List of works - Lucio Toma

3-heptylamino-5-phenylpyridazine derivatives as analogues of Acyl-CoA: cholesterol acyltransferase inhibitors containing the N-heptyl-N'-arylureidic moiety

scientific article published on 01 December 2006

5,6-Diphenylpyridazine derivatives as acyl-CoA:cholesterol acyltransferase inhibitors

scientific article published in November 2001

6-Chloropyridazin-3-yl derivatives active as nicotinic agents: synthesis, binding, and modeling studies.

scientific article published in August 2002

A bispericyclic transition structure allows for efficient relief of antiaromaticity enhancing reactivity and endo stereoselectivity in the dimerization of the fleeting cyclopentadienone.

scientific article

A comparative molecular modeling study of dydrogesterone with other progestational agents through theoretical calculations and nuclear magnetic resonance spectroscopy.

scientific article

A full conformational characterization of 13-ethylprogestogens through theoretical calculations and nuclear magnetic resonance spectroscopy

scientific article published on 03 November 2006

A new approach to the synthesis of beta-glycosidically linked oligosaccharides containing 2-acetamido-2-deoxy-D-mannose residues

scientific article published in June 1985

A theoretical study of the conformational behavior of analogues of alpha-L-rhamnose-1-phosphate

scientific article published in May 2004

An Exhaustive Conformational Evaluation of the HIV-1 Inhibitor BMS-378806 through Theoretical Calculations and Nuclear Magnetic Resonance Spectroscopy

article

An In-Depth Computational Study of Alkene Cyclopropanation Catalyzed by Fe(porphyrin)(OCH3) Complexes. The Environmental Effects on the Energy Barriers

scientific article published on 26 July 2020

An unexpected bispericyclic transition structure leading to 4+2 and 2+4 cycloadducts in the endo dimerization of cyclopentadiene.

scientific article published in February 2002

Anti-tumor-promoting effects of glycoglycerolipid analogues on two-stage mouse skin carcinogenesis.

scientific article

Base promoted air oxidation of 13beta-ethyl-11-methylenegon-4-en-17-one.

scientific article published in February 2002

Benzocondensed derivatives as rigid analogues of the mu-opioid agonist 3(8)-cinnamyl-8(3)-propionyl-3,8-diazabicyclo[3.2.1]octanes: synthesis, modeling, and affinity.

scientific article

Biological and computational evaluation of an oxadiazole derivative (MD77) as a new lead for direct STAT3 inhibitors

article published in 2012

Biotin and Biotin Analogues Specifically Modify the Fluorescence Decay of Avidin

Biphenyl versus phenylpyridazine derivatives: the role of the heterocycle in a series of acyl-CoA:cholesterol acyl transferase inhibitors

scientific article

Chemoenzymatic synthesis and antitumor promoting activity of 6'- and 3-esters of 2-O-beta-D-glucosylglycerol.

scientific article published on September 1999

Complete Characterization of the 3D Properties of the CCR5 Antagonist Vicriviroc through DFT Calculations, NMR Spectroscopy, and X-ray Analysis

Computational Mechanistic Study of the Julia–Kocieński Reaction

scientific article published on 27 February 2015

Cone Calix[4]arenes with Orientable Glycosylthioureido Groups at the Upper Rim: An In-Depth Analysis of Their Symmetry Properties.

scientific article published on 17 July 2015

Conformational analysis and stability of collagen peptides by CD and by 1H- and 13C-NMR spectroscopies

scientific article published on 01 January 2000

Conformational analysis of the trisaccharide components of the repeating units of the capsular polysaccharides of Streptococcus pneumoniae types 19F and 19A

scientific article published on 01 August 1992

Crystal structures of 10alpha-gon-5-enes from the synthetic pathway to desogestrel

scientific article published in August 2005

Crystallographic, spectroscopic, and theoretical investigation of the efficiently separated 21R and 21S-diastereoisomers of argatroban

scientific article

Cyclic and branched acyl chain galactoglycerolipids and their effect on anti-tumor-promoting activity.

