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List of works by Ulrich Brandt

'CO2-ligated' cytochrome c oxidase: characterization and comparison with the Cl- -ligated enzyme

scientific article

5-Hydroxydecanoate is metabolised in mitochondria and creates a rate-limiting bottleneck for beta-oxidation of fatty acids

scientific article published on 28 October 2004

A Common Mechanism Links Differently Acting Complex II Inhibitors to Cardioprotection: Modulation of Mitochondrial Reactive Oxygen Species Production

article

A central functional role for the 49-kDa subunit within the catalytic core of mitochondrial complex I.

scientific article

A high-definition native polyacrylamide gel electrophoresis system for the analysis of membrane complexes

scientific article

A salvage pathway maintains highly functional respiratory complex I

scientific article published on 02 April 2020

A scaffold of accessory subunits links the peripheral arm and the distal proton-pumping module of mitochondrial complex I ⬇️

scientific article published on July 15, 2011

A single external enzyme confers alternative NADH:ubiquinone oxidoreductase activity in Yarrowia lipolytica.

scientific article

ATR-FTIR Redox Difference Spectroscopy ofYarrowia lipolyticaand Bovine Complex I†

scientific article published on 01 May 2006

Ablation of mitochondrial DNA results in widespread remodeling of the mitochondrial complexome

scientific article published on 20 September 2021

Accessory NUMM (NDUFS6) subunit harbors a Zn-binding site and is essential for biogenesis of mitochondrial complex I.

scientific article published on 20 April 2015

Age-related changes in the mitochondrial proteome of the fungus Podospora anserina analyzed by 2D-DIGE and LC-MS/MS.

scientific article

Ambivalent effects of diazoxide on mitochondrial ROS production at respiratory chain complexes I and III.

scientific article

Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice

scientific article

Analysis of dichlorodihydrofluorescein and dihydrocalcein as probes for the detection of intracellular reactive oxygen species.

scientific article published on December 2004

Analysis of the binding of P -chlorophenyl-methoxybenzyl-ketoxime (CPMB-Oxime) to mitochondrial cytochrome c reductase

scientific article published on 01 August 1991

Application of the obligate aerobic yeast Yarrowia lipolytica as a eucaryotic model to analyse Leigh syndrome mutations in the complex I core subunits PSST and TYKY

article

Application of the yeast Yarrowia lipolytica as a model to analyse human pathogenic mutations in mitochondrial complex I (NADH:ubiquinone oxidoreductase).

scientific article

Architecture of complex I and its implications for electron transfer and proton pumping.

scientific article published on 07 February 2009

Barth syndrome cells display widespread remodeling of mitochondrial complexes without affecting metabolic flux distribution

scientific article published on 01 September 2018

Biallelic variants in WARS2 encoding mitochondrial tryptophanyl-tRNA synthase in six individuals with mitochondrial encephalopathy

scientific article published on 14 September 2017

Bifurcated ubihydroquinone oxidation in the cytochrome bc1 complex by proton-gated charge transfer.

scientific article published on May 1996

Binding of MOA-stilbene to the mitochondrial cytochrome bc1 complex is affected by the protonation state of a redox–Bohr group of the `Rieske' iron–sulfur protein

scientific article published on 01 October 1997

Binding of detergents and inhibitors to bovine complex I - a novel purification procedure for bovine complex I retaining full inhibitor sensitivity

scientific article published on 01 July 2000

Biophysical and structural characterization of proton-translocating NADH-dehydrogenase (complex I) from the strictly aerobic yeast Yarrowia lipolytica

scientific article published on 01 July 2000

Cardiolipin stabilizes respiratory chain supercomplexes

scientific article (publication date: 26 December 2003)

Chapter 26 Measurement of superoxide formation by mitochondrial complex I of Yarrowia lipolytica

scientific article published in January 2009

Characterisation of binding of the methoxyacrylate inhibitors to mitochondrial cytochrome c reductase.

