List of works - Pei-Qiang Huang

A concise and fully selective synthesis of the ant venom alkaloid (3S,5R,8S,9S)-3-butyl-5-propyl-8-hydroxyindolizidine

scientific article published on 24 August 2009

A flexible approach for the asymmetric syntheses of hyacinthacines A2, A3 and structural confirmation of hyacinthacine A3.

scientific article published on 3 March 2010

A flexible approach to (S)-5-alkyl tetramic acid derivatives: application to the asymmetric synthesis of (+)-preussin and protected (3S,4S)-AHPPA

scientific article published on 01 November 2003

A flexible asymmetric approach to methyl 5-alkyltetramates and its application in the synthesis of cytotoxic marine natural product belamide A.

scientific article published on 19 November 2010

A formal enantioselective total synthesis of FR901483

scientific article published on 31 August 2012

A general approach to (5S,6R)-6-alkyl-5-benzyloxy-2-piperidinones: application to the asymmetric syntheses of neurokinin substance P receptor antagonist (-)-L-733,061 and (-)-deoxocassine.

scientific article

A new approach for asymmetric synthesis of (R)-3-methylpyrrolidine alkaloids from (S)-malic acid

scientific article

A new approach to 3-hydroxyprolinol derivatives by samarium diiodide-mediated reductive coupling of chiral nitrone with carbonyl compounds.

scientific article published on 2 June 2009

A new method for the construction of the hydroxylated tropane skeleton: enantioselective synthesis of (-)-Bao Gong Teng A

scientific article published on 25 November 2010

A versatile approach for the asymmetric syntheses of (1R,9aR)-epiquinamide and (1R,9aR)-homopumiliotoxin 223G.

scientific article published in March 2006

Asymmetric Total Synthesis and Absolute Configuration Determination of (-)-Verrupyrroloindoline

scientific article published on 03 July 2018

Asymmetric syntheses and Wnt signal inhibitory activity of melleumin A and four analogues of melleumins A and B.

scientific article

Asymmetric synthesis of the cytotoxic marine natural product (+)-awajanomycin and its C-11 epimer.

scientific article published in June 2010

Asymmetric total synthesis of (-)-awajanomycin

scientific article published on 01 November 2009

Asymmetric vinylogous Mannich reactions: a versatile approach to functionalized heterocycles

scientific article published on 19 August 2011

Biomimetic Enantioselective Total Synthesis of (-)-Robustanoids A and B and Analogues

scientific article published on 18 April 2019

Chemoselective Synthesis of α-Amino-α-cyanophosphonates by Reductive Gem-Cyanation-Phosphonylation of Secondary Amides

scientific article published on 06 May 2019

Chemoselective reductive alkynylation of tertiary amides by Ir and Cu(i) bis-metal sequential catalysis

scientific article published in September 2016

Complementary stereocontrolled approaches to 2-pyrrolidinones bearing a vicinal amino diol subunit with three continuous chiral centers: a formal asymmetric synthesis of (-)-detoxinine

scientific article published on 20 October 2007

Complexity generation by chemical synthesis: a five-step synthesis of (-)-chaetominine from L-tryptophan and its biosynthetic implications.

scientific article published in May 2014

Detailed studies on the enantioselective synthesis and HPLC enantioseparation of N-protected 3-hydroxyglutarimides

scientific article

Direct reductive coupling of secondary amides: chemoselective formation of vicinal diamines and vicinal amino alcohols.

scientific article

Direct transformation of secondary amides into secondary amines: triflic anhydride activated reductive alkylation

scientific article published on 13 July 2012

Direct, one-pot sequential reductive alkylation of lactams/amides with Grignard and organolithium reagents through lactam/amide activation

scientific article published on 01 April 2010

Diversity-oriented asymmetric synthesis of hapalosin: construction of three small C9/C4/C3-modified hapalosin analogue libraries

scientific article

Double Addition of Alkynyllithium Reagents to Amides/Lactams: A Direct and Flexible Synthesis of 3-Amino-1,4-diynes Bearing an Aza-Quaternary Carbon Center

scientific article published on 09 July 2019

Dual catalysis for enantioselective convergent synthesis of enantiopure vicinal amino alcohols

scientific article published on 29 January 2018

Efficient and chemoselective alkylation of amines/amino acids using alcohols as alkylating reagents under mild conditions

scientific article published on 9 September 2010

Enamines as Surrogates of Alkene Carbanions for the Reductive Alkenylation of Secondary Amides: An Approach to Allylamines

scientific article published on 31 January 2018

Enantiodivergent synthesis of both enantiomers of marine alkaloids haliclorensin and isohaliclorensin, a constituent of halitulin

scientific article published on 01 April 2004

Enantioselective synthesis of the R-enantiomer of the feeding deterrent (S)-ypaoamide

scientific article published in October 2009

Enantioselective total syntheses of (+)-stemofoline and three congeners based on a biogenetic hypothesis

scientific article published on 20 October 2020

Enantioselective total syntheses of (-)-FR901483 and (+)-8-epi-FR901483

scientific article published on 18 December 2012

Formations of mixed-valence oxovanadiumV,IV citrates and homocitrate with N-heterocycle chelated ligand

scientific article published on 23 August 2008

General and chemoselective bisphosphonylation of secondary and tertiary amides.

