List of works - Christina I. Schroeder

A novel 4/7-conotoxin LvIA from Conus lividus that selectively blocks 3 2 vs. 6/ 3 2 3 nicotinic acetylcholine receptors

scientific article

AChBP-targeted α-conotoxin correlates distinct binding orientations with nAChR subtype selectivity

scientific article

Approaches to the stabilization of bioactive epitopes by grafting and peptide cyclization.

scientific article published on 13 November 2015

Bimodal Imaging of Mouse Peripheral Nerves with Chlorin Tracers

scientific article published on 06 January 2021

Bioactive Compounds Isolated from Neglected Predatory Marine Gastropods.

scientific article

Calcium-Mediated Allostery of the EGF Fold

scientific article published on 09 May 2018

Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of action

scientific article published on 11 May 2020

Chemical synthesis, 3D structure, and ASIC binding site of the toxin mambalgin-2

scientific article

Correction: Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of action

scientific article published on 17 June 2020

Cyclic Penta- and Hexaleucine Peptides without N-Methylation Are Orally Absorbed

scientific article

Cyclic alpha-conotoxin peptidomimetic chimeras as potent GLP-1R agonists

scientific article published on 29 August 2015

Design and synthesis of truncated EGF-A peptides that restore LDL-R recycling in the presence of PCSK9 in vitro

scientific article

Development of Novel Melanocortin Receptor Agonists Based on the Cyclic Peptide Framework of Sunflower Trypsin Inhibitor-1.

scientific article published on 31 March 2018

Development of a μO-Conotoxin Analogue with Improved Lipid Membrane Interactions and Potency for the Analgesic Sodium Channel NaV1.8.

scientific article published on 29 March 2016

Development of small molecules that mimic the binding of omega-conotoxins at the N-type voltage-gated calcium channel

scientific article

Discovery and characterisation of novel peptides from Amazonian stinging ant venoms with antiparasitic activity

scientific article published on 01 April 2020

Discovery, Pharmacological Characterisation and NMR Structure of the Novel µ-Conotoxin SxIIIC, a Potent and Irreversible NaV Channel Inhibitor

scientific article published on 02 October 2020

Disulfide-rich macrocyclic peptides as templates in drug design

scientific article published on 06 March 2014

Effects of Chirality at Tyr13 on the Structure−Activity Relationships of ω-Conotoxins fromConus magus†

scientific article published on 01 May 1999

Effects of Lys2 to Ala2 substitutions on the structure and potency of ω-conotoxins MVIIA and CVID

scientific article published on 01 January 2012

Efficient Enzymatic Ligation of Inhibitor Cystine Knot Spider Venom Peptides: Using Sortase A To Form Double-Knottins That Probe Voltage-Gated Sodium Channel NaV1.7.

scientific article published on 12 September 2018

Efficient enzymatic cyclization of an inhibitory cystine knot-containing peptide

scientific article

Enzymatic Ligation of a Pore Blocker Toxin and a Gating Modifier Toxin: Creating Double-Knotted Peptides with Improved Sodium Channel NaV1.7 Inhibition

scientific article published on 16 December 2019

Fluorescence Imaging of Peripheral Nerves by a Nav1.7-Targeted Inhibitor Cystine Knot Peptide

scientific article published on 08 November 2019

Fmoc-based synthesis of disulfide-rich cyclic peptides.

scientific article published on 11 June 2014

Gating modifier toxins isolated from spider venom: Modulation of voltage-gated sodium channels and the role of lipid membranes

scientific article published on 27 April 2018

High-throughput synthesis of peptide α-thioesters: a safety catch linker approach enabling parallel hydrogen fluoride cleavage.

scientific article published on 3 March 2014

Identification of a Novel Class of Nicotinic Receptor Antagonists

scientific article published in Journal of Biological Chemistry

Inhibition of the norepinephrine transporter by the venom peptide chi-MrIA. Site of action, Na+ dependence, and structure-activity relationship

scientific article published on 28 July 2003

Interaction of Tarantula Venom Peptide ProTx-II with Lipid Membranes Is a Prerequisite for Its Inhibition of Human Voltage-gated Sodium Channel NaV1.7.

scientific article published on 16 June 2016

Isolation and structure-activity of mu-conotoxin TIIIA, a potent inhibitor of tetrodotoxin-sensitive voltage-gated sodium channels

scientific article published in December 2006

Lateral self-association of VWF involves the Cys2431-Cys2453 disulfide/dithiol in the C2 domain

Lengths of the C-Terminus and Interconnecting Loops Impact Stability of Spider-Derived Gating Modifier Toxins

scientific article published on 12 August 2017

Manipulation of a spider peptide toxin alters its affinity for lipid bilayers and potency and selectivity for voltage-gated sodium channel subtype 1.7.