scientific article

Characterization of a subcomplex of mitochondrial NADH:ubiquinone oxidoreductase (complex I) lacking the flavoprotein part of the N-module.

scientific article published on 15 March 2007

Characterization of two different acyl carrier proteins in complex I from Yarrowia lipolytica

scientific article published on 17 September 2009

Cluster N1 of complex I from Yarrowia lipolytica studied by pulsed EPR spectroscopy

scientific article published on 26 February 2006

Complexome profiling identifies TMEM126B as a component of the mitochondrial complex I assembly complex

scientific article published on 13 September 2012

Composition and stage dynamics of mitochondrial complexes in Plasmodium falciparum.

scientific article

Compound heterozygosity for severe and hypomorphic NDUFS2 mutations cause non-syndromic LHON-like optic neuropathy.

scientific article published on 28 December 2016

Control of ubiquinol oxidation at center P (Qo) of the cytochrome bc1 complex.

scientific article

Cryo-EM structure of respiratory complex I at work

scientific article published on 02 October 2018

Cryo-EM structure of respiratory complex I reveals a link to mitochondrial sulfur metabolism

scientific article published on 30 September 2016

Effects of mutation of residue I67 on redox-linked protonation processes in yeast cytochrome c oxidase.

scientific article published on March 1998

Efficient large scale purification of his-tagged proton translocating NADH:ubiquinone oxidoreductase (complex I) from the strictly aerobic yeast Yarrowia lipolytica

scientific article published in April 2001

Energy conservation by bifurcated electron-transfer in the cytochrome-bc1 complex

scientific article published on July 1996

Energy converting NADH:quinone oxidoreductase (complex I).

scientific article

Evolution and structural organization of the mitochondrial contact site (MICOS) complex and the mitochondrial intermembrane space bridging (MIB) complex.

scientific article published on 15 October 2015

Exploring the Ubiquinone Binding Cavity of Respiratory Complex I

scientific article published in Journal of Biological Chemistry

Exploring the catalytic core of complex I by Yarrowia lipolytica yeast genetics

scientific article published on June 1, 2001

Exploring the inhibitor binding pocket of respiratory complex I.

scientific article

External alternative NADH:ubiquinone oxidoreductase redirected to the internal face of the mitochondrial inner membrane rescues complex I deficiency in Yarrowia lipolytica

scientific article published in November 2001

Full recovery of the NADH:ubiquinone activity of complex I (NADH:ubiquinone oxidoreductase) from Yarrowia lipolytica by the addition of phospholipids

scientific article published in October 2002

Function of Conserved Acidic Residues in the PSST Homologue of Complex I (NADH:Ubiquinone Oxidoreductase) fromYarrowia lipolytica

scientific article published in Journal of Biological Chemistry

Functional dissection of the proton pumping modules of mitochondrial complex I

scientific article

Functional implications from an unexpected position of the 49-kDa subunit of NADH:ubiquinone oxidoreductase

scientific article published on 16 May 2003

Functional modules and structural basis of conformational coupling in mitochondrial complex I.

scientific article published in July 2010

Functional significance of conserved histidines and arginines in the 49-kDa subunit of mitochondrial complex I.

scientific article published on 5 March 2004

Functional sulfurtransferase is associated with mitochondrial complex I from Yarrowia lipolytica, but is not required for assembly of its iron-sulfur clusters

scientific article published on 21 November 2005

Generator-specific targets of mitochondrial reactive oxygen species

scientific article

HDQ (1-hydroxy-2-dodecyl-4(1H)quinolone), a high affinity inhibitor for mitochondrial alternative NADH dehydrogenase: evidence for a ping-pong mechanism

scientific article published on 8 November 2004

Halothane, isoflurane and sevoflurane inhibit NADH:ubiquinone oxidoreductase (complex I) of cardiac mitochondria

scientific article published in November 2002

Heterocyclic analogues of squamocin as inhibitors of mitochondrial complex I. On the role of the terminal lactone of annonaceous acetogenins

