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List of works by Isabel Varela-Nieto

A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection.

scientific article

A murine model for the del(GJB6-D13S1830) deletion recapitulating the phenotype of human DFNB1 hearing impairment: generation and functional and histopathological study

scientific article published on 11 April 2024

A network of growth and transcription factors controls neuronal differentation and survival in the developing ear.

scientific article published on January 2007

AKT signaling mediates IGF-I survival actions on otic neural progenitors

scientific article

Acidic sphingomyelinase downregulates the liver-specific methionine adenosyltransferase 1A, contributing to tumor necrosis factor-induced lethal hepatitis

scientific article published on March 2004

Age-regulated function of autophagy in the mouse inner ear.

scientific article published on 30 July 2015

Age-related functional and structural retinal modifications in the Igf1-/- null mouse.

scientific article published on 28 February 2012

An inositol phosphoglycan stimulates glycolysis in human platelets

scientific article published in October 1991

Anti-apoptotic actions of insulin-like growth factors: lessons from development and implications in neoplastic cell transformation.

scientific article published on January 2007

Autophagy in the Vertebrate Inner Ear.

scientific article

Autophagy resolves early retinal inflammation in Igf1-deficient mice

scientific article published on 21 July 2016

Behavioral phenotype of maLPA1-null mice: increased anxiety-like behavior and spatial memory deficits

scientific article

Betaine-homocysteine S-methyltransferase deficiency causes increased susceptibility to noise-induced hearing loss associated with plasma hyperhomocysteinemia

scientific article published on 12 February 2019

Biomarkers in Vestibular Schwannoma-Associated Hearing Loss

scientific article published on 18 September 2019

C-Raf deficiency leads to hearing loss and increased noise susceptibility

scientific article

Cell death in the nervous system: lessons from insulin and insulin-like growth factors.

scientific article published on August 2003

Ceramide Kinase Inhibition Blocks IGF-1-Mediated Survival of Otic Neurosensory Progenitors by Impairing AKT Phosphorylation

scientific article published in 2021

Cochlear Homocysteine Metabolism at the Crossroad of Nutrition and Sensorineural Hearing Loss

scientific article

Cochlear abnormalities in insulin-like growth factor-1 mouse mutants

scientific article published in August 2002

Comparative gene expression study of the vestibular organ of the Igf1 deficient mouse using whole-transcript arrays

scientific article published on September 2015

Comparison of different aminoglycoside antibiotic treatments to refine ototoxicity studies in adult mice

scientific article published on 26 October 2009

Complementary and distinct roles of autophagy, apoptosis and senescence during early inner ear development

article

Corrigendum to: Swept-sine noise-induced damage as a hearing loss model for preclinical assays.

scientific article published on 12 May 2015

Corrigendum: Transforming growth factor β1 inhibition protects from noise-induced hearing loss

scientific article published on 8 May 2015

Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1) accelerates progressive hearing loss

scientific article published on 02 April 2019

Differential organ phenotypes after postnatal Igf1r gene conditional deletion induced by tamoxifen in UBC-CreERT2; Igf1r fl/fl double transgenic mice.

scientific article published on 20 September 2014

Direct drug application to the round window: a comparative study of ototoxicity in rats.

scientific article published in November 2009

Drug development for noise-induced hearing loss

scientific article published on 25 August 2020

Dual-Specificity Phosphatase 1 (DUSP1) Has a Central Role in Redox Homeostasis and Inflammation in the Mouse Cochlea

scientific article published in 2021

Dysfunction of programmed embryo senescence is linked to genetic developmental defects

scientific article published in May 2023

Early otic development depends on autophagy for apoptotic cell clearance and neural differentiation.

scientific article

Editorial: Aging, neurogenesis and neuroinflammation in hearing loss and protection.

scientific article published on 17 July 2015

Editorial: Hormones and Neural Aging: Lessons From Experimental Models

scientific article published on 15 November 2018

Editorial: Inner ear biology: Development, physiopathology, repair and recovery

scientific article published on 13 October 2022

Editorial: Neuroimmunology of the Inner Ear

scientific article published in 2021

Editorial: Otologic Trauma, Pathology, and Therapy

scientific article published in 2022

Editorial: The Role of Cellular Senescence in Health and Disease

scientific article published in 2022

Erratum to: IGF-1 deficiency causes atrophic changes associated with upregulation of VGluT1 and downregulation of MEF2 transcription factors in the mouse cochlear nuclei

scientific article published on 22 November 2014

European scientific, ethical, and legal issues on human stem cell research and regenerative medicine

