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List of works by Ana Sebastião

A1 and A2A receptor activation by endogenous adenosine is required for VIP enhancement of K+ -evoked [3H]-GABA release from rat hippocampal nerve terminals.

scientific article published on 5 November 2007

A1R-A2AR heteromers coupled to Gs and G i/0 proteins modulate GABA transport into astrocytes.

scientific article published on 10 May 2013

Activation of adenosine A2A receptor facilitates brain-derived neurotrophic factor modulation of synaptic transmission in hippocampal slices.

scientific article published in March 2004

Activation of adenosine A2A receptors induces TrkB translocation and increases BDNF-mediated phospho-TrkB localization in lipid rafts: implications for neuromodulation

scientific article published on June 2010

Activation of type 1 cannabinoid receptor (CB1R) promotes neurogenesis in murine subventricular zone cell cultures

scientific article

Adenine nucleotide analogues, including gamma-phosphate-substituted analogues, are metabolised extracellularly in innervated frog sartorius muscle

scientific article published on November 3, 1992

Adenosine A(2A) Receptors as novel upstream regulators of BDNF-mediated attenuation of hippocampal Long-Term Depression (LTD).

scientific article published on 18 December 2013

Adenosine A(2A) receptor blockade reverts hippocampal stress-induced deficits and restores corticosterone circadian oscillation.

scientific article published on 28 February 2012

Adenosine A(2A) receptor modulation of hippocampal CA3-CA1 synapse plasticity during associative learning in behaving mice

scientific article published on 11 February 2009

Adenosine A1 Receptor Suppresses Tonic GABAA Receptor Currents in Hippocampal Pyramidal Cells and in a Defined Subpopulation of Interneurons

scientific article published in December 2014

Adenosine A2A receptor activation is determinant for BDNF actions upon GABA and glutamate release from rat hippocampal synaptosomes.

scientific article published on 9 October 2015

Adenosine A2A receptors activation facilitates neuromuscular transmission in the pre-symptomatic phase of the SOD1(G93A) ALS mice, but not in the symptomatic phase.

scientific article

Adenosine A2A receptors control the extracellular levels of adenosine through modulation of nucleoside transporters activity in the rat hippocampus.

scientific article published in May 2005

Adenosine A2A receptors enhance GABA transport into nerve terminals by restraining PKC inhibition of GAT-1.

scientific article published on 7 February 2009

Adenosine A2A receptors facilitate synaptic NMDA currents in CA1 pyramidal neurons.

scientific article published on 17 October 2018

Adenosine A2A receptors in neuronal outgrowth: a target for nerve regeneration?

scientific article published on May 2016

Adenosine A2A receptors stimulate acetylcholine release from nerve terminals of the rat hippocampus

scientific article published on 01 August 1995

Adenosine Kinase Deficiency in the Brain Results in Maladaptive Synaptic Plasticity.

scientific article

Adenosine and Related Drugs in Brain Diseases: Present and Future in Clinical Trials ⬇️

scientific article published on January 1, 2011

Adenosine and adenine nucleotides are independently released from both the nerve terminals and the muscle fibres upon electrical stimulation of the innervated skeletal muscle of the frog

scientific article published on 01 September 1993

Adenosine and epilepsy-thinking beyond A(1) receptors.

scientific article published on 13 February 2010

Adenosine by activating A1 receptors prevents GABAA-mediated actions during hypoxia in the rat hippocampus

scientific article published in September 1996

Adenosine inhibits human astrocyte proliferation independently of adenosine receptor activation

scientific article published on 07 December 2019

Adenosine receptor interactions in the hippocampus

Adenosine receptors and the central nervous system.

scientific article published on January 2009

Adenosine receptors in the nervous system: pathophysiological implications.

scientific article

Adenosine: does it have a neuroprotective role after all?

scientific article published on 01 September 2000

Age-related changes of glycine receptor at the rat hippocampus: from the embryo to the adult.

scientific article

Amyotrophic Lateral Sclerosis (ALS) and Adenosine Receptors.