scientific article published in February 2006

Histidine 129 in the 75-kDa subunit of mitochondrial complex I from Yarrowia lipolytica is not a ligand for [Fe4S4] cluster N5 but is required for catalytic activity

scientific article published on 30 November 2004

Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma are highly dependent on oxidative phosphorylation

scientific article published on 18 January 2016

Human ind1, an iron-sulfur cluster assembly factor for respiratory complex I

scientific article

Hypoxic reoxygenation during initial reperfusion attenuates cardiac dysfunction and limits ischemia-reperfusion injury after cardioplegic arrest in a porcine model

scientific article

Identification and Characterization of a Novel 9.2-kDa Membrane Sector-associated Protein of Vacuolar Proton-ATPase from Chromaffin Granules ⬇️

scientific article published on May 1, 1998

Identification of the mitochondrial ND3 subunit as a structural component involved in the active/deactive enzyme transition of respiratory complex I.

scientific article

Inside View of a Giant Proton Pump ⬇️

scientific article published on May 23, 2013

Isolation and characterization of QCR10, the nuclear gene encoding the 8.5-kDa subunit 10 of the Saccharomyces cerevisiae cytochrome bc1 complex.

scientific article

K(ATP) channel-independent targets of diazoxide and 5-hydroxydecanoate in the heart

scientific article published in August 2002

K+-independent actions of diazoxide question the role of inner membrane KATP channels in mitochondrial cytoprotective signaling

scientific article published on 18 May 2006

Kinetic properties and ligand binding of the eleven-subunit cytochrome-c oxidase from Saccharomyces cerevisiae isolated with a novel large-scale purification method.

scientific article

LRPPRC is necessary for polyadenylation and coordination of translation of mitochondrial mRNAs

scientific article

Laser-induced liquid bead ion desorption-MS of protein complexes from blue-native gels, a sensitive top-down proteomic approach

scientific article

Locking loop movement in the ubiquinone pocket of complex I disengages the proton pumps

scientific article published in Nature Communications

Loss of PINK1 impairs stress-induced autophagy and cell survival

scientific article

Loss of mitochondrial peptidase Clpp leads to infertility, hearing loss plus growth retardation via accumulation of CLPX, mtDNA and inflammatory factors

scientific article

MOA-stilbene: A new tool for investigation of the reactions of the chloroplast cytochrome bf complex

scientific article published on 01 December 1992

MOA-stilbene: a new effector of the Qisite of the chloroplast cytochromebfcomplex

scientific article published on 01 August 1991

MRPS36 provides a structural link in the eukaryotic 2-oxoglutarate dehydrogenase complex

scientific article published in 2023

Mechanism of thiazolidinedione-dependent cell death in Jurkat T cells.

scientific article published on 26 February 2007

Mitochondrial DNA copy number and function decrease with age in the short-lived fish Nothobranchius furzeri

scientific article published on 27 June 2011

Mitochondrial complex I is deficient in renal oncocytomas

scientific article published on 4 July 2003

Mitochondrial dysfunction, peroxidation damage and changes in glutathione metabolism in PARK6.

scientific article published on 30 November 2006

Mitochondrial dysfunction: an early event in Alzheimer pathology accumulates with age in AD transgenic mice

scientific article

Mitochondrial respiratory chain complexes as sources and targets of thiol-based redox-regulation.

scientific article published on 19 February 2014

Mitochondrial telomerase reverse transcriptase binds to and protects mitochondrial DNA and function from damage

scientific article published on 5 March 2009

Mitochondrion-derived reactive oxygen species lead to enhanced amyloid beta formation

scientific article published on 28 February 2012

Molecular mechanisms of superoxide production by the mitochondrial respiratory chain.

scientific article published on January 2012

Mutational analysis of assembly and function of the iron-sulfur protein of the cytochrome bc1 complex in Saccharomyces cerevisiae.

