List of works - Diego Dal Ben

1,2,4-triazolo[1,5-a]quinoxaline derivatives and their simplified analogues as adenosine A₃ receptor antagonists. Synthesis, structure-affinity relationships and molecular modeling studies.

scientific article published on 27 November 2014

2',3'-O-Substituted ATP derivatives as potent antagonists of purinergic P2X3 receptors and potential analgesic agents

scientific article

8-(2-Furyl)adenine derivatives as A₂A adenosine receptor ligands.

scientific article published on 17 October 2013

8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands

scientific article published on 23 February 2009

A Novel Class of Dopamine D4 Receptor Ligands Bearing an Imidazoline Nucleus

scientific article published on 15 March 2016

Adenine-based acyclic nucleotides as novel P2X3 receptor ligands.

scientific article published in August 2009

Adenosine A2A receptor antagonists: new 8-substituted 9-ethyladenines as tools for in vivo rat models of Parkinson's disease

scientific article

Adenosine Receptors as Neuroinflammation Modulators: Role of A1 Agonists and A2A Antagonists

scientific article published on 21 July 2020

Amide bond direction modulates G-quadruplex recognition and telomerase inhibition by 2,6 and 2,7 bis-substituted anthracenedione derivatives

scientific article published on 25 September 2007

Amino-3,5-Dicyanopyridines Targeting the Adenosine Receptors Ranging from Pan Ligands to Combined A1/A2B Partial Agonists

scientific article published on 22 October 2019

Antioxidant-Conjugated 1,2,4-Triazolo[4,3-a]pyrazin-3-one Derivatives: Highly Potent and Selective Human A2A Adenosine Receptor Antagonists Possessing Protective Efficacy in Neuropathic Pain

scientific article published on 10 September 2019

Antiproliferative evaluation of isofuranodiene on breast and prostate cancer cell lines.

scientific article published on 22 May 2014

Antiviral properties of deazaadenine nucleoside derivatives.

scientific article published on January 2006

Approaches for designing and discovering purinergic drugs for gastrointestinal diseases

scientific article published on 31 March 2020

Comparison and optimization of transient transfection methods at human astrocytoma cell line 1321N1.

scientific article

DNA topoisomerase II structures and anthracycline activity: insights into ternary complex formation.

scientific article published on January 2007

Design, synthesis and evaluation in an LPS rodent model of neuroinflammation of a novel 18F-labelled PET tracer targeting P2X7.

scientific article published on 04 April 2017

Design, synthesis, and biological evaluation of new mitonafide derivatives as potential antitumor drugs

scientific article published on 15 August 2008

Development of novel pyridazinone-based adenosine receptor ligands.

scientific article published on 30 March 2018

Different efficacy of adenosine and NECA derivatives at the human A3 adenosine receptor: insight into the receptor activation switch.

scientific article

Emerging Roles of Purinergic Signaling in Diabetes.

scientific article published on 26 February 2018

Erratum to: Molecular modelling study of 2-phenylethynyladenosine (PEAdo) derivatives as highly selective A(3) adenosine receptor ligands

scientific article

Evaluation of adenine as scaffold for the development of novel P2X3 receptor antagonists.

scientific article published on 24 April 2013

Evidence for the existence of a specific g protein-coupled receptor activated by guanosine

scientific article published on 15 April 2011

Exploring the 2- and 5-positions of the pyrazolo[4,3-d]pyrimidin-7-amino scaffold to target human A1 and A2A adenosine receptors

scientific article published on 23 April 2016

Exploring the 7-oxo-thiazolo[5,4-d]pyrimidine core for the design of new human adenosine A3 receptor antagonists. Synthesis, molecular modeling studies and pharmacological evaluation

scientific article published on 04 April 2015

Fragment optimization for GPCRs by molecular dynamics free energy calculations: Probing druggable subpockets of the A 2A adenosine receptor binding site

scientific article

Highlights on the development of A(2A) adenosine receptor agonists and antagonists

scientific article

Identification of alpha1-adrenoceptor subtypes involved in contraction of young CD rat epididymal vas deferens

scientific journal article

Imidazo[1,2-a]pyrazin-8-amine core for the design of new adenosine receptor antagonists: Structural exploration to target the A3 and A2A subtypes.