scientific article published on 16 April 2018

An adenosine analogue inhibits NMDA receptor-mediated responses in bipolar cells of the rat retina

scientific article published on 01 March 1999

Anxiety Assessment in Pre-clinical Tests and in Clinical Trials: A Critical Review

scientific article published on 01 January 2018

Ascorbate/Fe(3+)-induced peroxidation and inhibition of the binding of A1 adenosine receptor ligands in rat brain membranes

scientific article published on 01 March 1995

Axonal elongation and dendritic branching is enhanced by adenosine A2A receptors activation in cerebral cortical neurons

scientific article published on 12 June 2015

BDNF modulates glycine uptake in hippocampal synaptosomes by decreasing membrane insertion of glycine transporter 2.

scientific article published on 10 June 2016

BDNF, via truncated TrkB receptor, modulates GlyT1 and GlyT2 in astrocytes.

scientific article

BDNF-induced presynaptic facilitation of GABAergic transmission in the hippocampus of young adults is dependent of TrkB and adenosine A2A receptors.

scientific article published on 20 February 2016

Biological activities of N6,C8-disubstituted adenosine derivatives as partial agonists at rat brain adenosine A1 receptors

scientific article published in September 1997

Brain-Derived Neurotrophic Factor (BDNF) Role in Cannabinoid-Mediated Neurogenesis

scientific article published on 28 November 2018

Brain-derived neurotrophic factor (BDNF) enhances GABA transport by modulating the trafficking of GABA transporter-1 (GAT-1) from the plasma membrane of rat cortical astrocytes

scientific article published on 3 October 2011

Brain-derived neurotrophic factor facilitates glutamate and inhibits GABA release from hippocampal synaptosomes through different mechanisms

scientific article published in July 2004

Brain-derived neurotrophic factor inhibits GABA uptake by the rat hippocampal nerve terminals

scientific article published on 16 April 2008

Brain-derived neurotrophic factor mediates neuroprotection against Aβ-induced toxicity through a mechanism independent on adenosine 2A receptor activation

scientific article published on 12 September 2015

Caffeine and adenosine.

scientific article

Caffeine has a dual influence on NMDA receptor-mediated glutamatergic transmission at the hippocampus

scientific article published on 06 October 2020

Calcitonin gene-related peptide in the hamster seminal vesicle and coagulating gland: an immunohistochemical, autoradiographical, and pharmacological study

scientific article published in January 1996

Cannabinoid Actions on Neural Stem Cells: Implications for Pathophysiology

scientific article published on 05 April 2019

Cannabinoid CB(1) and adenosine A(1) receptors independently inhibit hippocampal synaptic transmission

scientific article published on 24 September 2009

Challenges and promises in the development of neurotrophic factor-based therapies for Parkinson's disease.

scientific article published on April 2014

Chronic and acute adenosine A2A receptor blockade prevents long-term episodic memory disruption caused by acute cannabinoid CB1 receptor activation

scientific article

Chronic, intermittent treatment with a cannabinoid receptor agonist impairs recognition memory and brain network functional connectivity

scientific article published on 27 September 2018

Control of glutamate release by complexes of adenosine and cannabinoid receptors

scientific article published on 23 January 2020

Depression Assessment in Clinical Trials and Pre-clinical Tests: A Critical Review

scientific article published on 01 January 2018

Differential role of the proteasome in the early and late phases of BDNF-induced facilitation of LTP.

scientific article published in February 2015

Dissecting neurovascular coupling mechanisms: a role for adenosine A2A receptor: An Editorial highlight for 'Correlation of transient adenosine release and oxygen changes in the caudate-putamen'.

scientific article published on 15 December 2016

Dissecting striatal adenosine-cannabinoid receptor interactions. New clues from rats over-expressing adenosine A2A receptors.

scientific article published on 25 January 2016

Dopamine-galanin receptor heteromers modulate cholinergic neurotransmission in the rat ventral hippocampus.

scientific article

Downregulated Glia Interplay and Increased miRNA-155 as Promising Markers to Track ALS at an Early Stage

scientific article published on 13 June 2017

Dual Influence of Endocannabinoids on Long-Term Potentiation of Synaptic Transmission.

scientific article published on 19 December 2017

Dysregulation of TrkB Receptors and BDNF Function by Amyloid-β Peptide is Mediated by Calpain

scientific article

Early changes of neuromuscular transmission in the SOD1(G93A) mice model of ALS start long before motor symptoms onset

scientific article

Ecto-5'-nucleotidase is associated with cholinergic nerve terminals in the hippocampus but not in the cerebral cortex of the rat.