scientific article published on 05 March 2020

Membrane-binding properties of gating modifier and pore-blocking toxins: Membrane interaction is not a prerequisite for modification of channel gating

scientific article published on 02 February 2016

N- and c-terminal extensions of μ-conotoxins increase potency and selectivity for neuronal sodium channels

scientific article published on 10 February 2012

Neuronally micro-conotoxins from Conus striatus utilize an alpha-helical motif to target mammalian sodium channels

scientific article published on 3 June 2008

Omega-conotoxin CVIB differentially inhibits native and recombinant N- and P/Q-type calcium channels

scientific article published in January 2007

Omega-conotoxin CVID inhibits a pharmacologically distinct voltage-sensitive calcium channel associated with transmitter release from preganglionic nerve terminals

scientific article

Peptide-Membrane Interactions Affect the Inhibitory Potency and Selectivity of Spider Toxins ProTx-II and GpTx-1

scientific article published on 21 December 2018

Peptides from Mamba Venom as Pain Killers

scientific article published on 04 February 2013

Peptides – From Discovery to Therapeutics

Rational design and synthesis of an orally bioavailable peptide guided by NMR amide temperature coefficients

scientific article

Recent progress towards pharmaceutical applications of disulfide-rich cyclic peptides

scientific article published on September 2013

Recifin A, Initial Example of the Tyr-Lock Peptide Structural Family, Is a Selective Allosteric Inhibitor of Tyrosyl-DNA Phosphodiesterase I

scientific article published on 02 December 2020

Semienzymatic Cyclization of Disulfide-rich Peptides Using Sortase A

scientific article published on 7 March 2014

Spinal actions of ω-conotoxins, CVID, MVIIA and related peptides in a rat neuropathic pain model.

scientific article published on September 2013

Structural and functional characterization of chimeric cyclotides from the Möbius and trypsin inhibitor subfamilies

scientific article published on 3 August 2016

Substrate-Guided Design of Selective FXIIa Inhibitors Based on the Plant-Derived Momordica cochinchinensis Trypsin Inhibitor-II (MCoTI-II) Scaffold

scientific article published on 19 July 2016

Synthesis and biological evaluation of nonpeptide mimetics of omega-conotoxin GVIA.

scientific article published in August 2004

Targeted Delivery of Cyclotides via Conjugation to a Nanobody

scientific article published on 05 October 2018

The alpha2delta auxiliary subunit reduces affinity of omega-conotoxins for recombinant N-type (Cav2.2) calcium channels

scientific article

The insecticidal wasp toxin Γ-Pompilidotoxin is a linear peptide modulating voltage-gated sodium channels

scientific article published on 01 April 2020

Therapeutic potential of conopeptides

scientific article published on June 2012

Truncated Glucagon-like Peptide-1 and Exendin-4 α-Conotoxin pl14a Peptide Chimeras Maintain Potency and α-Helicity and Reveal Interactions Vital for cAMP Signaling in Vitro.

scientific article published on 10 May 2016

chi-Conopeptide pharmacophore development: toward a novel class of norepinephrine transporter inhibitor (Xen2174) for pain

scientific article published in November 2009

ω-Conotoxins GVIA, MVIIA and CVID: SAR and Clinical Potential

scientific article published on 6 April 2006

List of works by Christina I. Schroeder

A novel 4/7-conotoxin LvIA from Conus lividus that selectively blocks 3 2 vs. 6/ 3 2 3 nicotinic acetylcholine receptors

AChBP-targeted α-conotoxin correlates distinct binding orientations with nAChR subtype selectivity

Approaches to the stabilization of bioactive epitopes by grafting and peptide cyclization.

Bimodal Imaging of Mouse Peripheral Nerves with Chlorin Tracers

Bioactive Compounds Isolated from Neglected Predatory Marine Gastropods.

Calcium-Mediated Allostery of the EGF Fold

Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of action

Chemical synthesis, 3D structure, and ASIC binding site of the toxin mambalgin-2

Correction: Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of action

Cyclic Penta- and Hexaleucine Peptides without N-Methylation Are Orally Absorbed

Cyclic alpha-conotoxin peptidomimetic chimeras as potent GLP-1R agonists

Design and synthesis of truncated EGF-A peptides that restore LDL-R recycling in the presence of PCSK9 in vitro

Development of Novel Melanocortin Receptor Agonists Based on the Cyclic Peptide Framework of Sunflower Trypsin Inhibitor-1.

Development of a μO-Conotoxin Analogue with Improved Lipid Membrane Interactions and Potency for the Analgesic Sodium Channel NaV1.8.

