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List of works by Mauro Botta

1,2-hydroxypyridonate/terephthalamide complexes of gadolinium(III): synthesis, stability, relaxivity, and water exchange properties

scientific article

1,2-hydroxypyridonates as contrast agents for magnetic resonance imaging: TREN-1,2-HOPO.

scientific article

195Pt NMR spectroscopy: A chemometric approach

1H and 17O NMR relaxometric and computational study on macrocyclic Mn(II) complexes.

scientific article

1H and 17O NMR relaxometric study in aqueous solution of Gd(III) complexes of EGTA-like derivatives bearing methylenephosphonic groups

scientific article

6-Carboxamido-5,4-Hydroxypyrimidinones: A New Class of Heterocyclic Ligands and Their Evaluation as Gadolinium Chelating Agents ⬇️

scientific article published on December 17, 2001

A Bisamide Derivative of [Mn(1,4-DO2A)] - Solution Thermodynamic, Kinetic, and NMR Relaxometric Studies

A Calix[4]arene GdIII Complex Endowed with High Stability, Relaxivity, and Binding Affinity to Serum Albumin

scholarly article by Silvio Aime et al published 17 December 2001 in Angewandte Chemie International Edition

A Chemical Strategy for the Relaxivity Enhancement of GdIII Chelates Anchored on Mesoporous Silica Nanoparticles ⬇️

scientific article published on September 17, 2010

A highly stable gadolinium complex with a fast, associative mechanism of water exchange.

scientific article

A multinuclear NMR relaxometry study of ternary adducts formed between heptadentate Gd(III) chelates and L-lactate

scientific article

A new bifunctional Gd(III) complex of enhanced efficacy for MR-molecular imaging applications

scientific article

A new ditopic Gd(III) complex functionalized with an adamantyl moiety as a versatile building block for the preparation of supramolecular assemblies

scientific article published on 08 October 2013

A new ytterbium chelate as contrast agent in chemical shift imaging and temperature sensitive probe for MR spectroscopy

scientific article published on 01 May 1996

A pentadentate member of the picolinate family for Mn(ii) complexation and an amphiphilic derivative

scientific article published on 01 January 2019

A structural and (1)H NMR relaxometric study on novel layered carboxyalkylaminophosphonate nanocrystals with Gd(III) ions located in the framework

scientific article published on 26 October 2015

AAZTA-based bifunctional chelating agents for the synthesis of multimeric/dendrimeric MRI contrast agents.

scientific article

Aggregation in amphiphilic macrocycle-substituted Gd(3+) DOTA-type chelates is affected by the regiochemistry of substitution

scientific article published on 18 February 2015

Amphiphilic Ditopic Bis-Aqua Gd-AAZTA-like Complexes Enhance Relaxivity of Lipidic MRI Nanoprobes.

scientific article

An esterase-activated magnetic resonance contrast agent.

scientific article

Analysis of the Relaxometric Properties of Extremely Rapidly Exchanging Gd3+ Chelates: Lessons from a Comparison of Four Isomeric Chelates

scientific article published on 14 June 2020

Application of the Ugi four-component reaction to the synthesis of ditopic bifunctional chelating agents

scientific article published on 19 August 2009

Aryl-phosphonate lanthanide complexes and their fluorinated derivatives: investigation of their unusual relaxometric behavior and potential application as dual frequency 1H/19F MRI probes

scientific article

Carbon coated microshells containing nanosized Gd(iii) oxidic phases for multiple bio-medical applications

scientific article published on 08 October 2008

Characterisation and evaluation of paramagnetic fluorine labelled glycol chitosan conjugates for (19)F and (1)H magnetic resonance imaging

scientific article published on 17 August 2013

Chemical Shift and Relaxation Reagents in NMR*

Cleavable β-cyclodextrin nanocapsules incorporating Gd(III)-chelates as bioresponsive MRI probes

scientific article published on 26 January 2011

Combination of solid-state NMR and 1H NMR relaxometry for the study of intercalated saponite clays with the macrocyclic derivatives of Gd(iii) and Y(iii)

scientific article published on 29 April 2020

Combined high resolution NMR and 1H and 17O relaxometric study sheds light on the solution structure and dynamics of the lanthanide(III) complexes of HPDO3A.

