List of works - Christopher P Regan

Assessment of the clinical cardiac drug-drug interaction associated with the combination of hepatitis C virus nucleotide inhibitors and amiodarone in guinea pigs and rhesus monkeys

scientific article published on 30 July 2016

Attenuation of scratch-induced reactive astrogliosis by novel EphA4 kinase inhibitors.

scientific article

Block of peripheral nerve sodium channels selectively inhibits features of neuropathic pain in rats.

scientific article published on 21 November 2005

Calcitonin gene-related peptide receptor antagonism does not affect the severity of myocardial ischemia during atrial pacing in dogs with coronary artery stenosis

scientific article

Captopril prevents vascular and fibrotic changes but not cardiac hypertrophy in aortic-banded rats

scientific article published on 01 September 1996

Comparison of the intrinsic vasorelaxant and inotropic effects of the antiarrhythmic agents vernakalant and flecainide in human isolated vascular and cardiac tissues

scientific article published in March 2013

Comparison of the vasoconstrictor effects of the calcitonin gene-related peptide receptor antagonist telcagepant (MK-0974) and zolmitriptan in human isolated coronary arteries

Design and synthesis of novel isoquinoline-3-nitriles as orally bioavailable Kv1.5 antagonists for the treatment of atrial fibrillation

scientific article published on 01 November 2006

Development of a smooth muscle-targeted cre recombinase mouse reveals novel insights regarding smooth muscle myosin heavy chain promoter regulation.

scientific article

Discovery of MK-3207: A Highly Potent, Orally Bioavailable CGRP Receptor Antagonist

scientific article published on 12 January 2010

Discovery of triarylethanolamine inhibitors of the Kv1.5 potassium channel

scientific article published on 04 March 2010

Early, short-term treatment with captopril permanently attenuates cardiovascular changes in spontaneously hypertensive rats

scientific article published on 01 November 1997

Effects of the prototype serotonin 5-HT(1B/1D) receptor agonist sumatriptan and the calcitonin gene-related peptide (CGRP) receptor antagonist CGRP(8-37) on myocardial reactive hyperemic response in conscious dogs

scientific article published on 17 September 2009

Hemodynamic and cardiac neurotransmitter-releasing effects in conscious dogs of attention- and wake-promoting agents: a comparison of d-amphetamine, atomoxetine, modafinil, and a novel quinazolinone H3 inverse agonist

scientific article published in January 2009

In vivo antiarrhythmic and cardiac electrophysiologic effects of a novel diphenylphosphine oxide IKur blocker (2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide

scientific article

In vivo cardiac electrophysiologic and antiarrhythmic effects of an isoquinoline IKur blocker, ISQ-1, in rat, dog, and nonhuman primate

scientific article

In vivo cardiac electrophysiologic effects of a novel diphenylphosphine oxide IKur blocker, (2-Isopropyl-5-methylcyclohexyl) diphenylphosphine oxide, in rat and nonhuman primate

scientific article published on 21 October 2005

Interaction of CArG Elements and a GC-rich Repressor Element in Transcriptional Regulation of the Smooth Muscle Myosin Heavy Chain Gene in Vascular Smooth Muscle Cells ⬇️

scientific article published on November 21, 1997

Lack of protection with a novel, selective melanocortin receptor subtype-4 agonist RY767 in a rat transient middle cerebral artery occlusion stroke model

scientific article published on 4 December 2008

MK-0448, a specific Kv1.5 inhibitor: safety, pharmacokinetics, and pharmacodynamic electrophysiology in experimental animal models and humans

scientific article published on 11 October 2012

Molecular mechanisms of decreased smooth muscle differentiation marker expression after vascular injury.

scientific article

Novel method to assess cardiac electrophysiology in the rat: characterization of standard ion channel blockers

scientific article published in July 2005

Pharmacological properties of MK-3207, a potent and orally active calcitonin gene-related peptide receptor antagonist

scientific article

Positive- and negative-acting Kruppel-like transcription factors bind a transforming growth factor beta control element required for expression of the smooth muscle cell differentiation marker SM22alpha in vivo.

scientific article

Potent antagonists of the Kv1.5 potassium channel: synthesis and evaluation of analogous N,N-diisopropyl-2-(pyridine-3-yl)acetamides

scientific article published on 01 September 2006

Pressure-independent effects of AT1-receptor antagonism on cardiovascular remodeling in aortic-banded rats

scientific article published on 01 May 1997

Salt-induced hypertension in normotensive spontaneously hypertensive rats

scientific article published on 01 June 1994

Selective expression of an endogenous inhibitor of FAK regulates proliferation and migration of vascular smooth muscle cells

scientific article

Shortening of the electromechanical window in the ketamine/xylazine-anesthetized guinea pig model to assess pro-arrhythmic risk in early drug development

scientific article published in July 2016

Smooth Muscle–Specific Expression of the Smooth Muscle Myosin Heavy Chain Gene in Transgenic Mice Requires 5′-Flanking and First Intronic DNA Sequence ⬇️

scientific article published on May 4, 1998

Smooth muscle-targeted knockout of connexin43 enhances neointimal formation in response to vascular injury

scientific article

The prototype serotonin 5-HT 1B/1D agonist sumatriptan increases the severity of myocardial ischemia during atrial pacing in dogs with coronary artery stenosis.

scientific article published in June 2009

List of works by Christopher P Regan

Assessment of the clinical cardiac drug-drug interaction associated with the combination of hepatitis C virus nucleotide inhibitors and amiodarone in guinea pigs and rhesus monkeys

Attenuation of scratch-induced reactive astrogliosis by novel EphA4 kinase inhibitors.