scientific article published in August 1992

Effect of 5'-(N-ethylcarboxamido)adenosine on adenosine transport in cultured chromaffin cells

scientific article published on 01 June 1990

Effects of carbamazepine and novel 10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide derivatives on synaptic transmission in rat hippocampal slices

scientific article

Endogenous adenosine modulation of 22Na uptake by rat brain synaptosomes

scientific article published in October 2003

Enhanced LTP in aged rats: Detrimental or compensatory?

scientific article published on 23 November 2016

Enhanced adenosine A2A receptor facilitation of synaptic transmission in the hippocampus of aged rats

scientific article published in August 2003

Enhancement of AMPA currents and GluR1 membrane expression through PKA‐coupled adenosine A2A receptors ⬇️

scientific article published on November 15, 2010

Enhancement of LTP in aged rats is dependent on endogenous BDNF.

scientific article published on 27 April 2011

Enhancement of long-term potentiation by brain-derived neurotrophic factor requires adenosine A2A receptor activation by endogenous adenosine

scientific article published on 8 February 2008

Enhancement of transmission at the frog neuromuscular junction by adenosine deaminase: evidence for an inhibitory role of endogenous adenosine on neuromuscular transmission

scientific article published on 01 December 1985

Evidence for functionally important adenosine A2a receptors in the rat hippocampus.

scientific article

Evidence for the presence of excitatory A2 adenosine receptors in the rat hippocampus

scientific article published in April 1992

Ex vivo model of epilepsy in organotypic slices-a new tool for drug screening

scientific article published on 11 July 2018

Extracellular alpha-synuclein oligomers modulate synaptic transmission and impair LTP via NMDA-receptor activation.

scientific article published on August 2012

Extracellular metabolism of adenine nucleotides and adenosine in the innervated skeletal muscle of the frog

scientific article published on 01 May 1991

From A1 to A3 en passant Through A2A Receptors in the Hippocampus: Pharmacological Implications ⬇️

scientific article published on September 1, 2012

Further evidence for adenosine A3 receptors.

scientific article

GAT-3 Dysfunction Generates Tonic Inhibition in External Globus Pallidus Neurons in Parkinsonian Rodents

scientific article published on 01 May 2018

Glial cell line-derived neurotrophic factor (GDNF) enhances dopamine release from striatal nerve endings in an adenosine A2A receptor-dependent manner.

scientific article published on 28 August 2006

Glutamate Transporters in Hippocampal LTD/LTP: Not Just Prevention of Excitotoxicity

scientific article published on 06 August 2019

GlyT1 and GlyT2 in brain astrocytes: expression, distribution and function

scientific article published on 26 March 2013

Glycine Receptor Activation Impairs ATP-Induced Calcium Transients in Cultured Cortical Astrocytes.

scientific article published in January 2017

Hippocampal GABAergic transmission: a new target for adenosine control of excitability

scientific article

Hippocampal synaptic dysfunction in the SOD1G93A mouse model of Amyotrophic Lateral Sclerosis: Reversal by adenosine A2AR blockade

scientific article published on 17 April 2020

Homeostatic control of synaptic activity by endogenous adenosine is mediated by adenosine kinase.

scientific article

Homeostatic plasticity induced by brief activity deprivation enhances long-term potentiation in the mature rat hippocampus

scientific article published on 10 September 2014

Hypoxia-ischemia alters nucleotide and nucleoside catabolism and Na+,K+-ATPase activity in the cerebral cortex of newborn rats.

scientific article

Impact of in vivo chronic blockade of adenosine A2A receptors on the BDNF-mediated facilitation of LTP.

scientific article published on 18 April 2014

Impaired TrkB receptor signaling contributes to memory impairment in APP/PS1 mice.

scientific article

In vivo Bio-Distribution and Toxicity Evaluation of Polymeric and Lipid-Based Nanoparticles: A Potential Approach for Chronic Diseases Treatment

scientific article published on 05 November 2020

Influence of age on BDNF modulation of hippocampal synaptic transmission: interplay with adenosine A2A receptors.

scientific article

Inhibition of NMDA Receptors Prevents the Loss of BDNF Function Induced by Amyloid β.