scientific article

Comparative in vitro studies of MR imaging probes for metabotropic glutamate subtype-5 receptor targeting

scientific article published on September 2013

Complete on/off responsive ParaCEST MRI contrast agents for copper and zinc

scientific article published on 01 August 2018

Controlling water exchange rates in potential Mn2+-based MRI agents derived from NO2A2

scientific article published on 01 March 2019

Correlation of Water Exchange Rate with Isomeric Composition in Diastereoisomeric Gadolinium Complexes of Tetra(carboxyethyl)dota and Related Macrocyclic Ligands

article

Definition of the Labile Capping Bond Effect in Lanthanide Complexes

scientific article

Dendrimeric Gd(III) complex of a monophosphinated DOTA analogue: optimizing relaxivity by reducing internal motion.

scientific article published on 18 March 2005

Dendrimeric gadolinium chelate with fast water exchange and high relaxivity at high magnetic field strength.

scientific article

Dendrimeric β-cyclodextrin/Gd(III) chelate supramolecular host-guest adducts as high-relaxivity MRI probes

scientific article

Dendrimersomes: a new vesicular nano-platform for MR-molecular imaging applications

scientific article published on 19 February 2014

Design principles and theory of paramagnetic fluorine-labelled lanthanide complexes as probes for (19)F magnetic resonance: a proof-of-concept study

scientific article published in January 2010

Developing the family of picolinate ligands for Mn2+ complexation.

scientific article

Direct NMR Spectroscopic Observation of a Lanthanide-Coordinated Water Molecule whose Exchange Rate Is Dependent on the Conformation of the Complexes

scientific article published on 01 October 1998

Disperse and cationic azo dyes from heterocyclic intermediates

Dramatic increase of selectivity for heavy lanthanide(III) cations by tuning the flexibility of polydentate chelators

scientific article

Effect of a mesitylene-based ligand cap on the relaxometric properties of Gd(III) hydroxypyridonate MRI contrast agents.

scientific article published in September 2009

Efficient relaxivity enhancement in dendritic gadolinium complexes: effective motional coupling in medium molecular weight conjugates

scientific article published on 17 December 2004

Equilibrium and NMR relaxometric studies on the s-triazine-based heptadentate ligand PTDITA showing high selectivity for Gd3+ ions.

scientific article

Evaluation of Water Exchange Kinetics on [Ln(AAZTAPh-NO2)(H2O)q](x) Complexes Using Proton Nuclear Magnetic Resonance.

scientific article

Fast and easy access to efficient bifunctional chelators for MRI applications.

scientific article published on 10 May 2009

Fe(III)-templated Gd(III) self-assemblies-a new route toward macromolecular MRI contrast agents

scientific article

First in vivo MRI study on theranostic dendrimersomes

scientific article published on 07 January 2017

Gadolinium(III) 1,2-hydroxypyridonate-based complexes: toward MRI contrast agents of high relaxivity.

scientific article

Gadolinium(III) Complexes of dota-DerivedN-Sulfonylacetamides (H4(dota-NHSO2R)=10-{2-[(R)sulfonylamino]-2-oxoethyl}-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic Acid): A New Class of Relaxation Agents for Magnetic Resonance Imaging Applications

Gd(DOTP)5-outer-sphere relaxation enhancement promoted by nitrogen bases.

scientific article published on November 1993

Gd(III)-BASED CONTRAST AGENTS FOR MRI

Gd-enhanced MR images of substrates other than water

scientific article

GdDOTAGA(C18)2: an efficient amphiphilic Gd(iii) chelate for the preparation of self-assembled high relaxivity MRI nanoprobes.

scientific article published on 15 October 2015

Glycoconjugates of gadolinium complexes for MRI applications

scientific article

Hetero-tripodal hydroxypyridonate gadolinium complexes: syntheses, relaxometric properties, water exchange dynamics, and human serum albumin binding.