scientific article published on 22 September 2006

Cyclic glycopeptidomimetics through a versatile sugar-based scaffold

scientific article published on 9 April 2009

DFT Conformational Studies of Chiral Bis-Binaphthyl Porphyrins and Their Metal Complexes Employed as Cyclopropanation Catalysts

Design of novel conformationally restricted analogues of glutamic acid

Design, synthesis, and pharmacological characterization of novel, potent NMDA receptor antagonists

scientific article published in December 2004

Diazabicyclo analogues of maraviroc: synthesis, modeling, NMR studies and antiviral activity

scientific article published on 16 December 2016

Enantioselective synthesis and olfactory evaluation of bicyclic alpha- and gamma-ionone derivatives: the 3D arrangement of key molecular features relevant to the violet odor of ionones

scientific article published in September 2009

Enzymic acylation of methyl D- and L-glycopyranosides: influence of the 3-hydroxyl group

scientific article published on 01 November 1993

Halide-Controlled Extending-Shrinking Motion of a Covalent Cage

scientific article published on 27 March 2019

Immobilization of the acylase from Escherichia coli on glyoxyl-agarose gives efficient catalyst for the synthesis of cephalosporins.

scientific article published on 6 September 2007

Inhibition of activated murine T-lymphocytes by synthetic glycoglycerolipid analogues

scientific article

Inhibitory effect of stabilized analogues of glycoglycerolipids on Epstein-Barr virus activation and mouse skin tumor promotion.

scientific article published in December 2002

Inhibitory effects of fatty acid monoesters of 2-O-beta-D-glucosylglycerol on Epstein-Barr virus activation.

scientific article published in January 1998

Inhibitory effects of monoacylated 2-O-beta-galactosylglycerols on Epstein-Barr virus activation: the significant role of the hexanoyl chain

scientific article published in August 1999

Mechanism of falcipain-2 inhibition by α,β-unsaturated benzo[1,4]diazepin-2-one methyl ester

scientific article published on 11 September 2012

Modeling and Spectroscopic Studies of Synthetic Diazabicyclo Analogs of the HIV-1 Inhibitor BMS-378806 and Evaluation of Their Antiviral Activity

article

Modeling of synthetic phosphono and carba analogues of N-acetyl-alpha-D-mannosamine 1-phosphate, the repeating unit of the capsular polysaccharide from Neisseria meningitidis serovar A.

scientific article published on 10 July 2009

Modeling, synthesis and NMR characterization of novel chimera compounds targeting STAT3

Molecular dynamics simulations of the Salmonella typhi Vi antigenic polysaccharide and effects of the introduction of a zwitterionic motif.

scientific article published on 24 June 2011

Mono- and disubstituted-3,8-diazabicyclo[3.2.1]octane derivatives as analgesics structurally related to epibatidine: synthesis, activity, and modeling

scientific article published in February 1998

Mono- or diphenylpyridazines connected to N-(2,4-difluorophenyl)-N'-heptylurea as acyl-CoA:cholesterol acyltransferase inhibitors

scientific article

Monocyclic analogues of the μ-opioid agonist 3,8-diazabicyclo [3.2.1]octanes: Synthesis, modeling, and activity

Multivalent presentation of a hydrolytically stable GM(3) lactone mimetic as modulator of melanoma cells motility and adhesion.

scientific article published on 24 March 2013

Novel adrenoceptor antagonists with a tricyclic pyrrolodipyridazine skeleton

scientific article published on 01 January 1999

Novel potent AMPA/kainate receptor antagonists: synthesis and anticonvulsant activity of a series of 2-[(4-alkylsemicarbazono)-(4-amino-phenyl)methyl]-4,5-methylenedioxyphenylacetic acid alkyl esters

scientific article published in September 2002

Self-Assembly of Pseudorotaxane Structures from a Dicopper(II) Molecular Cage and Dicarboxylate Axles

scientific article

Stable GM3 lactone mimetic raises antibodies specific for the antigens expressed on melanoma cells

scientific article published on 01 August 2010

Synthesis and anti-tumor-promoting activity of glycoglycerolipid analogues lacking the glycerol backbone

scientific article

Synthesis and enantiopharmacology of new AMPA-kainate receptor agonists.