scientific article published on 11 April 2018

Inhibitory and excitatory effects of adenosine receptor agonists on evoked transmitter release from phrenic nerve endings of the rat ⬇️

scientific article published on June 1, 1991

Interaction between Cannabinoid Type 1 and Type 2 Receptors in the Modulation of Subventricular Zone and Dentate Gyrus Neurogenesis

scientific article published on 10 August 2017

Interactions between adenosine and phorbol esters or lithium at the frog neuromuscular junction

scientific article published on May 1990

Interleukin-6 upregulates neuronal adenosine A1 receptors: implications for neuromodulation and neuroprotection.

scientific article published on 7 November 2007

Ischemia-induced synaptic plasticity drives sustained expression of calcium-permeable AMPA receptors in the hippocampus

scientific article

Lipid rafts, synaptic transmission and plasticity: Impact in age-related neurodegenerative diseases ⬇️

scientific article published on July 20, 2012

Maternal separation impairs long term-potentiation in CA1-CA3 synapses and hippocampal-dependent memory in old rats

scientific article published on 25 January 2014

Mechanisms of regulation of olfactory transduction and adaptation in the olfactory cilium.

scientific article published on 21 August 2014

Memory deficits induced by chronic cannabinoid exposure are prevented by adenosine A2AR receptor antagonism

scientific article published on 16 May 2019

MicroRNA-34a Modulates Neural Stem Cell Differentiation by Regulating Expression of Synaptic and Autophagic Proteins.

scientific article published on 28 June 2014

Microglia Dysfunction Caused by the Loss of Rhoa Disrupts Neuronal Physiology and Leads to Neurodegeneration

scientific article published on 01 June 2020

Modeling the functional network of primary intercellular Ca2+ wave propagation in astrocytes and its application to study drug effects.

scientific article published on 8 May 2014

Modulation of GABA transport by adenosine A1R-A2AR heteromers, which are coupled to both Gs- and G(i/o)-proteins

scientific article published on 01 November 2011

Modulation of cGMP accumulation by adenosine A1 receptors at the hippocampus: influence of cGMP levels and gender

scientific article published on 7 October 2014

Modulation of subventricular zone oligodendrogenesis: a role for hemopressin?

scientific article

Multicompartment Microreactors Prevent Excitotoxic Dysfunctions In Rat Primary Cortical Neurons

scientific article published on 31 August 2020

N6-cyclohexyladenosine inhibits veratridine-stimulated 22Na uptake by rat brain synaptosomes

scientific article

Neural Stem Cells and Cannabinoids in the Spotlight as Potential Therapy for Epilepsy

scientific article published on 03 October 2020

Neural commitment of human pluripotent stem cells under defined conditions recapitulates neural development and generates patient-specific neural cells.

scientific article

Neuritic growth impairment and cell death by unconjugated bilirubin is mediated by NO and glutamate, modulated by microglia, and prevented by glycoursodeoxycholic acid and interleukin-10.

scientific article published on 13 February 2012

Neuroinflammation after neonatal hypoxia-ischemia is associated with alterations in the purinergic system: adenosine deaminase 1 isoenzyme is the most predominant after insult

scientific article

Neuromodulation and metamodulation by adenosine: Impact and subtleties upon synaptic plasticity regulation.

scientific article

Neuromuscular transmission modulation by adenosine upon aging.

scientific article published on 23 February 2012

Neuronal ENT1 takes up synaptic adenosine even under hypoxia/ischemia ⬇️

scientific article published on May 19, 2011

Neuroprotection afforded by adenosine A2A receptor blockade is modulated by corticotrophin-releasing factor (CRF) in glutamate injured cortical neurons

scientific article published in November 2012

Nitric oxide mediates interactions between GABAA receptors and adenosine A1 receptors in the rat hippocampus

scientific article published on 2 June 2006

On the high affinity of 8-cyclohexylcaffeine for the presynaptic inhibitory adenosine receptor present in rat motor nerve terminals

scientific article published in June 1997

On the type of receptor involved in the inhibitory action of adenosine at the neuromuscular junction

scientific article published on April 1985

P2Y1 receptor inhibits GABA transport through a calcium signalling-dependent mechanism in rat cortical astrocytes.