scientific article

High relaxivity Mn(2+)-based MRI contrast agents.

scientific article

High relaxivity gadolinium hydroxypyridonate-viral capsid conjugates: nanosized MRI contrast agents.

scientific article

High-resolution NMR and relaxometric studies of Ln(III) complexes of relevance to MRI

Highly luminescent Eu(3+) and Tb(3+) macrocyclic complexes bearing an appended phenanthroline chromophore

scientific article

Highly soluble tris-hydroxypyridonate Gd(III) complexes with increased hydration number, fast water exchange, slow electronic relaxation, and high relaxivity

scientific article

Hyperfine coupling constants on inner-sphere water molecules of a triazacyclononane-based Mn(II) complex and related systems relevant as MRI contrast agents.

scientific article

Identification of emissive lanthanide complexes suitable for cellular imaging that resist quenching by endogenous anti-oxidants

scientific article

Importance of Outer-Sphere and Aggregation Phenomena in the Relaxation Properties of Phosphonated Gadolinium Complexes with Potential Applications as MRI Contrast Agents

scientific article published on 06 March 2015

In Vivo Magnetic Resonance Imaging Detection of Paramagnetic Liposomes Loaded with Amphiphilic Gadolinium(III) Complexes: Impact of Molecular Structure on Relaxivity and Excretion Efficiency

scientific article published on 03 June 2013

Isostructural series of nine-coordinate chiral lanthanide complexes based on triazacyclononane

scientific article

Large photoacoustic effect enhancement for ICG confined inside MCM-41 mesoporous silica nanoparticles

scientific article published on 9 December 2016

Large relaxivity enhancement of paramagnetic lipid nanoparticles by restricting the local motions of the Gd(III) chelates

scientific article

Lower denticity leading to higher stability: structural and solution studies of Ln(III)-OBETA complexes.

scientific article

Lower ligand denticity leading to improved thermodynamic and kinetic stability of the Gd3+ complex: the strange case of OBETA.

scientific article

MRI nanoprobes based on chemical exchange saturation transfer: Ln(III) chelates anchored on the surface of mesoporous silica nanoparticles

scientific article published on 01 August 2014

Macrocyclic Pyclen-Based Gd3+ Complex with High Relaxivity and pH Response

scientific article published on 07 May 2020

Magnetic resonance contrast agents from viral capsid shells: a comparison of exterior and interior cargo strategies

scientific article

Maximizing the relaxivity of HSA-bound gadolinium complexes by simultaneous optimization of rotation and water exchange

scientific article published on 26 October 2007

Mn(ii) complexes of novel hexadentate AAZTA-like chelators: a solution thermodynamics and relaxometric study ⬇️

scientific article published on January 26, 2011

Mn2+ Complexes Containing Sulfonamide Groups with pH-Responsive Relaxivity

scientific article published on 23 September 2020

Modifying LnHPDO3A Chelates for Improved T1 and CEST MRI Applications

scientific article published on 20 February 2019

Mono-, bi-, and trinuclear bis-hydrated Mn(2+) complexes as potential MRI contrast agents

scientific article

Multifunctional receptor-targeted nanocomplexes for magnetic resonance imaging and transfection of tumours

scientific article

Multimodal contrast agents for in vivo neuroanatomical analysis of monosynaptic connections

scientific article published on 19 June 2013

NMR conformational study of the lanthanide(III) complexes of DOTA in aqueous solution

NMR relaxometric study of new Gd(III) macrocyclic complexes and their interaction with human serum albumin.

scientific article

NMR studies of BPTI aggregation by using paramagnetic relaxation reagents

scientific article published on 03 April 2006

NMR, Relaxometric, and Structural Studies of the Hydration and Exchange Dynamics of Cationic Lanthanide Complexes of Macrocyclic Tetraamide Ligands

scientific article published in 1999

New calcium-selective smart contrast agents for magnetic resonance imaging

scientific article

Novel functionalized pyridine-containing DTPA-like ligand. Synthesis, computational studies and characterization of the corresponding GdIII complex

scientific article published on 25 June 2007

Novel gadolinium(III) polyaminocarboxylate macrocyclic complexes as potential magnetic resonance imaging contrast agents.