scientific article published on 27 January 2015

General one-pot reductive gem-bis-alkylation of tertiary lactams/amides: rapid construction of 1-azaspirocycles and formal total synthesis of (±)-cephalotaxine

scientific article published on 16 August 2013

Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation

scientific article

Induction of Autophagic Death in Cancer Cells by Agonizing TR3 and Attenuating Akt2 Activity

scientific article published on 20 August 2015

Intermolecular Dehydrative [4 + 2] Aza-Annulation of N-Arylamides with Alkenes: A Direct and Divergent Entrance to Aza-Heterocycles

scientific article published on 26 February 2019

Iridium-Catalyzed Reductive Alkylations of Secondary Amides

scientific article published on 31 July 2018

Mechanism for the regioselective asymmetric addition of grignard reagents to malimides: A computational exploration

scientific article published in January 2007

Metal-Free C-H Alkyliminylation and Acylation of Alkenes with Secondary Amides

scientific article published on 29 June 2016

Mild Metal-Free Hydrosilylation of Secondary Amides to Amines

scientific article published on 21 April 2016

Modular enantioselective synthesis of 8-aza-prostaglandin E1

scientific article published on 30 August 2013

NSAID sulindac and its analog bind RXRalpha and inhibit RXRalpha-dependent AKT signaling

scientific article

Ni-Catalyzed cross-coupling reactions of N-acylpyrrole-type amides with organoboron reagents

scientific article published on 10 November 2017

One-pot cross-coupling of N-acyl N,O-acetals with alpha,beta-unsaturated compounds.

scientific article published on 13 October 2009

One-pot reductive coupling of N-acylcarbamates with activated alkenes: application to the asymmetric synthesis of pyrrolo[1,2-a]azepin-5-one ring system and (-)-xenovenine

scientific article

Organocatalytic, Asymmetric Total Synthesis of (-)-Haliclonin A.

scientific article published on 17 February 2016

Organocatalytic, Enantioselective Reductive Bis-functionalization of Secondary Amides: One-Pot Construction of Chiral 2,2-Disubstituted 3-Iminoindoline

scientific article published on 03 September 2019

Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway

scientific article

Palladium-Catalyzed [3 + 2]-C-C/N-C Bond-Forming Annulation

scientific article published on 13 June 2018

Reductive hydroxyalkylation/alkylation of amines with lactones/esters

scientific article published on 02 July 2012

Samarium diiodide promoted generation and asymmetric hydroxyalkylation of N,O-diprotected (3S)-3-pyrrolidinol 2-carbanions

scientific article published in February 2005

SmI2-mediated coupling of nitrones and tert-butanesulfinyl imines with allenoates: synthesis of β-methylenyl-γ-lactams and tetramic acids

scientific article published on 10 April 2012

SmI2-mediated intermolecular coupling of γ-lactam N-α-radicals with activated alkenes: asymmetric synthesis of 11-hydroxylated analogues of the lead compounds CP-734432 and PF-04475270.

scientific article published on 14 August 2012

SmI2-mediated radical coupling strategy to Securinega alkaloids: total synthesis of (-)-14,15-dihydrosecurinine and formal total synthesis of (-)-securinine

scientific article published on 24 December 2014

SmI2-mediated radical cross-couplings of α-hydroxylated aza-hemiacetals and N,S-acetals with α,β-unsaturated compounds: asymmetric synthesis of (+)-hyacinthacine A2, (-)-uniflorine A, and (+)-7-epi-casuarine

scientific article published on 26 May 2011

Studies towards an enantioselective total synthesis of sarain A: a concise asymmetric construction of the diazatricyclic core

scientific article published on 01 September 2010

Substrate-Controlled Chemoselective Reactions of Isocyanoacetates with Amides and Lactams

scientific article

Synthesis and SAR study of modulators inhibiting tRXRα-dependent AKT activation.

scientific article published on 18 January 2013

Tertiary amide-based Knoevenagel-type reactions: a direct, general, and chemoselective approach to enaminones.

