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List of works by Haiping Hao

A Promising Microtubule Inhibitor Deoxypodophyllotoxin Exhibits Better Efficacy to Multidrug-Resistant Breast Cancer than Paclitaxel via Avoiding Efflux Transport.

scientific article published on 9 March 2018

A chemical family-based strategy for uncovering hidden bioactive molecules and multicomponent interactions in herbal medicines.

scientific article

A diet-microbial metabolism feedforward loop modulates intestinal stem cell renewal in the stressed gut

scientific article published on 11 January 2021

A fast carrier chromatin immunoprecipitation method applicable to microdissected tissue samples.

scientific article

A high-resolution peak fractionation approach for streamlined screening of nuclear-factor-E2-related factor-2 activators in Salvia miltiorrhiza

scientific article

A novel intestinal-restricted FXR agonist

scientific article published on 3 June 2017

A sensitive and specific liquid chromatography/tandem mass spectrometry method for determination of echinacoside and its pharmacokinetic application in rats

scientific article

A strategy for screening of high-quality enzyme inhibitors from herbal medicines based on ultrafiltration LC-MS and in silico molecular docking

scientific article published in January 2015

A strategy for the identification of combinatorial bioactive compounds contributing to the holistic effect of herbal medicines.

scientific article

An NQO1-initiated and p53-independent apoptotic pathway determines the anti-tumor effect of tanshinone IIA against non-small cell lung cancer

scientific article

An approach to identifying sequential metabolites of a typical phenylethanoid glycoside, echinacoside, based on liquid chromatography-ion trap-time of flight mass spectrometry analysis.

scientific article published on 21 July 2009

An integral strategy toward the rapid identification of analogous nontarget compounds from complex mixtures

scientific article published on 26 June 2013

Bioactive equivalence of combinatorial components identified in screening of an herbal medicine.

scientific article

Boronic Derivatization of Monoacylglycerol and Monitoring in Biofluids

scientific article published on 30 April 2019

Butyrate Suppresses the Proliferation of Colorectal Cancer Cells via Targeting Pyruvate Kinase M2 and Metabolic Reprogramming.

scientific article

Butyrate suppresses motility of colorectal cancer cells via deactivating Akt/ERK signaling in histone deacetylase dependent manner.

scientific article published on 24 November 2017

Cadmium and arsenic override NF-κB developmental regulation of the intestinal UGT1A1 gene and control of hyperbilirubinemia.

scientific article published on 6 April 2016

Cardiotonic Pill Reduces Myocardial Ischemia-Reperfusion Injury via Increasing EET Concentrations in Rats.

scientific article published on 5 May 2016

Characterization of isochlorogenic acid A metabolites in rats using high-performance liquid chromatography/quadrupole time-of-flight mass spectrometry

scientific article

Characterization of metabolites of tanshinone IIA in rats by liquid chromatography/tandem mass spectrometry

article

Characterization of pharmacokinetic profiles and metabolic pathways of 20(S)-ginsenoside Rh1 in vivo and in vitro

scientific article published on 5 March 2009

Chemical dampening of Ly6C(hi) monocytes in the periphery produces anti-depressant effects in mice

scientific article

Combined effects of a high-fat diet and chronic valproic acid treatment on hepatic steatosis and hepatotoxicity in rats

scientific article

Combined obeticholic acid and apoptosis inhibitor treatment alleviates liver fibrosis.

scientific article published on 27 November 2018

Comparison of bioactive components and pharmacological activities of ophiopogon japonicas extracts from different geographical origins

scientific article published on 7 February 2017

Conjugation site analysis of antibody-drug-conjugates (ADCs) by signature ion fingerprinting and normalized area quantitation approach using nano-liquid chromatography coupled to high resolution mass spectrometry

scientific article published on 02 December 2016

Construction of the Fingerprints of Ginseng Stem and Leaf Saponin Reference Substances and Spiked Plasma Sample by LC-ESI/MS and Its Application to Analyzing the Compounds Absorbed into Blood after Oral Administration of Ginseng Stem and Leaf Saponin

scientific article published on 01 September 2007

Cytochrome P450 2J2: distribution, function, regulation, genetic polymorphisms and clinical significance

scientific article

Cytochrome P450 Dysregulations in Thioacetamide-Induced Liver Cirrhosis in Rats and the Counteracting Effects of Hepatoprotective Agents

scientific article published on 20 January 2012

De-novo NAD+ synthesis regulates SIRT1-FOXO1 apoptotic pathway in response to NQO1 substrates in lung cancer cells.