scientific article

Novel paramagnetic clays obtained through intercalation of Gd3+-complexes

scientific article published on 01 June 2018

Novel paramagnetic macromolecular complexes derived from the linkage of a macrocyclic Gd(III) complex to polyamino acids through a squaric acid moiety.

scientific article

Novel stable dendrimersome formulation for safe bioimaging applications.

scientific article published on July 2015

Nuclear magnetic resonance studies of neutral lanthanide(III) complexes with tetraaza-macrocyclic ligands containing three phosphinate and one carboxamide co-ordinating arms

On the role of the counter-ion in defining water structure and dynamics: order, structure and dynamics in hydrophilic and hydrophobic gadolinium salt complexes

scientific article

One-pot synthesis of a piperidine-based rigidified DTPA analogue and its bifunctional chelating agent

scientific article published on 20 February 2012

Optimising the relaxivities of Mn2+ complexes by targeting human serum albumin (HSA).

scientific article published on 20 June 2017

Optimization of the Relaxivity of MRI Contrast Agents: Effect of Poly(ethylene glycol) Chains on the Water-Exchange Rates of GdIII Complexes ⬇️

scientific article published on October 31, 2001

Optimized relaxivity and stability of [Gd(H(2,2)-1,2-HOPO)(H2O)]- for use as an MRI contrast agent.

scientific article

Optimizing the high-field relaxivity by self-assembling of macrocyclic Gd(III) complexes

scientific article

Orthogonal synthesis of a heterodimeric ligand for the development of the Gd(III)-Ga(III) ditopic complex as a potential pH-sensitive MRI/PET probe

scientific article published on 01 February 2013

Paramagnetic GdIIIFeIII heterobimetallic complexes of DTPA-bis-salicylamide

Periodic trends and hidden dynamics of magnetic properties in three series of triazacyclononane lanthanide complexes

scientific article published on 22 May 2019

Photoacoustic ratiometric assessment of mitoxantrone release from theranostic ICG-conjugated mesoporous silica nanoparticles

scientific article published on 01 October 2019

Picolinate-containing macrocyclic Mn2+ complexes as potential MRI contrast agents.

scientific article

Picture of a chelate in exchange: the crystal structure of NaHoDOTMA, a 'semi'-hydrated chelate.

scientific article published on March 2013

Polycatechol Nanoparticle MRI Contrast Agents.

scientific article published on 17 December 2015

Polymeric Gd-DOTA amphiphiles form spherical and fibril-shaped nanoparticle MRI contrast agents

scientific article published on 22 March 2016

Properties, Solution State Behavior, and Crystal Structures of Chelates of DOTMA ⬇️

scientific article published on August 5, 2011

Prototropic and Water-Exchange Processes in Aqueous Solutions of Gd(III) Chelates

PrototropicvsWhole Water Exchange Contributions to the Solvent Relaxation Enhancement in the Aqueous Solution of a Cationic Gd3+Macrocyclic Complex

scientific article published in 1997

Relaxivity modulation in Gd-functionalised mesoporous silicas

scientific article published on 21 January 2009

Relaxometric and solution NMR structural studies on ditopic lanthanide(III) complexes of a phosphinate analogue of DOTA with a fast rate of water exchange.

scientific article published on 29 March 2006

Relaxometric evaluation of novel manganese(II) complexes for application as contrast agents in magnetic resonance imaging

scientific article

Responsive Mn(II) complexes for potential applications in diagnostic Magnetic Resonance Imaging.

scientific article

Scaling Laws at the Nano Size: The Effect of Particle Size and Shape on the Magnetism and Relaxivity of Iron Oxide Nanoparticle Contrast Agents.

scientific article published on June 2013

Selective Anchoring of GdIII Chelates on the External Surface of Organo‐Modified Mesoporous Silica Nanoparticles: A New Chemical Strategy To Enhance Relaxivity ⬇️

scientific article published on December 11, 2012

Selective functionalization of mesoporous silica nanoparticles with ibuprofen and Gd(III) chelates: a new probe for potential theranostic applications

scientific article published on 05 October 2015

Self-aggregated dinuclear lanthanide(III) complexes as potential bimodal probes for magnetic resonance and optical imaging.

