P450 enzymes.

scientific article

Species differences in the hepatic formation of green pigments following the administration of norethindrone.

scientific article

Species differences in the substrate specificity of hepatic cytochrome P-448 from polycyclic hydrocarbon-treated animals.

scientific article published on January 1979

Specific inhibition of human CYP1A2 using a targeted antibody

scientific article published on 01 July 1997

Stereoselective excretion of (3-methoxy-4-sulphooxyphenyl)ethylene glycol (MHPG sulphate) in the dog.

scientific article published on October 1980

Systems toxicology: from basic research to risk assessment

scientific article published on 21 January 2014

Testicular dysgenesis syndrome and the estrogen hypothesis: a quantitative meta-analysis

scientific article

Testicular dysgenesis syndrome and the estrogen hypothesis: a quantitative meta-analysis

scientific article published on 01 September 2008

The cardiac effects of terfenadine after inhibition of its metabolism by grapefruit juice

scientific article published on 01 January 1997

The effects of catecholamines upon the metabolism of foreign compounds and upon the distribution of perfusate in the isolated liver of the rat.

scientific article

The food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine activates S-phase checkpoint and apoptosis, and induces gene mutation in human lymphoblastoid TK6 cells

scientific article

The inducibility and catalytic activity of cytochromes P450c (P450IA1) and P450d (P450IA2) in rat tissues

scientific article published on 01 February 1990

The mutagenicity of benzo[a]pyrene in mouse small intestine.

scientific article published in January 1999

The new normal chemical landscape: the future of risk assessment toward optimum consumer safety

scientific article published in March 2024

The significance of sample mass in the analysis of steroid estrogens in sewage sludges and the derivation of partition coefficients in wastewaters.

scientific article published on 15 April 2009

Thiazopyr and thyroid disruption: case study within the context of the 2006 IPCS Human Relevance Framework for analysis of a cancer mode of action.

scientific article published on November 2006

Treatment and removal strategies for estrogens from wastewater.

scientific article published on March 2008

Urinary N2-(2'-deoxyguanosin-8-yl)PhIP as a biomarker for PhIP exposure

scientific article published on 23 January 2004

Using mode of action information to improve regulatory decision-making: an ECETOC/ILSI RF/HESI workshop overview.

scientific article published on March 2011

List of works by Alan Boobis

4-Aminobiphenyl and DNA reactivity: case study within the context of the 2006 IPCS Human Relevance Framework for Analysis of a cancer mode of action for humans.

A data-based assessment of alternative strategies for identification of potential human cancer hazards

A sensitive and robust method for the determination of alkylphenol polyethoxylates and their carboxylic acids and their transformation in a trickling filter wastewater treatment plant

A strategy for investigating the CYP superfamily using targeted antibodies is a paradigm for functional genomic studies.

Adduction of the chloroform metabolite phosgene to lysine residues of human histone H2B.

Adducts of the chloroform metabolite phosgene

Affinity and potency of proinhibitory antipeptide antibodies against CYP2D6 is enhanced using cyclic peptides as immunogens

Agricultural chemical safety assessment: A multisector approach to the modernization of human safety requirements.

Alternative (non-animal) methods for cosmetics testing: current status and future prospects-2010.

An assessment of human liver-derived in vitro systems to predict the in vivo metabolism and clearance of almokalant

An inhibitory monoclonal anti-protein antibody and an anti-peptide antibody share an epitope on rat cytochrome P-450 enzymes CYP1A1 and CYP1A2.

Analysis of the N-(deoxyguanosin-8-yl) adduct of the food derived carcinogen PhIP using capillary electrophoresis

Application of the TTC concept to unknown substances found in analysis of foods

Approaches to carcinogenic risk assessment for polycyclic aromatic hydrocarbons: a UK perspective

Assay of caffeine metabolism in vitro by human liver microsomes using radio-high-performance liquid chromatography

Assessment of P450 induction in the marmoset monkey using targeted anti-peptide antibodies

Assessment of uncertainty in a probabilistic model of consumer exposure to pesticide residues in food.

BRAFO tiered approach for benefit–risk assessment of foods

Benchmark dose (BMD) modeling: current practice, issues, and challenges.

Bosentan decreases the plasma concentration of sildenafil when coprescribed in pulmonary hypertension

C-terminal antibodies (CTAbs): a simple and broadly applicable approach for the rapid generation of protein-specific antibodies with predefined specificity

CYP3A7 protein expression is high in a fraction of adult human livers and partially associated with the CYP3A7*1C allele

Cancer Research UK procedures in manufacture and toxicology of radiotracers intended for pre-phase I positron emission tomography studies in cancer patients.