scientific article published on 23 August 2016

Determination of 20(S)-ginsenoside Rh1 and its aglycone 20(S)-protopanaxatriol in rat plasma by sensitive LC-APCI-MS method and its application to pharmacokinetic study

scientific article

Determination of sodium tanshinone IIA sulfonate in plasma by liquid chromatography-electrospray ionisation-tandem mass spectrometry

scientific article

Development and Evaluation of Controlled and Simultaneous Release of Compound Danshen Based on a Novel Colon-Specific Osmotic Pump Capsule

scientific article published on 02 January 2020

Diagnostic fragment-ion-based extension strategy for rapid screening and identification of serial components of homologous families contained in traditional Chinese medicine prescription using high-resolution LC-ESI- IT-TOF/MS: Shengmai injection as

scientific article published in February 2009

Differential effect of Shenmai injection, a herbal preparation, on the cytochrome P450 3A-mediated 1'-hydroxylation and 4-hydroxylation of midazolam

scientific article published in August 2009

Differential regulations of blood pressure and perturbed metabolism by total ginsenosides and conventional antihypertensive agents in spontaneously hypertensive rats

scientific article published on August 1, 2010

Disturbance of hepatic and intestinal UDP-glucuronosyltransferase in rats with trinitrobenzene sulfonic acid-induced colitis

scientific article published in January 2013

Dual roles of IL-18 in colitis through regulation of the function and quantity of goblet cells.

scientific article

Dysregulations of UDP-glucuronosyltransferases in rats with valproic acid and high fat diet induced fatty liver

scientific article published on 18 September 2013

Dysregulations of intestinal and colonic UDP-glucuronosyltransferases in rats with type 2 diabetes

scientific article published on 2 April 2013

Effects of diammonium glycyrrhizinate on hepatic and intestinal UDP-Glucuronosyltransferases in rats: Implication in herb-drug interactions

scientific article published on 01 July 2016

Effects of iridoid total glycoside from Cornus officinalis on prevention of glomerular overexpression of transforming growth factor beta 1 and matrixes in an experimental diabetes model

scientific article published in July 2004

Effects of short-term and long-term pretreatment of Schisandra lignans on regulating hepatic and intestinal CYP3A in rats

scientific article published on 9 September 2009

Enhanced glycometabolism as a mechanism of NQO1 potentiated growth of NSCLC revealed by metabolomic profiling

scientific article published on 29 December 2017

Epidermal growth factor receptor induced Erk phosphorylation in the suprachiasmatic nucleus

scientific article

Epidermal growth factor receptor-induced circadian-time-dependent gene regulation in suprachiasmatic nucleus

scientific article

Extensive intestinal first-pass elimination and predominant hepatic distribution of berberine explain its low plasma levels in rats.

scientific article published on 15 July 2010

FXR modulators for enterohepatic and metabolic diseases

scientific article published on 08 October 2018

Farnesoid X Receptor Regulation of the NLRP3 Inflammasome Underlies Cholestasis-Associated Sepsis.

scientific article published on April 2017

Farnesoid X receptor activation promotes cell proliferation via PDK4-controlled metabolic reprogramming

scientific article

Gas chromatography/time-of-flight mass spectrometry based metabonomic approach to differentiating hypertension- and age-related metabolic variation in spontaneously hypertensive rats

scientific article

Ginsenosides Regulate PXR/NF-κB Signaling and Attenuate Dextran Sulfate Sodium-Induced Colitis.

scientific article published on 18 May 2015

Ginsenosides synergize with mitomycin C in combating human non-small cell lung cancer by repressing Rad51-mediated DNA repair

scientific article published on 24 August 2017

Global detection and identification of components from Yunnan Baiyao based on liquid chromatography hybrid ion trap time-of-flight mass spectrometry

scientific article published in June 2013

Global detection and identification of nontarget components from herbal preparations by liquid chromatography hybrid ion trap time-of-flight mass spectrometry and a strategy

scientific article

Glycyrrhizin Alleviates Nonalcoholic Steatohepatitis via Modulating Bile Acids and Meta-Inflammation

scholarly article by Tingting Yan et al published September 2018 in Drug Metabolism and Disposition

Glycyrrhizin Protects against Acetaminophen-Induced Acute Liver Injury via Alleviating Tumor Necrosis Factor α-Mediated Apoptosis.

