List of works - Hirofumi Hashimoto

A role of nesfatin-1/NucB2 in dehydration-induced anorexia

scientific article

Activation of Nesfatin-1-Containing Neurones in the Hypothalamus and Brainstem by Peripheral Administration of Anorectic Hormones and Suppression of Feeding via Central Nesfatin-1 in Rats

scientific article published on 20 May 2016

Adrenomedullin 2 (AM2)/intermedin is a more potent activator of hypothalamic oxytocin-secreting neurons than AM possibly through an unidentified receptor in rats.

scientific article published on 14 February 2007

Adrenomedullin 2 protects rat cerebral endothelial cells from oxidative damage in vitro.

scientific article

Adrenomedullin 2/intermedin-like immunoreactivity in the hypothalamus and brainstem of rats

scientific article published on 04 March 2008

An intrinsic vasopressin system in the olfactory bulb is involved in social recognition

scientific article

Brain-derived neurotrophic factor inhibits spontaneous inhibitory postsynaptic currents in the rat supraoptic nucleus

scientific article published on 31 December 2008

Central and peripheral cardiovascular actions of adrenomedullin 5, a novel member of the calcitonin gene-related peptide family, in mammals.

scientific article published in May 2008

Central effects of ghrelin, a unique peptide, on appetite and fluid/water drinking behavior.

scientific article published on June 2011

Centrally administered adrenomedullin 2 activates hypothalamic oxytocin-secreting neurons, causing elevated plasma oxytocin level in rats.

scientific article published on 14 June 2005

Centrally administered adrenomedullin 5 activates oxytocin-secreting neurons in the hypothalamus and elevates plasma oxytocin level in rats.

scientific article published on 6 May 2009

Centrally administered ghrelin potently inhibits water intake induced by angiotensin II and hypovolemia in rats.

scientific article published on 18 September 2009

Centrally administered neuropeptide W-30 activates magnocellular neurosecretory cells in the supraoptic and paraventricular nuclei with neurosecretion in rats

scientific article published in August 2006

Centrally and peripherally administered ghrelin potently inhibits water intake in rats

scientific article

Chronic osmotic stimuli increase salusin-beta-like immunoreactivity in the rat hypothalamo-neurohypophyseal system: possible involvement of salusin-beta on [Ca2+]i increase and neurohypophyseal hormone release from the axon terminals.

scientific article published on 28 November 2007

Development of ghrelin resistance in a cancer cachexia rat model using human gastric cancer-derived 85As2 cells and the palliative effects of the Kampo medicine rikkunshito on the model

scientific article

Differences in acid-induced currents between oxytocin-mRFP1 and vasopressin-eGFP neurons isolated from the supraoptic and paraventricular nuclei of transgenic rats

scientific article

Downregulation of prolactin-releasing peptide gene expression in the hypothalamus and brainstem of diabetic rats

scientific article published on 03 July 2007

Effects of a subconvulsive dose of kainic acid on the gene expressions of the arginine vasopressin, oxytocin and neuronal nitric oxide synthase in the rat hypothalamus

scientific article

Effects of central administration of oxytocin-saporin cytotoxin on chronic inflammation and feeding/drinking behaviors in adjuvant arthritic rats

scientific article published on 06 April 2016

Effects of cholecystokinin (CCK)-8 on hypothalamic oxytocin-secreting neurons in rats lacking CCK-A receptor

scientific journal article

Effects of food deprivation on the hypothalamic feeding-regulating peptides gene expressions in serotonin depleted rats

scientific article published on 27 October 2013

Effects of peripherally administered cholecystokinin-8 and secretin on feeding/drinking and oxytocin-mRFP1 fluorescence in transgenic rats

scientific article

Effects of the short chain sugar acid 2-buten-4-olide on the hypothalamo-pituitary-adrenal axis in normal and adjuvant-induced arthritic rats

scientific article published in January 2007

Exaggerated response of a vasopressin-enhanced green fluorescent protein transgene to nociceptive stimulation in the rat.

scientific article published in October 2009

Expression of immediate early genes and vasopressin heteronuclear RNA in the paraventricular and supraoptic nuclei of rats after acute osmotic stimulus.

scientific article

Expression of the genes encoding hypothalamic feeding-related neuropeptides in the streptozotocin-induced diabetic rats with variable hyperglycemia and hyperphagia

scientific article published on 20 March 2019

Fluorescent Visualisation of Oxytocin in the Hypothalamo-neurohypophysial/-spinal Pathways After Chronic Inflammation in Oxytocin-Monomeric Red Fluorescent Protein 1 Transgenic Rats.

