List of works by Roland Houben

Activation of the MAP kinase pathway induces apoptosis in the Merkel cell carcinoma cell line UISO.

scientific article published on 3 May 2007

Activation of the PI3K/AKT pathway in Merkel cell carcinoma

scientific article

An intact retinoblastoma protein-binding site in Merkel cell polyomavirus large T antigen is required for promoting growth of Merkel cell carcinoma cells

scientific article published on 27 April 2011

Artesunate Affects T Antigen Expression and Survival of Virus-Positive Merkel Cell Carcinoma

scientific article published on 09 April 2020

BIK is involved in BRAF/MEK inhibitor induced apoptosis in melanoma cell lines.

scientific article

BRAF inhibition causes resilience of melanoma cell lines by inducing the secretion of FGF1

scientific article published on 20 September 2018

CD147 impacts angiogenesis and metastasis formation.

scientific article

Characterization of functional domains in the Merkel cell polyoma virus Large T antigen

scientific article published on 19 September 2014

Characterization of six Merkel cell polyomavirus-positive Merkel cell carcinoma cell lines: Integration pattern suggest that large T antigen truncating events occur before or during integration

scientific article published on 04 April 2019

Coincident Metastatic Melanoma and Merkel Cell Carcinoma with Complete Remission on Treatment with Pembrolizumab

scientific article published on 01 November 2017

Combination with γ-secretase inhibitor prolongs treatment efficacy of BRAF inhibitor in BRAF-mutated melanoma cells.

scientific article published on 18 March 2016

Comparable expression and phosphorylation of the retinoblastoma protein in Merkel cell polyoma virus-positive and negative Merkel cell carcinoma

scientific article published in February 2010

Constitutive activation of the Ras-Raf signaling pathway in metastatic melanoma is associated with poor prognosis

scientific article

Dendritic cell based antitumor vaccination: impact of functional indoleamine 2,3-dioxygenase expression.

scientific article

Detection of the Merkel cell polyomavirus in the neuroendocrine component of combined Merkel cell carcinoma.

scientific article published on 28 March 2018

Diagnostic accuracy of a panel of immunohistochemical and molecular markers to distinguish Merkel cell carcinoma from other neuroendocrine carcinomas

scientific article published on 22 October 2018

Differential gene expression in apoptotic 32Dcl3 cells: induction of metallothionein.

scientific article

Distinction of 2 different primary Merkel cell carcinomas in 1 patient by Merkel cell polyomavirus genome analysis.

scientific article

Elucidating the mechanism of action of domatinostat (4SC-202) in cutaneous T cell lymphoma cells

scientific article published on 18 March 2019

Expression of Merkelcell polyomavirus (MCPyV) large T-antigen in Merkel cell carcinoma lymph node metastases predicts poor outcome.

scientific article published on August 2017

Expression of the tetraspanins CD9, CD37, CD63, and CD151 in Merkel cell carcinoma: strong evidence for a posttranscriptional fine-tuning of CD9 gene expression

scientific article published on 29 January 2010

Immunogenicity of constitutively active V599EBRaf

scientific article

Impact of the CCR5 gene polymorphism on the survival of metastatic melanoma patients receiving immunotherapy

scientific article published on 2 October 2007

LASP1, a Newly Identified Melanocytic Protein with a Possible Role in Melanin Release, but Not in Melanoma Progression

scientific article published on 10 June 2015

Lack of Wnt5A expression in Merkel cell carcinoma.

scientific article published on January 2010

Lack of correlation between IGFBP7 expression and BRAF mutational status in melanoma

scientific article published on 15 October 2009

MAPK-independent impairment of T-cell responses by the multikinase inhibitor sorafenib

scientific article published on 3 February 2009

MC polyomavirus is frequently present in Merkel cell carcinoma of European patients.

scientific article

Matrix metalloproteinase induction in the tumor stroma does not depend on CD147 expression in murine B16 melanoma.

scientific article published on 20 August 2007

Mechanisms of p53 restriction in Merkel cell carcinoma cells are independent of the Merkel cell polyoma virus T antigens.

scientific article published on 5 April 2013

Melanoma stem cells: targets for successful therapy?

scientific article published on 30 May 2008

Membrane-binding and activation of LKB1 by phosphatidic acid is essential for development and tumour suppression.