scientific article published on 10 March 2016

HIF-1α Preconditioning Potentiates Antioxidant Activity in Ischemic Injury: The Role of Sequential Administration of Dihydrotanshinone I and Protocatechuic Aldehyde in Cardioprotection

scientific article published on 03 April 2019

Herb-drug interactions: in vivo and in vitro effect of Shenmai injection, a herbal preparation, on the metabolic activities of hepatic cytochrome P450 3A1/2, 2C6, 1A2, and 2E1 in rats

scientific article published on 11 September 2009

Herbal drug discovery for the treatment of nonalcoholic fatty liver disease

scientific article published on 10 December 2019

Identification of a Novel Intestinal First Pass Metabolic Pathway: NQO1 Mediated Quinone Reduction and Subsequent Glucuronidation

scientific article published on 01 February 2007

Identification of effective combinatorial markers for quality standardization of herbal medicines

scientific article published on 13 April 2014

Identification of tanshinone IIA metabolites in rat liver microsomes by liquid chromatography-tandem mass spectrometry

scientific article published on 10 January 2006

In vitro inhibitory effects of ethanol extract of Danshen (Salvia miltiorrhiza) and its components on the catalytic activity of soluble epoxide hydrolase.

scientific article published on 26 February 2015

Induction of cytochromes P450 1A1 and 1A2 by tanshinones in human HepG2 hepatoma cell line.

scientific article published on 22 January 2011

Influence of UDP-glucuronosyltransferase polymorphisms on valproic acid pharmacokinetics in Chinese epilepsy patients

scientific article published on 5 April 2012

Influence of segmental and selected ion monitoring on quantitation of multi-component using high-pressure liquid chromatography–quadrupole mass spectrometry: Simultaneous detection of 16 saponins in rat plasma as a case

scientific article published on 28 April 2010

Inhibitory Effects of Danshen components on CYP2C8 and CYP2J2.

scientific article published on 21 April 2018

Inhibitory effects of seven components of danshen extract on catalytic activity of cytochrome P450 enzyme in human liver microsomes

scientific article published on 14 April 2008

Insights into drug discovery from natural medicines using reverse pharmacokinetics

scientific article published on 28 February 2014

Integral pharmacokinetics of multiple lignan components in normal, CCl4-induced hepatic injury and hepatoprotective agents pretreated rats and correlations with hepatic injury biomarkers.

scientific article published on 30 June 2010

Integrative Omics Analysis Revealed that Metabolic Intervention Combined with Metronomic Chemotherapy Selectively Kills Cancer Cells

scientific article published on 28 May 2019

Intestinal mucosal metabolites-guided detection of trace-level ginkgo biloba extract metabolome

scientific article published on 05 August 2019

Intestinal peroxisome proliferator‐activated receptor α‐fatty acid‐binding protein 1 axis modulates nonalcoholic steatohepatitis

scientific article published in 2022

Isochlorogenic acid A affects P450 and UGT enzymes in vitro and in vivo

scientific article published on 01 November 2016

Kynurenic acid/GPR35 axis restricts NLRP3 inflammasome activation and exacerbates colitis in mice with social stress

scientific article published on 18 February 2019

LC/MS Based Tools and Strategies on Qualitative and Quantitative Analysis of Herbal Components in Complex Matrixes

scientific article published on November 1, 2012

Ligand-protein target screening from cell matrices using reactive desorption electrospray ionization-mass spectrometry via a native-denatured exchange approach

scientific article published on 01 January 2019

Long-Acting Release Microspheres Containing Novel GLP-1 Analog as an Antidiabetic System

scientific article published on 24 May 2018

Mechanism-based inhibitory and peroxisome proliferator-activated receptor α-dependent modulating effects of silybin on principal hepatic drug-metabolizing enzymes.

scientific article published on 13 January 2015

Metabolic Pathway Extension Approach for Metabolomic Biomarker Identification

scientific article

Metabolic Profile, Enzyme Kinetics, and Reaction Phenotyping of β-Lapachone Metabolism in Human Liver and Intestine in Vitro

scientific article published on 16 November 2012

Metabolomic investigation into variation of endogenous metabolites in professional athletes subject to strength-endurance training

scientific article

Metabolomics-Proteomics Combined Approach Identifies Differential Metabolism-Associated Molecular Events between Senescence and Apoptosis.

scientific article published on 3 May 2017

Metabonomic characterization of early atherosclerosis in hamsters with induced cholesterol

scientific article

Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity.