Carbamazepine: a 'blind' assessment of CVP-associated metabolism and interactions in human liver-derived in vitro systems

Chemical carcinogenicity revisited 3: Risk assessment of carcinogenic potential based on the current state of knowledge of carcinogenesis in humans

Combined assay for phenacetin and paracetamol in plasma using capillary column gas chromatography—negative-ion mass spectrometry ⬇️

Comparative analysis of CYP3A expression in human liver suggests only a minor role for CYP3A5 in drug metabolism

Comparative studies on the cytochrome p450-associated metabolism and interaction potential of selegiline between human liver-derived in vitro systems

Comparison of the in vivo and in vitro rates of formation of the three main oxidative metabolites of antipyrine in man ⬇️

Considering new methodologies in strategies for safety assessment of foods and food ingredients

Critical analysis of literature on low-dose synergy for use in screening chemical mixtures for risk assessment

Critical appraisal of the assessment of benefits and risks for foods, 'BRAFO Consensus Working Group'

Cross-reaction of antibodies to coupling groups used in the production of anti-peptide antibodies

Cruciferous vegetable consumption alters the metabolism of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in humans

Cumulative risk assessment of pesticide residues in food.

Current knowledge and recent developments in consumer exposure assessment of pesticides: a UK perspective.

Cytochrome P450 3A expression in the human fetal liver: evidence that CYP3A5 is expressed in only a limited number of fetal livers

Cytochrome P450 expression in human hepatocytes and hepatoma cell lines: molecular mechanisms that determine lower expression in cultured cells

Defective Spermatogenesis: Martin et al. Respond.

Determination of a human hepatic microsomal scaling factor for predicting in vivo drug clearance

Determination of steroid estrogens in wastewater by high performance liquid chromatography-tandem mass spectrometry

Development of a comprehensive panel of antibodies against the major xenobiotic metabolising forms of cytochrome P450 in humans

Developmental changes in hepatic activation of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in rabbit

Diazinon is activated by CYP2C19 in human liver

Differential expression of cytochrome P450 enzymes in cultured and intact foetal rat ventral mesencephalon

Differential induction of antipyrine metabolism by rifampicin.

Differential maintenance of cytochrome P450 enzymes in cultured precision-cut human liver slices

Dissociation of neutrophil emigration and metabolic activity in lobar pneumonia and bronchiectasis

Distribution and induction of CYP3A1 and CYP3A2 in rat liver and extrahepatic tissues

Drug interactions

Drug oxidation in Asian vegetarians

Effect of cruciferous vegetable consumption on heterocyclic aromatic amine metabolism in man.

Effect of washing the hepatic microsomal fraction in sucrose solutions and in sucrose solution containing EDTA upon the metabolism of foreign compounds

Effects of pharmaceuticals and other active chemicals at biological targets: mechanisms, interactions, and integration into PB-PK/PD models.

Elucidation of toxicity pathways in lung epithelial cells induced by silicon dioxide nanoparticles

Establishing the level of safety concern for chemicals in food without the need for toxicity testing.

Evaluation of the utility of the lifetime mouse bioassay in the identification of cancer hazards for humans

Evidence for a direct role of intracellular calcium in paracetamol toxicity

Evidence for nitric oxide participation in down-regulation of CYP2B1/2 gene expression at the pretranslational level

Exposure to and activation of dietary heterocyclic amines in humans.

Expression and distribution of CYP2C enzymes in rat basal ganglia.

Expression and localization of CYP3A4 and CYP3A5 in human lung

Expression of CYP1A1, CYP1B1 and CYP3A, and polycyclic aromatic hydrocarbon-DNA adduct formation in bronchoalveolar macrophages of smokers and non-smokers

Expression of CYP3A4 in human breast tumour and non-tumour tissues

Expression of cytochromes P450 3A and P-glycoprotein in human large intestine in paired tumour and normal samples

Expression of xenobiotic-metabolizing cytochrome P450 forms in human full-term placenta

Expression of xenobiotic-metabolizing cytochrome P450s in human pulmonary tissues

Fate and occurrence of alkylphenolic compounds in sewage sludges determined by liquid chromatography tandem mass spectrometry.

Food and Chemical Toxicology publishes papers that further scientific understanding of issues of public concern

Food-derived heterocyclic amine mutagens: variable metabolism and significance to humans

Genetic analysis of PHIP intestinal mutations in MutaMouse

Genetic and other sources of variation in the activity of serum paraoxonase/diazoxonase in humans: consequences for risk from exposure to diazinon

Genetic polymorphism in drug oxidation: in vitro studies of human debrisoquine 4-hydroxylase and bufuralol 1'-hydroxylase activities

Global food supply. Reevaluate pesticides for food security and safety.

Guidance for the classification of carcinogens under the Globally Harmonised System of Classification and Labelling of Chemicals (GHS).

High affinity phenacetin O-deethylase is catalysed specifically by cytochrome P450d (P450IA2) in the liver of the rat

Human health and endocrine disruption: a simple multicriteria framework for the qualitative assessment of end point specific risks in a context of scientific uncertainty.

Human risk assessment of heavy metals: principles and applications.

IPCS framework for analyzing the relevance of a cancer mode of action for humans.