scientific article

Merkel Cell Polyomavirus Large T Antigen is Dispensable in G2 and M-Phase to Promote Proliferation of Merkel Cell Carcinoma Cells

scientific article published on 14 October 2020

Merkel Cell Polyomavirus T Antigens Induce Merkel Cell-Like Differentiation in GLI1-Expressing Epithelial Cells

scientific article published on 21 July 2020

Merkel cell carcinoma and Merkel cell polyomavirus: evidence for hit-and-run oncogenesis

scientific article published on 18 August 2011

Merkel cell carcinomas infiltrated with CD33+ myeloid cells and CD8+ T cells are associated with improved outcome

scientific article published on 19 December 2017

Merkel cell polyomavirus status is not associated with clinical course of Merkel cell carcinoma.

scientific article published on 12 May 2011

Merkel cell polyomavirus-infected Merkel cell carcinoma cells require expression of viral T antigens

scientific article

Merkel cell polyomavirus-positive Merkel cell carcinoma cells do not require expression of the viral small T antigen.

scientific article published on 25 February 2013

Microencapsulated transplantation of allogeneic islets into specifically presensitized recipients

scientific article published on 01 April 1994

Microphthalmia-associated transcription factor gene amplification in metastatic melanoma is a prognostic marker for patient survival, but not a predictive marker for chemosensitivity and chemotherapy response

scientific article published on 01 November 2007

Microvessel density and expression of vascular endothelial growth factor and its receptors in different subtypes of primary cutaneous B-cell lymphoma

scientific article

Morphologic and immunophenotypical features distinguishing Merkel cell polyomavirus-positive and negative Merkel cell carcinoma

scientific article published on 14 June 2019

No evidence for association of HPyV6 or HPyV7 with different skin cancers

scientific article published on 8 September 2011

Overexpression of the KIT/SCF in uveal melanoma does not translate into clinical efficacy of imatinib mesylate.

scientific article

Phospho-ERK staining is a poor indicator of the mutational status of BRAF and NRAS in human melanoma.

scientific article

Production of purified alginates suitable for use in immunoisolated transplantation

scientific article published on 01 January 1994

RB1 is the crucial target of the Merkel cell polyomavirus Large T antigen in Merkel cell carcinoma cells.

scientific article

RKIP does not contribute to MAP kinase pathway silencing in the Merkel Cell Carcinoma cell line UISO.

scientific article published on 24 October 2007

Regulation of glycolysis by Raf protein serine/threonine kinases

scientific article

Response to Shuda et al.

scientific article

Response to imatinib mesylate depends on the presence of the V559A-mutated KIT oncogene

scientific article published in January 2010

Role of matrix metalloproteinases in melanoma cell invasion

scientific article

Serine 220 phosphorylation of the Merkel cell polyomavirus large T antigen crucially supports growth of Merkel cell carcinoma cells.

scientific article published on 18 September 2015

Significant correlation of peptidyl-prolyl isomerase overexpression in Merkel cell carcinoma with overall survival of patients

scientific article published on 29 November 2010

Survivin downregulation is not required for T antigen knockdown mediated cell growth inhibition in MCV infected merkel cell carcinoma cells

scientific article published on 13 December 2012

The HSP70 modulator MAL3-101 inhibits Merkel cell carcinoma.

scientific article

The TGF-β-inducible miR-23a cluster attenuates IFN-γ levels and antigen-specific cytotoxicity in human CD8⁺ T cells

scientific article

The carcinogenic potential of tacrolimus ointment beyond immune suppression: a hypothesis creating case report.

scientific article

The effect of resveratrol in combination with irradiation and chemotherapy: study using Merkel cell carcinoma cell lines

scientific article published on 8 November 2013

The identification of patient-specific mutations reveals dual pathway activation in most patients with melanoma and activated receptor tyrosine kinases in BRAF/NRAS wild-type melanomas

scientific article published on 18 December 2018

Transplantation of microencapsulated islets in rats: evidence for induction of fibrotic overgrowth by islet alloantigens released from microcapsules

scientific article published on 01 April 1994

Type I and II IFNs inhibit Merkel cell carcinoma via modulation of the Merkel cell polyomavirus T antigens.

scientific article

Unique Role of Histone Methyltransferase PRDM8 in the Tumorigenesis of Virus-Negative Merkel Cell Carcinoma

scientific article published on 24 April 2020

VEGF-A inhibition as a potential therapeutic approach in Merkel cell carcinoma

article

[Immunologic isolation of transplanted islets of Langerhans: microcapsules with defined molecular limits]

scientific article published on 01 December 1993

[Kinase inhibitors for the therapy of malignant melanoma].

scientific article

[New therapeutic approaches for solid tumors: histone deacetylase, methyltransferase and proteasome inhibitors].

scientific article

p53 regulation by TRP2 is not pervasive in melanoma

scientific article published on 27 January 2014

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