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List of works by Richard M Sharpe

"Additional" effects of phthalate mixtures on fetal testosterone production

scientific article published on 25 June 2008

A plea for risk assessment of endocrine disrupting chemicals

scientific article published on 11 August 2013

Analgesic exposure in pregnant rats affects fetal germ cell development with inter-generational reproductive consequences

scientific article published on 27 January 2016

Androgen action in the masculinization programming window and development of male reproductive organs.

scientific article published on 30 November 2009

Androgen action via testicular arteriole smooth muscle cells is important for Leydig cell function, vasomotion and testicular fluid dynamics

scientific article

Androgen action via testicular peritubular myoid cells is essential for male fertility

scientific article

Androgen receptor signalling in peritubular myoid cells is essential for normal differentiation and function of adult Leydig cells

scientific article published on 09 June 2011

Anogenital distance plasticity in adulthood: implications for its use as a biomarker of fetal androgen action

scientific article

Aquaporin 9 expression in the developing rat epididymis is modulated by steroid hormones

scientific article

Bisphenol A and Metabolic Syndrome

scientific article published on 01 June 2010

Bisphenol A exposure and sexual dysfunction in men: editorial commentary on the article 'Occupational exposure to bisphenol-A (BPA) and the risk of self-reported male sexual dysfunction' Li et al., 2009.

scientific article published on 10 November 2009

Clinical review: Anogenital distance or digit length ratio as measures of fetal androgen exposure: relationship to male reproductive development and its disorders

scientific article published on 08 April 2013

Comparative effects of di(n-butyl) phthalate exposure on fetal germ cell development in the rat and in human fetal testis xenografts

scientific article

Critical androgen-sensitive periods of rat penis and clitoris development

scientific article

Deletion of androgen receptor in the smooth muscle of the seminal vesicles impairs secretory function and alters its responsiveness to exogenous testosterone and estradiol

scientific article

Diethylstilboestrol exposure does not reduce testosterone production in human fetal testis xenografts

scientific article

Do Phthalates Affect Steroidogenesis by the Human Fetal Testis? Exposure of Human Fetal Testis Xenografts to Di-n-Butyl Phthalate

scientific article published on 11 January 2012

Dynamic changes in DNA modification states during late gestation male germ line development in the rat

scientific article

Effect of androgen treatment during foetal and/or neonatal life on ovarian function in prepubertal and adult rats

scientific article published on 20 October 2011

Effect of fetal or neonatal exposure to monobutyl phthalate (MBP) on testicular development and function in the marmoset

scientific article published on 02 June 2009

Effects of di(n-butyl) phthalate exposure on foetal rat germ-cell number and differentiation: identification of age-specific windows of vulnerability.

scientific article published on 18 February 2011

Effects of environmental pollutants on the reproduction and welfare of ruminants

scientific article

Effects of inducible nitric oxide synthase (iNOS) deficiency in mice on Sertoli cell proliferation and perinatal testis development

scientific article published on 15 March 2012

Effects of monobutyl and di(n-butyl) phthalate in vitro on steroidogenesis and Leydig cell aggregation in fetal testis explants from the rat: comparison with effects in vivo in the fetal rat and neonatal marmoset and in vitro in the human

scientific article

Endocrine disruption and human health effects—a call to action ⬇️

scientific article published on September 20, 2011

Environmental/lifestyle effects on spermatogenesis

scientific article

Exposure to a complex cocktail of environmental endocrine-disrupting compounds disturbs the kisspeptin/GPR54 system in ovine hypothalamus and pituitary gland

scientific article published on 05 June 2009

Exposure to chemical cocktails before or after conception--- the effect of timing on ovarian development

scientific article published on 20 June 2013

Fetal programming of adult Leydig cell function by androgenic effects on stem/progenitor cells

scientific article

Foetal and post-natal exposure of sheep to sewage sludge chemicals disrupts sperm production in adulthood in a subset of animals.

scientific article

Foetal hypothalamic and pituitary expression of gonadotrophin-releasing hormone and galanin systems is disturbed by exposure to sewage sludge chemicals via maternal ingestion.

scientific article published on 02 March 2010

Germ cell differentiation in the marmoset (Callithrix jacchus) during fetal and neonatal life closely parallels that in the human.

scientific article published on 11 August 2008

Glucocorticoids amplify dibutyl phthalate-induced disruption of testosterone production and male reproductive development

scientific article published on 9 October 2009

Human and ecological risk assessment of a crop protection chemical: a case study with the azole fungicide epoxiconazole

scientific article

Identification in rats of a programming window for reproductive tract masculinization, disruption of which leads to hypospadias and cryptorchidism

scientific article

In utero exposure to di(n-butyl) phthalate and testicular dysgenesis: comparison of fetal and adult end points and their dose sensitivity

scientific article

In utero exposure to low doses of environmental pollutants disrupts fetal ovarian development in sheep

scientific article published on 23 April 2008

Inter-relationship between testicular dysgenesis and Leydig cell function in the masculinization programming window in the rat

scientific article

Intratubular germ cell neoplasia of the human testis: heterogeneous protein expression and relation to invasive potential.