scientific article

Microsomal cytochrome p450-mediated metabolism of protopanaxatriol ginsenosides: metabolite profile, reaction phenotyping, and structure-metabolism relationship.

scientific article published on 16 July 2010

Modeling the VPAC2-activated cAMP/PKA signaling pathway: from receptor to circadian clock gene induction

scientific article

Monocyte-derived multipotent cell delivered programmed therapeutics to reverse idiopathic pulmonary fibrosis

scientific article published on 27 May 2020

Mouse B-Type Lamins Are Required for Proper Organogenesis But Not by Embryonic Stem Cells

scientific article published on November 24, 2011

NAD(P)H:Quinone Oxidoreductase 1 (NQO1) as a Therapeutic and Diagnostic Target in Cancer

scientific article published on 07 May 2018

NAMPT inhibition synergizes with NQO1-targeting agents in inducing apoptotic cell death in non-small cell lung cancer cells

scientific article published on 01 August 2016

Noncanonical farnesoid X receptor signaling inhibits apoptosis and impedes liver fibrosis

scientific article

Nontargeted diagnostic ion network analysis (NINA): A software to streamline the analytical workflow for untargeted characterization of natural medicines

scientific article

Oxidative demethylenation and subsequent glucuronidation are the major metabolic pathways of berberine in rats

scientific article published in November 2009

PPARα-UGT axis activation represses intestinal FXR-FGF15 feedback signalling and exacerbates experimental colitis.

scientific article

Peripheral anti-inflammatory effects explain the ginsenosides paradox between poor brain distribution and anti-depression efficacy

scientific article published on August 16, 2011

Peripheral immunomodulation with ginsenoside Rg1 ameliorates neuroinflammation-induced behavioral deficits in rats

scientific article published on 23 October 2013

Pharmacodynamics and potential synergistic effects of Mai-Luo-Ning injection on cardiovascular protection, based on molecular docking

scientific article published on 01 November 2015

Pharmacokinetic and absolute bioavailability study of total panax notoginsenoside, a typical multiple constituent traditional chinese medicine (TCM) in rats

scientific article published in May 2007

Pharmacokinetics, Absorption and Tissue Distribution of Tanshinone IIA Solid Dispersion

scientific article published on 06 October 2006

Pharmacokinetics, tissue distribution and excretion of a new photodynamic drug deuxemether

scientific article published on 12 January 2008

Pharmacokinetics-Pharmacology Disconnection of Herbal Medicines and its Potential Solutions with Cellular Pharmacokinetic-Pharmacodynamic Strategy

scientific article published on June 1, 2012

Post acquisition data processing techniques for lipid analysis by quadrupole time-of-flight mass spectrometry.

scientific article

Probing specific ligand-protein interactions by native-denatured exchange mass spectrometry

scientific article published on 30 July 2018

Protocatechualdehyde Synergizes with Aspirin at the Platelet Cyclooxygenase-1 Level

scientific article published on 04 July 2011

Qualitative and quantitative determination of complicated herbal components by liquid chromatography hybrid ion trap time-of-flight mass spectrometry and a relative exposure approach to herbal pharmacokinetics independent of standards

scientific article published on 02 June 2010

Quantification of endostar in rat plasma by LC–MS/MS and its application in a pharmacokinetic study

scientific article published on 22 July 2012

Quantitative analysis of neurochemical panel in rat brain and plasma by liquid chromatography-tandem mass spectrometry

scientific article published in November 2012

Quantitative determination of atractylenolide III in rat plasma by liquid chromatography electrospray ionization mass spectrometry

scientific article published on 01 December 2005

Quantitative structure-ion intensity relationship strategy to the prediction of absolute levels without authentic standards

scientific article published on 17 July 2013

Rapid identification of ophiopogonins and ophiopogonones in Ophiopogon japonicus extract with a practical technique of mass defect filtering based on high resolution mass spectrometry

scientific article published on 14 January 2012

Reduction of p53 by knockdown of the UGT1 locus in colon epithelial cells causes an increase in tumorigenesis.

scientific article

Regioselective glucuronidation of tanshinone iia after quinone reduction: identification of human UDP-glucuronosyltransferases, species differences, and interaction potential.

scientific article

Regulation of Mammalian UDP-Glucuronosyltransferases

scientific article published on 01 January 2018

Regulation of proinflammatory monocyte activation by the kynurenine-AhR axis underlies immunometabolic control of depressive behavior in mice.