scientific article

Pertussis toxin-sensitive G proteins mediate the inhibition of basal phosphoinositide metabolism caused by adenosine A1 receptors in rat hippocampal slices.

scientific article

Platinum Nanoparticle-Based Microreactors as Support for Neuroblastoma Cells

scientific article published on 30 October 2017

Postsynaptic action of brain-derived neurotrophic factor attenuates alpha7 nicotinic acetylcholine receptor-mediated responses in hippocampal interneurons.

scientific article

Predominance of adenosine excitatory over inhibitory effects on transmission at the neuromuscular junction of infant rats

scientific article published on 29 September 2009

Presymptomatic and symptomatic ALS SOD1(G93A) mice differ in adenosine A1 and A2A receptor-mediated tonic modulation of neuromuscular transmission

scientific article

Purine nucleosides in neuroregeneration and neuroprotection.

scientific article

Purinergic modulation of the evoked release of [3H]acetylcholine from the hippocampus and cerebral cortex of the rat: role of the ectonucleotidases

scientific article

Rare Diseases of Neurodevelopment: Maintain the Mystery or Use a Dazzling Tool for Investigation? The Case of Rett Syndrome

scientific article published on 21 June 2019

Regulation of TrkB receptor translocation to lipid rafts by adenosine A(2A) receptors and its functional implications for BDNF-induced regulation of synaptic plasticity

scientific article

Regulation of hippocampal cannabinoid CB1 receptor actions by adenosine A1 receptors and chronic caffeine administration: implications for the effects of Δ9-tetrahydrocannabinol on spatial memory

scientific article

Solubilized rat brain adenosine receptors have two high-affinity binding sites for 1,3-dipropyl-8-cyclopentylxanthine

scientific article published in October 1991

Spintronic platforms for biomedical applications.

scientific article published on 07 December 2011

Subtypes of adenosine receptors

scientific article published on 01 August 1988

Synaptic mechanisms of adenosine A2A receptor-mediated hyperexcitability in the hippocampus

scientific article published on 29 November 2014

Tauroursodeoxycholic Acid Enhances Mitochondrial Biogenesis, Neural Stem Cell Pool, and Early Neurogenesis in Adult Rats

scientific article published on 22 May 2017

Tauroursodeoxycholic acid suppresses amyloid β-induced synaptic toxicity in vitro and in APP/PS1 mice.

scientific article published on 22 May 2012

The Role of cGMP on Adenosine A 1 Receptor-mediated Inhibition of Synaptic Transmission at the Hippocampus.

scientific article published on 22 April 2016

The combined inhibitory effect of the adenosine A1 and cannabinoid CB1 receptors on cAMP accumulation in the hippocampus is additive and independent of A1 receptor desensitization

scientific article published on 18 January 2015

The giant miniature endplate potentials frequency is increased in aged rats

scientific article published on 28 October 2014

The inhibitory adenosine receptor at the neuromuscular junction and hippocampus of the rat: antagonism by 1,3,8-substituted xanthines.

scientific article published in October 1990

Tonic adenosine A1 and A2A receptor activation is required for the excitatory action of VIP on synaptic transmission in the CA1 area of the hippocampus

scientific article published on 9 October 2006

Triggering of BDNF facilitatory action on neuromuscular transmission by adenosine A2A receptors.

scientific article published on 21 June 2006

TrkB-ICD Fragment, Originating From BDNF Receptor Cleavage, Is Translocated to Cell Nucleus and Phosphorylates Nuclear and Axonal Proteins

scientific article published on 01 February 2019

Tuning and fine-tuning of synapses with adenosine.

scientific article published on September 2009

VIP enhances both pre- and postsynaptic GABAergic transmission to hippocampal interneurones leading to increased excitatory synaptic transmission to CA1 pyramidal cells.

scientific article published on 25 October 2004

VIP enhances synaptic transmission to hippocampal CA1 pyramidal cells through activation of both VPAC1 and VPAC2 receptors.

scientific article published in July 2005

VPAC1 and VPAC2 receptor activation on GABA release from hippocampal nerve terminals involve several different signalling pathways.

scientific article

VPAC2 receptor activation mediates VIP enhancement of population spikes in the CA1 area of the hippocampus

scientific article published in July 2006

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