scientific article

Separation of intra- and extracellular lactate NMR signals using a lanthanide shift reagent

scientific article published in January 2002

Solution Structure of Ln(III) Complexes with Macrocyclic Ligands Through Theoretical Evaluation of 1H NMR Contact Shifts

scientific article published on 06 December 2012

Solution properties of the Ln(III) complexes of a novel octadentate chelator with rigidified iminodiacetate arms.

scientific article

Strategies to enhance signal intensity with paramagnetic fluorine-labelled lanthanide complexes as probes for 19F magnetic resonance

scientific article

Structural Features of Europium(II)-Containing Cryptates That Influence Relaxivity.

scientific article

Structural variations across the lanthanide series of macrocyclic DOTA complexes: insights into the design of contrast agents for magnetic resonance imaging.

scientific article

Structural, luminescence, and NMR studies of the reversible binding of acetate, lactate, citrate, and selected amino acids to chiral diaqua ytterbium, gadolinium, and europium complexes

scientific article

Structure and Function of Iron-Loaded Synthetic Melanin.

scientific article

Structure and relaxivity of macrocyclic gadolinium complexes incorporating pyridyl and 4-morpholinopyridyl substituents

Substituent effects on Gd(III)-based MRI contrast agents: optimizing the stability and selectivity of the complex and the number of coordinated water molecules.

scientific article

Supramolecular assemblies based on amphiphilic Mn2+-complexes as high relaxivity MRI probes

scientific article published on 05 June 2018

Synthesis and characterisation of dimeric eight-coordinate lanthanide(III) complexes of a macrocyclic tribenzylphosphinate ligand

scientific article

Synthesis and solution thermodynamic study of rigidified and functionalised EGTA derivatives

scientific article published on 30 April 2008

Ternary complexes between cationic GdIII chelates and anionic metabolites in aqueous solution: an NMR relaxometric study

scientific article

The Selectivity of Reversible Oxy-Anion Binding in Aqueous Solution at a Chiral Europium and Terbium Center: Signaling of Carbonate Chelation by Changes in the Form and Circular Polarization of Luminescence Emission

scholarly article by James I. Bruce et al published October 2000 in Journal of the American Chemical Society

The cadmium binding domains in the metallothionein isoform Cd(7)-MT10 from Mytilus galloprovincialis revealed by NMR spectroscopy.

scientific article

The effect of ligand scaffold size on the stability of tripodal hydroxypyridonate gadolinium complexes.

scientific article published in April 2003

The use of a ditopic Gd(III) paramagnetic probe for investigating α-bungarotoxin surface accessibility.

scientific article

Thermodynamic stability, kinetic inertness and relaxometric properties of monoamide derivatives of lanthanide(III) DOTA complexes

scientific article published on 01 March 2015

Towards MRI contrast agents of improved efficacy. NMR relaxometric investigations of the binding interaction to HSA of a novel heptadentate macrocyclic triphosphonate Gd(III)-complex

Towards the rational design of MRI contrast agents: a practical approach to the synthesis of gadolinium complexes that exhibit optimal water exchange

scientific article

Tris(pyrone) chelates of Gd(III) as high solubility MRI-CA.

scientific article

Tuning the coordination number of hydroxypyridonate-based gadolinium complexes: implications for MRI contrast agents.

scientific article

[GdPCP2A(H(2)O)(2)](-): a paramagnetic contrast agent designed for improved applications in magnetic resonance imaging.

scientific article

[Yb(AAZTA)(H2O)]-: an unconventional ParaCEST MRI probe

scientific article published on 7 February 2018

pH-dependent modulation of relaxivity and luminescence in macrocyclic gadolinium and europium complexes based on reversible intramolecular sulfonamide ligation

scientific article published in August 2001

pH-responsive lanthanide complexes based on reversible ligation of a diphenylphosphinamide.

scientific article

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