scientific article published on 28 November 2017

Repression of intestinal transporters and FXR-FGF15 signaling explains bile acids dysregulation in experimental colitis-associated colon cancer.

scientific article published on 28 June 2017

Reversing effects of lignans on CCl4-induced hepatic CYP450 down regulation by attenuating oxidative stress

scientific article published on 05 June 2014

Reversing effects of silybin on TAA-induced hepatic CYP3A dysfunction through PXR regulation

scientific article published on 01 November 2013

SUMOylation inhibitors synergize with FXR agonists in combating liver fibrosis

scientific article published on 13 January 2020

Salicylic acid retention impairs aspirin reactivity in type 2 diabetes.

scientific article published on 25 November 2016

Simultaneous determination of ginsenoside Rg1, Re, Rd, Rb1 and ophiopogonin D in rat plasma by liquid chromatography/electrospray ionization mass spectrometric method and its application to pharmacokinetic study of 'SHENMAI' injection

scientific article

Simultaneous determination of panax notoginsenoside R1, ginsenoside Rg1, Rd, Re and Rb1 in rat plasma by HPLC/ESI/MS: platform for the pharmacokinetic evaluation of total panax notoginsenoside, a typical kind of multiple constituent traditional Chin

scientific article

Simultaneous determination of tanshinone IIA and cryptotanshinone in rat plasma by liquid chromatography-electrospray ionisation-mass spectrometry

scientific article

Simultaneous determination of tanshinone IIA and its three hydroxylated metabolites by liquid chromatography/tandem mass spectrometry

scientific article published in January 2006

Simultaneous quantification of cryptotanshinone and its active metabolite tanshinone IIA in plasma by liquid chromatography/tandem mass spectrometry (LC-MS/MS).

scientific article published on 19 September 2005

Stepped MSAll Relied Transition (SMART): An approach to rapidly determine optimal multiple reaction monitoring mass spectrometry parameters for small molecules

scientific article published on 20 December 2015

Stepped collisional energy MS(All) : an analytical approach for optimal MS/MS acquisition of complex mixture with diverse physicochemical properties.

scientific article

Strategies for Integral Metabolism Profile of Multiple Compounds in Herbal Medicines: Pharmacokinetics, Metabolites Characterization and Metabolic Interactions

scientific article published on November 1, 2011

Structural characterization of pregnane glycosides from Cynanchum auriculatum by liquid chromatography on a hybrid ion trap time-of-flight mass spectrometer.

scientific article

Subresidue-Resolution Footprinting of Ligand-Protein Interactions by Carbene Chemistry and Ion Mobility-Mass Spectrometry

scientific article published on 11 December 2019

Systems analysis of circadian time-dependent neuronal epidermal growth factor receptor signaling

scientific article

The Pharmacokinetic-Pharmacodynamic Model of Azithromycin for Lipopolysaccharide-Induced Depressive-Like Behavior in Mice

scientific article published on January 24, 2013

Thinking outside the brain for cognitive improvement: Is peripheral immunomodulation on the way?

scientific article

Thioacetamide Intoxication Triggers Transcriptional Up-Regulation but Enzyme Inactivation of UDP-Glucuronosyltransferases

scientific article published on 06 July 2011

Total ginsenosides extract induce autophagic cell death in NSCLC cells through activation of endoplasmic reticulum stress

scientific article published on 17 July 2019

Transport characteristics of ginkgolide B by Caco-2 cells and examination of ginkgolide B oral absorption potential using rat in situ intestinal loop method

scientific article published on 29 September 2007

Treat the brain and treat the periphery: toward a holistic approach to major depressive disorder.

scientific article published on 04 April 2015

UDP-glucuronosyltransferase 1A compromises intracellular accumulation and anti-cancer effect of tanshinone IIA in human colon cancer cells

scientific article

UDP-glucuronosyltransferase 1A determinates intracellular accumulation and anti-cancer effect of β-lapachone in human colon cancer cells

scientific article

Unidirectional inversion of ibuprofen in Caco-2 cells: developing a suitable model for presystemic chiral inversion study

scientific article published in April 2005

Validation and application of an LC-ESI-MS method for simultaneous determination of astilbin and its major metabolite 3'-O-methylastilbin in rat plasma.

scientific article

Wnt/β-Catenin Signaling in Liver Cancers

scientific article published on 02 July 2019

p53 dynamics orchestrates with binding affinity to target genes for cell fate decision.

scientific article published on 19 October 2017