scientific article

Innovative functional cAMP assay for studying G protein-coupled receptors: application to the pharmacological characterization of GPR17.

scientific article

Interaction model for anthracycline activity against DNA topoisomerase II.

scientific article published in June 2004

Investigation on 2',3'-O-Substituted ATP Derivatives and Analogs as Novel P2X3 Receptor Antagonists

scientific article published on 26 December 2018

Medicinal chemistry of P2X receptors: agonists and orthosteric antagonists.

scientific article

Modifications on the Amino-3,5-dicyanopyridine Core To Obtain Multifaceted Adenosine Receptor Ligands with Antineuropathic Activity

scientific article published on 26 July 2019

Molecular modeling study on potent and selective adenosine A(3) receptor agonists.

scientific article published on 22 September 2010

N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor

scientific article published on 20 February 2007

Neuropeptide S receptor: recent updates on nonpeptide antagonist discovery.

scientific article published on 30 March 2011

New potent and selective A1 adenosine receptor antagonists as potential tools for the treatment of gastrointestinal diseases.

scientific article published on 27 March 2018

Non-Nucleoside Agonists of the Adenosine Receptors: An Overview

scientific article published on 08 October 2019

Novel human adenosine receptor antagonists based on the 7-amino-thiazolo[5,4-d]pyrimidine scaffold. Structural investigations at the 2-, 5- and 7-positions to enhance affinity and tune selectivity

scientific article published on 31 December 2018

Novel potent and highly selective human A(3) adenosine receptor antagonists belonging to the 4-amido-2-arylpyrazolo[3,4-c]quinoline series: molecular docking analysis and pharmacological studies

scientific article

Overview on Radiolabel-Free in vitro Assays for GPCRs.

scientific article published on 8 August 2016

P2X7 Receptor as a Therapeutic Target

scientific article published on 4 January 2016

Pharmacological postconditioning of the rabbit heart with non-selective, A1 , A2A and A3 adenosine receptor agonists

scientific article published on 27 April 2014

Purinergic Ligands as Potential Therapeutic Tools for the Treatment of Inflammation-Related Intestinal Diseases.

scientific article published on 14 March 2018

Purinergic P2X receptors: structural models and analysis of ligand-target interaction.

scientific article published on 25 October 2014

Pyrazolo[1,5-c]quinazoline derivatives and their simplified analogues as adenosine receptor antagonists: synthesis, structure-affinity relationships and molecular modeling studies.

scientific article

Simulation and Comparative Analysis of Different Binding Modes of Non-nucleoside Agonists at the A2A Adenosine Receptor.

scientific article published on 28 June 2016

Simulation and comparative analysis of binding modes of nucleoside and non-nucleoside agonists at the A2B adenosine receptor

scientific article published on 20 December 2013

Synthesis and antitumor evaluation of bis aza-anthracene-9,10-diones and bis aza-anthrapyrazole-6-ones.

scientific article published on 31 January 2008

Synthesis and biological activity of trisubstituted adenines as A 2A adenosine receptor antagonists

scientific article published in January 2007

Synthesis and biological evaluation of 2-alkynyl-N6-methyl-5'-N-methylcarboxamidoadenosine derivatives as potent and highly selective agonists for the human adenosine A3 receptor

scientific article published in December 2009

Synthesis and stability studies of 2',3',5'-tri-O-acetyl-2-amino(-N6-cyclopentyl)-1-deazaadenosines

scientific article published in January 2007

Synthesis, structure-affinity relationships, and molecular modeling studies of novel pyrazolo[3,4-c]quinoline derivatives as adenosine receptor antagonists

scientific article published on 6 May 2011

The 1,2,4-Triazolo[4,3-a]pyrazin-3-one as a Versatile Scaffold for the Design of Potent Adenosine Human Receptor Antagonists. Structural Investigations to Target the A2A Receptor Subtype.

scientific article

The Anti-Inflammatory and Pain-Relieving Effects of AR170, an Adenosine A3 Receptor Agonist, in a Rat Model of Colitis

scientific article published on 21 June 2020

The G Protein-Coupled Receptor GPR17: Overview and Update.