scientific article

Fluorescent visualisation of the hypothalamic oxytocin neurones activated by cholecystokinin-8 in rats expressing c-fos-enhanced green fluorescent protein and oxytocin-monomeric red fluorescent protein 1 fusion transgenes

scientific article published in May 2014

Fluorescent visualization of oxytocin in the hypothalamo-neurohypophysial system

scientific article

Induction of the arginine vasopressin-enhanced green fluorescent protein fusion transgene in the rat locus coeruleus.

scientific article published in July 2010

Induction of the galanin-like peptide gene expression in the posterior pituitary gland after acute osmotic stimulus in rats.

scientific article

Inhibition of ghrelin-induced feeding in rats by pretreatment with a novel dual orexin receptor antagonist

scientific article published on 04 January 2017

Neuropeptide W-Induced Hypophagia is Mediated Through Corticotropin-Releasing Hormone-Containing Neurons

scientific article published on 19 February 2015

New cancer cachexia rat model generated by implantation of a peritoneal dissemination-derived human stomach cancer cell line.

scientific article published on 17 December 2013

Parathyroid hormone-related protein induces cachectic syndromes without directly modulating the expression of hypothalamic feeding-regulating peptides.

scientific article published on January 2007

Pathophysiological function of oxytocin secreted by neuropeptides: A mini review.

scientific article published on 16 August 2012

Possible Involvement of the Rat Hypothalamo-Neurohypophysial/-Spinal Oxytocinergic Pathways in Acute Nociceptive Responses.

scientific article

Possible contribution of pannexin channel to ATP-induced currents in vitro in vasopressin neurons isolated from the rat supraoptic nucleus

scientific article published on 15 April 2011

Possible involvement of central oxytocin in cisplatin-induced anorexia in rats

scientific article published on 14 June 2017

Prolactin-releasing peptide is a potent mediator of stress responses in the brain through the hypothalamic paraventricular nucleus

scientific article published on 30 May 2006

Response of arginine vasopressin-enhanced green fluorescent protein fusion gene in the hypothalamus of adjuvant-induced arthritic rats

scientific article published in March 2009

Similar changes of hypothalamic feeding-regulating peptides mRNAs and plasma leptin levels in PTHrP-, LIF-secreting tumors-induced cachectic rats and adjuvant arthritic rats.

scientific article published on May 2011

TRPV1 gene deficiency attenuates miniature EPSC potentiation induced by mannitol and angiotensin II in supraoptic magnocellular neurons.

scientific article published in January 2010

The ethanol metabolite acetaldehyde induces water and salt intake via two distinct pathways in the central nervous system of rats.

scientific article published on 19 August 2015

The gene expression of the hypothalamic feeding-regulating peptides in cisplatin-induced anorexic rats

scientific article published on 15 May 2013

The short chain sugar acid, 2-buten-4-olide, activates oxytocin-secreting neurons but not arginine vasopressin-secreting neurons in the hypothalamus of rats.

scientific article

Transgenic approach to express the channelrhodopsin 2 gene in arginine vasopressin neurons of rats

scientific article

List of works by Hirofumi Hashimoto

A role of nesfatin-1/NucB2 in dehydration-induced anorexia

Activation of Nesfatin-1-Containing Neurones in the Hypothalamus and Brainstem by Peripheral Administration of Anorectic Hormones and Suppression of Feeding via Central Nesfatin-1 in Rats

Adrenomedullin 2 (AM2)/intermedin is a more potent activator of hypothalamic oxytocin-secreting neurons than AM possibly through an unidentified receptor in rats.

Adrenomedullin 2 protects rat cerebral endothelial cells from oxidative damage in vitro.

Adrenomedullin 2/intermedin-like immunoreactivity in the hypothalamus and brainstem of rats

An intrinsic vasopressin system in the olfactory bulb is involved in social recognition

Brain-derived neurotrophic factor inhibits spontaneous inhibitory postsynaptic currents in the rat supraoptic nucleus

Central and peripheral cardiovascular actions of adrenomedullin 5, a novel member of the calcitonin gene-related peptide family, in mammals.

Central effects of ghrelin, a unique peptide, on appetite and fluid/water drinking behavior.

Centrally administered adrenomedullin 2 activates hypothalamic oxytocin-secreting neurons, causing elevated plasma oxytocin level in rats.

Centrally administered adrenomedullin 5 activates oxytocin-secreting neurons in the hypothalamus and elevates plasma oxytocin level in rats.

Centrally administered ghrelin potently inhibits water intake induced by angiotensin II and hypovolemia in rats.