scientific article published in June 2010

Expression and function of phospholipase A(2) in brain

scientific article

Folic acid as preventive therapy for hearing loss: effect of ototoxic drug consumption

scientific article published in 2020

Folic acid deficiency induces premature hearing loss through mechanisms involving cochlear oxidative stress and impairment of homocysteine metabolism

scientific article

Frailty in mouse ageing: A conceptual approach

scientific article

G6PD overexpression protects from oxidative stress and age-related hearing loss

scientific article published on 22 November 2020

Genetic, molecular and biochemical basis of the auditory aging: lessons from experimental models

scientific article published in 2022

Glycosyl phosphatidylinositol (GPI)/inositolphosphate glycan (IPG): an intracellular signalling system involved in the control of thyroid cell proliferation.

scientific article published on December 1998

Glycosyl-phosphatidylinositol-phospholipase Type D: A Possible Candidate for the Generation of Second Messengers

scientific article published in April 1997

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

Guía de práctica clínica sobre el manejo del schwannoma vestibular

scientific article published in March 2024

IGF-1 Controls Metabolic Homeostasis and Survival in HEI-OC1 Auditory Cells through AKT and mTOR Signaling

scientific article published on 19 January 2023

IGF-1 Haploinsufficiency Causes Age-Related Chronic Cochlear Inflammation and Increases Noise-Induced Hearing Loss

scientific article published in 2021

IGF-1 deficiency causes atrophic changes associated with upregulation of VGluT1 and downregulation of MEF2 transcription factors in the mouse cochlear nuclei.

scientific article published on 7 November 2014

Induction of cell growth by insulin and insulin-like growth factor-I is associated with Jun expression in the otic vesicle

scientific article

Inositol Phosphatides and Transmembrane Signaling

scientific article published on 18 January 2018

Inositol-phosphoglycan inhibits calcium oscillations in hepatocytes by reducing calcium entry

scientific article published in February 1997

Insulin receptor substrate 2 (IRS2)-deficient mice show sensorineural hearing loss that is delayed by concomitant protein tyrosine phosphatase 1B (PTP1B) loss of function

scientific article

Insulin-like Growth Factor 1 Signaling in Mammalian Hearing

scientific article published in 2021

Insulin-like growth factor 1 is required for survival of transit-amplifying neuroblasts and differentiation of otic neurons

scientific article published in October 2003

Intraoperative assessment of cochlear nerve functionality in various vestibular schwannoma scenarios: Lessons learned

scientific article published in May 2024

Introduction to structural and functional studies on nerve growth factor

scientific article published on 15 May 1999

Isolation and partial characterisation of insulin-mimetic inositol phosphoglycans from human liver.

scientific article published in August 1997

Jejunal microvilli atrophy and reduced nutrient transport in rats with advanced liver cirrhosis: improvement by Insulin-like Growth Factor I

scientific article

Lipid signalling: cellular events and their biophysical mechanisms

scholarly article by Edward A. Dennis published in September 2002

Liver cell proliferation requires methionine adenosyltransferase 2A mRNA up-regulation

scientific journal article

Long-Term Dietary Folate Deficiency Accelerates Progressive Hearing Loss on CBA/Ca Mice.

scientific article published on 31 August 2016

Long-term omega-3 fatty acid supplementation prevents expression changes in cochlear homocysteine metabolism and ameliorates progressive hearing loss in C57BL/6J mice

scientific article published on 31 July 2015

Loss of lysophosphatidic acid receptor LPA1 alters oligodendrocyte differentiation and myelination in the mouse cerebral cortex.

scientific article published on 17 September 2014

MPZL2, Encoding the Epithelial Junctional Protein Myelin Protein Zero-like 2, Is Essential for Hearing in Man and Mouse

scientific article published on 28 June 2018

Melanin precursors prevent premature age-related and noise-induced hearing loss in albino mice

scientific article published on 19 October 2009

Mild cognitive decline. A position statement of the Cognitive Decline Group of the European Innovation Partnership for Active and Healthy Ageing (EIPAHA).

scientific article

Modelling physical resilience in ageing mice

article

Molecular Basis of Deafness Caused by Insulin-like Growth Factor Type 1 Deficiency.

scholarly article

Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in Age-Related Hearing Loss

scientific article

Neuroglial Involvement in Abnormal Glutamate Transport in the Cochlear Nuclei of the Igf1−/− Mouse

scientific article published on 01 March 2019

Otic Neurogenesis Is Regulated by TGFβ in a Senescence-Independent Manner

scientific article published on 17 August 2020

Pattern of methionine adenosyltransferase isoenzyme expression during rat liver regeneration after partial hepatectomy

scientific article published on 01 April 1998

Phospholipase cleavage of glycosylphosphatidylinositol reconstituted in liposomal membranes.