scientific article published on 26 June 2014

The asymmetric total synthesis of (+)-N-acetyl norloline.

scientific article published on 5 November 2015

The four-step total synthesis of (-)-chaetominine.

scientific article published in February 2014

Titanocene(III)-Catalyzed Three-Component Reaction of Secondary Amides, Aldehydes, and Electrophilic Alkenes.

scientific article published on 25 September 2015

Total synthesis of (-)-sessilifoliamide J

scientific article published on 14 September 2012

Toward the total synthesis of haliclonin A: construction of a tricyclic substructure

scientific article published on 05 December 2012

Towards stereochemical control: A short formal enantioselective total synthesis of pumiliotoxins 251D and 237A.

scientific article

Umpolung of hemiaminals: titanocene-catalyzed dehydroxylative radical coupling reactions with activated alkenes

scientific article published on 18 February 2013

Versatile one-pot reductive alkylation of lactams/amides via amide activation: application to the concise syntheses of bioactive alkaloids (±)-bgugaine, (±)-coniine, (+)-preussin, and (-)-cassine.

scientific article published on November 2010

List of works by Pei-Qiang Huang

A concise and fully selective synthesis of the ant venom alkaloid (3S,5R,8S,9S)-3-butyl-5-propyl-8-hydroxyindolizidine

A flexible approach for the asymmetric syntheses of hyacinthacines A2, A3 and structural confirmation of hyacinthacine A3.

A flexible approach to (S)-5-alkyl tetramic acid derivatives: application to the asymmetric synthesis of (+)-preussin and protected (3S,4S)-AHPPA

A flexible asymmetric approach to methyl 5-alkyltetramates and its application in the synthesis of cytotoxic marine natural product belamide A.

A formal enantioselective total synthesis of FR901483

A general approach to (5S,6R)-6-alkyl-5-benzyloxy-2-piperidinones: application to the asymmetric syntheses of neurokinin substance P receptor antagonist (-)-L-733,061 and (-)-deoxocassine.

A new approach for asymmetric synthesis of (R)-3-methylpyrrolidine alkaloids from (S)-malic acid

A new approach to 3-hydroxyprolinol derivatives by samarium diiodide-mediated reductive coupling of chiral nitrone with carbonyl compounds.

A new method for the construction of the hydroxylated tropane skeleton: enantioselective synthesis of (-)-Bao Gong Teng A

A versatile approach for the asymmetric syntheses of (1R,9aR)-epiquinamide and (1R,9aR)-homopumiliotoxin 223G.

Asymmetric Total Synthesis and Absolute Configuration Determination of (-)-Verrupyrroloindoline

Asymmetric syntheses and Wnt signal inhibitory activity of melleumin A and four analogues of melleumins A and B.

Asymmetric synthesis of the cytotoxic marine natural product (+)-awajanomycin and its C-11 epimer.

Asymmetric total synthesis of (-)-awajanomycin

Asymmetric vinylogous Mannich reactions: a versatile approach to functionalized heterocycles

Biomimetic Enantioselective Total Synthesis of (-)-Robustanoids A and B and Analogues

Chemoselective Synthesis of α-Amino-α-cyanophosphonates by Reductive Gem-Cyanation-Phosphonylation of Secondary Amides

Chemoselective reductive alkynylation of tertiary amides by Ir and Cu(i) bis-metal sequential catalysis

Complementary stereocontrolled approaches to 2-pyrrolidinones bearing a vicinal amino diol subunit with three continuous chiral centers: a formal asymmetric synthesis of (-)-detoxinine

Complexity generation by chemical synthesis: a five-step synthesis of (-)-chaetominine from L-tryptophan and its biosynthetic implications.

Detailed studies on the enantioselective synthesis and HPLC enantioseparation of N-protected 3-hydroxyglutarimides

Direct reductive coupling of secondary amides: chemoselective formation of vicinal diamines and vicinal amino alcohols.

Direct transformation of secondary amides into secondary amines: triflic anhydride activated reductive alkylation

Direct, one-pot sequential reductive alkylation of lactams/amides with Grignard and organolithium reagents through lactam/amide activation

Diversity-oriented asymmetric synthesis of hapalosin: construction of three small C9/C4/C3-modified hapalosin analogue libraries

Double Addition of Alkynyllithium Reagents to Amides/Lactams: A Direct and Flexible Synthesis of 3-Amino-1,4-diynes Bearing an Aza-Quaternary Carbon Center

Dual catalysis for enantioselective convergent synthesis of enantiopure vicinal amino alcohols

Efficient and chemoselective alkylation of amines/amino acids using alcohols as alkylating reagents under mild conditions

Enamines as Surrogates of Alkene Carbanions for the Reductive Alkenylation of Secondary Amides: An Approach to Allylamines

Enantiodivergent synthesis of both enantiomers of marine alkaloids haliclorensin and isohaliclorensin, a constituent of halitulin

Enantioselective synthesis of the R-enantiomer of the feeding deterrent (S)-ypaoamide

Enantioselective total syntheses of (+)-stemofoline and three congeners based on a biogenetic hypothesis

Enantioselective total syntheses of (-)-FR901483 and (+)-8-epi-FR901483

Formations of mixed-valence oxovanadiumV,IV citrates and homocitrate with N-heterocycle chelated ligand

General and chemoselective bisphosphonylation of secondary and tertiary amides.