Block of peripheral nerve sodium channels selectively inhibits features of neuropathic pain in rats.

Calcitonin gene-related peptide receptor antagonism does not affect the severity of myocardial ischemia during atrial pacing in dogs with coronary artery stenosis

Captopril prevents vascular and fibrotic changes but not cardiac hypertrophy in aortic-banded rats

Comparison of the intrinsic vasorelaxant and inotropic effects of the antiarrhythmic agents vernakalant and flecainide in human isolated vascular and cardiac tissues

Comparison of the vasoconstrictor effects of the calcitonin gene-related peptide receptor antagonist telcagepant (MK-0974) and zolmitriptan in human isolated coronary arteries

Design and synthesis of novel isoquinoline-3-nitriles as orally bioavailable Kv1.5 antagonists for the treatment of atrial fibrillation

Development of a smooth muscle-targeted cre recombinase mouse reveals novel insights regarding smooth muscle myosin heavy chain promoter regulation.

Discovery of MK-3207: A Highly Potent, Orally Bioavailable CGRP Receptor Antagonist

Discovery of triarylethanolamine inhibitors of the Kv1.5 potassium channel

Early, short-term treatment with captopril permanently attenuates cardiovascular changes in spontaneously hypertensive rats

Effects of the prototype serotonin 5-HT(1B/1D) receptor agonist sumatriptan and the calcitonin gene-related peptide (CGRP) receptor antagonist CGRP(8-37) on myocardial reactive hyperemic response in conscious dogs

Hemodynamic and cardiac neurotransmitter-releasing effects in conscious dogs of attention- and wake-promoting agents: a comparison of d-amphetamine, atomoxetine, modafinil, and a novel quinazolinone H3 inverse agonist

In vivo antiarrhythmic and cardiac electrophysiologic effects of a novel diphenylphosphine oxide IKur blocker (2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide

In vivo cardiac electrophysiologic and antiarrhythmic effects of an isoquinoline IKur blocker, ISQ-1, in rat, dog, and nonhuman primate

In vivo cardiac electrophysiologic effects of a novel diphenylphosphine oxide IKur blocker, (2-Isopropyl-5-methylcyclohexyl) diphenylphosphine oxide, in rat and nonhuman primate

Interaction of CArG Elements and a GC-rich Repressor Element in Transcriptional Regulation of the Smooth Muscle Myosin Heavy Chain Gene in Vascular Smooth Muscle Cells ⬇️

Lack of protection with a novel, selective melanocortin receptor subtype-4 agonist RY767 in a rat transient middle cerebral artery occlusion stroke model

MK-0448, a specific Kv1.5 inhibitor: safety, pharmacokinetics, and pharmacodynamic electrophysiology in experimental animal models and humans

Molecular mechanisms of decreased smooth muscle differentiation marker expression after vascular injury.

Novel method to assess cardiac electrophysiology in the rat: characterization of standard ion channel blockers

Pharmacological properties of MK-3207, a potent and orally active calcitonin gene-related peptide receptor antagonist

Positive- and negative-acting Kruppel-like transcription factors bind a transforming growth factor beta control element required for expression of the smooth muscle cell differentiation marker SM22alpha in vivo.

Potent antagonists of the Kv1.5 potassium channel: synthesis and evaluation of analogous N,N-diisopropyl-2-(pyridine-3-yl)acetamides

Pressure-independent effects of AT1-receptor antagonism on cardiovascular remodeling in aortic-banded rats

Salt-induced hypertension in normotensive spontaneously hypertensive rats

Selective expression of an endogenous inhibitor of FAK regulates proliferation and migration of vascular smooth muscle cells

Shortening of the electromechanical window in the ketamine/xylazine-anesthetized guinea pig model to assess pro-arrhythmic risk in early drug development

Smooth Muscle–Specific Expression of the Smooth Muscle Myosin Heavy Chain Gene in Transgenic Mice Requires 5′-Flanking and First Intronic DNA Sequence ⬇️

Smooth muscle-targeted knockout of connexin43 enhances neointimal formation in response to vascular injury

The prototype serotonin 5-HT 1B/1D agonist sumatriptan increases the severity of myocardial ischemia during atrial pacing in dogs with coronary artery stenosis.