scientific article

Is it time to end concerns over the estrogenic effects of bisphenol A?

scientific article

Lessons learned in andrology: learning from experience - getting it wrong is alright

scientific article published in September 2014

Low Sperm Counts May Be Preventable

scientific article published on 01 September 2011

Male fertility and strategies for fertility preservation following childhood cancer treatment.

scientific article published on 03 March 2009

Neonatal estrogenic effects upon the male rat pituitary: early gonadotrophin attenuation precedes long-term recovery.

scientific article published on 30 June 2009

New insights into the role of androgens in wolffian duct stabilization in male and female rodents.

scientific article published on 8 January 2009

Obesogens and obesity--an alternative view?

scientific article published on June 2013

Organotypic cultures of prepubertal mouse testes: a method to study androgen action in sertoli cells while preserving their natural environment.

scientific article published on 8 July 2009

Peri-conceptional changes in maternal exposure to sewage sludge chemicals disturbs fetal thyroid gland development in sheep

scientific article published on 4 January 2013

Perinatal germ cell development and differentiation in the male marmoset (Callithrix jacchus): similarities with the human and differences from the rat

scientific article published on 15 January 2013

Prenatal plus postnatal exposure to Di(n-Butyl) phthalate and/or flutamide markedly reduces final sertoli cell number in the rat.

scientific article published on 14 April 2010

Prolonged exposure to acetaminophen reduces testosterone production by the human fetal testis in a xenograft model

scientific article

Proposed role for COUP-TFII in regulating fetal Leydig cell steroidogenesis, perturbation of which leads to masculinization disorders in rodents

scientific article (publication date: 2012)

Prostaglandins, masculinization and its disorders: effects of fetal exposure of the rat to the cyclooxygenase inhibitor- indomethacin

scientific article

Regulation of the germ stem cell niche as the foundation for adult spermatogenesis: a role for miRNAs?

scientific article published on 06 April 2014

Relationship between androgen action in the "male programming window," fetal sertoli cell number, and adult testis size in the rat.

scientific article published on 19 June 2008

Relative importance of prenatal and postnatal androgen action in determining growth of the penis and anogenital distance in the rat before, during and after puberty

scientific article published on 02 June 2011

Reproduction Symposium: does grazing on biosolids-treated pasture pose a pathophysiological risk associated with increased exposure to endocrine disrupting compounds?

scientific article

Role of Androgens in Fetal Testis Development and Dysgenesis

article

Selective ablation of the androgen receptor in mouse sertoli cells affects sertoli cell maturation, barrier formation and cytoskeletal development

scientific article (publication date: 2010)

Sertoli cell development and function in an animal model of testicular dysgenesis syndrome

scientific article published on 10 October 2007

Sertoli cell numbers and spermatogenic efficiency are increased in inducible nitric oxide synthase mutant mice

scientific article published on 10 August 2011

Smooth muscle cell-specific knockout of androgen receptor: a new model for prostatic disease.

scientific article published on 5 July 2011

Sperm counts and fertility in men: a rocky road ahead. Science & Society Series on Sex and Science

scientific article

Steroidogenesis in the fetal testis and its susceptibility to disruption by exogenous compounds

scientific article

Testicular dysgenesis syndrome: mechanistic insights and potential new downstream effects

scientific article published on February 2008

The Maestro (Mro) gene is dispensable for normal sexual development and fertility in mice

scientific article

The critical time window for androgen-dependent development of the Wolffian duct in the rat.

scientific article published on 12 April 2007

The downside of ‘inappropriate messaging’: new insight into the development of testicular germ cell tumours in young men? ⬇️

scientific article published on March 1, 2013

The effect of dihydrotestosterone exposure during or prior to the masculinization programming window on reproductive development in male and female rats

scientific article published on 17 January 2012

The origins and time of appearance of focal testicular dysgenesis in an animal model of testicular dysgenesis syndrome: evidence for delayed testis development?

article

Time-dependent and compartment-specific effects of in utero exposure to Di(n-butyl) phthalate on gene/protein expression in the fetal rat testis as revealed by transcription profiling and laser capture microdissection

scientific article published on 22 March 2007

Toward a multi-country monitoring system of reproductive health in the context of endocrine disrupting chemical exposure

scientific article published on September 2015

Toxicant-induced leakage of germ cell-specific proteins from seminiferous tubules in the rat: relationship to blood-testis barrier integrity and prospects for biomonitoring

scientific article published on 12 July 2010

Xenografting of human fetal testis tissue: a new approach to study fetal testis development and germ cell differentiation.

scientific article

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