Centrally administered neuropeptide W-30 activates magnocellular neurosecretory cells in the supraoptic and paraventricular nuclei with neurosecretion in rats

Centrally and peripherally administered ghrelin potently inhibits water intake in rats

Chronic osmotic stimuli increase salusin-beta-like immunoreactivity in the rat hypothalamo-neurohypophyseal system: possible involvement of salusin-beta on [Ca2+]i increase and neurohypophyseal hormone release from the axon terminals.

Development of ghrelin resistance in a cancer cachexia rat model using human gastric cancer-derived 85As2 cells and the palliative effects of the Kampo medicine rikkunshito on the model

Differences in acid-induced currents between oxytocin-mRFP1 and vasopressin-eGFP neurons isolated from the supraoptic and paraventricular nuclei of transgenic rats

Downregulation of prolactin-releasing peptide gene expression in the hypothalamus and brainstem of diabetic rats

Effects of a subconvulsive dose of kainic acid on the gene expressions of the arginine vasopressin, oxytocin and neuronal nitric oxide synthase in the rat hypothalamus

Effects of central administration of oxytocin-saporin cytotoxin on chronic inflammation and feeding/drinking behaviors in adjuvant arthritic rats

Effects of cholecystokinin (CCK)-8 on hypothalamic oxytocin-secreting neurons in rats lacking CCK-A receptor

Effects of food deprivation on the hypothalamic feeding-regulating peptides gene expressions in serotonin depleted rats

Effects of peripherally administered cholecystokinin-8 and secretin on feeding/drinking and oxytocin-mRFP1 fluorescence in transgenic rats

Effects of the short chain sugar acid 2-buten-4-olide on the hypothalamo-pituitary-adrenal axis in normal and adjuvant-induced arthritic rats

Exaggerated response of a vasopressin-enhanced green fluorescent protein transgene to nociceptive stimulation in the rat.

Expression of immediate early genes and vasopressin heteronuclear RNA in the paraventricular and supraoptic nuclei of rats after acute osmotic stimulus.

Expression of the genes encoding hypothalamic feeding-related neuropeptides in the streptozotocin-induced diabetic rats with variable hyperglycemia and hyperphagia

Fluorescent Visualisation of Oxytocin in the Hypothalamo-neurohypophysial/-spinal Pathways After Chronic Inflammation in Oxytocin-Monomeric Red Fluorescent Protein 1 Transgenic Rats.

Fluorescent visualisation of the hypothalamic oxytocin neurones activated by cholecystokinin-8 in rats expressing c-fos-enhanced green fluorescent protein and oxytocin-monomeric red fluorescent protein 1 fusion transgenes

Fluorescent visualization of oxytocin in the hypothalamo-neurohypophysial system

Induction of the arginine vasopressin-enhanced green fluorescent protein fusion transgene in the rat locus coeruleus.

Induction of the galanin-like peptide gene expression in the posterior pituitary gland after acute osmotic stimulus in rats.

Inhibition of ghrelin-induced feeding in rats by pretreatment with a novel dual orexin receptor antagonist

Neuropeptide W-Induced Hypophagia is Mediated Through Corticotropin-Releasing Hormone-Containing Neurons

New cancer cachexia rat model generated by implantation of a peritoneal dissemination-derived human stomach cancer cell line.

Parathyroid hormone-related protein induces cachectic syndromes without directly modulating the expression of hypothalamic feeding-regulating peptides.

Pathophysiological function of oxytocin secreted by neuropeptides: A mini review.

Possible Involvement of the Rat Hypothalamo-Neurohypophysial/-Spinal Oxytocinergic Pathways in Acute Nociceptive Responses.

Possible contribution of pannexin channel to ATP-induced currents in vitro in vasopressin neurons isolated from the rat supraoptic nucleus

Possible involvement of central oxytocin in cisplatin-induced anorexia in rats

Prolactin-releasing peptide is a potent mediator of stress responses in the brain through the hypothalamic paraventricular nucleus

Response of arginine vasopressin-enhanced green fluorescent protein fusion gene in the hypothalamus of adjuvant-induced arthritic rats

Similar changes of hypothalamic feeding-regulating peptides mRNAs and plasma leptin levels in PTHrP-, LIF-secreting tumors-induced cachectic rats and adjuvant arthritic rats.

TRPV1 gene deficiency attenuates miniature EPSC potentiation induced by mannitol and angiotensin II in supraoptic magnocellular neurons.

The ethanol metabolite acetaldehyde induces water and salt intake via two distinct pathways in the central nervous system of rats.

The gene expression of the hypothalamic feeding-regulating peptides in cisplatin-induced anorexic rats

The short chain sugar acid, 2-buten-4-olide, activates oxytocin-secreting neurons but not arginine vasopressin-secreting neurons in the hypothalamus of rats.

Transgenic approach to express the channelrhodopsin 2 gene in arginine vasopressin neurons of rats