General one-pot reductive gem-bis-alkylation of tertiary lactams/amides: rapid construction of 1-azaspirocycles and formal total synthesis of (±)-cephalotaxine

Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation

Induction of Autophagic Death in Cancer Cells by Agonizing TR3 and Attenuating Akt2 Activity

Intermolecular Dehydrative [4 + 2] Aza-Annulation of N-Arylamides with Alkenes: A Direct and Divergent Entrance to Aza-Heterocycles

Iridium-Catalyzed Reductive Alkylations of Secondary Amides

Mechanism for the regioselective asymmetric addition of grignard reagents to malimides: A computational exploration

Metal-Free C-H Alkyliminylation and Acylation of Alkenes with Secondary Amides

Mild Metal-Free Hydrosilylation of Secondary Amides to Amines

Modular enantioselective synthesis of 8-aza-prostaglandin E1

NSAID sulindac and its analog bind RXRalpha and inhibit RXRalpha-dependent AKT signaling

Ni-Catalyzed cross-coupling reactions of N-acylpyrrole-type amides with organoboron reagents

One-pot cross-coupling of N-acyl N,O-acetals with alpha,beta-unsaturated compounds.

One-pot reductive coupling of N-acylcarbamates with activated alkenes: application to the asymmetric synthesis of pyrrolo[1,2-a]azepin-5-one ring system and (-)-xenovenine

Organocatalytic, Asymmetric Total Synthesis of (-)-Haliclonin A.

Organocatalytic, Enantioselective Reductive Bis-functionalization of Secondary Amides: One-Pot Construction of Chiral 2,2-Disubstituted 3-Iminoindoline

Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway

Palladium-Catalyzed [3 + 2]-C-C/N-C Bond-Forming Annulation

Reductive hydroxyalkylation/alkylation of amines with lactones/esters

Samarium diiodide promoted generation and asymmetric hydroxyalkylation of N,O-diprotected (3S)-3-pyrrolidinol 2-carbanions

SmI2-mediated coupling of nitrones and tert-butanesulfinyl imines with allenoates: synthesis of β-methylenyl-γ-lactams and tetramic acids

SmI2-mediated intermolecular coupling of γ-lactam N-α-radicals with activated alkenes: asymmetric synthesis of 11-hydroxylated analogues of the lead compounds CP-734432 and PF-04475270.

SmI2-mediated radical coupling strategy to Securinega alkaloids: total synthesis of (-)-14,15-dihydrosecurinine and formal total synthesis of (-)-securinine

SmI2-mediated radical cross-couplings of α-hydroxylated aza-hemiacetals and N,S-acetals with α,β-unsaturated compounds: asymmetric synthesis of (+)-hyacinthacine A2, (-)-uniflorine A, and (+)-7-epi-casuarine

Studies towards an enantioselective total synthesis of sarain A: a concise asymmetric construction of the diazatricyclic core

Substrate-Controlled Chemoselective Reactions of Isocyanoacetates with Amides and Lactams

Synthesis and SAR study of modulators inhibiting tRXRα-dependent AKT activation.

Tertiary amide-based Knoevenagel-type reactions: a direct, general, and chemoselective approach to enaminones.

The asymmetric total synthesis of (+)-N-acetyl norloline.

The four-step total synthesis of (-)-chaetominine.

Titanocene(III)-Catalyzed Three-Component Reaction of Secondary Amides, Aldehydes, and Electrophilic Alkenes.

Total synthesis of (-)-sessilifoliamide J

Toward the total synthesis of haliclonin A: construction of a tricyclic substructure

Towards stereochemical control: A short formal enantioselective total synthesis of pumiliotoxins 251D and 237A.

Umpolung of hemiaminals: titanocene-catalyzed dehydroxylative radical coupling reactions with activated alkenes

Versatile one-pot reductive alkylation of lactams/amides via amide activation: application to the concise syntheses of bioactive alkaloids (±)-bgugaine, (±)-coniine, (+)-preussin, and (-)-cassine.