scientific article

Phosphorylation of glycosyl-phosphatidylinositol by phosphatidylinositol 3-kinase changes its properties as a substrate for phospholipases.

scientific article published in January 2005

Pollen-induced airway inflammation, hyper-responsiveness and apoptosis in a murine model of allergy

scientific article published in March 2007

Programmed cell death in the developing inner ear is balanced by nerve growth factor and insulin-like growth factor I

scientific article published on 01 February 2003

Programmed cell senescence during mammalian embryonic development

scientific article published on 14 November 2013

Protection of lipopolysaccharide-induced otic injury by a single dose administration of a novel dexamethasone formulation

scientific article published on 11 October 2023

Public investment in biomedical research in Europe

scientific article published in October 2015

RAF kinase activity regulates neuroepithelial cell proliferation and neuronal progenitor cell differentiation during early inner ear development

scientific article

RNA microarray analysis in prenatal mouse cochlea reveals novel IGF-I target genes: implication of MEF2 and FOXM1 transcription factors.

scientific article

RasGRF1 disruption causes retinal photoreception defects and associated transcriptomic alterations.

scientific article

Role of Glycosyl Phosphatidylinositols in Insulin Signaling

scientific article published on 18 January 2018

Role of Phosphatidylinositol in Protein Attachment

scientific article published on 18 January 2018

Sensorineural hearing loss in insulin-like growth factor I-null mice: a new model of human deafness

scientific article published in January 2006

Serum deprivation increases ceramide levels and induces apoptosis in undifferentiated HN9.10e cells

scientific article published on April 2002

Short-chain ceramide regulates hepatic methionine adenosyltransferase expression.

scientific article

Solid Lipid Nanoparticles Loaded with Glucocorticoids Protect Auditory Cells from Cisplatin-Induced Ototoxicity

scientific article published on 14 September 2019

Spatial and temporal segregation of auditory and vestibular neurons in the otic placode

scientific article published on 19 July 2008

Strict regulation of c-Raf kinase levels is required for early organogenesis of the vertebrate inner ear.

scientific article published in January 1999

Swept-sine noise-induced damage as a hearing loss model for preclinical assays

scientific article

Synthesis and investigation of the possible insulin-like activity of 1d-4-O- and 1d-6-O-(2-amino-2-deoxy-α-d-glucopyranosyl) myo-inositol 1-phosphate and 1d-6-O-(2-amino-2-deoxy-α-d-glucopyranosyl) myo-inositol 1,2-(cyclic phosphate)

scientific article published in November 1994

TGFβ2-induced senescence during early inner ear development

scientific article published on 11 April 2019

Tackling frailty and functional decline: Background of the action group A3 of the European innovation partnership for active and healthy ageing

article

Targeting cholesterol homeostasis to fight hearing loss: a new perspective

scientific article

The Role of Insulin-Like Growth Factor 1 in the Progression of Age-Related Hearing Loss

scientific article published on 12 December 2017

The Value of Mouse Models of Rare Diseases: A Spanish Experience

scientific article published on 14 October 2020

The expression of oxidative stress response genes is modulated by a combination of resveratrol and N-acetylcysteine to ameliorate ototoxicity in the rat cochlea.

scientific article published on 14 December 2017

The role of glycosyl-phosphatidylinositol in signal transduction

scientific article published in March 1998

Towards the in vitro reconstitution of caveolae. Asymmetric incorporation of glycosylphosphatidylinositol (GPI) and gangliosides into liposomal membranes

scientific article published on 01 August 1999

Transforming growth factor β1 inhibition protects from noise-induced hearing loss.

scientific article

Treatment with N- and C-terminal peptides of parathyroid hormone-related protein partly compensate the skeletal abnormalities in IGF-I deficient mice

scientific article

Trophic effects of insulin-like growth factor-I (IGF-I) in the inner ear.

scientific article published in October 2004

Tumors of the nervous system and hearing loss: Beyond vestibular schwannomas

scientific article published in June 2024

Uncovering cellular senescence as a therapeutic target in NF2-related vestibular schwannoma

scientific article published in January 2025

Use of Radical Oxygen Species Scavenger Nitrones to Treat Oxidative Stress-Mediated Hearing Loss: State of the Art and Challenges

scientific article published in 2021

Usefulness of Electrical Auditory Brainstem Responses to Assess the Functionality of the Cochlear Nerve Using an Intracochlear Test Electrode

scientific article

Wbp2 is required for normal glutamatergic synapses in the cochlea and is crucial for hearing.

scientific article

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