scientific article

The Length and Flexibility of the 2-Substituent of 9-Ethyladenine Derivatives Modulate Affinity and Selectivity for the Human A2A Adenosine Receptor

scientific article published on April 2016

The P2X7 Receptor in Infection and Inflammation.

scientific article

The aminopyridine-3,5-dicarbonitrile core for the design of new non-nucleoside-like agonists of the human adenosine A2B receptor.

scientific article published on 6 March 2018

The importance of alkynyl chain presence for the activity of adenine nucleosides/nucleotides on purinergic receptors.

scientific article published on January 2011

Toward the rational design of protein kinase casein kinase-2 inhibitors

scientific article

Update on novel purinergic P2X3 and P2X2/3 receptor antagonists and their potential therapeutic applications

scientific article published on 20 November 2019

List of works by Diego Dal Ben

1,2,4-triazolo[1,5-a]quinoxaline derivatives and their simplified analogues as adenosine A₃ receptor antagonists. Synthesis, structure-affinity relationships and molecular modeling studies.

2',3'-O-Substituted ATP derivatives as potent antagonists of purinergic P2X3 receptors and potential analgesic agents

8-(2-Furyl)adenine derivatives as A₂A adenosine receptor ligands.

8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands

A Novel Class of Dopamine D4 Receptor Ligands Bearing an Imidazoline Nucleus

Adenine-based acyclic nucleotides as novel P2X3 receptor ligands.

Adenosine A2A receptor antagonists: new 8-substituted 9-ethyladenines as tools for in vivo rat models of Parkinson's disease

Adenosine Receptors as Neuroinflammation Modulators: Role of A1 Agonists and A2A Antagonists

Amide bond direction modulates G-quadruplex recognition and telomerase inhibition by 2,6 and 2,7 bis-substituted anthracenedione derivatives

Amino-3,5-Dicyanopyridines Targeting the Adenosine Receptors Ranging from Pan Ligands to Combined A1/A2B Partial Agonists

Antioxidant-Conjugated 1,2,4-Triazolo[4,3-a]pyrazin-3-one Derivatives: Highly Potent and Selective Human A2A Adenosine Receptor Antagonists Possessing Protective Efficacy in Neuropathic Pain

Antiproliferative evaluation of isofuranodiene on breast and prostate cancer cell lines.

Antiviral properties of deazaadenine nucleoside derivatives.

Approaches for designing and discovering purinergic drugs for gastrointestinal diseases

Comparison and optimization of transient transfection methods at human astrocytoma cell line 1321N1.

DNA topoisomerase II structures and anthracycline activity: insights into ternary complex formation.

Design, synthesis and evaluation in an LPS rodent model of neuroinflammation of a novel 18F-labelled PET tracer targeting P2X7.

Design, synthesis, and biological evaluation of new mitonafide derivatives as potential antitumor drugs

Development of novel pyridazinone-based adenosine receptor ligands.

Different efficacy of adenosine and NECA derivatives at the human A3 adenosine receptor: insight into the receptor activation switch.

Emerging Roles of Purinergic Signaling in Diabetes.

Erratum to: Molecular modelling study of 2-phenylethynyladenosine (PEAdo) derivatives as highly selective A(3) adenosine receptor ligands

Evaluation of adenine as scaffold for the development of novel P2X3 receptor antagonists.

Evidence for the existence of a specific g protein-coupled receptor activated by guanosine

Exploring the 2- and 5-positions of the pyrazolo[4,3-d]pyrimidin-7-amino scaffold to target human A1 and A2A adenosine receptors

Exploring the 7-oxo-thiazolo[5,4-d]pyrimidine core for the design of new human adenosine A3 receptor antagonists. Synthesis, molecular modeling studies and pharmacological evaluation

Fragment optimization for GPCRs by molecular dynamics free energy calculations: Probing druggable subpockets of the A 2A adenosine receptor binding site

Highlights on the development of A(2A) adenosine receptor agonists and antagonists

Identification of alpha1-adrenoceptor subtypes involved in contraction of young CD rat epididymal vas deferens

Imidazo[1,2-a]pyrazin-8-amine core for the design of new adenosine receptor antagonists: Structural exploration to target the A3 and A2A subtypes.