scientific article

Synthesis and pharmacology of 3-hydroxy-delta2-isoxazoline-cyclopentane analogues of glutamic acid.

scientific article

Synthesis of 3,6-diazabicyclo[3.1.1]heptanes as novel ligands for neuronal nicotinic acetylcholine receptors

scientific article

Synthesis of 3,6-diazabicyclo[3.1.1]heptanes as novel ligands for the opioid receptors

scientific article

Synthesis, characterisation and catalytic use of iron porphyrin amino ester conjugates

Synthesis, conformational studies, binding assessment and liposome insertion of a thioether-bridged mimetic of the antigen GM3 ganglioside lactone

scientific article published on 01 September 2007

Synthesis, modeling, and crystallographic study of 3,4-disubstituted-1,2,5-oxadiazoles and evaluation of their ability to decrease STAT3 activity

article published in 2010

Synthesis, modelling, and mu-opioid receptor affinity of N-3(9)-arylpropenyl-N-9(3)-propionyl-3,9-diazabicycl

scientific article

Synthesis, molecular dynamics simulations, and biology of a carba-analogue of the trisaccharide repeating unit of Streptococcus pneumoniae 19F capsular polysaccharide

scientific article published on 20 August 2009

Synthesis, structure–activity relationships and stereochemical investigations of new tricyclic pyridazinone derivatives as potential STAT3 inhibitors

The Chemistry of Coumarin Derivatives. Part VI. Diels-Alder Trapping of 3-Methylene-2,4-chromandione. A New Entry to Substituted Pyrano[3,2-c]coumarins

The Photochemical Reaction between 1,4-Dicyanonaphthalene and benzyl ethers

The three corrugated surfaces of 1,4-divinyltetramethylene diradical intermediates and their connections to 1,2-divinylcyclobutane, 4-vinylcyclohexene, 1,5-cyclooctadiene, and two butadienes.

scientific article published in April 2005

Tricyclic pyrazoles. 3. Synthesis, biological evaluation, and molecular modeling of analogues of the cannabinoid antagonist 8-chloro-1-(2',4'-dichlorophenyl)-N-piperidin-1-yl-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide.

scientific article published in November 2005

List of works by Lucio Toma

3-heptylamino-5-phenylpyridazine derivatives as analogues of Acyl-CoA: cholesterol acyltransferase inhibitors containing the N-heptyl-N'-arylureidic moiety

5,6-Diphenylpyridazine derivatives as acyl-CoA:cholesterol acyltransferase inhibitors

6-Chloropyridazin-3-yl derivatives active as nicotinic agents: synthesis, binding, and modeling studies.

A bispericyclic transition structure allows for efficient relief of antiaromaticity enhancing reactivity and endo stereoselectivity in the dimerization of the fleeting cyclopentadienone.

A comparative molecular modeling study of dydrogesterone with other progestational agents through theoretical calculations and nuclear magnetic resonance spectroscopy.

A full conformational characterization of 13-ethylprogestogens through theoretical calculations and nuclear magnetic resonance spectroscopy

A new approach to the synthesis of beta-glycosidically linked oligosaccharides containing 2-acetamido-2-deoxy-D-mannose residues

A theoretical study of the conformational behavior of analogues of alpha-L-rhamnose-1-phosphate

An Exhaustive Conformational Evaluation of the HIV-1 Inhibitor BMS-378806 through Theoretical Calculations and Nuclear Magnetic Resonance Spectroscopy

An In-Depth Computational Study of Alkene Cyclopropanation Catalyzed by Fe(porphyrin)(OCH3) Complexes. The Environmental Effects on the Energy Barriers

An unexpected bispericyclic transition structure leading to 4+2 and 2+4 cycloadducts in the endo dimerization of cyclopentadiene.