scientific article published on June 1993

Mutations in ATP6V1E1 or ATP6V1A Cause Autosomal-Recessive Cutis Laxa

scientific article published on 29 December 2016

Mutations in Complex I Assembly Factor TMEM126B Result in Muscle Weakness and Isolated Complex I Deficiency

scientific article published on 29 June 2016

NOVA: a software to analyze complexome profiling data

scientific article

New pulsed EPR methods and their application to characterize mitochondrial complex I.

scientific article published on 12 February 2009

Oligomeric and fibrillar species of beta-amyloid (A beta 42) both impair mitochondrial function in P301L tau transgenic mice

scientific article published on 16 August 2008

Phospholipase A2-modified low density lipoprotein induces mitochondrial uncoupling and lowers reactive oxygen species in phagocytes.

scientific article published on 15 July 2009

Phospholipid specificity of bovine heart bc1 complex

scientific article published on 01 May 1990

Point mutation in cytochrome b of yeast ubihydroquinone:cytochrome-c oxidoreductase causing myxothiazol resistance and facilitated dissociation of the iron-sulfur subunit.

scientific article published in September 1992

Preface to complex I special issue

scientific article published on 21 April 2016

Primary skin fibroblasts as a model of Parkinson's disease

scientific article

Processing of the 24 kDa subunit mitochondrial import signal is not required for assembly of functional complex I in Yarrowia lipolytica

scientific article published in September 2004

Properties of the common inhibitor-binding domain in mitochondrial NADH-dehydrogenase (complex I).

scientific article

Protease maturation of the Rieske iron-sulphur protein after its insertion into the mitochondrial cytochrome bc1 complex of Saccharomyces cerevisiae.

scientific article

Protein S-nitrosylation and denitrosylation in the mouse spinal cord upon injury of the sciatic nerve

scientific article published on 14 May 2012

Proteomic and functional analyses reveal a mitochondrial dysfunction in P301L tau transgenic mice

scientific article published on 14 April 2005

Proton pumping by NADH:ubiquinone oxidoreductase. A redox driven conformational change mechanism?

scientific article

Proton pumping by complex I (NADH:ubiquinone oxidoreductase) from Yarrowia lipolytica reconstituted into proteoliposomes

scientific article

Proton-translocation by membrane-bound NADH:ubiquinone-oxidoreductase (complex I) through redox-gated ligand conduction

scientific article published on 01 January 1997

Purification of cytochrome-c oxidase retaining its pulsed form

scientific article published in July 1989

Reactivity of the Bacillus subtilis succinate dehydrogenase complex with quinones

scientific article published in September 1991

Relaxation filtered hyperfine (REFINE) spectroscopy: a novel tool for studying overlapping biological electron paramagnetic resonance signals applied to mitochondrial complex I.

scientific article published in April 2004

Remarkable substituent effect: beta-aminosquamocin, a potent dual inhibitor of mitochondrial complexes I and III.

scientific article

Role of Deprotonation Events in Ubihydroquinone:CytochromecOxidoreductase from Bovine Heart and Yeast Mitochondria

scientific article published on 01 September 1997

Secondary mitochondrial dysfunction in propionic aciduria: a pathogenic role for endogenous mitochondrial toxins.

scientific article published on August 2006

Semisynthesis and screening of a small library of pro-apoptotic squamocin analogues: selection and study of a benzoquinone hybrid with an improved biological profile.

scientific article

Significance of respirasomes for the assembly/stability of human respiratory chain complex I.

scientific article published on 18 June 2004

Single electron reduction of ‘slow’ and ‘fast’ cytochrome-c oxidase

scientific article published on 01 November 1991

Small single transmembrane domain (STMD) proteins organize the hydrophobic subunits of large membrane protein complexes.

scientific article published on 14 April 2010

Statin-Induced Myopathy Is Associated with Mitochondrial Complex III Inhibition.

scientific article published on September 2015

Structural and functional analysis of deficient mutants in subunit I of cytochrome c oxidase from Saccharomyces cerevisiae.

scientific article

Structural biology. Mechanistic insight from the crystal structure of mitochondrial complex I

scientific article

Structure and function of mitochondrial complex I.