Development of small molecules that mimic the binding of omega-conotoxins at the N-type voltage-gated calcium channel

Discovery and characterisation of novel peptides from Amazonian stinging ant venoms with antiparasitic activity

Discovery, Pharmacological Characterisation and NMR Structure of the Novel µ-Conotoxin SxIIIC, a Potent and Irreversible NaV Channel Inhibitor

Disulfide-rich macrocyclic peptides as templates in drug design

Effects of Chirality at Tyr13 on the Structure−Activity Relationships of ω-Conotoxins fromConus magus†

Effects of Lys2 to Ala2 substitutions on the structure and potency of ω-conotoxins MVIIA and CVID

Efficient Enzymatic Ligation of Inhibitor Cystine Knot Spider Venom Peptides: Using Sortase A To Form Double-Knottins That Probe Voltage-Gated Sodium Channel NaV1.7.

Efficient enzymatic cyclization of an inhibitory cystine knot-containing peptide

Enzymatic Ligation of a Pore Blocker Toxin and a Gating Modifier Toxin: Creating Double-Knotted Peptides with Improved Sodium Channel NaV1.7 Inhibition

Fluorescence Imaging of Peripheral Nerves by a Nav1.7-Targeted Inhibitor Cystine Knot Peptide

Fmoc-based synthesis of disulfide-rich cyclic peptides.

Gating modifier toxins isolated from spider venom: Modulation of voltage-gated sodium channels and the role of lipid membranes

High-throughput synthesis of peptide α-thioesters: a safety catch linker approach enabling parallel hydrogen fluoride cleavage.

Identification of a Novel Class of Nicotinic Receptor Antagonists

Inhibition of the norepinephrine transporter by the venom peptide chi-MrIA. Site of action, Na+ dependence, and structure-activity relationship

Interaction of Tarantula Venom Peptide ProTx-II with Lipid Membranes Is a Prerequisite for Its Inhibition of Human Voltage-gated Sodium Channel NaV1.7.

Isolation and structure-activity of mu-conotoxin TIIIA, a potent inhibitor of tetrodotoxin-sensitive voltage-gated sodium channels

Lateral self-association of VWF involves the Cys2431-Cys2453 disulfide/dithiol in the C2 domain

Lengths of the C-Terminus and Interconnecting Loops Impact Stability of Spider-Derived Gating Modifier Toxins

Manipulation of a spider peptide toxin alters its affinity for lipid bilayers and potency and selectivity for voltage-gated sodium channel subtype 1.7.

Membrane-binding properties of gating modifier and pore-blocking toxins: Membrane interaction is not a prerequisite for modification of channel gating

N- and c-terminal extensions of μ-conotoxins increase potency and selectivity for neuronal sodium channels

Neuronally micro-conotoxins from Conus striatus utilize an alpha-helical motif to target mammalian sodium channels

Omega-conotoxin CVIB differentially inhibits native and recombinant N- and P/Q-type calcium channels

Omega-conotoxin CVID inhibits a pharmacologically distinct voltage-sensitive calcium channel associated with transmitter release from preganglionic nerve terminals

Peptide-Membrane Interactions Affect the Inhibitory Potency and Selectivity of Spider Toxins ProTx-II and GpTx-1

Peptides from Mamba Venom as Pain Killers

Peptides – From Discovery to Therapeutics

Rational design and synthesis of an orally bioavailable peptide guided by NMR amide temperature coefficients

Recent progress towards pharmaceutical applications of disulfide-rich cyclic peptides

Recifin A, Initial Example of the Tyr-Lock Peptide Structural Family, Is a Selective Allosteric Inhibitor of Tyrosyl-DNA Phosphodiesterase I

Semienzymatic Cyclization of Disulfide-rich Peptides Using Sortase A

Spinal actions of ω-conotoxins, CVID, MVIIA and related peptides in a rat neuropathic pain model.

Structural and functional characterization of chimeric cyclotides from the Möbius and trypsin inhibitor subfamilies

Substrate-Guided Design of Selective FXIIa Inhibitors Based on the Plant-Derived Momordica cochinchinensis Trypsin Inhibitor-II (MCoTI-II) Scaffold

Synthesis and biological evaluation of nonpeptide mimetics of omega-conotoxin GVIA.

Targeted Delivery of Cyclotides via Conjugation to a Nanobody

The alpha2delta auxiliary subunit reduces affinity of omega-conotoxins for recombinant N-type (Cav2.2) calcium channels

The insecticidal wasp toxin Γ-Pompilidotoxin is a linear peptide modulating voltage-gated sodium channels

Therapeutic potential of conopeptides

Truncated Glucagon-like Peptide-1 and Exendin-4 α-Conotoxin pl14a Peptide Chimeras Maintain Potency and α-Helicity and Reveal Interactions Vital for cAMP Signaling in Vitro.

chi-Conopeptide pharmacophore development: toward a novel class of norepinephrine transporter inhibitor (Xen2174) for pain

ω-Conotoxins GVIA, MVIIA and CVID: SAR and Clinical Potential