Anti-tumor-promoting effects of glycoglycerolipid analogues on two-stage mouse skin carcinogenesis.

Base promoted air oxidation of 13beta-ethyl-11-methylenegon-4-en-17-one.

Benzocondensed derivatives as rigid analogues of the mu-opioid agonist 3(8)-cinnamyl-8(3)-propionyl-3,8-diazabicyclo[3.2.1]octanes: synthesis, modeling, and affinity.

Biological and computational evaluation of an oxadiazole derivative (MD77) as a new lead for direct STAT3 inhibitors

Biotin and Biotin Analogues Specifically Modify the Fluorescence Decay of Avidin

Biphenyl versus phenylpyridazine derivatives: the role of the heterocycle in a series of acyl-CoA:cholesterol acyl transferase inhibitors

Chemoenzymatic synthesis and antitumor promoting activity of 6'- and 3-esters of 2-O-beta-D-glucosylglycerol.

Complete Characterization of the 3D Properties of the CCR5 Antagonist Vicriviroc through DFT Calculations, NMR Spectroscopy, and X-ray Analysis

Computational Mechanistic Study of the Julia–Kocieński Reaction

Cone Calix[4]arenes with Orientable Glycosylthioureido Groups at the Upper Rim: An In-Depth Analysis of Their Symmetry Properties.

Conformational analysis and stability of collagen peptides by CD and by 1H- and 13C-NMR spectroscopies

Conformational analysis of the trisaccharide components of the repeating units of the capsular polysaccharides of Streptococcus pneumoniae types 19F and 19A

Crystal structures of 10alpha-gon-5-enes from the synthetic pathway to desogestrel

Crystallographic, spectroscopic, and theoretical investigation of the efficiently separated 21R and 21S-diastereoisomers of argatroban

Cyclic and branched acyl chain galactoglycerolipids and their effect on anti-tumor-promoting activity.

Cyclic glycopeptidomimetics through a versatile sugar-based scaffold

DFT Conformational Studies of Chiral Bis-Binaphthyl Porphyrins and Their Metal Complexes Employed as Cyclopropanation Catalysts

Design of novel conformationally restricted analogues of glutamic acid

Design, synthesis, and pharmacological characterization of novel, potent NMDA receptor antagonists

Diazabicyclo analogues of maraviroc: synthesis, modeling, NMR studies and antiviral activity

Enantioselective synthesis and olfactory evaluation of bicyclic alpha- and gamma-ionone derivatives: the 3D arrangement of key molecular features relevant to the violet odor of ionones

Enzymic acylation of methyl D- and L-glycopyranosides: influence of the 3-hydroxyl group

Halide-Controlled Extending-Shrinking Motion of a Covalent Cage

Immobilization of the acylase from Escherichia coli on glyoxyl-agarose gives efficient catalyst for the synthesis of cephalosporins.

Inhibition of activated murine T-lymphocytes by synthetic glycoglycerolipid analogues

Inhibitory effect of stabilized analogues of glycoglycerolipids on Epstein-Barr virus activation and mouse skin tumor promotion.

Inhibitory effects of fatty acid monoesters of 2-O-beta-D-glucosylglycerol on Epstein-Barr virus activation.

Inhibitory effects of monoacylated 2-O-beta-galactosylglycerols on Epstein-Barr virus activation: the significant role of the hexanoyl chain

Mechanism of falcipain-2 inhibition by α,β-unsaturated benzo[1,4]diazepin-2-one methyl ester

Modeling and Spectroscopic Studies of Synthetic Diazabicyclo Analogs of the HIV-1 Inhibitor BMS-378806 and Evaluation of Their Antiviral Activity

Modeling of synthetic phosphono and carba analogues of N-acetyl-alpha-D-mannosamine 1-phosphate, the repeating unit of the capsular polysaccharide from Neisseria meningitidis serovar A.