scientific article published on 24 February 2016

Structure-function relationships in mitochondrial complex I of the strictly aerobic yeast Yarrowia lipolytica

scientific article published in August 2005

Studies on the effect of stigmatellin derivative on cytochrome band the Rieske iron-sulfur cluster of cytochrome c reductase from bovine heart mitochondria

scientific article published on 01 September 1988

Subcomplexes of human ATP synthase mark mitochondrial biosynthesis disorders

Substrate-inducible versions of internal alternative NADH: ubiquinone oxidoreductase from Yarrowia lipolytica

scientific article published in December 2006

Subunit composition of mitochondrial complex I from the yeast Yarrowia lipolytica.

scientific article published in July 2004

Subunit mass fingerprinting of mitochondrial complex I.

scientific article

Superoxide Radical Formation by Pure Complex I (NADH:Ubiquinone Oxidoreductase) from Yarrowia lipolytica

scientific article published in Journal of Biological Chemistry

Superoxide production by cytochrome bc1 complex: a mathematical model

scientific article published on 7 June 2014

Synthesis and inhibitory action of novel acetogenin mimics with bovine heart mitochondrial complex I.

scientific article published in March 2004

The Assembly Pathway of Mitochondrial Respiratory Chain Complex I.

scientific article published on 30 September 2016

The Redox-Bohr Group Associated with Iron-Sulfur Cluster N2 of Complex I

scientific article published in Journal of Biological Chemistry

The Toxoplasma gondii type-II NADH dehydrogenase TgNDH2-I is inhibited by 1-hydroxy-2-alkyl-4(1H)quinolones.

scientific article

The chemistry and mechanics of ubihydroquinone oxidation at center P (Qo) of the cytochrome bc1 complex ⬇️

scientific article published on June 10, 1998

The complete mitochondrial genome of yarrowia lipolytica

scientific article published on January 2001

The iron-sulphur protein Ind1 is required for effective complex I assembly

scientific article published on 22 May 2008

The m-AAA Protease Associated with Neurodegeneration Limits MCU Activity in Mitochondria

scientific journal article

The mechanism of mitochondrial superoxide production by the cytochrome bc1 complex

scientific article published on 3 June 2008

The membrane scaffold SLP2 anchors a proteolytic hub in mitochondria containing PARL and the i-AAA protease YME1L.

scientific article published on 13 October 2016

The molecular basis for the natural resistance of the cytochrome bc1 complex from strobilurin-producing basidiomycetes to center Qp inhibitors

scientific article published in January 1996

The proton pumping stoichiometry of purified mitochondrial complex I reconstituted into proteoliposomes

The protonmotive Q cycle in mitochondria and bacteria.

scientific article published on January 1994

The structure of eukaryotic and prokaryotic complex I.

scientific article

Three classes of inhibitors share a common binding domain in mitochondrial complex I (NADH:ubiquinone oxidoreductase).

scientific article published in January 1999

Three molecules of ubiquinone bind specifically to mitochondrial cytochrome bc1 complex

scientific article published on 31 July 2001

Tight binding of NADPH to the 39-kDa subunit of complex I is not required for catalytic activity but stabilizes the multiprotein complex

scientific article published on 19 September 2006

Tracing the tail of ubiquinone in mitochondrial complex I.

scientific article

Two aspartic acid residues in the PSST-homologous NUKM subunit of complex I from Yarrowia lipolytica are essential for catalytic activity

scientific article published on 20 August 2003

Two-dimensional native electrophoretic analysis of respiratory supercomplexes from Yarrowia lipolytica

scientific article published in May 2009

Ubiquinol-cytochrome-c reductase from human and bovine mitochondria

scientific article

Uncoupling activity and physicochemical properties of derivatives of fluazinam

scientific article published on 01 July 1992

Unmasking a temperature-dependent effect of theP. anserinai-AAA protease on aging and development ⬇️

scientific article published on December 15, 2011

Yarrowia lipolytica, a yeast genetic system to study mitochondrial complex I.

scientific article

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