Innovative functional cAMP assay for studying G protein-coupled receptors: application to the pharmacological characterization of GPR17.

Interaction model for anthracycline activity against DNA topoisomerase II.

Investigation on 2',3'-O-Substituted ATP Derivatives and Analogs as Novel P2X3 Receptor Antagonists

Medicinal chemistry of P2X receptors: agonists and orthosteric antagonists.

Modifications on the Amino-3,5-dicyanopyridine Core To Obtain Multifaceted Adenosine Receptor Ligands with Antineuropathic Activity

Molecular modeling study on potent and selective adenosine A(3) receptor agonists.

N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor

Neuropeptide S receptor: recent updates on nonpeptide antagonist discovery.

New potent and selective A1 adenosine receptor antagonists as potential tools for the treatment of gastrointestinal diseases.

Non-Nucleoside Agonists of the Adenosine Receptors: An Overview

Novel human adenosine receptor antagonists based on the 7-amino-thiazolo[5,4-d]pyrimidine scaffold. Structural investigations at the 2-, 5- and 7-positions to enhance affinity and tune selectivity

Novel potent and highly selective human A(3) adenosine receptor antagonists belonging to the 4-amido-2-arylpyrazolo[3,4-c]quinoline series: molecular docking analysis and pharmacological studies

Overview on Radiolabel-Free in vitro Assays for GPCRs.

P2X7 Receptor as a Therapeutic Target

Pharmacological postconditioning of the rabbit heart with non-selective, A1 , A2A and A3 adenosine receptor agonists

Purinergic Ligands as Potential Therapeutic Tools for the Treatment of Inflammation-Related Intestinal Diseases.

Purinergic P2X receptors: structural models and analysis of ligand-target interaction.

Pyrazolo[1,5-c]quinazoline derivatives and their simplified analogues as adenosine receptor antagonists: synthesis, structure-affinity relationships and molecular modeling studies.

Simulation and Comparative Analysis of Different Binding Modes of Non-nucleoside Agonists at the A2A Adenosine Receptor.

Simulation and comparative analysis of binding modes of nucleoside and non-nucleoside agonists at the A2B adenosine receptor

Synthesis and antitumor evaluation of bis aza-anthracene-9,10-diones and bis aza-anthrapyrazole-6-ones.

Synthesis and biological activity of trisubstituted adenines as A 2A adenosine receptor antagonists

Synthesis and biological evaluation of 2-alkynyl-N6-methyl-5'-N-methylcarboxamidoadenosine derivatives as potent and highly selective agonists for the human adenosine A3 receptor

Synthesis and stability studies of 2',3',5'-tri-O-acetyl-2-amino(-N6-cyclopentyl)-1-deazaadenosines

Synthesis, structure-affinity relationships, and molecular modeling studies of novel pyrazolo[3,4-c]quinoline derivatives as adenosine receptor antagonists

The 1,2,4-Triazolo[4,3-a]pyrazin-3-one as a Versatile Scaffold for the Design of Potent Adenosine Human Receptor Antagonists. Structural Investigations to Target the A2A Receptor Subtype.

The Anti-Inflammatory and Pain-Relieving Effects of AR170, an Adenosine A3 Receptor Agonist, in a Rat Model of Colitis

The G Protein-Coupled Receptor GPR17: Overview and Update.

The Length and Flexibility of the 2-Substituent of 9-Ethyladenine Derivatives Modulate Affinity and Selectivity for the Human A2A Adenosine Receptor

The P2X7 Receptor in Infection and Inflammation.

The aminopyridine-3,5-dicarbonitrile core for the design of new non-nucleoside-like agonists of the human adenosine A2B receptor.

The importance of alkynyl chain presence for the activity of adenine nucleosides/nucleotides on purinergic receptors.

Toward the rational design of protein kinase casein kinase-2 inhibitors

Update on novel purinergic P2X3 and P2X2/3 receptor antagonists and their potential therapeutic applications