Modeling, synthesis and NMR characterization of novel chimera compounds targeting STAT3

Molecular dynamics simulations of the Salmonella typhi Vi antigenic polysaccharide and effects of the introduction of a zwitterionic motif.

Mono- and disubstituted-3,8-diazabicyclo[3.2.1]octane derivatives as analgesics structurally related to epibatidine: synthesis, activity, and modeling

Mono- or diphenylpyridazines connected to N-(2,4-difluorophenyl)-N'-heptylurea as acyl-CoA:cholesterol acyltransferase inhibitors

Monocyclic analogues of the μ-opioid agonist 3,8-diazabicyclo [3.2.1]octanes: Synthesis, modeling, and activity

Multivalent presentation of a hydrolytically stable GM(3) lactone mimetic as modulator of melanoma cells motility and adhesion.

Novel adrenoceptor antagonists with a tricyclic pyrrolodipyridazine skeleton

Novel potent AMPA/kainate receptor antagonists: synthesis and anticonvulsant activity of a series of 2-[(4-alkylsemicarbazono)-(4-amino-phenyl)methyl]-4,5-methylenedioxyphenylacetic acid alkyl esters

Self-Assembly of Pseudorotaxane Structures from a Dicopper(II) Molecular Cage and Dicarboxylate Axles

Stable GM3 lactone mimetic raises antibodies specific for the antigens expressed on melanoma cells

Synthesis and anti-tumor-promoting activity of glycoglycerolipid analogues lacking the glycerol backbone

Synthesis and enantiopharmacology of new AMPA-kainate receptor agonists.

Synthesis and pharmacology of 3-hydroxy-delta2-isoxazoline-cyclopentane analogues of glutamic acid.

Synthesis of 3,6-diazabicyclo[3.1.1]heptanes as novel ligands for neuronal nicotinic acetylcholine receptors

Synthesis of 3,6-diazabicyclo[3.1.1]heptanes as novel ligands for the opioid receptors

Synthesis, characterisation and catalytic use of iron porphyrin amino ester conjugates

Synthesis, conformational studies, binding assessment and liposome insertion of a thioether-bridged mimetic of the antigen GM3 ganglioside lactone

Synthesis, modeling, and crystallographic study of 3,4-disubstituted-1,2,5-oxadiazoles and evaluation of their ability to decrease STAT3 activity

Synthesis, modelling, and mu-opioid receptor affinity of N-3(9)-arylpropenyl-N-9(3)-propionyl-3,9-diazabicycl

Synthesis, molecular dynamics simulations, and biology of a carba-analogue of the trisaccharide repeating unit of Streptococcus pneumoniae 19F capsular polysaccharide

Synthesis, structure–activity relationships and stereochemical investigations of new tricyclic pyridazinone derivatives as potential STAT3 inhibitors

The Chemistry of Coumarin Derivatives. Part VI. Diels-Alder Trapping of 3-Methylene-2,4-chromandione. A New Entry to Substituted Pyrano[3,2-c]coumarins

The Photochemical Reaction between 1,4-Dicyanonaphthalene and benzyl ethers

The three corrugated surfaces of 1,4-divinyltetramethylene diradical intermediates and their connections to 1,2-divinylcyclobutane, 4-vinylcyclohexene, 1,5-cyclooctadiene, and two butadienes.

Tricyclic pyrazoles. 3. Synthesis, biological evaluation, and molecular modeling of analogues of the cannabinoid antagonist 8-chloro-1-(2',4'-dichlorophenyl)-N-piperidin-1-yl-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide.

Ureido-Pyridazinone Derivatives: Insights into the Structural and Conformational Properties for STAT3 Inhibition